WO2005065429A3 - Composition and method for treatment of hepatic encephalopathy - Google Patents

Composition and method for treatment of hepatic encephalopathy Download PDF

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Publication number
WO2005065429A3
WO2005065429A3 PCT/US2005/000001 US2005000001W WO2005065429A3 WO 2005065429 A3 WO2005065429 A3 WO 2005065429A3 US 2005000001 W US2005000001 W US 2005000001W WO 2005065429 A3 WO2005065429 A3 WO 2005065429A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
treatment
lactulose
hepatic encephalopathy
peg
Prior art date
Application number
PCT/US2005/000001
Other languages
French (fr)
Other versions
WO2005065429B1 (en
WO2005065429A2 (en
Inventor
George M Halow
Original Assignee
George M Halow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by George M Halow filed Critical George M Halow
Publication of WO2005065429A2 publication Critical patent/WO2005065429A2/en
Publication of WO2005065429A3 publication Critical patent/WO2005065429A3/en
Publication of WO2005065429B1 publication Critical patent/WO2005065429B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The inventions provide an improved treatment for hepatic encephalopathy characterized by hyperammonemia and/or constipation, comprising the oral administration of polyethylene glycol (PEG) in amounts sufficient to reduce plasma levels of ammonia and/or to alleviate constipation. Preferably, the PEG is administered in combination with lactulose, which provides a palatale composition with lactulose, which provides a palatable composition for the treatment of HE with excellent therapeutic benefits and reduced side effects as compared to lactulose alone.
PCT/US2005/000001 2003-12-31 2005-01-03 Composition and method for treatment of hepatic encephalopathy WO2005065429A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/748,185 2003-12-31
US10/748,185 US7256202B2 (en) 2003-12-31 2003-12-31 Composition and method for treatment of hepatic encephalopathy

Publications (3)

Publication Number Publication Date
WO2005065429A2 WO2005065429A2 (en) 2005-07-21
WO2005065429A3 true WO2005065429A3 (en) 2006-02-23
WO2005065429B1 WO2005065429B1 (en) 2006-04-06

Family

ID=34700855

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/000001 WO2005065429A2 (en) 2003-12-31 2005-01-03 Composition and method for treatment of hepatic encephalopathy

Country Status (2)

Country Link
US (2) US7256202B2 (en)
WO (1) WO2005065429A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006017672B4 (en) * 2006-04-12 2008-07-03 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Composition for use as a laxative
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
MX2011003548A (en) 2008-10-02 2011-06-21 Salix Pharmaceuticals Ltd Methods of treating hepatic encephalopathy.
IES20110480A2 (en) * 2010-11-04 2012-07-18 Norgine Bv A solid formulation for oral administration comprising polyethylene glycol and mannitol
EP2887806B1 (en) 2012-07-20 2019-11-13 University Of Rochester Method of treating and preventing brain impairment using na+-k+ -2ci- cotransporter isoform 1 inhibitors
CA2926466C (en) * 2013-10-03 2021-11-16 Frederic Bushman Compositions comprising a defined microbiome and methods of use thereof
US10058576B2 (en) 2013-10-03 2018-08-28 The Trustees Of The University Of Pennsylvania Compositions and methods comprising a defined microbiome and methods of use thereof
EA201692106A1 (en) 2014-04-29 2017-04-28 КОЛОНАРИКОНСЕПТС ЭлЭлСи FOOD PRODUCTS, SYSTEMS, METHODS AND KITS FOR REPLACING ELECTROLYTES
AU2016226380A1 (en) 2015-03-02 2017-09-21 Colonaryconcepts Llc Compounds and methods for PEG metabolite and PEG breakdown product assays
EP3399973A4 (en) * 2016-01-08 2019-09-04 Colonaryconcepts LLC Food based delivery of therapeutic agent for treatment of hepatic encephalopathy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1230918A2 (en) * 1997-08-01 2002-08-14 Francesco Vicidomini An aqueous enteroclysis solution for the treatment of hepatic encephalopathy

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505309A (en) * 1967-09-25 1970-04-07 Research Corp Process for lactulose
JPS4944331B1 (en) * 1971-05-31 1974-11-27
US4100161A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Promotion of protein synthesis and suppression of urea formation in the body by keto analogs of essential amino acids
CA1054436A (en) * 1975-07-04 1979-05-15 Katsuto Okada Process for preparing a lactulose-containing powder for feed
US4147773A (en) * 1977-12-12 1979-04-03 Morinaga Milk Industry Co., Ltd. Powdery composition comprising viable Bifidobacteria cells and lactulose
US4966236A (en) * 1987-08-12 1990-10-30 Texas Iron Works, Inc. Cementing method and arrangement
CA1329805C (en) * 1988-03-18 1994-05-24 Hendrikus W. Weterings Method of preparing solid lactulose
US4996236A (en) * 1988-06-22 1991-02-26 Takeda Chemical Industries, Ltd. Therapeutic composition for hepatic encephalopathy
ATE138922T1 (en) * 1990-10-12 1996-06-15 Duphar Int Res SOLID LACTULOSE
US5571783A (en) * 1993-03-09 1996-11-05 Clintec Nutrition Company Composition and method for treating patients with hepatic disease
DE4314705A1 (en) * 1993-05-04 1994-11-10 Bolder Arzneimittel Gmbh Lactulose pastilles
US6444198B1 (en) * 1999-02-22 2002-09-03 Smithkline Beecham Corporation Effervescent laxatives
DE60033019D1 (en) * 1999-03-17 2007-03-08 Morinaga & Co MEDICINES, FOODS, BEVERAGES AND FEED CONTAINING A COCOA COMPONENT
DE60137235D1 (en) * 2000-08-25 2009-02-12 Wakamoto Pharma Co Ltd L. salivarius strain containing probiotic products
US6645481B1 (en) * 2000-09-28 2003-11-11 Braintree Laboratories, Inc. Method of achieving overnight laxation and control of bowel function
SI1663257T1 (en) * 2003-07-09 2009-06-30 Braintree Lab Use of laxatives for treating irritable bowel syndrome

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1230918A2 (en) * 1997-08-01 2002-08-14 Francesco Vicidomini An aqueous enteroclysis solution for the treatment of hepatic encephalopathy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ATTAR ET AL.: "Comparison of a low dose polythylene glycol elecrolyte solution with lactulose for treatment of chronic constipation.", GUT, vol. 44, 1999, pages 226 - 230, XP001053493 *
ROBIN ET AL.: "Use of polythylene glycol 4000 in hepatic encephalopathy linked to digestive hemorraging.", GASTROENTEROL CLIN BIOL., vol. 18, no. 12, 1994, pages 1146 *

Also Published As

Publication number Publication date
US7256202B2 (en) 2007-08-14
US20050142099A1 (en) 2005-06-30
WO2005065429A2 (en) 2005-07-21
US20070269403A1 (en) 2007-11-22

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