WO2005067737A1 - Complement alimentaire destine a combler les deficits nutritionnels - Google Patents

Complement alimentaire destine a combler les deficits nutritionnels Download PDF

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Publication number
WO2005067737A1
WO2005067737A1 PCT/FR2004/003404 FR2004003404W WO2005067737A1 WO 2005067737 A1 WO2005067737 A1 WO 2005067737A1 FR 2004003404 W FR2004003404 W FR 2004003404W WO 2005067737 A1 WO2005067737 A1 WO 2005067737A1
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WIPO (PCT)
Prior art keywords
food supplement
agent
food
supplement according
vitamin
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PCT/FR2004/003404
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English (en)
French (fr)
Inventor
Marianne Hotchen
Original Assignee
Arandi Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of WO2005067737A1 publication Critical patent/WO2005067737A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a food supplement making it possible to correct the nutritional deficiencies associated with many pathologies, and to reduce the risk factors for the progression or complication of the pathology.
  • Food supplements can be defined as foodstuffs whose purpose is to supplement the normal diet and which constitute a concentrated source of nutrients or other substances having a nutritional and / or physiological effect. These supplements which are generally marketed in the form of doses, namely, forms of presentation such as capsules, lozenges, tablets, pills and other similar forms, as well as sachets of powder, ampoules of liquid, vials fitted with drop counters and other similar forms of liquid or powder preparations intended to be taken in measured units of small quantity. Food supplements are available through various commercial sources, including health food stores, grocery stores, pharmacies, etc.
  • One of the first food supplements was in the form of a multi-vitamin tablet or capsule. and minerals, available in pharmacies.
  • the most widespread food supplements include vitamins, minerals, nutrients or other substances having a nutritional or physiological effect of synthetic, or natural, animal, or vegetable origin.
  • Food supplements are mainly used for weight loss (25%), well-being (45%) and beauty (25%). Due to regulatory restrictions, uses relating to diseases (prevention, treatment or cure) are not authorized, even if most of the products contain elements with confirmed pharmacological activity. According to Community regulations, food supplements can mention three categories of claims: nutritional, functional and relating to the reduction of a risk of disease (health claim).
  • food supplements can include plants, coming from one or more sources, because plants are known for their phytotherapeutic activity. They may also include nutrients such as vitamins and / or minerals.
  • Application EP 1 355 540 describes a food supplement with a slimming effect, which strengthens the skeletal muscle and protects the cardiovascular system, the components of said supplement being the following L-carnitine propionyl, coenzyme Qlo, nicotinamide, riboflavin and pantothenic acid.
  • the patent FR 2 747 017 relates to a food supplement intended to ensure and develop an optimal supply of natural substances which a healthy organism needs, both at the level of the skin and of the organism in general.
  • the supplement described in this reference contains natural extracts of the following fruits and vegetables: fig, bitter orange, lime, lime, carrot, parsley, celery, fennel, tomato, parsnip.
  • Application WO 02 054 890 relates to a food supplement for maintaining and improving the good health of the skin, comprising the following compounds: lycopene, carotenoids, biotin, chromium and selenium.
  • the application US 2002 172 724 relates to a composition making it possible to reduce the risk of loss of bone density, comprising in particular a compound of calcium and inulin, in a dietetically acceptable form.
  • Organic diseases are usually accompanied by a metabolic deficiency. They are treated with specific medications and appropriate support measures. Thus, pre-diabetic conditions and type II diabetes are treated with a variety of pharmacological agents intended to reduce blood sugar levels or insulin resistance.
  • Metabolic therapies are used when significant blood glucose abnormalities are detected and anti-aggregating agents are commonly prescribed to delay the onset of the vascular complication of diabetes in the retina or retinopathy. Usually a diet is also advised, but is not always followed well.
  • Selenium a powerful antioxidant, also has an inhibitory effect on the aggregation of blood platelets, cells which play a role in the generation of vascular complications.
  • Vitamin E helps decrease diabetic retinopathy (defined above) and vitamin C is active in preventing retinopathy and cataracts.
  • Osteoarthritis is the most common chronic rheumatic disease. Various factors can be implicated in its appearance, such as age, obesity, genetic factors, etc. Osteoarthritis is usually treated with anti-inflammatory drugs to reduce pain and signs. inflammation.
  • Metabolic deficiencies (such as vitamin deficiency) involved in the pathology are much less often taken into consideration, although their accumulation contributes to the imbalance of the organism and constitutes an additional risk for the evolution of the disease and its complications.
  • a selenium deficiency can lead to the inhibition of the synthesis of type II collagen by chondrocytes (the cells that generate cartilage).
  • Vitamin C deficiency decreases the inhibition of arylsulfatase, an enzyme that destroys the sulfate bonds in glycosaminoglycans, essential components of cartilage.
  • zinc naturally present in healthy chondrocytes and the extracellular matrix, is reduced, in quantity, by 50% in certain forms of rheumatic disease.
  • Vitamin D Low levels of vitamin D have been inversely correlated with increased severity of Osteoarthritis and loss of cartilage.
  • Vitamin B6 deficiency causes a decrease in the concentration of proteoglycans in the cartilage, making it more fragile. It therefore appears from the above that the accompanying measures for certain diseases are not always sufficient to completely control the pathology and prevent the generation of risk factors for various complications.
  • the nutritional deficiencies usually associated with these diseases are very rarely taken into consideration: thus, the vitamins, minerals, trace elements and antioxidants present in a patient are not part of the biological assessments carried out for the majority of diseases.
  • One of the aims of the present invention is to provide health professionals and patients with natural and pleasant means of filling their nutritional deficits linked to their disease, and of optimizing the conditions for their specific treatment.
  • Another aim is to prepare a food supplement intended to accompany the specific drug treatment of a determined disease, in order to correct the nutritional deficiencies linked to this disease, and to reduce the risk of complications and / or progression towards possible complications .
  • Yet another object of the invention is to prepare a food supplement acting in synergy with a medicament intended to treat a specific disease.
  • the food supplement according to the invention is characterized in that it comprises a pasty matrix based on polymerized carbohydrates giving it a solid or semi-solid gelled consistency, in which one or more nutrients and / or ingredients having a nutritional effect are incorporated. and / or physiological.
  • the pasty matrix is based on fructo-oligosaccharides giving it a filamentous structure.
  • the nutrients and / or ingredients are advantageously chosen from extracts of plant origin, fruits, vegetables, plants, and / or of animal origin, vitamins, macro-elements and trace elements.
  • the extracts used are crude or purified and / or correspond to synthetic products authorized for human consumption.
  • Fruit, vegetable, and / or plant extracts correspond in particular to concentrated juices, pulp and dry extracts or powders.
  • the following vegetables are advantageously used: cabbage, carrot, garlic, onion, broccoli, artichoke, celery, card, mushrooms, spinach, fennel, olive, purslane, soybeans, or their mixtures.
  • Suitable plants include: turmeric, ginger, saffron, nutmeg, thyme, rosemary, cumin, chilli, mint, paprika, sage.
  • Other plant extracts are chosen from: angelica, oats, bamboo, banaba, burdock, boswella, chamomile, cordalys, echinacea, ash, garcinia, ginseng, gingko, griffonia, cola, lithotamus, neem, mastic, blueberry, olive, nettle, poplar, licorice, rose, scrutellar, shitake, silgesbeckia, green tea, white tea, black tea, violet, or their mixtures.
  • Vitamins are selected, in particular, from the group comprising vitamin A, vitamin B1, vitamin B2, vitamin B3 (PP), vitamin B5, vitamin B6, vitamin B9, vitamin B12, vitamin C , vitamin D, vitamin E, vitamin K, or their mixtures.
  • the minerals are chosen in particular from the group comprising calcium, magnesium, iron, phosphorus, potassium, sodium or their mixtures. As trace elements, mention will be made of those of the group comprising copper, iron, iodine, manganese, selenium, zinc, chromium, molybdenum, fluorine, or their mixtures.
  • the carbohydrates are advantageously chosen from the group comprising simple dares (for example: glucose, mannose, galactose ribose, fructose), derivatives of dares (for example: lactose, sucrose, maltose, glucuronic acid, fucose), polysaccharides (starches, glycogen, cellulose), heterosides or their mixtures.
  • the proteins are chosen from the group comprising by amino acids (for example arginine, aspartic acid, glutamine etc.), amino acid derivatives (for example carnitine, omithine, hydroxyproline, glutathione, etc.), and proteins or their mixtures or their derivatives.
  • the lipids are chosen from the group comprising by fats of vegetable or animal origin, fatty acids (for example palmitic, stearic, oleic, linoleic, linolenic, arachidonic acid), lipid alcohols (for example glycerol, ethanolamine , serine, choline, inositol), neutral lipids (for example glyceride, diglyceride), complex lipids (for example lecithin, phosphatidyl - serine, phosphatidyl inositol, sphingolipids, cerebrosides), or mixtures thereof.
  • fatty acids for example palmitic, stearic, oleic, linoleic, linolenic, arachidonic acid
  • lipid alcohols for example glycerol, ethanolamine , serine, choline, inositol
  • neutral lipids for example glyceride, diglyceride
  • the pasty matrix serving as a base for the food supplement of the invention further comprises a humidifying agent, or a diluting agent, an emulsifying, stabilizing and / or gelling agent, a sweetening agent, an agent flavor developer, food flavoring agent, food coloring agent and / or coating agent.
  • the sweetening agent is for example a natural sugar such as glucose, fructose, sucrose, sorbitol, xylitol and / or an artificial sweetening agent, such as for example aspartame, acesulfame, saccharin or others from group E 900 to
  • E 1520 or mixtures thereof.
  • the following ingredients can also be incorporated into the pasty matrix, for example food flavoring agents, such as fruit flavorings, natural or synthetic, food coloring agents chosen for example from the group E100 to E180 and / or coating.
  • Other products include preservatives, chosen for example from the group E200 to E 297, antioxidants chosen in particular from the group E300 to E 321, emulsifiers, stabilizers and / or gelling agents.
  • the acidifying or basifying agents are chosen in particular from the group
  • Preferred food supplements contain approximately 10% to 70% by weight of active ingredients, that is to say with nutritional and / or physiological effect, relative to the total weight of said supplements.
  • Food supplement characterized in that the amount of the various constituents of the basic formulation varies in particular from 30% to 90% by weight relative to the total weight of said supplement.
  • the active ingredients present in the food supplement of the invention have not undergone any alteration during the preparation of said supplement.
  • the pasty matrices of the invention are firstly prepared by heating the constituents used up to a temperature not exceeding about 60 ° C., and the active ingredients are added thereto.
  • the food supplements of the present invention may for example be taken in association with accompanying specific treatments suitable for the following pathologies: cardiovascular diseases, gastrointestinal diseases, neurological diseases, infectious diseases, dermatological diseases, osteoarticular diseases, metabolic diseases, degenerative diseases, etc., this list however not being exhaustive.
  • Preferred food supplement formulations are in 10 g portions, chewable, in individual packaging.
  • the pleasant taste of the supplements facilitates the proper monitoring of their prescription. These portions are advantageously taken outside of meals and outside of medication.
  • the following examples illustrate the invention. They do not limit it in any way.
  • Example 1 - Food supplement intended for subjects affected by glucose intolerance syndrome or type 2 diabetes.
  • the composition of such a food supplement comprises: - a grape seed extract, a powerful antioxidant, 10-50 g / kg, especially 30 g / kg.
  • - L-carnitine to prevent neuropathy 1-20g / kg, especially 15g / kg - Vitamin B12 to prevent neuropathic pain 0.1-0.5 mg / kg, especially 0.3 mg / kg - Vitamin C to prevent cataracts and retinopathy 3-20 g / kg, especially 6 g / kg - Vitamin E to prevent "retinopathy" 0.5-2 g / kg, especially 1, 2 g / kg -
  • Magnesium to correct deficits due to diabetes 10-50 g / kg, in particular 30 g / kg - Chromium to improve sugar metabolism 5-15 mg / kg, in particular 12.5 mg / kg - Zinc to protect the insulin receptor gene for oxidation 0.2-1.5 g / kg, especially 1.2
  • the method of administration of the supplement described above is as follows: It may be advisable, for each subject receiving a prescription for a specific treatment for a disease or a diet for the same disease, by a doctor and / or a pharmacist and / or another healthcare professional, to take a daily portion of the food supplement as described above, in order to improve his general balance and his well-being, and to reduce the risks of complications of his disease.
  • a portion of the food supplement as described above will be taken regularly, outside of meal times or medication, in order to benefit in the long term from the activity of the ingredients gathered in the pasty matrix, easy to chew and fondant in the mouth.
  • the supplement as described above improves the general balance and well-being of subjects affected by a glucose intolerance syndrome or type 2 diabetes, and makes it possible to reduce the risks of complications related to their illness.
  • Example 2 Food supplement intended for subjects affected by a degenerative joint disease such as osteoarthritis
  • the composition of such a food supplement comprises: - An extract of Boswella serrata, 10-100 g / kg, in particular 50 g / kg for its anti-inflammatory activity
  • Camellia sinensis 10-100 g / kg, especially 50 g / kg, to prevent degradation of the cartilage
  • Glucosamine 10/100 g / kg, especially 50 g / kg, to protect the cartilage and reduce inflammation
  • Vitamins B3, B6, B9, B12 respectively 0.5-2 mg / kg, in particular 1, 8 mg / kg, 0.1-0.3 mg / kg, in particular 0.2 mg / kg, 0, 01-0.05 mg / kg, in particular 0.03 mg / kg and 0.01-0.05 mg / kg, in particular 0.3 mg / kg, to contribute to the reduction of inflammation,
  • Vitamin C (3-20 g / kg, especially 6 g / kg) and vitamin E (0.5- 2 g / kg, especially 1.2 g / kg) to limit oxidative stress on the cartilage and reduce joint pain
  • Vitamin D3 (0.5-2 mg / kg, especially 1.5 mg / kg) to reduce the breakdown of cartilage
  • - Zinc 0.5-1.5 mg / kg, in particular 1, 2 mg / kg, to compensate for the reduced levels found in arthritic cartilage, in a pasty matrix composed of A - Beet fructo-oligosaccharides, 100- 800 g / kg, in particular 500 g / kg, to provide fibers, texture and softness and to increase natural immunity through its specific pre-biotic activity,
  • - Tomato concentrate 50-250 g / kg, especially 100 g / kg, a source of antioxidant lycopene, - Gelatin, 5-30 g / kg, especially 20 g / kg, gelling agent
  • the method of administration of the supplement described above is the same as that described in Example 1.
  • the supplement makes it possible to improve the general balance of the organism and the well-being of the subjects affected by osteoarthritis and allows reduce the risk of complications related to their illness.
  • the composition of such a food supplement comprises: - L-arginine (anti-atherogen, vasodilator) 2-20 g / kg, especially 10g / kg - Omega 3 fatty acids (cardiovascular protection) 50-200 g / kg, especially 100g / kg - Olive extract (antioxidant): 10-100 g / kg, especially 50g / kg - Oat extract (lowers triglyceride levels) 10-1.00 g / kg, especially 50g / kg - Kola extract (lowers fat absorption): 10-100 g / kg, especially 50g / kg - Vitamin B6: (decreases the rate of homocysteine: fight against cardiovascular complications): 0.1-0.3 g / kg, in particular 0.2g / kg - Vitamin B9 (decreases the rate of homocysteine: fight against cardiovascular complications):
  • Example 4 Food Supplement Intended for Suits Affected by Gastric Pathology The composition of such a food supplement comprises: an extract of Griffonia (rebalances mood, anti-stress) 10 g / kg, in particular 50 g / kg - an extract of Ascherrule (nervous sedative, anti-stress) 10-100 g / kg, in particular 50 g / kg - an extract of deglycyrrhinized licorice (anti-ulcer, anti-bleeding) 10- 100 g / kg, in particular 50 g / kg - an extract of Pistacia lentiscus (helps fight helicobacter pylori infections) 10-100 g / kg, especially 50 g / kg - Glutamine (amino acid participating in the health of the gastric mucosa) - Vitamin A (anti-inflammatory effect) 20-100 g / kg, especially 40mg / kg - Copper (contributes to the repair of the damaged mucosa) 50-300
  • Example 5 - Food supplement intended for people affected by arterial hypertension The composition of such a food supplement comprises: - A shark cartilage extract (contributes to lowering the blood pressure and the parathyroid hormone level) 10-100 g / kg, in particular 50 g / kg - A Hogweed spondyle extract (contributes to reducing hypertension and renal failure), 10-100 g / kg, in particular 50 g / kg - Omega 3 fatty acids (cardiovascular protection ) 50-200 g / kg, in particular 100 g / kg - L-arginine (amino acid vasodilator, anti-atherogenic and anti-platelet adhesion) 5-50 g / kg, in particular 20g / kg - Taurine (anti-stress derivative) 5-10 g / kg, in particular 20g / kg - Ubiquinone (antioxidant stabilizing membrane, increases resistance to effort and decreases ischemia) 1-10 g / kg, in particular 5 g / kg
  • L-arginine - antioxidant 3- 20 g / kg, in particular 6 g / kg - Vitamin E (reduces the triglyceride level): 0.5-2 g / kg, in particular 1, 2 g / kg - Magnesium (anti-stress - helps to fight against the formation of atheroma plaques) 10-50 g / kg, in particular 30 g / kg in a pasty matrix composed of: - Beet fructo-oligosaccharides, 100-800 g / kg, especially 500 g / kg to provide fibers, texture and softness and to increase natural immunity through its specific pre-biotic activity - Concentrated mandarin juice, 50-250 g / kg, especially 100 g / kg - Coconut pulp 50-250 g / kg, in particular 100 g / kg - Gelatin, 5-30 g / kg in particular 20 g / kg, gelling agent - Excipients: aroma, citric acid, coloring agent qs - Water
  • Example 6 Food Supplement Intended for Substances Treated by Antibiotic Therapy for a Bacterial Infection The composition of such a food supplement comprises: an extract of thyme (anti-mycotic) 10 g / kg, in particular 50 g / kg.
PCT/FR2004/003404 2003-12-29 2004-12-29 Complement alimentaire destine a combler les deficits nutritionnels WO2005067737A1 (fr)

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FR0315534 2003-12-29
FR0315534A FR2864426A1 (fr) 2003-12-29 2003-12-29 Complement alimentaire destine a combler les deficits nutritionnels

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20081478A1 (it) * 2008-08-06 2010-02-07 Moldes S R L Formulazione di gel acquoso per la somministrazione di sostanze farmaceutiche e/o nutritive
US8951507B2 (en) 2009-10-14 2015-02-10 Symrise Ag Formulation with irritation reducing action comprising bisabolol and [6]-paradol

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