WO2005094902A3 - Nanoparticles comprising luminescent substances as contrast agent for optical imaging - Google Patents

Nanoparticles comprising luminescent substances as contrast agent for optical imaging Download PDF

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Publication number
WO2005094902A3
WO2005094902A3 PCT/IB2005/051021 IB2005051021W WO2005094902A3 WO 2005094902 A3 WO2005094902 A3 WO 2005094902A3 IB 2005051021 W IB2005051021 W IB 2005051021W WO 2005094902 A3 WO2005094902 A3 WO 2005094902A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical imaging
contrast agent
nanoparticles
luminescent substances
core
Prior art date
Application number
PCT/IB2005/051021
Other languages
French (fr)
Other versions
WO2005094902A2 (en
Inventor
Claus Feldmann
Original Assignee
Philips Intellectual Property
Koninkl Philips Electronics Nv
Claus Feldmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Intellectual Property, Koninkl Philips Electronics Nv, Claus Feldmann filed Critical Philips Intellectual Property
Publication of WO2005094902A2 publication Critical patent/WO2005094902A2/en
Publication of WO2005094902A3 publication Critical patent/WO2005094902A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/77Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
    • C09K11/7766Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing two or more rare earth metals
    • C09K11/7774Aluminates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/57Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing manganese or rhenium
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/74Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing arsenic, antimony or bismuth

Abstract

A contrast agent for optical imaging comprising particles (1) consisting of at least a core (2), wherein the core comprises luminescent substances absorbing and emitting electromagnetic radiation at different wavelengths.
PCT/IB2005/051021 2004-04-01 2005-03-24 Nanoparticles comprising luminescent substances as contrast agent for optical imaging WO2005094902A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101351 2004-04-01
EP04101351.7 2004-04-01

Publications (2)

Publication Number Publication Date
WO2005094902A2 WO2005094902A2 (en) 2005-10-13
WO2005094902A3 true WO2005094902A3 (en) 2006-05-26

Family

ID=34961991

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/051021 WO2005094902A2 (en) 2004-04-01 2005-03-24 Nanoparticles comprising luminescent substances as contrast agent for optical imaging

Country Status (1)

Country Link
WO (1) WO2005094902A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1920784A1 (en) * 2006-11-13 2008-05-14 Koninklijke Philips Electronics N.V. Radiation sensitizers in ionizing radiation therapy and imaging
DE102007039335A1 (en) * 2007-08-20 2009-02-26 Henkel Ag & Co. Kgaa Luminescent composite materials
CN104178160A (en) * 2013-05-22 2014-12-03 海洋王照明科技股份有限公司 Cerium terbium double-doped nitrogen silicon lanthanum luminescent material and preparation method and application thereof
US10124072B2 (en) * 2013-09-18 2018-11-13 Caliper Life Sciences, Inc. In-vivo reactive species imaging
US9642923B2 (en) * 2014-02-24 2017-05-09 Verily Life Sciences Llc Engineered particles with polarization contrast and alignment control for enhanced imaging
KR102379752B1 (en) * 2020-08-19 2022-03-28 국민대학교산학협력단 Nanoparticles and compositions for biological imaging based on X-ray attenuation

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5893999A (en) * 1993-09-13 1999-04-13 Kabushiki Kaisha Toshiba Ultrafine inorganic phosphor, specifically binding material labeled with this phosphor, and detection method using this specific binding material
WO2001086299A2 (en) * 2000-05-05 2001-11-15 Bayer Aktiengesellschaft Doped nanoparticles as biolabels
WO2003037788A1 (en) * 2001-11-01 2003-05-08 Oxonica Limited Water soluble luminescent nanoparticles
WO2003038011A2 (en) * 2001-11-01 2003-05-08 Oxonica Limited Luminescent nanomaterials
US6699723B1 (en) * 1997-11-25 2004-03-02 The Regents Of The University Of California Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
WO2004018590A1 (en) * 2002-08-20 2004-03-04 Oxonica Limited Luminescent compounds
WO2005051846A2 (en) * 2003-11-24 2005-06-09 Universite Claude Bernard Lyon I Method for producing a nanostructured submicronic powder of sesquioxide, oxohydroxide, hydroxide or rare-earth mixed oxide
WO2005058360A2 (en) * 2003-12-17 2005-06-30 Philips Intellectual Property & Standards Gmbh Radiation therapy and medical imaging using uv emitting nanoparticles

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5893999A (en) * 1993-09-13 1999-04-13 Kabushiki Kaisha Toshiba Ultrafine inorganic phosphor, specifically binding material labeled with this phosphor, and detection method using this specific binding material
US6699723B1 (en) * 1997-11-25 2004-03-02 The Regents Of The University Of California Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
WO2001086299A2 (en) * 2000-05-05 2001-11-15 Bayer Aktiengesellschaft Doped nanoparticles as biolabels
WO2003037788A1 (en) * 2001-11-01 2003-05-08 Oxonica Limited Water soluble luminescent nanoparticles
WO2003038011A2 (en) * 2001-11-01 2003-05-08 Oxonica Limited Luminescent nanomaterials
WO2004018590A1 (en) * 2002-08-20 2004-03-04 Oxonica Limited Luminescent compounds
WO2005051846A2 (en) * 2003-11-24 2005-06-09 Universite Claude Bernard Lyon I Method for producing a nanostructured submicronic powder of sesquioxide, oxohydroxide, hydroxide or rare-earth mixed oxide
WO2005058360A2 (en) * 2003-12-17 2005-06-30 Philips Intellectual Property & Standards Gmbh Radiation therapy and medical imaging using uv emitting nanoparticles

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FELDMANN C ET AL: "INORGANIC LUMINESCENT MATERIALS: 100 YEARS OF RESEARCH AND APPLICATION", ADVANCED FUNCTIONAL MATERIALS, WILEY VCH, WIENHEIM, DE, vol. 13, no. 7, July 2003 (2003-07-01), pages 511 - 516, XP001164632, ISSN: 1616-301X *
TORCHILIN V P: "TAT PEPTIDE-MODIFIED LIPOSOMES FOR INTRACELLULAR DELIVERY OF DRUGS AND DNA", CELLULAR AND MOLECULAR BIOLOGY LETTERS, UNIVERSITY OF WROCAW. INSTITUTE OF BIOCHEMISTRY, WROCAW, PL, vol. 7, no. 2, 2002, pages 265 - 267, XP008061723, ISSN: 1425-8153 *
ZIJLMANS H J M A A ET AL: "Detection of cell and tissue surface antigens using up-converting phosphors: A new reporter technology", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 267, no. 1, 1 February 1999 (1999-02-01), pages 30 - 36, XP002185942, ISSN: 0003-2697 *

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