WO2005105040A3 - Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications - Google Patents

Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications Download PDF

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Publication number
WO2005105040A3
WO2005105040A3 PCT/US2005/013296 US2005013296W WO2005105040A3 WO 2005105040 A3 WO2005105040 A3 WO 2005105040A3 US 2005013296 W US2005013296 W US 2005013296W WO 2005105040 A3 WO2005105040 A3 WO 2005105040A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical agents
soluble
applications
water
formulations
Prior art date
Application number
PCT/US2005/013296
Other languages
French (fr)
Other versions
WO2005105040A2 (en
Inventor
Wenjie Li
Amy Nguyen
Edward Alosio
Bricini Faith Bim Dema-Ala
Original Assignee
Micelle Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micelle Products Inc filed Critical Micelle Products Inc
Publication of WO2005105040A2 publication Critical patent/WO2005105040A2/en
Publication of WO2005105040A3 publication Critical patent/WO2005105040A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Abstract

Aqueous liquid or gel formulations of fat soluble vitamins, essential nutrients and other pharmaceutical agents have enhanced concentration of the active components relative to known compositions and therefore have enhanced bioavailability. The aqueous solutions or gels form a free flowing powder when they are absorbed on a suitable pharmaceutically acceptable solid carrier, such as silicon dioxide, maltodextrin, magnesium oxide, aluminum hydroxide, magnesium trisilicate, starch or sugars, or encapsulated by polymers such as gelatin, pectin, chitosan and the like.
PCT/US2005/013296 2004-04-26 2005-04-19 Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications WO2005105040A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56536304P 2004-04-26 2004-04-26
US60/565,363 2004-04-26

Publications (2)

Publication Number Publication Date
WO2005105040A2 WO2005105040A2 (en) 2005-11-10
WO2005105040A3 true WO2005105040A3 (en) 2006-10-19

Family

ID=34966409

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/013296 WO2005105040A2 (en) 2004-04-26 2005-04-19 Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications

Country Status (2)

Country Link
US (1) US20050238675A1 (en)
WO (1) WO2005105040A2 (en)

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US8147815B2 (en) * 2005-12-16 2012-04-03 Celmatrix Corporation Topical administration carrier composition and therapeutic formulations comprising same
US8148374B2 (en) 2007-02-23 2012-04-03 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
DE102008008554A1 (en) * 2008-02-12 2009-08-13 Sebapharma Gmbh & Co. Cosmetic or medicinal preparation containing biotin
EA022950B1 (en) * 2008-05-02 2016-03-31 Джилид Сайэнс, Инк. Use of silicon dioxide carrier particles to improve the processability of a pharmaceutical agent
DE102009008094A1 (en) * 2009-02-09 2010-08-19 Barnikol-Keuten, Doris, Dr. In situ adhesive gel-forming preparations, in particular for topical application to moisturized skin / mucosa
EP2488022B1 (en) 2009-10-16 2018-01-10 Mochida Pharmaceutical Co., Ltd. Compositions
CZ302789B6 (en) 2009-11-25 2011-11-09 Zentiva, K. S. Method of increasing solubility of pharmaceutically active compounds and targeted (controlled) transport thereof into intestine
TW201138782A (en) 2010-04-26 2011-11-16 Besins Healthcare Lu Sarl Low-oil pharmaceutical emulsion compositions comprising progestogen
JP2015527877A (en) * 2012-07-03 2015-09-24 コーニンクレッカ フィリップス エヌ ヴェ Method and apparatus for increasing the solubility of fat-soluble nutrients in water
CN104411185A (en) * 2012-07-03 2015-03-11 皇家飞利浦有限公司 A method and apparatus for increasing the solubility of fat-soluble nutrient in water
DE102012014581A1 (en) * 2012-07-24 2014-01-30 Azoba Health Care Ag vitamin preparation
PL2919903T3 (en) 2012-11-14 2020-12-14 W.R. Grace & Co. - Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide
AU2014239651A1 (en) * 2013-03-14 2015-10-15 Pharmaceutical Productions Inc. Method of treating vitamin B12 deficiency
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
AU2016324349A1 (en) * 2015-09-17 2018-02-15 Pharmako Biotechnologies Pty Limited Ubiquinone and ubiquinol compositions, and methods relating thereto
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US9962444B2 (en) 2016-09-27 2018-05-08 Shane Malek Pharmacokinetically extended action topical hair growth formulation, and administration method
US10656059B2 (en) 2018-03-07 2020-05-19 Alcala Pharmaceutical, Inc. Method for qualitative and quantitative multiplexing of drug analytes from biological samples
CN109105723B (en) * 2018-08-29 2022-12-09 湖北欣和生物科技有限公司 Beta-carotene emulsion and preparation method thereof
CN115515566A (en) * 2020-02-11 2022-12-23 艾德文治疗公司 Compositions of vitamin A palmitate, processes for their preparation, uses and methods including them

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WO2000061113A1 (en) * 1999-04-12 2000-10-19 Phares Pharmaceuticals Research N.V. Lipid aggregate forming compositions and their uses
WO2003066025A1 (en) * 2002-02-01 2003-08-14 Micelle Products, Inc. Clear micellized formulations of beta-carotene for treating leukoplakia
WO2004054540A2 (en) * 2002-12-12 2004-07-01 Micelle Laboratories, Inc. Solid compositions with improved bio-availability of insoluble or poorly water soluble drugs and a corresponding process for preparing such

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EP0165352A2 (en) * 1984-05-01 1985-12-27 Bioglan Laboratories (Aust.) Pty. Limited Clear micellized solutions of fat soluble essential nutrients
WO1994021231A1 (en) * 1993-03-22 1994-09-29 Betatene Limited Therapeutic agent for the treatment of melanomas
WO2000061113A1 (en) * 1999-04-12 2000-10-19 Phares Pharmaceuticals Research N.V. Lipid aggregate forming compositions and their uses
WO2003066025A1 (en) * 2002-02-01 2003-08-14 Micelle Products, Inc. Clear micellized formulations of beta-carotene for treating leukoplakia
WO2004054540A2 (en) * 2002-12-12 2004-07-01 Micelle Laboratories, Inc. Solid compositions with improved bio-availability of insoluble or poorly water soluble drugs and a corresponding process for preparing such

Also Published As

Publication number Publication date
US20050238675A1 (en) 2005-10-27
WO2005105040A2 (en) 2005-11-10

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