WO2005105053A3 - Active drug delivery in the gastrointestinal tract - Google Patents

Active drug delivery in the gastrointestinal tract Download PDF

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Publication number
WO2005105053A3
WO2005105053A3 PCT/IL2005/000301 IL2005000301W WO2005105053A3 WO 2005105053 A3 WO2005105053 A3 WO 2005105053A3 IL 2005000301 W IL2005000301 W IL 2005000301W WO 2005105053 A3 WO2005105053 A3 WO 2005105053A3
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
drug delivery
gastrointestinal tract
active drug
drug
Prior art date
Application number
PCT/IL2005/000301
Other languages
French (fr)
Other versions
WO2005105053A2 (en
Inventor
Yossi Gross
Yoram Sela
Ziv Belsky
Rina Lev
Daniel Goldstein
Original Assignee
Pill Pharma Ltd E
Yossi Gross
Yoram Sela
Ziv Belsky
Rina Lev
Daniel Goldstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/838,072 external-priority patent/US20040267240A1/en
Application filed by Pill Pharma Ltd E, Yossi Gross, Yoram Sela, Ziv Belsky, Rina Lev, Daniel Goldstein filed Critical Pill Pharma Ltd E
Priority to RU2006143632/14A priority Critical patent/RU2006143632A/en
Priority to JP2007512710A priority patent/JP2007536377A/en
Priority to CA002562741A priority patent/CA2562741A1/en
Priority to EP05718874A priority patent/EP1746977A4/en
Priority to AU2005237318A priority patent/AU2005237318A1/en
Publication of WO2005105053A2 publication Critical patent/WO2005105053A2/en
Publication of WO2005105053A3 publication Critical patent/WO2005105053A3/en
Priority to IL178655A priority patent/IL178655A0/en
Priority to US11/579,246 priority patent/US20080063703A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00147—Holding or positioning arrangements
    • A61B1/00156—Holding or positioning arrangements using self propulsion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70—Manipulators specially adapted for use in surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70—Manipulators specially adapted for use in surgery
    • A61B34/72—Micromanipulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37205—Microstimulators, e.g. implantable through a cannula
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K13/00—Thermometers specially adapted for specific purposes
    • G01K13/20—Clinical contact thermometers for use with humans or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00011—Operational features of endoscopes characterised by signal transmission
    • A61B1/00016—Operational features of endoscopes characterised by signal transmission using wireless means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
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    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0008—Temperature signals
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • A61B5/036—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs by means introduced into body tracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
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    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
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    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/3756—Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Apparatus (30) for drug administration is provided, including an ingestible capsule (32), which includes a drug (36), stored by the capsule (32), and an environmentally-sensitive mechanism (18), adapted to change a state thereof responsively to a disposition of the capsule (32) within a gastrointestinal (GI) tract (50) of a subject. The capsule (32) further includes first and second electrodes (16), and a control component (14), adapted to facilitate passage of the drug (36), in response to a change of state of the environmentally-sensitive mechanism (18), through an epithelial layer of the GI tract (50) by driving the first and second electrodes (16) to apply a series of pulses at a current of less than about 10 mA, at a frequency of between about 12 Hz and about 24 Hz, and with a pulse duration of between about 0.5 milliseconds and about 3 milliseconds. Other embodiments are also described.
PCT/IL2005/000301 2004-05-03 2005-03-16 Active drug delivery in the gastrointestinal tract WO2005105053A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
RU2006143632/14A RU2006143632A (en) 2004-05-03 2005-03-16 ACTIVE DELIVERY OF THE MEDICINE IN THE GASTROINTESTINAL TRACT
JP2007512710A JP2007536377A (en) 2004-05-03 2005-03-16 Delivery of active ingredients in the gastrointestinal tract
CA002562741A CA2562741A1 (en) 2004-05-03 2005-03-16 Active drug delivery in the gastrointestinal tract
EP05718874A EP1746977A4 (en) 2004-05-03 2005-03-16 Active drug delivery in the gastrointestinal tract
AU2005237318A AU2005237318A1 (en) 2004-05-03 2005-03-16 Active drug delivery in the gastrointestinal tract
IL178655A IL178655A0 (en) 2004-05-03 2006-10-16 Active drug delivery in the gastrointestinal tract
US11/579,246 US20080063703A1 (en) 2004-05-03 2007-08-17 Active Drug Delivery in the Gastrointestinal Tract

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/838,072 2004-05-03
US10/838,072 US20040267240A1 (en) 2003-01-29 2004-05-03 Active drug delivery in the gastrointestinal tract
US10/901,742 US20050058701A1 (en) 2003-01-29 2004-07-29 Active drug delivery in the gastrointestinal tract
US10/901,742 2004-07-29

Publications (2)

Publication Number Publication Date
WO2005105053A2 WO2005105053A2 (en) 2005-11-10
WO2005105053A3 true WO2005105053A3 (en) 2006-05-18

Family

ID=35242213

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2005/000301 WO2005105053A2 (en) 2004-05-03 2005-03-16 Active drug delivery in the gastrointestinal tract

Country Status (8)

Country Link
US (2) US20050058701A1 (en)
EP (1) EP1746977A4 (en)
JP (1) JP2007536377A (en)
KR (1) KR20070005724A (en)
AU (1) AU2005237318A1 (en)
CA (1) CA2562741A1 (en)
RU (1) RU2006143632A (en)
WO (1) WO2005105053A2 (en)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682521B2 (en) * 2000-03-23 2004-01-27 Dennis N. Petrakis Temperature activated systems
JP4150663B2 (en) * 2003-12-25 2008-09-17 オリンパス株式会社 In-subject position detection system
US8092549B2 (en) * 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8000784B2 (en) * 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
US7850676B2 (en) * 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US8337482B2 (en) * 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US20050234440A1 (en) * 2004-04-19 2005-10-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System with a sensor for perfusion management
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US8353896B2 (en) * 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US8024036B2 (en) 2007-03-19 2011-09-20 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US8361013B2 (en) * 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US20070010868A1 (en) * 2004-04-19 2007-01-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumenally-active device
US20070244520A1 (en) * 2004-04-19 2007-10-18 Searete Llc Lumen-traveling biological interface device and method of use
US9011329B2 (en) * 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US8512219B2 (en) * 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US20080108868A1 (en) * 2004-12-02 2008-05-08 Christopher Paul Swain Device, System and Method of In-Vivo Electro-Stimulation
US7702385B2 (en) 2005-11-16 2010-04-20 Boston Scientific Neuromodulation Corporation Electrode contact configurations for an implantable stimulator
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
JP2008540023A (en) * 2005-05-19 2008-11-20 イー−ピル ファーマ リミティド Ingestible device for nitric oxide production in tissues
DE102005032378A1 (en) * 2005-07-08 2007-01-11 Siemens Ag Magnetic navigable endoscopy capsule with sensor for detecting a physiological size
DE102005032371A1 (en) * 2005-07-08 2007-01-11 Siemens Ag endoscopy capsule
JP5341513B2 (en) * 2005-07-20 2013-11-13 ニール・アール．・イウリアーノ Medication compliance system and related methods
US9047746B1 (en) 2005-07-20 2015-06-02 Neil Euliano Electronic medication compliance monitoring system and associated methods
US7983458B2 (en) * 2005-09-20 2011-07-19 Capso Vision, Inc. In vivo autonomous camera with on-board data storage or digital wireless transmission in regulatory approved band
US20070129602A1 (en) * 2005-11-22 2007-06-07 Given Imaging Ltd. Device, method and system for activating an in-vivo imaging device
CN101340944B (en) * 2005-12-22 2013-04-03 皇家飞利浦电子股份有限公司 Device for controlled release of chemical molecules
US8936629B2 (en) 2006-04-12 2015-01-20 Invention Science Fund I Llc Autofluorescent imaging and target ablation
US20080058786A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20120035438A1 (en) 2006-04-12 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Path selection by a lumen traveling device in a body tub tree based on previous path
DE102006019419B4 (en) * 2006-04-26 2008-02-14 Siemens Ag Actuator, in particular an endo robot
DE602007012684D1 (en) * 2006-05-11 2011-04-07 Koninkl Philips Electronics Nv DEVICE FOR MEDICINAL ADMINISTRATION AND / OR MONITORING OF A PATIENT'S CONDITION
JP4716922B2 (en) * 2006-05-23 2011-07-06 オリンパスメディカルシステムズ株式会社 Capsule type medical device and drug introduction system using the same
US20080172073A1 (en) * 2006-06-16 2008-07-17 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Active blood vessel sleeve
US8163003B2 (en) 2006-06-16 2012-04-24 The Invention Science Fund I, Llc Active blood vessel sleeve methods and systems
RU2009101475A (en) * 2006-06-20 2010-07-27 Конинклейке Филипс Электроникс, Н.В. (Nl) ELECTRONIC CAPSULE AND METHOD FOR TREATING A GASTROINTESTINAL DISEASE
US9550050B2 (en) 2006-09-25 2017-01-24 MEDIMETRICS Personalized Drug Delivery B.V. Medicament delivery apparatus
EP2121107B1 (en) 2006-12-18 2012-10-31 Eatlittle Inc. Device for delivery of a substance
WO2008091260A2 (en) * 2007-01-19 2008-07-31 Capso Vision, Inc. In vivo device with balloon stabilizer and valve
US8187174B2 (en) * 2007-01-22 2012-05-29 Capso Vision, Inc. Detection of when a capsule camera enters into or goes out of a human body and associated operations
US20080268037A1 (en) * 2007-04-24 2008-10-30 Igor Igorevich Stukanov Autonomous method for oral delivery of a healing substance to a target place in gastrointestinal tract of humans or animals
ATE530178T1 (en) 2007-05-23 2011-11-15 Amcol International Corp PHYLLOSSILICATES INTERACTING WITH CHOLESTEROL AND METHOD FOR REDUCING HYPERCHOLESTEROLEMIA IN A MAMMAL
US8303573B2 (en) 2007-10-17 2012-11-06 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8789536B2 (en) * 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090105561A1 (en) * 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8707964B2 (en) * 2007-10-31 2014-04-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8808276B2 (en) * 2007-10-23 2014-08-19 The Invention Science Fund I, Llc Adaptive dispensation in a digestive tract
US8808271B2 (en) * 2007-10-31 2014-08-19 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8333754B2 (en) * 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090163894A1 (en) * 2007-10-31 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8109920B2 (en) * 2007-10-31 2012-02-07 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090137866A1 (en) * 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
JP6230772B2 (en) * 2008-02-18 2017-11-15 シュトコ・ツェーン・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Administration of drugs to patients
US8287902B2 (en) 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
US20110306878A1 (en) 2009-02-26 2011-12-15 Liquidia Technologies, Inc. Interventional drug delivery system and associated methods
JP5284846B2 (en) * 2009-03-30 2013-09-11 オリンパス株式会社 In vivo observation system and method of operating the in vivo observation system
US20100256518A1 (en) * 2009-04-01 2010-10-07 Yu Chris C Micro-Devices for Biomedical Applications and Method of Use of Same
JP2010240104A (en) * 2009-04-03 2010-10-28 Olympus Corp In-vivo observation system and method for driving in-vivo observation system
US20100286628A1 (en) * 2009-05-07 2010-11-11 Rainbow Medical Ltd Gastric anchor
US8414559B2 (en) * 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US20110066175A1 (en) * 2009-05-07 2011-03-17 Rainbow Medical Ltd. Gastric anchor
WO2010144016A1 (en) 2009-06-09 2010-12-16 Neuronano Ab Microelectrode and multiple microelectrodes comprising means for releasing drugs into the tissue
US8682440B2 (en) * 2009-08-03 2014-03-25 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US8562589B2 (en) 2009-12-24 2013-10-22 Rani Therapeutics, Llc Swallowable drug delivery device and method of delivery
CA2785168C (en) * 2009-12-24 2018-04-17 Incube Labs, Llc Swallowable drug delivery device and methods of drug delivery
US8696740B2 (en) 2010-01-05 2014-04-15 The Johns Hopkins University Implantable pressure-actuated drug delivery systems and methods of manufacture and use
AU2010347732A1 (en) * 2010-03-10 2012-10-04 Incube Labs, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2011127252A2 (en) 2010-04-07 2011-10-13 Proteus Biomedical, Inc. Miniature ingestible device
EP2592992A4 (en) * 2010-07-12 2014-04-23 Therasyn Sensors Inc A device and methods for in vivo monitoring of an individual
US20180296814A1 (en) * 2010-08-17 2018-10-18 Progenity, Inc. Administration of drugs to a patient
US8776802B2 (en) * 2010-08-25 2014-07-15 Brown University Methods and systems for prolonged localization of drug delivery
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
PL2726141T3 (en) * 2011-06-29 2020-06-15 Rani Therapeutics, Llc Device for the oral delivery of therapeutic compounds
US9622809B2 (en) * 2011-09-23 2017-04-18 Weinberg Medical Physics Inc Apparatus and method for spatially selective interventional neuroparticles
WO2013129013A1 (en) * 2012-02-29 2013-09-06 ソニー株式会社 Medical device, medical system and program
US10245436B2 (en) * 2012-07-17 2019-04-02 Stimwave Technologies Incorporated Miniature implantable device and methods
US9131842B2 (en) 2012-08-16 2015-09-15 Rock West Solutions, Inc. System and methods for locating relative positions of multiple patient antennas
US10045713B2 (en) * 2012-08-16 2018-08-14 Rock West Medical Devices, Llc System and methods for triggering a radiofrequency transceiver in the human body
JP5580383B2 (en) * 2012-10-05 2014-08-27 株式会社 資生堂 Beauty device, energization method and recording medium
US11149123B2 (en) 2013-01-29 2021-10-19 Otsuka Pharmaceutical Co., Ltd. Highly-swellable polymeric films and compositions comprising the same
US20140221741A1 (en) * 2013-02-07 2014-08-07 Capso Vision, Inc. Self Assembly of In-Vivo Capsule System
EP2969369B1 (en) * 2013-03-13 2022-03-09 Cynosure, LLC Controlled photomechanical and photothermal tissue treatment in the picosecond regime
JP6796484B2 (en) * 2013-03-15 2020-12-09 ラニ セラピューティクス， エルエルシー Device for oral delivery of therapeutic compounds
JP6511439B2 (en) * 2013-06-04 2019-05-15 プロテウス デジタル ヘルス， インコーポレイテッド Systems, devices, and methods for data collection and outcome assessment
CA2920858A1 (en) * 2013-08-09 2015-02-12 The General Hospital Corporation Method and apparatus for treating dermal melasma
US10463269B2 (en) 2013-09-25 2019-11-05 Bardy Diagnostics, Inc. System and method for machine-learning-based atrial fibrillation detection
WO2015048194A1 (en) 2013-09-25 2015-04-02 Bardy Diagnostics, Inc. Self-contained personal air flow sensing monitor
US9655538B2 (en) 2013-09-25 2017-05-23 Bardy Diagnostics, Inc. Self-authenticating electrocardiography monitoring circuit
US9408551B2 (en) 2013-11-14 2016-08-09 Bardy Diagnostics, Inc. System and method for facilitating diagnosis of cardiac rhythm disorders with the aid of a digital computer
US9615763B2 (en) 2013-09-25 2017-04-11 Bardy Diagnostics, Inc. Ambulatory electrocardiography monitor recorder optimized for capturing low amplitude cardiac action potential propagation
US10433751B2 (en) 2013-09-25 2019-10-08 Bardy Diagnostics, Inc. System and method for facilitating a cardiac rhythm disorder diagnosis based on subcutaneous cardiac monitoring data
US10806360B2 (en) 2013-09-25 2020-10-20 Bardy Diagnostics, Inc. Extended wear ambulatory electrocardiography and physiological sensor monitor
US20190167139A1 (en) 2017-12-05 2019-06-06 Gust H. Bardy Subcutaneous P-Wave Centric Insertable Cardiac Monitor For Long Term Electrocardiographic Monitoring
US9619660B1 (en) 2013-09-25 2017-04-11 Bardy Diagnostics, Inc. Computer-implemented system for secure physiological data collection and processing
US10820801B2 (en) 2013-09-25 2020-11-03 Bardy Diagnostics, Inc. Electrocardiography monitor configured for self-optimizing ECG data compression
US10888239B2 (en) 2013-09-25 2021-01-12 Bardy Diagnostics, Inc. Remote interfacing electrocardiography patch
US9730593B2 (en) 2013-09-25 2017-08-15 Bardy Diagnostics, Inc. Extended wear ambulatory electrocardiography and physiological sensor monitor
US11723575B2 (en) 2013-09-25 2023-08-15 Bardy Diagnostics, Inc. Electrocardiography patch
US9700227B2 (en) 2013-09-25 2017-07-11 Bardy Diagnostics, Inc. Ambulatory electrocardiography monitoring patch optimized for capturing low amplitude cardiac action potential propagation
US10624551B2 (en) 2013-09-25 2020-04-21 Bardy Diagnostics, Inc. Insertable cardiac monitor for use in performing long term electrocardiographic monitoring
US10799137B2 (en) 2013-09-25 2020-10-13 Bardy Diagnostics, Inc. System and method for facilitating a cardiac rhythm disorder diagnosis with the aid of a digital computer
US10433748B2 (en) 2013-09-25 2019-10-08 Bardy Diagnostics, Inc. Extended wear electrocardiography and physiological sensor monitor
US10251576B2 (en) 2013-09-25 2019-04-09 Bardy Diagnostics, Inc. System and method for ECG data classification for use in facilitating diagnosis of cardiac rhythm disorders with the aid of a digital computer
US9345414B1 (en) 2013-09-25 2016-05-24 Bardy Diagnostics, Inc. Method for providing dynamic gain over electrocardiographic data with the aid of a digital computer
US10736531B2 (en) 2013-09-25 2020-08-11 Bardy Diagnostics, Inc. Subcutaneous insertable cardiac monitor optimized for long term, low amplitude electrocardiographic data collection
AU2014340223B2 (en) 2013-10-22 2019-04-04 Rock West Medical Devices, Llc System to localize swallowable pill sensor with three transmitting elements
US10521561B1 (en) 2013-12-17 2019-12-31 Etectrx, Inc. Electronic compliance system and associated methods
WO2015105873A1 (en) * 2014-01-07 2015-07-16 Animal Oralectrics Llc Treatment of oral maladies using electrical current
US9492396B2 (en) 2014-07-15 2016-11-15 Yossi Gross Enhanced drug delivery pill
CN104147706A (en) * 2014-08-29 2014-11-19 重庆邮电大学 Minitype stomach disease treatment device based on blue light sterilization
US20160067466A1 (en) 2014-09-05 2016-03-10 Elwha LLC, a limited company of the State of Delaware Systems, methods, and devices addressing the gastro-intestinal tract
US10183154B2 (en) * 2014-09-05 2019-01-22 Elwha Llc Systems, methods, and devices addressing the gastro-intestinal tract
US20160066855A1 (en) * 2014-09-05 2016-03-10 Elwha LLC, a limited liability company of the State of Delaware Systems, methods, and devices addressing the gastro-intestinal tract
US10098526B2 (en) * 2015-03-17 2018-10-16 Capsovision Inc. Capsule device having variable specific gravity
US11660436B1 (en) 2015-08-04 2023-05-30 Verily Life Sciences Llc Device, system, and formulation for oral delivery of functionalized particles
US9770591B2 (en) 2015-12-29 2017-09-26 Rainbow Medical Ltd. Disc therapy
US10518085B2 (en) 2015-12-29 2019-12-31 Rainbow Medical Ltd. Disc therapy
US9950156B2 (en) 2016-09-13 2018-04-24 Rainbow Medical Ltd. Disc therapy
GB2554354B (en) 2016-09-21 2021-06-02 Vibrant Ltd Systems for adaptive treatment of disorders in the gastrointestinal tract
JP2019535377A (en) 2016-10-26 2019-12-12 プロテウス デジタル ヘルス， インコーポレイテッド Method for producing capsules with ingestible event markers
US10888277B1 (en) 2017-01-30 2021-01-12 Vibrant Ltd Method for treating diarrhea and reducing Bristol stool scores using a vibrating ingestible capsule
US10905378B1 (en) 2017-01-30 2021-02-02 Vibrant Ltd Method for treating gastroparesis using a vibrating ingestible capsule
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
IL301683A (en) 2017-05-17 2023-05-01 Massachusetts Inst Technology Self-righting systems and related components and methods
WO2019008565A1 (en) * 2017-07-03 2019-01-10 Check-Cap Ltd. Bacteria sampling and dispersion capsule
WO2019082171A1 (en) * 2017-10-27 2019-05-02 Alvit Pharma Oral cannabinoid compositions with improved bioavailability
CN112020343B (en) * 2018-03-30 2023-09-19 维布兰特公司 Gastrointestinal treatment system including vibrating capsule and method of use thereof
US11504024B2 (en) 2018-03-30 2022-11-22 Vibrant Ltd. Gastrointestinal treatment system including a vibrating capsule, and method of use thereof
US10537720B2 (en) 2018-04-09 2020-01-21 Vibrant Ltd. Method of enhancing absorption of ingested medicaments for treatment of parkinsonism
US11638678B1 (en) 2018-04-09 2023-05-02 Vibrant Ltd. Vibrating capsule system and treatment method
US11510590B1 (en) 2018-05-07 2022-11-29 Vibrant Ltd. Methods and systems for treating gastrointestinal disorders
WO2019222570A1 (en) * 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Systems for electrical stimulation
US10675248B2 (en) 2018-08-14 2020-06-09 Alma Therapeutics Ltd. Expandable pill
US20200093740A1 (en) * 2018-09-25 2020-03-26 Incube Labs, Llc Ingestible device with expandable enclosure
JP7311917B2 (en) 2019-01-03 2023-07-20 ヴァイブラント リミテッド A device for delivering an ingestible agent into a user's gastrointestinal tract
GB201900780D0 (en) 2019-01-21 2019-03-06 Vibrant Ltd Device and method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user
GB201901470D0 (en) 2019-02-04 2019-03-27 Vibrant Ltd Vibrating capsule for gastrointestinal treatment, and method of use thereof
US11096579B2 (en) 2019-07-03 2021-08-24 Bardy Diagnostics, Inc. System and method for remote ECG data streaming in real-time
US11116451B2 (en) 2019-07-03 2021-09-14 Bardy Diagnostics, Inc. Subcutaneous P-wave centric insertable cardiac monitor with energy harvesting capabilities
US11696681B2 (en) * 2019-07-03 2023-07-11 Bardy Diagnostics Inc. Configurable hardware platform for physiological monitoring of a living body
US11123197B2 (en) 2019-09-03 2021-09-21 Rainbow Medical Ltd. Hydropneumatic artificial intervertebral disc
KR102428203B1 (en) * 2020-02-25 2022-08-04 서울대학교산학협력단 Alternating Magnetic Field Generating Apparatus and System for Treatment
WO2021176361A1 (en) * 2020-03-02 2021-09-10 Craft Health Pte Ltd Method of manufacturing oral dosage forms for extended drug release
KR102362824B1 (en) * 2020-06-01 2022-02-11 숙명여자대학교산학협력단 Method and apparatus for generating anti-cancer substances in situ
US20230263956A1 (en) * 2020-08-10 2023-08-24 Massachusetts Institute Of Technology Ingestible drug delivery device
WO2022224055A1 (en) * 2021-04-20 2022-10-27 Cochlear Limited Body chamber therapeutic substance delivery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5170801A (en) * 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5217449A (en) * 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH337989A (en) * 1957-04-09 1959-04-30 Perrenoud Jean Pierre Dr Capsule
US3057344A (en) * 1957-05-21 1962-10-09 Abella Carlos Alberto Capsule for the study of the digestive tract and method of using the same
US3315660A (en) * 1963-08-08 1967-04-25 Carlos A Abella Capsule for insertion in the digestive track
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs
US4239040A (en) * 1976-10-19 1980-12-16 Kabushiki Kaisha Daini Seikosha Capsule for medical use
DE2928477C3 (en) * 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Device for the release of substances at defined locations in the digestive tract
JPS57163309A (en) * 1981-04-01 1982-10-07 Olympus Optical Co Ltd Capsule apparatus for medical use
US4869248A (en) * 1987-04-17 1989-09-26 Narula Onkar S Method and apparatus for localized thermal ablation
EP0398960B1 (en) * 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
US4844076A (en) * 1988-08-26 1989-07-04 The Johns Hopkins University Ingestible size continuously transmitting temperature monitoring pill
US5474785A (en) * 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5167626A (en) * 1990-10-02 1992-12-01 Glaxo Inc. Medical capsule device actuated by radio-frequency (RF) signal
US5158537A (en) * 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5279607A (en) * 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5318557A (en) * 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
IE70735B1 (en) * 1994-08-15 1996-12-11 Elan Med Tech Orally administrable delivery device
US5551953A (en) * 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
US5697896A (en) * 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
US5778882A (en) * 1995-02-24 1998-07-14 Brigham And Women's Hospital Health monitoring system
US5735817A (en) * 1995-05-19 1998-04-07 Shantha; T. R. Apparatus for transsphenoidal stimulation of the pituitary gland and adjoining brain structures
US6175763B1 (en) * 1996-03-29 2001-01-16 Alza Corporation Electrotransport drug delivery device having tactile signaling means
UA48221C2 (en) * 1996-04-01 2002-08-15 Валєрій Івановіч Кобозєв Electrical gastro-intestinal tract stimulator
US6718201B1 (en) * 1996-06-07 2004-04-06 Alza Corporation Electrotransport agent delivery method and apparatus
US6024717A (en) * 1996-10-24 2000-02-15 Vibrx, Inc. Apparatus and method for sonically enhanced drug delivery
US6091872A (en) * 1996-10-29 2000-07-18 Katoot; Mohammad W. Optical fiber imaging system
US6246904B1 (en) * 1996-12-17 2001-06-12 Alza Corporation Electrotransport drug delivery reservoirs containing inert fillers
DE19717023C2 (en) * 1997-04-23 2003-02-06 Micronas Gmbh Device for treating malignant, tumorous tissue areas
US6775569B2 (en) * 1997-11-05 2004-08-10 Hisamitsu Pharmaceutical Co., Inc. Electroporation device for in vivo delivery of therapeutic agents
US6579690B1 (en) * 1997-12-05 2003-06-17 Therasense, Inc. Blood analyte monitoring through subcutaneous measurement
ES2281940T3 (en) * 1997-12-17 2007-10-01 Alza Corporation IONTOPHORESIS WITH PROGRAMMED ADJUSTMENT OF THE ELECTRICAL POWER.
JPH11239621A (en) * 1998-02-25 1999-09-07 Hisamitsu Pharmaceut Co Inc Iontophoresis device
US6322532B1 (en) * 1998-06-24 2001-11-27 3M Innovative Properties Company Sonophoresis method and apparatus
US6302874B1 (en) * 1998-07-13 2001-10-16 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
US6464687B1 (en) * 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
ATE290902T1 (en) * 1999-04-16 2005-04-15 Johnson & Johnson Consumer DEVICE FOR IONTOPHORETIC ADMINISTRATION OF MEDICATION WITH INTERNAL SENSORS
US7171263B2 (en) * 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
WO2000074767A2 (en) * 1999-06-08 2000-12-14 Altea Technologies, Inc. Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
US6853858B2 (en) * 2000-05-08 2005-02-08 Brainsgate, Ltd. Administration of anti-inflammatory drugs into the central nervous system
US6327426B1 (en) * 2000-10-26 2001-12-04 Ceramatec, Inc. Apparatus and method for delivering a beneficial agent
US6929636B1 (en) * 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US7160258B2 (en) * 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
RU2203697C2 (en) * 2001-08-14 2003-05-10 Государственное учреждение системы высшего и послевузовского профессионального образования "Сибирский государственный медицинский университет" Device for performing organ and tissue electrostimulation
JP2002186672A (en) * 2001-09-28 2002-07-02 Olympus Optical Co Ltd Medical capsule device
KR20050098277A (en) * 2003-01-29 2005-10-11 이-필 파마 리미티드 Active drug delivery in the gastrointestinal tract

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5170801A (en) * 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5217449A (en) * 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same

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