WO2005110282A1 - Differential covering and coating methods - Google Patents
Differential covering and coating methods Download PDFInfo
- Publication number
- WO2005110282A1 WO2005110282A1 PCT/US2004/039162 US2004039162W WO2005110282A1 WO 2005110282 A1 WO2005110282 A1 WO 2005110282A1 US 2004039162 W US2004039162 W US 2004039162W WO 2005110282 A1 WO2005110282 A1 WO 2005110282A1
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- WO
- WIPO (PCT)
- Prior art keywords
- medical appliance
- stent
- appliance
- scaffolding
- medical
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2002/065—Y-shaped blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0051—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
Definitions
- the present invention relates generally to methods of covering and/or coating medical devices and more particularly to methods of manipulating the compliance of the cover to modify fluid mechanics on the interior of the medical device and the friction points on the exterior thereof.
- Stents are devices that are inserted into a vessel or passage to keep the lumen open and prevent closure due to a stricture, external compression, or internal obstruction.
- stents are commonly used to keep blood vessels open in the coronary arteries and they are frequently inserted into the ureters to maintain drainage from the kidneys, the bile duct for pancreatic cancer or cholangiocarcinoma or the esophagus for strictures or cancer.
- Vascular as well as not vascular stenting has evolved significantly; unfortunately there remain significant limitations with respect to the technology for producing stents suitable to various portions of a patient's anatomy.
- the stent had to be manufactured from multiple materials, at least one for each characteristic desired. As a result, many of these stents are woven from two or more metals having differing shape-memories for example. Unfortunately, braided stents are vulnerable to premature obsolescence. Moreover, providing multiple material types in a single stent may lead to inconsistent characteristics along the surface area of the stent. This is particularly undesirable when the stent is to be placed in vascular or nonvascular lumens that have been occluded for one reason or another. The stent needs to be stiffer in some regions while more flexible in others.
- cardiovascular stents since many medical device companies have chosen to use poorly adapted cardiovascular stents for Pulmonary, Gl and Peripheral Vascular indications, many of the anatomical differences in the lumens are not accounted for in stent design. For example, the pulsation of the cardiovascular lumen and the concomitant radial force requirements of a cardiovascular stent differ substantially from that of a tightly constricted lumen such as the trachea during repeated coughing. When a stent developed for the former is indicated for the latter, the stent tends to fail under the extreme conditions and lose its elasticity and therefore its ability of ensure airway patency. Non-vascular lumens also tend to have ciliated epithelia so as to facilitate clearance of fluids and particulates.
- coated stents were not specifically designed for ciliated lumen in that the external coating damages the cilia and prevents the body's natural clearing function.
- the coating itself is usually made of a predominately hydrophilic polymer, which can lead to mucous formation and/or fluid stagnation. Stagnation of fluids or material passing through the lumen can lead to additional complications such as in stent restenosis or bacterial infections. Therefore, there remains an existing need for a therapeutic stent that can have varying characteristics along its surface area while being stamped, not braded, from a single base material.
- a covered stent that is preferably covered internally such that the outer scaffolding surface of the stent is raised from the outer surface of the coating.
- cilia function is only partially limited and mucociliary clearance is not significantly affected.
- a need also remains for a coating that itself has anti-adherent properties or is complexed with an anti-adherent such that bacteria, fungi or other microbials cannot colonize the cover in particular and the stent generally.
- a cover for the proximal and distal ends of the stent that prevent epitheli ⁇ liz ⁇ tion and granulation tissue formation while achieving the benefits of traditional uncovered stents.
- a principal purpose of the present invention to provide a stent, in accordance with an exemplary embodiment of the present invention, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones.
- it is an objective of a preferred embodiment in accordance with the present invention to provide a stent that is easily installed, yet in alternative embodiments, removable.
- the stent in accordance with this embodiment of the present invention would not cause material infections and may be capable of reducing infection. Therefore, a principal objective of a preferred embodiment in accordance with the present invention is to provide a prosthesis that is suitable for both permanent and temporary use while being easy to insert, reposition and remove.
- a principal objective of a preferred embodiment of the present invention is to provide a stent that may be stamped from preferably a single material that is capable of maintaining its axial working length when radially compressed. To this end, the stent does not have a seam that could aggravate luminal tissue.
- an exemplary embodiment in accordance with the present invention is to provide a prosthesis that will have superior internal to external diameter ratio, superior radial force with dynamic expansion, while being suitable for use in pediatric and adult patients with malignant and benign disease.
- a principal objective of an exemplary stent in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to radial forces.
- An additional objective in accordance with a preferred embodiment of the present invention is to provide a prosthesis that minimizes cilia destruction at the site of implantation.
- the preferred prosthesis is coated internally with a polyurethane such that the surfaces of the struts that come into contact with the lumen of the patient are elevated above the surface of the coating such that the cilia can move to allow for free fluid action of ciliated epithelium.
- Still another objective in accordance with the present invention is to provide a cover and method for applying the cover to a stent.
- the cover may be applied such that the cover is at various levels of compliance with respect to the stent struts. To this end, it provides an opportunity to manipulate flow mechanics for the inner diameter of the stent as well as the friction points of the outer diameter of the stent.
- Yet another objective in accordance with the present invention is to provide covering about the distal end, the proximal end or combination so as to retain the benefits of an uncovered stent while retaining the ability to remove the stent. Moreover, the end only and full stent covering may be provided in addition to the coating to eliminate galvanic current. Further objectives, features and advantages of the invention will be apparent from the following detailed description taken in conjunction with the accompanying drawings.
- FIG. 1 shows a perspective view of the cross-section of select struts of an exemplary stent with a covering applied to the internal diameter so as to cause the cover to conform to the stent struts.
- FIG. 2 shows an alternative perspective view of the select stent strut cross-section of FIG. 1 where the cover is not compliant with the stent struts.
- FIG. 3 shows an enlarged perspective view of a stent viewed from one end through the lumen thereof showing the compliant cover of FIG. 1 .
- FIG. 4 shows an alternative end-to-end perspective view of the stent where the cover is super-compliant in certain regions of the stent such that the cover extends through the interstices toward the outer surface of the stent.
- FIG. 5 shows an enlarged perspective view of the struts where the cover does not conform to the geometry of the struts.
- a preferred embodiment of the stent provides a stent that prevents epithelialization of the stent and is not subject to premature elongation and foreshortening but is capable of engaging the desired implantation location.
- the stent also retains its axial length while undergoing radial compression.
- the stent is preferably formed from a composite material selected from the group consisting essentially of Ni, C, Co, Cu, Cr, H, Fe, Nb, O, Ti and combinations thereof.
- the composite material is generally formed into a compressed tube from which the stent is etched and is formed on a suitable shaping device to give the stent the desired external geometry.
- the stent is preferably formed on a shaping tool that has substantially the desired contour of the external stent dimensions.
- optical photography and/or optical videography of the target lumen may be conducted prior to stent formation.
- the geometry of corresponding zones and connector regions of the stent then can be etched and formed in accordance with the requirements of that target lumen. For example, if the stent were designed for the trachea, which has a substantially D shaped lumen and additionally the middle zones needed to be softer than the end zones, the stent could be designed to those specifications. Stent angles may be modified to provide different characteristics to different zones of the stent.
- a patient specific prosthesis could be engineered.
- These techniques can be adapted to other non-vascular lumen but is very well suited for vascular applications where patient specific topography is a function of a variety of factors such as genetics, lifestyle, etc.
- stents in accordance with the present invention can take on an infinite number of characteristic combinations as zones and segments within a zone can be modified by changing angles, segment lengths and segment thicknesses during the etching and forming stages of stent engineering or during post formation processing and polishing steps.
- FIGS. 1 -3 show the preferred interstice geometry. Not shown are a wide variety of interstice geometries that are also acceptable alternatives to the preferred, namely, U, V, W, Z, S and X geometries to name a few.
- the stent also is formed of memory metal and preferably has unique geometrical interstices that are laser etched therein. However, other conventional ways of forming interstices in unitary stents, though not equivalent are contemplated, may be employed and would be within the skill set of one in the art.
- the stent has circumferential bands extending perpendicularly with respect to the luminal device's longitudinal axis. These bands are referred to generally as zones.
- a connector connects these bands to one another; the connector is an additional means for adjusting stent functionality.
- the connector defines a substantially U shaped member, but could define other geometries such as U, V, W, Z, S and X to name a few.
- a plurality of eyelets that allow a physician to purse string the stent with suture to facilitate removability.
- the eyelets are preferably between about 200 ⁇ m and 300 ⁇ im, however, the eyelets may be smaller or larger to accommodate the need of the target site.
- the preferred eyelet size is about 350 ⁇ m as the preferred suture type is 4-0.
- the medic ⁇ l appliance may be pre-threaded with suture or the user may provide the suture after implantation.
- An exemplary stent in accordance with the present invention with relatively great torsionality and radial flexibility would be rated soft.
- An exemplary soft rated stent comprises distance between U shaped connectors of about 4.5 ⁇ m in the compressed state (i.e., contracted in the 3mm tube subject to laser etching).
- the length of the crossing member is preferably about 1 .0 ⁇ m.
- the lengths of the leg members are preferably about 1 .5 ⁇ long.
- the leg members may further comprise feet that attached to the remainder of the stent scaffolding. The feet can be adjusted from a standard length of about 0.25 ⁇ m to further adjust the characteristics of the stent.
- the softness index or relative flexibility can be increase by increasing the various lengths discussed above.
- a U shaped connector with short legs deviating from the crossing member at angles greater than 90° will be extremely rigid and resistant to torsional strain as compared to a U shaped connector with longer legs diverging from the crossing member at angles less than 90°.
- the interstices themselves may define various shapes that by their very nature afford novel functionality to the stent.
- the changes of functionality are more a function of the dimensional differences of the various shapes rather than a function of the shapes themselves. Therefore, it is important to keep in mind that the dimensional differences discussed in the previous paragraph are determinative of the functionality accorded the stent by the varying interstice geometries.
- FIGS. 1 -3 also show the coating provided in select embodiments in accordance with the present invention.
- the coating preferably comprises a stable polymeric material such as polyurethane that can be deposited on a stent to form a thin film.
- the film preferably forms layers when annealed to the stent such that the hydrophobic moieties within the polymer are predominately oriented outward and the hydrophilic moieties are predominately oriented inward.
- the relative hydroaffinity may be altered depending on the characteristics desired by the user.
- the coating would more suitably have a predominately hydrophilic outer surface.
- the physiochemical parameters such as surface-free energy, charge density provide a substantial barrier to biofilm formation in general and ligand-binding events mediated by microbial adhesions and extracellular polymers.
- additional anti-adherents know in the art may be applied to provide lubricity as well as an additional barrier for microbials.
- a preferred coating in accordance with the present invention would be hydrophilic and hydroscope to ensure the surface would always be wet which prevents mucostasis as well as microbial adherence.
- preferred stents in accordance with the present invention are covered from the interior of the stent lumen such that the stent scaffolding.
- the cover may be strategically applied to either form a strut compliant membrane, a non-compliant membrane within the internal diameter of the stent or incrementally in between.
- One of the principal functions of the variable covering method is to enhance friction points on the exterior of the stent and/or control flow dynamics through the interior lumen of the stent. Making specific reference to FIGS.
- the stent struts 100 are shown with the interior lumen surface 120 facing upward.
- a compliant cover forms angles between the struts 100 that can cause fluid retention. If this is a desirable characteristic based on the target lumen of the stent, such covering can be achieved by using a compliant heating mechanism when coupling the cover 200 to the struts.
- the cover 200 would be applied to the struts 100 with a non-compliant device so as to prevent the cover 200 from conforming to the contours of the stent struts 100.
- the stent is preferably coated in a multi-step process, which comprises providing a stent and initially spraying the stent with a polymeric material to coat the struts. Though the steps may be reversed it is preferable to follow the spraying step with the interior coating step.
- the stent is placed into a hollow mold to retain the stent shape as the internal diameter of the stent is coated with the polymeric material to form a non-porous cover 200.
- An alternative cover could be porous for breathability or selective leaching.
- the cover 100 can be provided in sheets or additional spray applications, however, the preferred embodiment is thin sheets. Sheets are generally preferred to facilitate the proper orientation of the polymer side chains to ensure that the desired moiety (e.g., hydrophilic and/or hydrophobic) is facing the lumen.
- an application device such as a balloon or other device in which temperature can be regulated is implanted to sandwich the layer of polymer between the stent inner diameter and the balloon.
- the balloon is expanded and heated to a temperature of about between 200° and 400° F to anneal the polymer to the stent.
- Preferred polymers such as various designer polyurethanes (e.g., Cronoflex ® manufactured by Cardiotech International) are suitable for such applications but other polymers are acceptable.
- Degree of conformity may depend on the compliance of the balloon as well as the presence or absence of a collar about the external surface of the stent.
- the collar may have ribs complementary to the stent interstices or alternatively recessed wells to facilitate the extent of super compliance of the cover. Additionally, the same methods may be employed to cover and coat portions of the stent rather than the complete stent.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2004319771A AU2004319771A1 (en) | 2003-11-20 | 2004-11-20 | Differential covering and coating methods |
JP2006541609A JP2007512107A (en) | 2003-11-20 | 2004-11-20 | Differential coating and coating method |
CA002546809A CA2546809A1 (en) | 2003-11-20 | 2004-11-20 | Differential covering and coating methods |
EP04822000A EP1689328A4 (en) | 2003-11-20 | 2004-11-20 | Differential covering and coating methods |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US10/288,615 US7527644B2 (en) | 2002-11-05 | 2002-11-05 | Stent with geometry determinated functionality and method of making the same |
US10/718,217 | 2003-11-20 | ||
US10/718,217 US7959671B2 (en) | 2002-11-05 | 2003-11-20 | Differential covering and coating methods |
Publications (1)
Publication Number | Publication Date |
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WO2005110282A1 true WO2005110282A1 (en) | 2005-11-24 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US2004/039162 WO2005110282A1 (en) | 2002-11-05 | 2004-11-20 | Differential covering and coating methods |
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US (1) | US7959671B2 (en) |
WO (1) | WO2005110282A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7794495B2 (en) * | 2006-07-17 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Controlled degradation of stents |
US20090011117A1 (en) * | 2007-07-03 | 2009-01-08 | Endotronix, Inc. | Methods for texturing a surface of an endovascular implant |
WO2009123624A1 (en) * | 2008-04-01 | 2009-10-08 | Hewlett-Packard Development Company, L.P. | Method and system for coating an article |
US9907684B2 (en) | 2013-05-08 | 2018-03-06 | Aneuclose Llc | Method of radially-asymmetric stent expansion |
CN105705118B (en) | 2013-09-12 | 2018-03-30 | 波士顿科学国际有限公司 | Support with anti-displacement connector |
EP3119354B1 (en) | 2014-03-18 | 2018-06-06 | Boston Scientific Scimed, Inc. | Reduced granulation and inflammation stent design |
WO2016054536A1 (en) | 2014-10-02 | 2016-04-07 | Boston Scientific Scimed, Inc. | Controlled ingrowth feature for antimigration |
CN107106310B (en) | 2014-10-22 | 2019-03-22 | 波士顿科学国际有限公司 | Bracket with flexible hinge |
WO2016073597A1 (en) | 2014-11-06 | 2016-05-12 | Boston Scientific Scimed, Inc. | Tracheal stent |
US10307273B2 (en) | 2015-03-03 | 2019-06-04 | Boston Scientific Scimed, Inc. | Stent with anti-migration features |
CA2977681A1 (en) | 2015-03-05 | 2016-09-09 | Merit Medical Systems, Inc. | Vascular prosthesis deployment device and method of use |
US10470906B2 (en) | 2015-09-15 | 2019-11-12 | Merit Medical Systems, Inc. | Implantable device delivery system |
JP7131742B2 (en) | 2016-09-29 | 2022-09-06 | メリット・メディカル・システムズ・インコーポレイテッド | A flexible member for receiving a vascular prosthesis and assisting in its deployment |
US11628078B2 (en) | 2017-03-15 | 2023-04-18 | Merit Medical Systems, Inc. | Transluminal delivery devices and related kits and methods |
EP3595594A4 (en) | 2017-03-15 | 2021-04-21 | Merit Medical Systems, Inc. | Transluminal stents and related methods |
USD836194S1 (en) | 2017-03-21 | 2018-12-18 | Merit Medical Systems, Inc. | Stent deployment device |
KR20220128410A (en) | 2020-01-13 | 2022-09-20 | 보스톤 싸이엔티픽 싸이메드 인코포레이티드 | migration-resistant stents |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6423092B2 (en) * | 1999-12-22 | 2002-07-23 | Ethicon, Inc. | Biodegradable stent |
WO2005030086A2 (en) | 2003-09-24 | 2005-04-07 | Alveolus Inc. | Covered stent with geometry determinated functionality and method of making the same |
Family Cites Families (391)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3818511A (en) | 1972-11-17 | 1974-06-25 | Medical Prod Corp | Medical prosthesis for ducts or conduits |
GB2056023B (en) | 1979-08-06 | 1983-08-10 | Ross D N Bodnar E | Stent for a cardiac valve |
US4441215A (en) | 1980-11-17 | 1984-04-10 | Kaster Robert L | Vascular graft |
SE445884B (en) | 1982-04-30 | 1986-07-28 | Medinvent Sa | DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION |
US4680031A (en) | 1982-11-29 | 1987-07-14 | Tascon Medical Technology Corporation | Heart valve prosthesis |
US5776116A (en) | 1983-01-24 | 1998-07-07 | Icu Medical, Inc. | Medical connector |
US4665906A (en) * | 1983-10-14 | 1987-05-19 | Raychem Corporation | Medical devices incorporating sim alloy elements |
US5190546A (en) | 1983-10-14 | 1993-03-02 | Raychem Corporation | Medical devices incorporating SIM alloy elements |
US5067957A (en) | 1983-10-14 | 1991-11-26 | Raychem Corporation | Method of inserting medical devices incorporating SIM alloy elements |
FR2556210B1 (en) | 1983-12-08 | 1988-04-15 | Barra Jean Aubert | VENOUS PROSTHESIS AND PROCESS FOR PRODUCING THE SAME |
JPS6198254A (en) | 1984-10-19 | 1986-05-16 | ザ・ベントリー―ハリス・マニュファクチュアリング・カンパニー | Prosthetic stent |
US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US5102417A (en) * | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4820262A (en) * | 1985-12-12 | 1989-04-11 | Medical Engineering Corporation | Ureteral stent |
SE453258B (en) | 1986-04-21 | 1988-01-25 | Medinvent Sa | ELASTIC, SELF-EXPANDING PROTEST AND PROCEDURE FOR ITS MANUFACTURING |
US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
US4820298A (en) | 1987-11-20 | 1989-04-11 | Leveen Eric G | Internal vascular prosthesis |
US5032128A (en) | 1988-07-07 | 1991-07-16 | Medtronic, Inc. | Heart valve prosthesis |
CA1322628C (en) * | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
US4856516A (en) | 1989-01-09 | 1989-08-15 | Cordis Corporation | Endovascular stent apparatus and method |
US5364340A (en) | 1989-01-25 | 1994-11-15 | Coll Milton E | Ureteral stent-catheter having varying internal diameter and method of use |
US5292331A (en) * | 1989-08-24 | 1994-03-08 | Applied Vascular Engineering, Inc. | Endovascular support device |
IE73670B1 (en) * | 1989-10-02 | 1997-07-02 | Medtronic Inc | Articulated stent |
US5229431A (en) | 1990-06-15 | 1993-07-20 | Corvita Corporation | Crack-resistant polycarbonate urethane polymer prostheses and the like |
US5064435A (en) | 1990-06-28 | 1991-11-12 | Schneider (Usa) Inc. | Self-expanding prosthesis having stable axial length |
US5356423A (en) | 1991-01-04 | 1994-10-18 | American Medical Systems, Inc. | Resectable self-expanding stent |
US5073694A (en) | 1991-02-21 | 1991-12-17 | Synthes (U.S.A.) | Method and apparatus for laser cutting a hollow metal workpiece |
US5383925A (en) | 1992-09-14 | 1995-01-24 | Meadox Medicals, Inc. | Three-dimensional braided soft tissue prosthesis |
DE4122923C1 (en) | 1991-07-11 | 1993-01-28 | Willy Ruesch Ag, 7053 Kernen, De | |
US5443498A (en) | 1991-10-01 | 1995-08-22 | Cook Incorporated | Vascular stent and method of making and implanting a vacsular stent |
US5876445A (en) * | 1991-10-09 | 1999-03-02 | Boston Scientific Corporation | Medical stents for body lumens exhibiting peristaltic motion |
US5662713A (en) | 1991-10-09 | 1997-09-02 | Boston Scientific Corporation | Medical stents for body lumens exhibiting peristaltic motion |
ATE157525T1 (en) | 1991-10-11 | 1997-09-15 | Angiomed Ag | DEVICE FOR EXPANDING A STENOSIS |
US5354309A (en) | 1991-10-11 | 1994-10-11 | Angiomed Ag | Apparatus for widening a stenosis in a body cavity |
CA2380683C (en) | 1991-10-28 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Expandable stents and method for making same |
FR2683449A1 (en) * | 1991-11-08 | 1993-05-14 | Cardon Alain | ENDOPROTHESIS FOR TRANSLUMINAL IMPLANTATION. |
US5683448A (en) | 1992-02-21 | 1997-11-04 | Boston Scientific Technology, Inc. | Intraluminal stent and graft |
US5817102A (en) | 1992-05-08 | 1998-10-06 | Schneider (Usa) Inc. | Apparatus for delivering and deploying a stent |
JP2660101B2 (en) | 1992-05-08 | 1997-10-08 | シュナイダー・(ユーエスエイ)・インコーポレーテッド | Esophageal stent and delivery device |
DE4220295A1 (en) | 1992-06-20 | 1993-12-23 | Angiomed Ag | Device for correcting the position of a stent |
US6336938B1 (en) | 1992-08-06 | 2002-01-08 | William Cook Europe A/S | Implantable self expanding prosthetic device |
US5562725A (en) | 1992-09-14 | 1996-10-08 | Meadox Medicals Inc. | Radially self-expanding implantable intraluminal device |
EP0676936A1 (en) | 1992-12-30 | 1995-10-18 | Schneider (Usa) Inc. | Apparatus for deploying body implantable stents |
DE4303181A1 (en) * | 1993-02-04 | 1994-08-11 | Angiomed Ag | Implantable catheter |
SG85682A1 (en) | 1993-03-11 | 2002-01-15 | Medinol Ltd | Stent |
US5345057A (en) | 1993-03-25 | 1994-09-06 | Lasag Ag | Method of cutting an aperture in a device by means of a laser beam |
EP0621015B1 (en) | 1993-04-23 | 1998-03-18 | Schneider (Europe) Ag | Stent with a covering layer of elastic material and method for applying the layer on the stent |
SE505436C2 (en) | 1993-04-27 | 1997-08-25 | Ams Medinvent Sa | prostatic stent |
US6685736B1 (en) * | 1993-09-30 | 2004-02-03 | Endogad Research Pty Limited | Intraluminal graft |
DE4334140C2 (en) | 1993-10-07 | 1996-04-18 | Angiomed Ag | Stent and device with stent |
RU2089131C1 (en) | 1993-12-28 | 1997-09-10 | Сергей Апполонович Пульнев | Stent-expander |
US5876418A (en) | 1994-01-13 | 1999-03-02 | Angiomed Ag | Device for providing a duct in a living body |
ATE166782T1 (en) * | 1994-02-25 | 1998-06-15 | Fischell Robert | STENT WITH A MULTIPLE CLOSED CIRCULAR STRUCTURES |
US5643312A (en) | 1994-02-25 | 1997-07-01 | Fischell Robert | Stent having a multiplicity of closed circular structures |
US5449373A (en) | 1994-03-17 | 1995-09-12 | Medinol Ltd. | Articulated stent |
US6461381B2 (en) | 1994-03-17 | 2002-10-08 | Medinol, Ltd. | Flexible expandable stent |
US5733303A (en) * | 1994-03-17 | 1998-03-31 | Medinol Ltd. | Flexible expandable stent |
US5843120A (en) | 1994-03-17 | 1998-12-01 | Medinol Ltd. | Flexible-expandable stent |
US6464722B2 (en) | 1994-03-17 | 2002-10-15 | Medinol, Ltd. | Flexible expandable stent |
EP0679372B1 (en) | 1994-04-25 | 1999-07-28 | Advanced Cardiovascular Systems, Inc. | Radiopaque stent markers |
DE4418336A1 (en) * | 1994-05-26 | 1995-11-30 | Angiomed Ag | Stent for widening and holding open receptacles |
EP0792627B2 (en) | 1994-06-08 | 2003-10-29 | Cardiovascular Concepts, Inc. | System for forming a bifurcated graft |
US6736843B1 (en) | 1994-07-25 | 2004-05-18 | Advanced Cardiovascular Systems, Inc. | Cylindrically-shaped balloon-expandable stent |
US5591157A (en) * | 1994-09-07 | 1997-01-07 | Hennings; David R. | Method and apparatus for tympanic membrane shrinkage |
US6746482B2 (en) | 1994-10-17 | 2004-06-08 | Baxter International Inc. | Method for producing medical devices and devices so produced |
EP0788332B1 (en) | 1994-10-27 | 2000-11-08 | Boston Scientific Limited | Stent delivery device |
US5836964A (en) | 1996-10-30 | 1998-11-17 | Medinol Ltd. | Stent fabrication method |
CA2134997C (en) | 1994-11-03 | 2009-06-02 | Ian M. Penn | Stent |
CA2163824C (en) | 1994-11-28 | 2000-06-20 | Richard J. Saunders | Method and apparatus for direct laser cutting of metal stents |
DE4446036C2 (en) | 1994-12-23 | 1999-06-02 | Ruesch Willy Ag | Placeholder for placement in a body tube |
US5575818A (en) | 1995-02-14 | 1996-11-19 | Corvita Corporation | Endovascular stent with locking ring |
CA2213403C (en) | 1995-02-22 | 2007-01-16 | Menlo Care, Inc. | Covered expanding mesh stent |
US7204848B1 (en) | 1995-03-01 | 2007-04-17 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
CA2186029C (en) | 1995-03-01 | 2003-04-08 | Brian J. Brown | Improved longitudinally flexible expandable stent |
US6818014B2 (en) | 1995-03-01 | 2004-11-16 | Scimed Life Systems, Inc. | Longitudinally flexible expandable stent |
US6896696B2 (en) | 1998-11-20 | 2005-05-24 | Scimed Life Systems, Inc. | Flexible and expandable stent |
DE19508805C2 (en) * | 1995-03-06 | 2000-03-30 | Lutz Freitag | Stent for placement in a body tube with a flexible support structure made of at least two wires with different shape memory functions |
US5556414A (en) | 1995-03-08 | 1996-09-17 | Wayne State University | Composite intraluminal graft |
US6579314B1 (en) | 1995-03-10 | 2003-06-17 | C.R. Bard, Inc. | Covered stent with encapsulated ends |
US6451047B2 (en) | 1995-03-10 | 2002-09-17 | Impra, Inc. | Encapsulated intraluminal stent-graft and methods of making same |
US5591197A (en) * | 1995-03-14 | 1997-01-07 | Advanced Cardiovascular Systems, Inc. | Expandable stent forming projecting barbs and method for deploying |
EP0734698B9 (en) * | 1995-04-01 | 2006-07-05 | Variomed AG | Stent for transluminal implantation into hollow organs |
BE1009278A3 (en) * | 1995-04-12 | 1997-01-07 | Corvita Europ | Guardian self-expandable medical device introduced in cavite body, and medical device with a stake as. |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US5593442A (en) * | 1995-06-05 | 1997-01-14 | Localmed, Inc. | Radially expansible and articulated vessel scaffold |
US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
AU716005B2 (en) * | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
US5833707A (en) | 1995-07-05 | 1998-11-10 | Advanced Cardiovascular Systems, Inc. | Removable stent and method of deployment |
US5769882A (en) | 1995-09-08 | 1998-06-23 | Medtronic, Inc. | Methods and apparatus for conformably sealing prostheses within body lumens |
US5702418A (en) | 1995-09-12 | 1997-12-30 | Boston Scientific Corporation | Stent delivery system |
US6689162B1 (en) | 1995-10-11 | 2004-02-10 | Boston Scientific Scimed, Inc. | Braided composite prosthesis |
US5776161A (en) | 1995-10-16 | 1998-07-07 | Instent, Inc. | Medical stents, apparatus and method for making same |
US5628788A (en) * | 1995-11-07 | 1997-05-13 | Corvita Corporation | Self-expanding endoluminal stent-graft |
DE69526857T2 (en) | 1995-11-27 | 2003-01-02 | Schneider Europ Gmbh Buelach | Stent for use in one pass |
US6719782B1 (en) * | 1996-01-04 | 2004-04-13 | Endovascular Technologies, Inc. | Flat wire stent |
US5938682A (en) | 1996-01-26 | 1999-08-17 | Cordis Corporation | Axially flexible stent |
JP2000504594A (en) | 1996-02-02 | 2000-04-18 | トランスバスキュラー インコーポレイテッド | Method and apparatus for blocking flow in a blood vessel |
EP1477133B9 (en) | 1996-03-05 | 2007-11-21 | Evysio Medical Devices Ulc | Expandable stent |
US6796997B1 (en) | 1996-03-05 | 2004-09-28 | Evysio Medical Devices Ulc | Expandable stent |
CA2192520A1 (en) * | 1996-03-05 | 1997-09-05 | Ian M. Penn | Expandable stent and method for delivery of same |
CA2199890C (en) | 1996-03-26 | 2002-02-05 | Leonard Pinchuk | Stents and stent-grafts having enhanced hoop strength and methods of making the same |
US6533805B1 (en) * | 1996-04-01 | 2003-03-18 | General Surgical Innovations, Inc. | Prosthesis and method for deployment within a body lumen |
US5824042A (en) | 1996-04-05 | 1998-10-20 | Medtronic, Inc. | Endoluminal prostheses having position indicating markers |
US5713949A (en) * | 1996-08-06 | 1998-02-03 | Jayaraman; Swaminathan | Microporous covered stents and method of coating |
JP4636634B2 (en) | 1996-04-26 | 2011-02-23 | ボストン サイエンティフィック サイムド,インコーポレイテッド | Intravascular stent |
US6241760B1 (en) | 1996-04-26 | 2001-06-05 | G. David Jang | Intravascular stent |
US6251133B1 (en) * | 1996-05-03 | 2001-06-26 | Medinol Ltd. | Bifurcated stent with improved side branch aperture and method of making same |
UA58485C2 (en) | 1996-05-03 | 2003-08-15 | Медінол Лтд. | Method for manufacture of bifurcated stent (variants) and bifurcated stent (variants) |
US5800514A (en) | 1996-05-24 | 1998-09-01 | Meadox Medicals, Inc. | Shaped woven tubular soft-tissue prostheses and methods of manufacturing |
EP0844853B1 (en) | 1996-05-31 | 2003-12-17 | Ave Galway Limited | Bifurcated endovascular stents |
US8728143B2 (en) | 1996-06-06 | 2014-05-20 | Biosensors International Group, Ltd. | Endoprosthesis deployment system for treating vascular bifurcations |
US5697971A (en) | 1996-06-11 | 1997-12-16 | Fischell; Robert E. | Multi-cell stent with cells having differing characteristics |
US5922020A (en) | 1996-08-02 | 1999-07-13 | Localmed, Inc. | Tubular prosthesis having improved expansion and imaging characteristics |
US5755781A (en) | 1996-08-06 | 1998-05-26 | Iowa-India Investments Company Limited | Embodiments of multiple interconnected stents |
US6174329B1 (en) * | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
US5797887A (en) | 1996-08-27 | 1998-08-25 | Novovasc Llc | Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation |
US5807404A (en) * | 1996-09-19 | 1998-09-15 | Medinol Ltd. | Stent with variable features to optimize support and method of making such stent |
US6451044B1 (en) | 1996-09-20 | 2002-09-17 | Board Of Regents, The University Of Texas System | Method and apparatus for heating inflammed tissue |
EP0934035B8 (en) * | 1996-09-26 | 2006-01-18 | Boston Scientific Scimed, Inc. | Support structure/membrane composite medical device |
US5755776A (en) | 1996-10-04 | 1998-05-26 | Al-Saadon; Khalid | Permanent expandable intraluminal tubular stent |
US5868781A (en) * | 1996-10-22 | 1999-02-09 | Scimed Life Systems, Inc. | Locking stent |
US6325826B1 (en) * | 1998-01-14 | 2001-12-04 | Advanced Stent Technologies, Inc. | Extendible stent apparatus |
US6692483B2 (en) * | 1996-11-04 | 2004-02-17 | Advanced Stent Technologies, Inc. | Catheter with attached flexible side sheath |
WO1998020810A1 (en) | 1996-11-12 | 1998-05-22 | Medtronic, Inc. | Flexible, radially expansible luminal prostheses |
US6027527A (en) | 1996-12-06 | 2000-02-22 | Piolax Inc. | Stent |
EP0946222A1 (en) | 1996-12-13 | 1999-10-06 | Data Sciences International, Inc. | Biocompatible medical devices with polyurethane surface |
US5868782A (en) | 1996-12-24 | 1999-02-09 | Global Therapeutics, Inc. | Radially expandable axially non-contracting surgical stent |
US5906759A (en) * | 1996-12-26 | 1999-05-25 | Medinol Ltd. | Stent forming apparatus with stent deforming blades |
IT1289815B1 (en) | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT AND RELATED PRODUCTION PROCESS |
FR2758253B1 (en) | 1997-01-10 | 1999-04-02 | Nycomed Lab Sa | IMPLANTABLE DEVICE FOR THE TREATMENT OF A BODY DUCT |
US5827321A (en) | 1997-02-07 | 1998-10-27 | Cornerstone Devices, Inc. | Non-Foreshortening intraluminal prosthesis |
FR2760351B1 (en) | 1997-03-04 | 1999-05-28 | Bernard Glatt | HELICAL STENT FORMING DEVICE AND MANUFACTURING METHOD THEREOF |
ATE287679T1 (en) * | 1997-03-05 | 2005-02-15 | Boston Scient Ltd | COMPLIANT MULTI-LAYER STENT DEVICE |
US5911732A (en) | 1997-03-10 | 1999-06-15 | Johnson & Johnson Interventional Systems, Co. | Articulated expandable intraluminal stent |
US5853419A (en) | 1997-03-17 | 1998-12-29 | Surface Genesis, Inc. | Stent |
US6096071A (en) | 1998-03-26 | 2000-08-01 | Yadav; Jay S. | Ostial stent |
ES2193291T3 (en) | 1997-03-27 | 2003-11-01 | Hercules Inc | USE OF WATERPROOF PROTECTIVE COATING COMPOSITIONS FOR INDUSTRIAL COATINGS AND WATERY COATING COMPOSITIONS. |
US5902475A (en) | 1997-04-08 | 1999-05-11 | Interventional Technologies, Inc. | Method for manufacturing a stent |
US6240616B1 (en) * | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US6776792B1 (en) | 1997-04-24 | 2004-08-17 | Advanced Cardiovascular Systems Inc. | Coated endovascular stent |
US6033433A (en) | 1997-04-25 | 2000-03-07 | Scimed Life Systems, Inc. | Stent configurations including spirals |
US6451049B2 (en) | 1998-04-29 | 2002-09-17 | Sorin Biomedica Cardio, S.P.A. | Stents for angioplasty |
IT1292295B1 (en) | 1997-04-29 | 1999-01-29 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT |
DE19718339A1 (en) * | 1997-04-30 | 1998-11-12 | Schering Ag | Polymer coated stents, processes for their manufacture and their use for restenosis prophylaxis |
US5957929A (en) | 1997-05-02 | 1999-09-28 | Micro Therapeutics, Inc. | Expandable stent apparatus and method |
US5741327A (en) | 1997-05-06 | 1998-04-21 | Global Therapeutics, Inc. | Surgical stent featuring radiopaque markers |
DE29708803U1 (en) * | 1997-05-17 | 1997-07-31 | Jomed Implantate Gmbh | Radially expandable stent for implantation in a body vessel in the area of a vascular branch |
DE29708879U1 (en) * | 1997-05-20 | 1997-07-31 | Jomed Implantate Gmbh | Coronary stent |
US5836966A (en) | 1997-05-22 | 1998-11-17 | Scimed Life Systems, Inc. | Variable expansion force stent |
CA2235911C (en) | 1997-05-27 | 2003-07-29 | Schneider (Usa) Inc. | Stent and stent-graft for treating branched vessels |
BE1011180A6 (en) * | 1997-05-27 | 1999-06-01 | Medicorp R & D Benelux Sa | Luminal endoprosthesis AUTO EXPANDABLE. |
EP0884029B1 (en) | 1997-06-13 | 2004-12-22 | Gary J. Becker | Expandable intraluminal endoprosthesis |
US6203536B1 (en) | 1997-06-17 | 2001-03-20 | Medtronic, Inc. | Medical device for delivering a therapeutic substance and method therefor |
US6723121B1 (en) * | 1997-06-18 | 2004-04-20 | Scimed Life Systems, Inc. | Polycarbonate-polyurethane dispersions for thrombo-resistant coatings |
US6165195A (en) | 1997-08-13 | 2000-12-26 | Advanced Cardiovascylar Systems, Inc. | Stent and catheter assembly and method for treating bifurcations |
US6316522B1 (en) | 1997-08-18 | 2001-11-13 | Scimed Life Systems, Inc. | Bioresorbable hydrogel compositions for implantable prostheses |
US6746476B1 (en) | 1997-09-22 | 2004-06-08 | Cordis Corporation | Bifurcated axially flexible stent |
ES2290995T3 (en) | 1997-09-24 | 2008-02-16 | Med Institute, Inc. | RADIALLY EXPANDABLE ENDOPROTESIS. |
US6071308A (en) | 1997-10-01 | 2000-06-06 | Boston Scientific Corporation | Flexible metal wire stent |
US6013091A (en) | 1997-10-09 | 2000-01-11 | Scimed Life Systems, Inc. | Stent configurations |
DE19746882A1 (en) | 1997-10-23 | 1999-04-29 | Angiomed Ag | Expandable stent for tubular anatomical structures such as bile-ducts |
US6120534A (en) | 1997-10-29 | 2000-09-19 | Ruiz; Carlos E. | Endoluminal prosthesis having adjustable constriction |
US6033435A (en) * | 1997-11-03 | 2000-03-07 | Divysio Solutions Ulc | Bifurcated stent and method for the manufacture and delivery of same |
US6309414B1 (en) | 1997-11-04 | 2001-10-30 | Sorin Biomedica Cardio S.P.A. | Angioplasty stents |
NO311781B1 (en) | 1997-11-13 | 2002-01-28 | Medinol Ltd | Metal multilayer stents |
US6330884B1 (en) | 1997-11-14 | 2001-12-18 | Transvascular, Inc. | Deformable scaffolding multicellular stent |
US6267782B1 (en) | 1997-11-20 | 2001-07-31 | St. Jude Medical, Inc. | Medical article with adhered antimicrobial metal |
DE19754747A1 (en) | 1997-12-10 | 1999-06-17 | Impag Gmbh Medizintechnik | Device for being implanted into hollow space of human body in particular into gullet |
US6179867B1 (en) * | 1998-01-16 | 2001-01-30 | Advanced Cardiovascular Systems, Inc. | Flexible stent and method of use |
EP0945107A3 (en) | 1998-01-23 | 2000-01-19 | Arterial Vascular Engineering, Inc. | Helical stent |
US6533807B2 (en) | 1998-02-05 | 2003-03-18 | Medtronic, Inc. | Radially-expandable stent and delivery system |
US5931866A (en) | 1998-02-24 | 1999-08-03 | Frantzen; John J. | Radially expandable stent featuring accordion stops |
US6488701B1 (en) * | 1998-03-31 | 2002-12-03 | Medtronic Ave, Inc. | Stent-graft assembly with thin-walled graft component and method of manufacture |
WO1999044543A1 (en) | 1998-03-04 | 1999-09-10 | Scimed Life Systems, Inc. | Improved stent cell configurations |
US5938697A (en) | 1998-03-04 | 1999-08-17 | Scimed Life Systems, Inc. | Stent having variable properties |
WO1999044535A1 (en) | 1998-03-05 | 1999-09-10 | Boston Scientific Limited | Intraluminal stent |
US6019778A (en) * | 1998-03-13 | 2000-02-01 | Cordis Corporation | Delivery apparatus for a self-expanding stent |
US5935162A (en) | 1998-03-16 | 1999-08-10 | Medtronic, Inc. | Wire-tubular hybrid stent |
US6132461A (en) | 1998-03-27 | 2000-10-17 | Intratherapeutics, Inc. | Stent with dual support structure |
EP1067885B1 (en) | 1998-04-02 | 2006-10-18 | Salviac Limited | Delivery catheter |
US6436133B1 (en) | 1998-04-15 | 2002-08-20 | Joseph G. Furst | Expandable graft |
US6206916B1 (en) | 1998-04-15 | 2001-03-27 | Joseph G. Furst | Coated intraluminal graft |
WO1999056663A2 (en) | 1998-05-05 | 1999-11-11 | Scimed Life Systems, Inc. | Stent with smooth ends |
DE19822157B4 (en) | 1998-05-16 | 2013-01-10 | Abbott Laboratories Vascular Enterprises Ltd. | Radially expandable stent for implantation in a body vessel |
US6740113B2 (en) | 1998-05-29 | 2004-05-25 | Scimed Life Systems, Inc. | Balloon expandable stent with a self-expanding portion |
EP1082072B8 (en) | 1998-06-04 | 2014-03-05 | New York University | Endovascular thin film devices for treating and preventing stroke |
US6171334B1 (en) | 1998-06-17 | 2001-01-09 | Advanced Cardiovascular Systems, Inc. | Expandable stent and method of use |
US6461380B1 (en) | 1998-07-28 | 2002-10-08 | Advanced Cardiovascular Systems, Inc. | Stent configuration |
US6159239A (en) | 1998-08-14 | 2000-12-12 | Prodesco, Inc. | Woven stent/graft structure |
CA2340652C (en) | 1998-08-20 | 2013-09-24 | Cook Incorporated | Coated implantable medical device comprising paclitaxel |
DE19839646A1 (en) | 1998-08-31 | 2000-03-09 | Jomed Implantate Gmbh | Stent |
US6682554B2 (en) * | 1998-09-05 | 2004-01-27 | Jomed Gmbh | Methods and apparatus for a stent having an expandable web structure |
DE19840645A1 (en) | 1998-09-05 | 2000-03-09 | Jomed Implantate Gmbh | Stent |
US6755856B2 (en) | 1998-09-05 | 2004-06-29 | Abbott Laboratories Vascular Enterprises Limited | Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation |
US6193744B1 (en) | 1998-09-10 | 2001-02-27 | Scimed Life Systems, Inc. | Stent configurations |
US6432126B1 (en) | 1998-09-30 | 2002-08-13 | C.R. Bard, Inc. | Flexible vascular inducing implants |
US6547814B2 (en) | 1998-09-30 | 2003-04-15 | Impra, Inc. | Selective adherence of stent-graft coverings |
US6273909B1 (en) | 1998-10-05 | 2001-08-14 | Teramed Inc. | Endovascular graft system |
US6042597A (en) | 1998-10-23 | 2000-03-28 | Scimed Life Systems, Inc. | Helical stent design |
US6475234B1 (en) | 1998-10-26 | 2002-11-05 | Medinol, Ltd. | Balloon expandable covered stents |
WO2000027463A1 (en) | 1998-11-11 | 2000-05-18 | Mark Wilson Ian Webster | Bifurcation stent and delivery systems |
US6238335B1 (en) | 1998-12-11 | 2001-05-29 | Enteric Medical Technologies, Inc. | Method for treating gastroesophageal reflux disease and apparatus for use therewith |
US6733523B2 (en) | 1998-12-11 | 2004-05-11 | Endologix, Inc. | Implantable vascular graft |
JP4189127B2 (en) | 1998-12-11 | 2008-12-03 | エンドロジックス、インク | Intraluminal artificial blood vessels |
US6660030B2 (en) | 1998-12-11 | 2003-12-09 | Endologix, Inc. | Bifurcation graft deployment catheter |
US6383204B1 (en) | 1998-12-15 | 2002-05-07 | Micrus Corporation | Variable stiffness coil for vasoocclusive devices |
US6743252B1 (en) | 1998-12-18 | 2004-06-01 | Cook Incorporated | Cannula stent |
US6530950B1 (en) | 1999-01-12 | 2003-03-11 | Quanam Medical Corporation | Intraluminal stent having coaxial polymer member |
US6673102B1 (en) * | 1999-01-22 | 2004-01-06 | Gore Enterprises Holdings, Inc. | Covered endoprosthesis and delivery system |
AU768150B2 (en) | 1999-01-22 | 2003-12-04 | W.L. Gore & Associates, Inc. | A biliary stent-graft |
WO2000044309A2 (en) | 1999-02-01 | 2000-08-03 | Board Of Regents, The University Of Texas System | Woven bifurcated and trifurcated stents and methods for making the same |
US6361557B1 (en) * | 1999-02-05 | 2002-03-26 | Medtronic Ave, Inc. | Staplebutton radiopaque marker |
US6695876B1 (en) * | 1999-02-12 | 2004-02-24 | Thomas R. Marotta | Endovascular prosthesis |
US6248122B1 (en) | 1999-02-26 | 2001-06-19 | Vascular Architects, Inc. | Catheter with controlled release endoluminal prosthesis |
US6251134B1 (en) | 1999-02-28 | 2001-06-26 | Inflow Dynamics Inc. | Stent with high longitudinal flexibility |
US6273910B1 (en) | 1999-03-11 | 2001-08-14 | Advanced Cardiovascular Systems, Inc. | Stent with varying strut geometry |
DE29904817U1 (en) | 1999-03-16 | 1999-05-27 | Amg Handelsgesellschaft Fuer A | Blood vessel support device |
US6620192B1 (en) | 1999-03-16 | 2003-09-16 | Advanced Cardiovascular Systems, Inc. | Multilayer stent |
US6364903B2 (en) | 1999-03-19 | 2002-04-02 | Meadox Medicals, Inc. | Polymer coated stent |
US6325825B1 (en) | 1999-04-08 | 2001-12-04 | Cordis Corporation | Stent with variable wall thickness |
CA2370180C (en) | 1999-04-15 | 2009-07-07 | Smart Therapeutics, Inc. | Intravascular stent and method of treating neurovascular vessel lesion |
US6730116B1 (en) | 1999-04-16 | 2004-05-04 | Medtronic, Inc. | Medical device for intraluminal endovascular stenting |
US6273911B1 (en) | 1999-04-22 | 2001-08-14 | Advanced Cardiovascular Systems, Inc. | Variable strength stent |
US6375676B1 (en) | 1999-05-17 | 2002-04-23 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent with enhanced delivery precision and stent delivery system |
JP4299973B2 (en) | 1999-05-20 | 2009-07-22 | ボストン サイエンティフィック リミテッド | Stent delivery system with a shrink stabilizer |
US6673103B1 (en) * | 1999-05-20 | 2004-01-06 | Scimed Life Systems, Inc. | Mesh and stent for increased flexibility |
US6398802B1 (en) | 1999-06-21 | 2002-06-04 | Scimed Life Systems, Inc. | Low profile delivery system for stent and graft deployment |
US6312459B1 (en) | 1999-06-30 | 2001-11-06 | Advanced Cardiovascular Systems, Inc. | Stent design for use in small vessels |
US6258121B1 (en) * | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
US6551351B2 (en) | 1999-07-02 | 2003-04-22 | Scimed Life Systems | Spiral wound stent |
US6409754B1 (en) | 1999-07-02 | 2002-06-25 | Scimed Life Systems, Inc. | Flexible segmented stent |
US6780497B1 (en) | 1999-08-05 | 2004-08-24 | Gore Enterprise Holdings, Inc. | Surface modified expanded polytetrafluoroethylene devices and methods of producing the same |
US6299622B1 (en) | 1999-08-19 | 2001-10-09 | Fox Hollow Technologies, Inc. | Atherectomy catheter with aligned imager |
US6514268B2 (en) | 1999-08-30 | 2003-02-04 | Alcon Universal Ltd. | Method of operating microsurgical instruments |
US6293968B1 (en) | 1999-09-02 | 2001-09-25 | Syde A. Taheri | Inflatable intraluminal vascular stent |
US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6503556B2 (en) | 2000-12-28 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Methods of forming a coating for a prosthesis |
US6383213B2 (en) | 1999-10-05 | 2002-05-07 | Advanced Cardiovascular Systems, Inc. | Stent and catheter assembly and method for treating bifurcations |
FR2799363B1 (en) | 1999-10-11 | 2001-11-30 | Braun Celsa Sa | MEDICAL IMPLANT IN MEANDRES IN ZIGZAG |
US20010047200A1 (en) | 1999-10-13 | 2001-11-29 | Raymond Sun | Non-foreshortening intraluminal prosthesis |
US6420378B1 (en) | 1999-10-15 | 2002-07-16 | Supergen, Inc. | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same |
US6331189B1 (en) | 1999-10-18 | 2001-12-18 | Medtronic, Inc. | Flexible medical stent |
DE19951477A1 (en) | 1999-10-26 | 2001-05-03 | Biotronik Mess & Therapieg | Stent |
DE19951611A1 (en) | 1999-10-26 | 2001-05-10 | Biotronik Mess & Therapieg | Stent with a closed structure |
US6428569B1 (en) * | 1999-11-09 | 2002-08-06 | Scimed Life Systems Inc. | Micro structure stent configurations |
US6679910B1 (en) * | 1999-11-12 | 2004-01-20 | Latin American Devices Llc | Intraluminal stent |
US6280466B1 (en) | 1999-12-03 | 2001-08-28 | Teramed Inc. | Endovascular graft system |
US6673107B1 (en) * | 1999-12-06 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Bifurcated stent and method of making |
US6387120B2 (en) | 1999-12-09 | 2002-05-14 | Advanced Cardiovascular Systems, Inc. | Stent and catheter assembly and method for treating bifurcations |
US6702849B1 (en) * | 1999-12-13 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers |
US6981987B2 (en) | 1999-12-22 | 2006-01-03 | Ethicon, Inc. | Removable stent for body lumens |
US6908624B2 (en) | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6537311B1 (en) | 1999-12-30 | 2003-03-25 | Advanced Cardiovascular Systems, Inc. | Stent designs for use in peripheral vessels |
US6471721B1 (en) | 1999-12-30 | 2002-10-29 | Advanced Cardiovascular Systems, Inc. | Vascular stent having increased radiopacity and method for making same |
US6942674B2 (en) | 2000-01-05 | 2005-09-13 | Integrated Vascular Systems, Inc. | Apparatus and methods for delivering a closure device |
US6322586B1 (en) | 2000-01-10 | 2001-11-27 | Scimed Life Systems, Inc. | Catheter tip designs and method of manufacture |
US6312458B1 (en) | 2000-01-19 | 2001-11-06 | Scimed Life Systems, Inc. | Tubular structure/stent/stent securement member |
US6355063B1 (en) | 2000-01-20 | 2002-03-12 | Impra, Inc. | Expanded PTFE drug delivery graft |
US6344044B1 (en) * | 2000-02-11 | 2002-02-05 | Edwards Lifesciences Corp. | Apparatus and methods for delivery of intraluminal prosthesis |
US6723119B2 (en) | 2000-03-01 | 2004-04-20 | Medinol Ltd. | Longitudinally flexible stent |
SG86458A1 (en) * | 2000-03-01 | 2002-02-19 | Medinol Ltd | Longitudinally flexible stent |
EP1132060A2 (en) | 2000-03-09 | 2001-09-12 | LPL Systems Inc. | Expandable stent |
US6736838B1 (en) | 2000-03-22 | 2004-05-18 | Zuli Holdings Ltd. | Method and apparatus for covering a stent |
US6818247B1 (en) | 2000-03-31 | 2004-11-16 | Advanced Cardiovascular Systems, Inc. | Ethylene vinyl alcohol-dimethyl acetamide composition and a method of coating a stent |
WO2001076675A2 (en) | 2000-04-11 | 2001-10-18 | Scimed Life Systems, Inc. | Reinforced retention structures |
GB0009030D0 (en) | 2000-04-12 | 2000-05-31 | Angiomed Ag | Self-expanding metal stent and method of making it |
JP3654627B2 (en) | 2000-04-20 | 2005-06-02 | 川澄化学工業株式会社 | Stent |
US6352552B1 (en) | 2000-05-02 | 2002-03-05 | Scion Cardio-Vascular, Inc. | Stent |
AU781306B2 (en) | 2000-05-02 | 2005-05-12 | Cordis Corporation | Bifurcated stent and stent delivery system |
US6616689B1 (en) | 2000-05-03 | 2003-09-09 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
US6423091B1 (en) | 2000-05-16 | 2002-07-23 | Cordis Corporation | Helical stent having flat ends |
KR100360364B1 (en) | 2000-05-22 | 2002-11-13 | 주식회사 정성메디칼 | A metal stent for installation in the coronary artery |
US6764519B2 (en) | 2000-05-26 | 2004-07-20 | Scimed Life Systems, Inc. | Ureteral stent |
US20030139803A1 (en) | 2000-05-30 | 2003-07-24 | Jacques Sequin | Method of stenting a vessel with stent lumenal diameter increasing distally |
US6800089B1 (en) | 2000-05-31 | 2004-10-05 | Advanced Cardiovascular Systems, Inc. | Mechanical attachment method of cover materials on stents |
US6572646B1 (en) | 2000-06-02 | 2003-06-03 | Advanced Cardiovascular Systems, Inc. | Curved nitinol stent for extremely tortuous anatomy |
US6719991B2 (en) * | 2000-06-09 | 2004-04-13 | Baylor College Of Medicine | Combination of antimicrobial agents and bacterial interference to coat medical devices |
US6723373B1 (en) * | 2000-06-16 | 2004-04-20 | Cordis Corporation | Device and process for coating stents |
US6652579B1 (en) | 2000-06-22 | 2003-11-25 | Advanced Cardiovascular Systems, Inc. | Radiopaque stent |
US6805704B1 (en) | 2000-06-26 | 2004-10-19 | C. R. Bard, Inc. | Intraluminal stents |
US6540775B1 (en) * | 2000-06-30 | 2003-04-01 | Cordis Corporation | Ultraflexible open cell stent |
DE10033723C1 (en) | 2000-07-12 | 2002-02-21 | Siemens Ag | Surgical instrument position and orientation visualization device for surgical operation has data representing instrument position and orientation projected onto surface of patient's body |
US6709451B1 (en) * | 2000-07-14 | 2004-03-23 | Norman Noble, Inc. | Channeled vascular stent apparatus and method |
US6440162B1 (en) | 2000-07-26 | 2002-08-27 | Advanced Cardiovascular Systems, Inc. | Stent having increased scaffolding expandable bar arms |
US6808533B1 (en) | 2000-07-28 | 2004-10-26 | Atrium Medical Corporation | Covered stent and method of covering a stent |
US6613078B1 (en) | 2000-08-02 | 2003-09-02 | Hector Daniel Barone | Multi-component endoluminal graft assembly, use thereof and method of implanting |
US6773446B1 (en) | 2000-08-02 | 2004-08-10 | Cordis Corporation | Delivery apparatus for a self-expanding stent |
AU2001286419A1 (en) | 2000-08-07 | 2002-11-11 | Abbeymoor Medical, Inc. | Endourethral device and method |
WO2002015824A2 (en) | 2000-08-25 | 2002-02-28 | Kensey Nash Corporation | Covered stents, systems for deploying covered stents |
NO312223B1 (en) | 2000-09-05 | 2002-04-15 | Leiv Eiriksson Nyfotek As | Coated expandable stent |
US6478815B1 (en) | 2000-09-18 | 2002-11-12 | Inflow Dynamics Inc. | Vascular and endoluminal stents |
US6699278B2 (en) | 2000-09-22 | 2004-03-02 | Cordis Corporation | Stent with optimal strength and radiopacity characteristics |
US6554841B1 (en) | 2000-09-22 | 2003-04-29 | Scimed Life Systems, Inc. | Striped sleeve for stent delivery |
DE60125800T2 (en) | 2000-09-25 | 2007-10-11 | Boston Scientific Scimed, Inc., Maple Grove | INTRAVASCULAR STENT |
US6695833B1 (en) * | 2000-09-27 | 2004-02-24 | Nellix, Inc. | Vascular stent-graft apparatus and forming method |
US6805898B1 (en) | 2000-09-28 | 2004-10-19 | Advanced Cardiovascular Systems, Inc. | Surface features of an implantable medical device |
US6485508B1 (en) | 2000-10-13 | 2002-11-26 | Mcguinness Colm P. | Low profile stent |
US6764507B2 (en) | 2000-10-16 | 2004-07-20 | Conor Medsystems, Inc. | Expandable medical device with improved spatial distribution |
US6786918B1 (en) | 2000-10-17 | 2004-09-07 | Medtronic Vascular, Inc. | Stent delivery system |
US6663664B1 (en) | 2000-10-26 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent with time variable radial force |
US6758859B1 (en) | 2000-10-30 | 2004-07-06 | Kenny L. Dang | Increased drug-loading and reduced stress drug delivery device |
US6770086B1 (en) | 2000-11-02 | 2004-08-03 | Scimed Life Systems, Inc. | Stent covering formed of porous polytetraflouroethylene |
AU2002233936A1 (en) * | 2000-11-07 | 2002-05-21 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal stent, self-fupporting endoluminal graft and methods of making same |
US6843802B1 (en) | 2000-11-16 | 2005-01-18 | Cordis Corporation | Delivery apparatus for a self expanding retractable stent |
US6664335B2 (en) | 2000-11-30 | 2003-12-16 | Cardiac Pacemakers, Inc. | Polyurethane elastomer article with “shape memory” and medical devices therefrom |
US6645242B1 (en) | 2000-12-11 | 2003-11-11 | Stephen F. Quinn | Bifurcated side-access intravascular stent graft |
US6913617B1 (en) * | 2000-12-27 | 2005-07-05 | Advanced Cardiovascular Systems, Inc. | Method for creating a textured surface on an implantable medical device |
US6569194B1 (en) | 2000-12-28 | 2003-05-27 | Advanced Cardiovascular Systems, Inc. | Thermoelastic and superelastic Ni-Ti-W alloy |
US6540776B2 (en) * | 2000-12-28 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Sheath for a prosthesis and methods of forming the same |
US6565599B1 (en) | 2000-12-28 | 2003-05-20 | Advanced Cardiovascular Systems, Inc. | Hybrid stent |
US6641607B1 (en) | 2000-12-29 | 2003-11-04 | Advanced Cardiovascular Systems, Inc. | Double tube stent |
US6749627B2 (en) | 2001-01-18 | 2004-06-15 | Ev3 Peripheral, Inc. | Grip for stent delivery system |
US6899727B2 (en) | 2001-01-22 | 2005-05-31 | Gore Enterprise Holdings, Inc. | Deployment system for intraluminal devices |
US6752829B2 (en) | 2001-01-30 | 2004-06-22 | Scimed Life Systems, Inc. | Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same |
JP4819245B2 (en) | 2001-05-25 | 2011-11-24 | 株式会社カネカ | Stent |
CA2436642A1 (en) | 2001-02-01 | 2002-08-08 | Kaneka Corporation | Stent |
US6802846B2 (en) | 2001-02-12 | 2004-10-12 | Ams Research Corporation | Foreign body retrieval device and method |
US6540777B2 (en) * | 2001-02-15 | 2003-04-01 | Scimed Life Systems, Inc. | Locking stent |
US6623518B2 (en) | 2001-02-26 | 2003-09-23 | Ev3 Peripheral, Inc. | Implant delivery system with interlock |
US6955686B2 (en) | 2001-03-01 | 2005-10-18 | Cordis Corporation | Flexible stent |
US6679911B2 (en) * | 2001-03-01 | 2004-01-20 | Cordis Corporation | Flexible stent |
US6790227B2 (en) | 2001-03-01 | 2004-09-14 | Cordis Corporation | Flexible stent |
US6673104B2 (en) * | 2001-03-15 | 2004-01-06 | Scimed Life Systems, Inc. | Magnetic stent |
US6673105B1 (en) * | 2001-04-02 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Metal prosthesis coated with expandable ePTFE |
US6756007B2 (en) | 2001-04-04 | 2004-06-29 | Bard Peripheral Vascular, Inc. | Method for preparing an implantable prosthesis for loading into a delivery apparatus |
US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
US6660034B1 (en) | 2001-04-30 | 2003-12-09 | Advanced Cardiovascular Systems, Inc. | Stent for increasing blood flow to ischemic tissues and a method of using the same |
US7011675B2 (en) * | 2001-04-30 | 2006-03-14 | Boston Scientific Scimed, Inc. | Endoscopic stent delivery system and method |
US6685745B2 (en) * | 2001-05-15 | 2004-02-03 | Scimed Life Systems, Inc. | Delivering an agent to a patient's body |
US6749628B1 (en) * | 2001-05-17 | 2004-06-15 | Advanced Cardiovascular Systems, Inc. | Stent and catheter assembly and method for treating bifurcations |
US6821291B2 (en) | 2001-06-01 | 2004-11-23 | Ams Research Corporation | Retrievable stent and method of use thereof |
US6712844B2 (en) * | 2001-06-06 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | MRI compatible stent |
US6629994B2 (en) | 2001-06-11 | 2003-10-07 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US6818013B2 (en) | 2001-06-14 | 2004-11-16 | Cordis Corporation | Intravascular stent device |
US6673106B2 (en) | 2001-06-14 | 2004-01-06 | Cordis Neurovascular, Inc. | Intravascular stent device |
US6749629B1 (en) | 2001-06-27 | 2004-06-15 | Advanced Cardiovascular Systems, Inc. | Stent pattern with figure-eights |
US6676693B1 (en) * | 2001-06-27 | 2004-01-13 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for delivering a self-expanding stent |
US6695920B1 (en) | 2001-06-27 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Mandrel for supporting a stent and a method of using the mandrel to coat a stent |
US6673154B1 (en) * | 2001-06-28 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Stent mounting device to coat a stent |
US6656216B1 (en) | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
EP1273314A1 (en) | 2001-07-06 | 2003-01-08 | Terumo Kabushiki Kaisha | Stent |
DE60236093D1 (en) * | 2001-07-26 | 2010-06-02 | Merit Medical Systems Inc | REMOVABLE STENT |
US20030040803A1 (en) | 2001-08-23 | 2003-02-27 | Rioux Robert F. | Maintaining an open passageway through a body lumen |
US6641611B2 (en) | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
US6908480B2 (en) * | 2001-08-29 | 2005-06-21 | Swaminathan Jayaraman | Structurally variable stents |
US6656351B2 (en) | 2001-08-31 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Embolic protection devices one way porous membrane |
US6805703B2 (en) | 2001-09-18 | 2004-10-19 | Scimed Life Systems, Inc. | Protective membrane for reconfiguring a workpiece |
US6753071B1 (en) | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
DE60223886T2 (en) | 2001-10-22 | 2008-11-06 | Terumo K.K. | STENT AND METHOD FOR THE PRODUCTION THEREOF |
US20030077310A1 (en) * | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US20030083734A1 (en) | 2001-10-25 | 2003-05-01 | Curative Ag | Stent |
US6712843B2 (en) * | 2001-11-20 | 2004-03-30 | Scimed Life Systems, Inc | Stent with differential lengthening/shortening members |
US6776794B1 (en) | 2001-11-28 | 2004-08-17 | Advanced Cardiovascular Systems, Inc. | Stent pattern with mirror image |
US7014654B2 (en) | 2001-11-30 | 2006-03-21 | Scimed Life Systems, Inc. | Stent designed for the delivery of therapeutic substance or other agents |
US20030114919A1 (en) | 2001-12-10 | 2003-06-19 | Mcquiston Jesse | Polymeric stent with metallic rings |
US6752826B2 (en) | 2001-12-14 | 2004-06-22 | Thoratec Corporation | Layered stent-graft and methods of making the same |
US6866805B2 (en) | 2001-12-27 | 2005-03-15 | Advanced Cardiovascular Systems, Inc. | Hybrid intravascular stent |
US6805707B1 (en) | 2001-12-27 | 2004-10-19 | Advanced Cardiovascular Systems, Inc. | Stent with improved ring and link pattern |
US7163553B2 (en) | 2001-12-28 | 2007-01-16 | Advanced Cardiovascular Systems, Inc. | Intravascular stent and method of use |
US6893413B2 (en) | 2002-01-07 | 2005-05-17 | Eric C. Martin | Two-piece stent combination for percutaneous arterialization of the coronary sinus and retrograde perfusion of the myocardium |
US6981985B2 (en) * | 2002-01-22 | 2006-01-03 | Boston Scientific Scimed, Inc. | Stent bumper struts |
US7029493B2 (en) | 2002-01-25 | 2006-04-18 | Cordis Corporation | Stent with enhanced crossability |
US6989024B2 (en) * | 2002-02-28 | 2006-01-24 | Counter Clockwise, Inc. | Guidewire loaded stent for delivery through a catheter |
US6773448B2 (en) | 2002-03-08 | 2004-08-10 | Ev3 Inc. | Distal protection devices having controllable wire motion |
US20030187495A1 (en) | 2002-04-01 | 2003-10-02 | Cully Edward H. | Endoluminal devices, embolic filters, methods of manufacture and use |
US6911039B2 (en) | 2002-04-23 | 2005-06-28 | Medtronic Vascular, Inc. | Integrated mechanical handle with quick slide mechanism |
DE10221076A1 (en) | 2002-05-11 | 2003-11-27 | Ruesch Willy Gmbh | stent |
US6830638B2 (en) | 2002-05-24 | 2004-12-14 | Advanced Cardiovascular Systems, Inc. | Medical devices configured from deep drawn nickel-titanium alloys and nickel-titanium clad alloys and method of making the same |
US6656220B1 (en) | 2002-06-17 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US7044962B2 (en) | 2002-06-25 | 2006-05-16 | Scimed Life Systems, Inc. | Implantable prosthesis with displaceable skirt |
US6761731B2 (en) | 2002-06-28 | 2004-07-13 | Cordis Corporation | Balloon-stent interaction to help reduce foreshortening |
US6802859B1 (en) | 2002-07-12 | 2004-10-12 | Endovascular Technologies, Inc. | Endovascular stent-graft with flexible bifurcation |
MXPA05001845A (en) | 2002-08-15 | 2005-11-17 | Gmp Cardiac Care Inc | Stent-graft with rails. |
EP1585535A2 (en) | 2002-08-15 | 2005-10-19 | Osteotrophin LLC | Pthrp-derived modulators of smooth muscle proliferation |
EP1550477B1 (en) | 2002-08-23 | 2015-11-04 | National Cerebral and Cardiovascular Center | Stent and process for producing the same |
US6878162B2 (en) | 2002-08-30 | 2005-04-12 | Edwards Lifesciences Ag | Helical stent having improved flexibility and expandability |
US20040059406A1 (en) * | 2002-09-20 | 2004-03-25 | Cully Edward H. | Medical device amenable to fenestration |
US6818063B1 (en) | 2002-09-24 | 2004-11-16 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and method for minimizing coating defects |
US6821293B2 (en) | 2002-10-25 | 2004-11-23 | Medinol Ltd. | Mandrel and method for making stents |
US7914567B2 (en) | 2002-11-22 | 2011-03-29 | Oregon Health & Science University | Stent tissue graft prosthesis |
US6899729B1 (en) | 2002-12-18 | 2005-05-31 | Advanced Cardiovascular Systems, Inc. | Stent for treating vulnerable plaque |
US6896697B1 (en) | 2002-12-30 | 2005-05-24 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US6920677B2 (en) | 2003-02-27 | 2005-07-26 | Medtronic Vascular, Inc. | Method for manufacturing an endovascular support device |
US6984244B2 (en) * | 2003-03-27 | 2006-01-10 | Endovascular Technologies, Inc. | Delivery system for endoluminal implant |
US7279003B2 (en) | 2003-04-24 | 2007-10-09 | Medtronic Vascular, Inc. | Stent graft tapered spring |
WO2004103207A2 (en) | 2003-05-15 | 2004-12-02 | Applied Medical Resources Corporation | Echogenic stent |
US6979348B2 (en) | 2003-06-04 | 2005-12-27 | Medtronic Vascular, Inc. | Reflowed drug-polymer coated stent and method thereof |
US6916336B2 (en) | 2003-06-09 | 2005-07-12 | Avantec Vascular Corporation | Vascular prosthesis |
-
2003
- 2003-11-20 US US10/718,217 patent/US7959671B2/en active Active
-
2004
- 2004-11-20 WO PCT/US2004/039162 patent/WO2005110282A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6423092B2 (en) * | 1999-12-22 | 2002-07-23 | Ethicon, Inc. | Biodegradable stent |
WO2005030086A2 (en) | 2003-09-24 | 2005-04-07 | Alveolus Inc. | Covered stent with geometry determinated functionality and method of making the same |
Non-Patent Citations (1)
Title |
---|
See also references of EP1689328A4 * |
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US7959671B2 (en) | 2011-06-14 |
US20040127974A1 (en) | 2004-07-01 |
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