WO2005123775A1 - Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof - Google Patents
Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof Download PDFInfo
- Publication number
- WO2005123775A1 WO2005123775A1 PCT/SE2005/000993 SE2005000993W WO2005123775A1 WO 2005123775 A1 WO2005123775 A1 WO 2005123775A1 SE 2005000993 W SE2005000993 W SE 2005000993W WO 2005123775 A1 WO2005123775 A1 WO 2005123775A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protofibrils
- antibody
- protofibril
- agent
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
- G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2005254928A AU2005254928B2 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
PL05753672T PL1781703T3 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US11/570,995 US8106164B2 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
DK05753672.4T DK1781703T3 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble beta-amyloid peptide protofibrils and uses thereof |
CA2570130A CA2570130C (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
SI200531986T SI1781703T1 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
ES05753672.4T ES2537001T3 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
EP05753672.4A EP1781703B1 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US13/336,520 US8404459B2 (en) | 2004-06-21 | 2011-12-23 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US13/780,643 US8999936B2 (en) | 2004-06-21 | 2013-02-28 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US14/627,161 US20150307601A1 (en) | 2004-06-21 | 2015-02-20 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0401601-0 | 2004-06-21 | ||
SE0401601A SE0401601D0 (en) | 2004-06-21 | 2004-06-21 | Protofibril specific antibodies and uses thereof |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/570,995 A-371-Of-International US8106164B2 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US13/336,520 Division US8404459B2 (en) | 2004-06-21 | 2011-12-23 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005123775A1 true WO2005123775A1 (en) | 2005-12-29 |
Family
ID=32906833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2005/000993 WO2005123775A1 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
Country Status (13)
Country | Link |
---|---|
US (4) | US8106164B2 (en) |
EP (1) | EP1781703B1 (en) |
AU (1) | AU2005254928B2 (en) |
CA (1) | CA2570130C (en) |
CY (1) | CY1116776T1 (en) |
DK (1) | DK1781703T3 (en) |
ES (1) | ES2537001T3 (en) |
HU (1) | HUE025628T2 (en) |
PL (1) | PL1781703T3 (en) |
PT (1) | PT1781703E (en) |
SE (1) | SE0401601D0 (en) |
SI (1) | SI1781703T1 (en) |
WO (1) | WO2005123775A1 (en) |
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EP1660533A2 (en) * | 2003-09-12 | 2006-05-31 | The Regents of the University of California | Monoclonal antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence |
WO2007064917A2 (en) * | 2005-11-30 | 2007-06-07 | Abbott Laboratories | Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins |
CN1329413C (en) * | 2006-01-23 | 2007-08-01 | 南京医科大学 | Antibody for treating or preventing senile dementia, its expression vector and application in drug preparation |
WO2007108756A1 (en) * | 2006-03-23 | 2007-09-27 | Bioarctic Neuroscience Ab | Improved protofibril selective antibodies and the use thereof |
WO2008104580A1 (en) | 2007-03-01 | 2008-09-04 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
WO2008150949A1 (en) * | 2007-05-30 | 2008-12-11 | Abbott Laboratories | HUMANIZED ANTIBODIES TO Aß(20-42) GLOBULOMER AND USES THEREOF |
US7700719B2 (en) | 2000-07-07 | 2010-04-20 | Bioarctic Neuroscience Ab | Arctic β amyloid protofibril |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
US20100202968A1 (en) * | 2007-01-05 | 2010-08-12 | University Of Zurich | Method of Providing Disease-Specific Binding Molecules and Targets |
US20100209422A1 (en) * | 2007-11-16 | 2010-08-19 | The Rockefeller University | Antibodies specific for the protofibril form of beta-amyloid protein |
WO2010130946A1 (en) * | 2009-05-12 | 2010-11-18 | Sanofi-Aventis | Humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide |
WO2011001366A1 (en) | 2009-06-29 | 2011-01-06 | Bioartic Neuroscience Ab | N-terminal truncated amyloid beta protofibrils/ oligomers for use in therapeutic and diagnostic methods for alzheimer's disease |
WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
US7939075B2 (en) | 2007-01-11 | 2011-05-10 | Philipps-Universitaet Marburg | Human monoclonal anti-amyloid-beta antibodies |
WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
WO2011110613A1 (en) | 2010-03-10 | 2011-09-15 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
US8106164B2 (en) | 2004-06-21 | 2012-01-31 | Bioarctic Neuroscience Ab | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
WO2013007839A1 (en) | 2011-07-14 | 2013-01-17 | Adx Neurosciences Nv | Antibodies to phosphorylated tau aggregates |
RU2475500C2 (en) * | 2007-09-13 | 2013-02-20 | Деленекс Терапьютикс Аг | HUMANISED ANTIBODIES TO β-AMYLOID PEPTIDE |
US8497072B2 (en) | 2005-11-30 | 2013-07-30 | Abbott Laboratories | Amyloid-beta globulomer antibodies |
US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
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US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
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Also Published As
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US20090155246A1 (en) | 2009-06-18 |
HUE025628T2 (en) | 2016-04-28 |
EP1781703B1 (en) | 2015-05-06 |
CA2570130A1 (en) | 2005-12-29 |
US8404459B2 (en) | 2013-03-26 |
CY1116776T1 (en) | 2017-03-15 |
CA2570130C (en) | 2016-02-23 |
US20120230912A1 (en) | 2012-09-13 |
US20150307601A1 (en) | 2015-10-29 |
DK1781703T3 (en) | 2015-06-01 |
AU2005254928B2 (en) | 2011-11-10 |
SE0401601D0 (en) | 2004-06-21 |
ES2537001T3 (en) | 2015-06-01 |
PT1781703E (en) | 2015-08-24 |
US8106164B2 (en) | 2012-01-31 |
US8999936B2 (en) | 2015-04-07 |
US20130236452A1 (en) | 2013-09-12 |
SI1781703T1 (en) | 2015-08-31 |
AU2005254928A1 (en) | 2005-12-29 |
EP1781703A1 (en) | 2007-05-09 |
PL1781703T3 (en) | 2015-10-30 |
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