WO2006003500A8 - Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h`1,2,4!triazin-2-yl!-benzamide derivatives by deprotecting the hydroxyl-protected precursers - Google Patents
Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h`1,2,4!triazin-2-yl!-benzamide derivatives by deprotecting the hydroxyl-protected precursersInfo
- Publication number
- WO2006003500A8 WO2006003500A8 PCT/IB2005/002036 IB2005002036W WO2006003500A8 WO 2006003500 A8 WO2006003500 A8 WO 2006003500A8 IB 2005002036 W IB2005002036 W IB 2005002036W WO 2006003500 A8 WO2006003500 A8 WO 2006003500A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparing
- precursers
- triazin
- deprotecting
- dioxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA06014022A MXPA06014022A (en) | 2004-06-29 | 2005-06-16 | Methods for preparing p2x7 inhibitors. |
CA002571124A CA2571124A1 (en) | 2004-06-29 | 2005-06-16 | Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h`1,2,4!triazin-2-yl!-benzamide derivatives by deprotecting the hydroxyl-protected precursers |
BRPI0512781-5A BRPI0512781A (en) | 2004-06-29 | 2005-06-16 | Method for preparing 5- {4- (2-hydroxy-propyl) -3,5-dioxo-4,5-dihydro-3h- [1,2,4] triazin-2-yl} -benzamide derivatives by of the unprotection of hydroxyl protector precursors |
EP05757546A EP1776352A1 (en) | 2004-06-29 | 2005-06-16 | Method for preparing 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h[1,2,4]triazin-2-yl]-benzamide derivatives by deprotecting the hydroxyl-protected precursers |
JP2007518730A JP2008504360A (en) | 2004-06-29 | 2005-06-16 | 5- [4- (2-hydroxy-propyl) -3,5-dioxo-4,5-dihydro-3H-1,2,4-triazin-2-yl by deprotecting the hydroxyl protected precursor Method for producing benzamide derivative |
AU2005258911A AU2005258911A1 (en) | 2004-06-29 | 2005-06-16 | Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3H`1,2,4!triazin-2-YL!-benzamide derivatives by deprotecting the hydroxyl-protected precursers |
NO20065327A NO20065327L (en) | 2004-06-29 | 2006-11-20 | Process for the preparation of derivatives of 5- [4- (2-hydroxy-propyl) -3,5-dihydro-3H'1, 2,4 (triazin-2-yl) -benzamide. |
IL179461A IL179461A0 (en) | 2004-06-29 | 2006-11-21 | Method for preparing 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5,-dihydro-3h] 2,4-[triazin-2-yl]-benzamide derivatives by deprotecting the hydroxyl-protected precursers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58385104P | 2004-06-29 | 2004-06-29 | |
US60/583,851 | 2004-06-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006003500A1 WO2006003500A1 (en) | 2006-01-12 |
WO2006003500A8 true WO2006003500A8 (en) | 2006-04-13 |
Family
ID=34972172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/002036 WO2006003500A1 (en) | 2004-06-29 | 2005-06-16 | Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h`1,2,4!triazin-2-yl!-benzamide derivatives by deprotecting the hydroxyl-protected precursers |
Country Status (15)
Country | Link |
---|---|
US (1) | US7235657B2 (en) |
EP (1) | EP1776352A1 (en) |
JP (1) | JP2008504360A (en) |
CN (1) | CN1980902A (en) |
AR (1) | AR049653A1 (en) |
AU (1) | AU2005258911A1 (en) |
BR (1) | BRPI0512781A (en) |
CA (1) | CA2571124A1 (en) |
IL (1) | IL179461A0 (en) |
MX (1) | MXPA06014022A (en) |
NO (1) | NO20065327L (en) |
RU (1) | RU2006146675A (en) |
TW (1) | TW200612964A (en) |
WO (1) | WO2006003500A1 (en) |
ZA (1) | ZA200609579B (en) |
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PA8591801A1 (en) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | BENZAMID INHIBITORS OF THE P2X7 RECEIVER. |
CA2525437C (en) | 2003-05-12 | 2009-04-28 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
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EP2322149A1 (en) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Methods and compositions for the treatment of ischemia |
EA201201548A1 (en) | 2010-05-14 | 2013-05-30 | Эффектис Фармасьютиклз Аг | NEW WAYS TO GET P2X7R ANTAGONISTS |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
US9988373B2 (en) | 2013-12-26 | 2018-06-05 | Shionogi & Co., Ltd. | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same |
AU2016252686B2 (en) | 2015-04-24 | 2019-03-14 | Shionogi & Co., Ltd. | 6-membered heterocyclic derivative and pharmaceutical composition comprising same |
WO2017209265A1 (en) * | 2016-06-03 | 2017-12-07 | 塩野義製薬株式会社 | Bicyclic heterocyclic derivative and pharmaceutical composition containing same |
MX2019004107A (en) | 2016-10-17 | 2019-08-05 | Shionogi & Co | Bicyclic nitrogenated heterocyclic derivative and pharmaceutical composition containing same. |
JP6692113B2 (en) * | 2016-10-21 | 2020-05-13 | 塩野義製薬株式会社 | Pharmaceutical composition containing 6-membered heterocyclic derivative |
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-
2005
- 2005-06-16 BR BRPI0512781-5A patent/BRPI0512781A/en not_active IP Right Cessation
- 2005-06-16 AU AU2005258911A patent/AU2005258911A1/en not_active Abandoned
- 2005-06-16 CA CA002571124A patent/CA2571124A1/en not_active Abandoned
- 2005-06-16 RU RU2006146675/04A patent/RU2006146675A/en not_active Application Discontinuation
- 2005-06-16 WO PCT/IB2005/002036 patent/WO2006003500A1/en active Application Filing
- 2005-06-16 MX MXPA06014022A patent/MXPA06014022A/en unknown
- 2005-06-16 JP JP2007518730A patent/JP2008504360A/en not_active Abandoned
- 2005-06-16 EP EP05757546A patent/EP1776352A1/en not_active Withdrawn
- 2005-06-16 CN CNA2005800221022A patent/CN1980902A/en active Pending
- 2005-06-27 US US11/167,828 patent/US7235657B2/en not_active Expired - Fee Related
- 2005-06-27 AR ARP050102638A patent/AR049653A1/en unknown
- 2005-06-28 TW TW094121706A patent/TW200612964A/en unknown
-
2006
- 2006-11-17 ZA ZA200609579A patent/ZA200609579B/en unknown
- 2006-11-20 NO NO20065327A patent/NO20065327L/en not_active Application Discontinuation
- 2006-11-21 IL IL179461A patent/IL179461A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200609579B (en) | 2008-08-27 |
TW200612964A (en) | 2006-05-01 |
RU2006146675A (en) | 2008-07-10 |
BRPI0512781A (en) | 2008-04-08 |
NO20065327L (en) | 2006-12-18 |
CA2571124A1 (en) | 2006-01-12 |
MXPA06014022A (en) | 2007-02-08 |
JP2008504360A (en) | 2008-02-14 |
US20050288256A1 (en) | 2005-12-29 |
CN1980902A (en) | 2007-06-13 |
IL179461A0 (en) | 2007-05-15 |
US7235657B2 (en) | 2007-06-26 |
EP1776352A1 (en) | 2007-04-25 |
AR049653A1 (en) | 2006-08-23 |
WO2006003500A1 (en) | 2006-01-12 |
AU2005258911A1 (en) | 2006-01-12 |
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