WO2006004498A1 - Inhaler device that reduces the risk for miscounting a dosage - Google Patents
Inhaler device that reduces the risk for miscounting a dosage Download PDFInfo
- Publication number
- WO2006004498A1 WO2006004498A1 PCT/SE2005/000996 SE2005000996W WO2006004498A1 WO 2006004498 A1 WO2006004498 A1 WO 2006004498A1 SE 2005000996 W SE2005000996 W SE 2005000996W WO 2006004498 A1 WO2006004498 A1 WO 2006004498A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhaler
- position ensuring
- ensuring means
- inhaler device
- actuator body
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
- G06M1/00—Design features of general application
- G06M1/02—Housing
- G06M1/026—Connecting or supporting parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0073—Mechanical counters having a display or indicator on a ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0075—Mechanical counters having a display or indicator on a disc
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0081—Locking means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
Definitions
- Inhaler device that reduces the risk for miscounting a dosage
- the present invention relates to the art of inhaler devices, and in particular to an inhaler device that ensures that a canister assembly is correctly inserted into an actuator body.
- a canister might contain asthma medicine such as fluticasone propionate.
- Inhaler devices are commonly used for delivery of a wide range of medicaments.
- Such an inhaler device normally comprises an actuator body that holds a canister of medicament, the canister being actuated by compression to deliver a dose of medicament through a mouthpiece to a user.
- Canisters for holding a suspension or solution of a pharmaceutical substance in a propellant under pressure are well known.
- One such known canister to be used in an inhalation device comprises a can coupled with a metering valve.
- the metering valve consists of a body comprising a chamber, a valve stem (which extends from a head of the body) and a metering chamber, selectively communicable by the valve stem to the atmosphere via an L-shaped conduit within the valve body.
- the valve stem is axially displaceable between a first, extended position in which the metering chamber, and hence the canister, is closed to the atmosphere (since the L-shaped conduit is disposed wholly outside the metering chamber), and a second, depressed position, in which the metering chamber is in open communication with the outlet provided by the L-shaped conduit in the valve stem and through which a metered dose of propellant containing pharmaceutical substance is delivered.
- the valve stem Inserted in the inhaler device, the valve stem is inserted into a stem receiving body, which is part of the actuator body.
- An inhaler traditionally contains from 120 to 200 doses (shots) so any counter must be reliable, accurate and easy to read.
- dose counters in the prior art, some located near the valve region of the canister and some attached to the base end of the canister which due to the fact that the canister is in an inverted position in the inhaler mouthpiece means that the counter is on the top of the assembled inhaler and can be easily viewed.
- a counter attached to the base end of the canister forming an inhaler canister assembly is disclosed.
- a problem with the counter disclosed in US 4817822 is that the counter actuation member is arranged in a non protected position, whereby it can be actuated by mistake or tampered with.
- the inhaler canister assembly can be placed in the wrong orientation in the actuator body, whereby the inhaler device could be fired without actuating the counter.
- WO 02/067844 a counter attached to the base of the canister is disclosed where the counter actuator means extends along the whole periphery of the top edge of the actuator body.
- the counter actuation member could easily be tampered with.
- counters attached to canisters containing different medicament could easily be interchanged between different actuators and made to operate Summary of the Invention
- the object of the invention is to provide a new inhaler device, inhaler canister assembly and actuator body, which overcome one or more drawbacks of the prior art. This is achieved by the inhaler device as defined in claim I 3 the inhaler canister assembly as defined in claim 10 and the actuator body as defined in claim 11.
- One advantage with such a device is that there is a greatly reduced risk for miscounting when firing the device or tampering with the counter.
- Fig. 1 shows a partially sectional perspective view of an embodiment of an inhaler device according to the present invention.
- Fig. 2a shows a schematic front view of an inhaler device according to the present invention.
- Fig. 2b shows a schematic cross-sectional view along the line a — a of the inhaler device in fig. 2a.
- Figs. 3a and 3b show schematic views of the inhaler device of figs. 2a and 2b in a firing state.
- Fig. 4a shows a schematic top view of the inhaler can assembly of fig. 2a.
- Fig. 4b shows a schematic bottom view of the actuator body of fig. 2b.
- Fig. 5a shows a schematic front view of an embodiment of the inhaler device according to the present invention.
- Fig. 5b shows a schematic cross-sectional view along the line b — b of the inhaler device in fig. 5a.
- Fig. 6 shows a schematic cross-sectional view of the counter unit of fig. 1.
- an inhalation device 10 according to one embodiment of the invention is shown. It comprises an actuator body 20, which encloses a canister 30 holding the medicament.
- the medicament is delivered to the user through a valve stem 40 connected to the top of the canister 30 (lower part of the canister in the figure due to the invert position of the canister in the inhalation device).
- the medicament is inhaled by the user through a mouthpiece 50 that is apart of the actuator body 20.
- the mouthpiece 50 is in connection with the valve stem 40 via a stem receiving body 45 for receiving the medicament to be delivered.
- a dose counter unit 60 is provided at the base end of the canister 30, i.e. in the opposite end to the valve stem 40.
- the dose counter unit 60 is preferably permanently attached to the canister 30, in order to avoid that the counter unit 60 is removed from one canister 30 and attached on another canister 30 containing a different level of medicament.
- the canister 30 with the attached dose counter unit 60 is hereafter referred to as an inhaler can assembly 70.
- the inhaler can assembly 70 is pressed downwards whereby the valve stem 40 is forced into a position where it delivers a dose of medicament, or by other words is fired. This is in conformity with many inhalation devices according to the prior art and will not be described in more detail here.
- the counting is related to the downward motion of the inhaler can assembly 70.
- the dose counter unit 60 should increase the number of counted doses by one every time a dose has been delivered.
- the dose counter unit 60 can either count up from zero or count down from a predetermined maximum number. Since undercounting is not to recommend due to the risk that the user believes that there is medicament left in the canister 30 when it actually is empty, the counter unit 60 usually is affected to count one count when the inhaler can assembly 70 has been pressed down a distance slightly less than is needed for delivering the dose of medicament.
- the dose counter unit 60 comprises a counter housing 80 and a counter mechanism 90 with a counter actuator 100 for actuating the counter mechanism 90.
- the housing 80 is, in a downwards directed surface thereof, provided with an aperture 110 that is adapted to receive a protrusion 120 from the top edge 130 of the actuator body 20 in a mating relationship.
- the aperture 110 and the protrusion 120 can be referred to as first and second position ensuring means respectively, as they ensure that the inhaler canister assembly 70 is received in the correct position with respect to the actuator body 20.
- the top edge 130 of the actuator body including the protrusion 120, and the bottom surface 140 of the counter housing 80 are so formed that depression of the inhaler canister assembly 70 cannot be performed unless the protrusion 120 and the aperture 110 are positioned in the correct mating position.
- the protrusion 120 extends through the aperture 110 into the counter housing 80 and engages the counter actuator 100, and hence actuates the counter mechanism 90.
- Figs. 2a, 2b, 3 a, 3b, 4a and 4b more clearly show the relationship between the protrusion 120 and the aperture 110 in the counter housing 60 of the inhaler can assembly 70.
- the inhaler device 10 has two states of operation: normal state and firing state. In the normal state that is shown in figs.2a and 2b, the metering valve of the canister 30 is closed and the protrusion 120 is aligned with the aperture 110 but not affecting the counter actuator 100.
- the protrusion 120 extends a small distance into the aperture 110, but in other embodiments the protrusion 120 may be located completely outside the aperture 110, as long as the protrusion 120 must enter the aperture 110 in order for the inhaler device 10 to be fired and for actuating the dose counter unit 60.
- the metering valve is depressed so that a metered dose of medicine is delivered to a user via the mouthpiece 50.
- the protrusion 120 extends through the aperture 110 into the counter housing 80 and actuates the counter actuator.
- the inhaler canister assembly 70 must be placed in the correct position with respect to the actuator body 20 in order for the protrusion 120 to fit into the aperture 110. If the inhaler canister assembly 70 is placed in the wrong position, the protrusion 120 will abut against the bottom surface 140 of the counter housing 80, and the firing operation cannot be performed. Furthermore, as the protrusion 120 will not extend through the aperture 110 into the counter housing 80, the counter actuator 100 is not actuated.
- the inhaler canister assembly 70 comprises first position ensuring means 110
- the actuator body 20 comprises second position ensuring means 120
- the first and second position ensuring means 110, 120 are complementary mating means
- the first and second position ensuring means 110, 120 are so arranged that the inhaler device 10 cannot be fired, nor the counter unit 60 be actuated unless the first and second position ensuring means 110, 120 are in a mating relationship.
- the protrusion 120 serves as the second position ensuring means, and it also serves to actuate the counter actuator 100 and thus the counter unit 60.
- the actuation of the counter actuator 100 might be performed by alternative means separated from the position ensuring means, as long as the counter actuator 100 cannot be actuated unless the first and second position ensuring means are in mating relationship.
- Figs. 5a and 5b schematically shows an alternative embodiment of the inhaler device according to the present invention, wherein the protrusion 120 is provided at a lower level 200 than the main portion of the upper edge 130 of the actuator body 20.
- the essentially vertical portions 210 of the upper edge 130 interacts with essentially vertical side portions 230 of the downwards extending sections 220 of the counter housing 80 in order to form a secondary pair of position ensuring means.
- the protrusion 120 is protected from accidental damage by the secondary pair of position ensuring means, as they e.g. prevents the protrusion 120 from excessive angular forces that can be applied by a user on the counter housing and potentially break the protrusion , if the secondary position ensuring means were not present. If the protrusion is damaged/removed, then the device could be fired and the counter would not count; therefore the device would undercount i.e. display that there were more doses remaining than there actually were, a dangerous situation.
- the counter actuator 100 By arranging the counter actuator 100 so that it is activated by the relatively small sized protrusion 120 that has to be inserted into a mating aperture 110 5 the risk for accidental actuation, as well as willful tampering is minimized, as it requires that a similar small sized object has to be introduced into the aperture 110.
- the protrusion 120 and the mating aperture 110 have a rectangular cross section, but it maybe given any suitable shape.
- the protrusion 120 may further be formed such that the aperture 110 or first position ensuring means takes the form of a grove or a slit in the counter housing 80.
- the shape of the protrusion/aperture 110, 120 is used to identify e.g. the content or concentration contained in the canister 30 and actuator bodies 20 adapted for delivering specific medicines, respectively, in order to avoid that a inhaler canister assembly 70 is used with an improper actuator body 20.
- the actuation of the inhaler device 10 is performed by a linear relative movement of the inhaler canister assembly 70 with respect to the actuator body 20.
- the actuation could also be an angular relative movement, or a combination thereof, and the first and second position ensuring means thus being adapted to the path of the movement.
- Fig. 6 shows a schematic cross sectional view of the inhaler canister assembly 70 of the inhaler device 10 in fig. 1, and the following description refers to both figures.
- the dose counter unit 60 comprises a protecting shield 150 that extends downwards from the counter unit 60 adjacent to the outer surface of the actuator body 20.
- the protecting shield 150 further ensures that that dose counter unit 60 cannot be actuated by mistake, as it is positioned adjacent to the aperture 110 and thus further obstructs access to the aperture 110.
- the shield 150 covers the protrusion 120 and the aperture 110 and thus protects them from being obstructed in their relative movement.
- the inner surface of the protecting shield 150 further serves as a guide means for guiding the protrusion 120 into mating relationship with the aperture 110.
- the inner surface of the protecting shield 150 can be provided with guide means in the form of ridges or the like.
- the dose counter unit 60 further comprises guiding means between the aperture and the outer surface of the canister 30 in the form of an inclined surface or ridge 160.
- the protecting shield provides a large surface which allows a clear label to be added to the front of the device (dose level, drug etc) because the counter is attached in the normal position for the drug label (around the base of the canister).
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0512999A BRPI0512999B8 (en) | 2004-07-05 | 2005-06-23 | inhaler device that reduces the risk of wrongly counting a dosage |
JP2007520262A JP4959559B2 (en) | 2004-07-05 | 2005-06-23 | Inhalation device that reduces the risk of counting errors |
US11/571,645 US8528545B2 (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage |
AU2005260195A AU2005260195C1 (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage |
EP05754095.7A EP1765441B1 (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage |
KR1020077000207A KR101247097B1 (en) | 2004-07-05 | 2005-06-23 | Inhaler Device That Reduces The Risk For Miscounting A Dosage |
MXPA06014658A MXPA06014658A (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage. |
CA2570078A CA2570078C (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage |
ES05754095.7T ES2679101T3 (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk of incorrectly counting a dosage |
NZ552104A NZ552104A (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage |
ZA2006/10423A ZA200610423B (en) | 2004-07-05 | 2006-12-12 | Inhaler device that reduces the risk for miscounting a dosage |
IL180099A IL180099A (en) | 2004-07-05 | 2006-12-14 | Inhaler device that reduces the risk for miscounting a dosage |
NO20070520A NO20070520L (en) | 2004-07-05 | 2007-01-26 | Inhaler device which reduces the risk of miscounting a dosage. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0401786-9 | 2004-07-05 | ||
SE0401786A SE0401786D0 (en) | 2004-07-05 | 2004-07-05 | Inhaler device |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006004498A1 true WO2006004498A1 (en) | 2006-01-12 |
Family
ID=32768797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2005/000996 WO2006004498A1 (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage |
Country Status (20)
Country | Link |
---|---|
US (1) | US8528545B2 (en) |
EP (1) | EP1765441B1 (en) |
JP (2) | JP4805923B2 (en) |
KR (1) | KR101247097B1 (en) |
CN (2) | CN101035582A (en) |
AR (1) | AR054295A1 (en) |
AU (1) | AU2005260195C1 (en) |
BR (1) | BRPI0512999B8 (en) |
CA (1) | CA2570078C (en) |
ES (1) | ES2679101T3 (en) |
IL (1) | IL180099A (en) |
MX (1) | MXPA06014658A (en) |
NO (1) | NO20070520L (en) |
NZ (1) | NZ552104A (en) |
SE (1) | SE0401786D0 (en) |
TR (1) | TR201809758T4 (en) |
TW (1) | TW200613019A (en) |
UY (1) | UY28998A1 (en) |
WO (1) | WO2006004498A1 (en) |
ZA (1) | ZA200610423B (en) |
Cited By (8)
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WO2007045475A1 (en) * | 2005-10-21 | 2007-04-26 | Novartis Ag | Dose counting device |
JP2008161548A (en) * | 2006-12-28 | 2008-07-17 | Yoshino Kogyosho Co Ltd | Medicine release apparatus |
WO2008121459A1 (en) * | 2007-04-02 | 2008-10-09 | 3M Innovative Properties Company | Dose counter |
JP2009542382A (en) * | 2006-07-11 | 2009-12-03 | フリードリッヒ ザンナー ゲーエムベーハー ウント コー カーゲー | Device for metering release of sprayable substances |
WO2010075240A1 (en) * | 2008-12-22 | 2010-07-01 | Novartis Ag | Medical device |
US8528545B2 (en) | 2004-07-05 | 2013-09-10 | Astrazeneca Ab | Inhaler device that reduces the risk for miscounting a dosage |
US8616196B2 (en) | 2004-07-02 | 2013-12-31 | Astrazeneca Ab | Inhalation device and a method for assembling said inhalation device |
US9168343B2 (en) | 1998-05-05 | 2015-10-27 | Trudell Medical International | Dispensing device |
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SE0401787D0 (en) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Inhaler device counter |
GB0425518D0 (en) | 2004-11-19 | 2004-12-22 | Clinical Designs Ltd | Substance source |
GB0428204D0 (en) | 2004-12-23 | 2005-01-26 | Clinical Designs Ltd | Medicament container |
ME01610B (en) * | 2005-08-24 | 2014-09-20 | Boehringer Ingelheim Int | Atomiser comprising a counter and an end of operation lock |
GB0518400D0 (en) * | 2005-09-09 | 2005-10-19 | Clinical Designs Ltd | Dispenser |
GB0904040D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
GB0904059D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
GB2469068B (en) * | 2009-03-31 | 2011-03-09 | Naseem Bari | Usage indicator |
SI2432532T1 (en) * | 2009-05-18 | 2014-11-28 | Norton Healthcare Limited | Dry-powder inhaler |
US9202164B2 (en) | 2011-09-26 | 2015-12-01 | Trudell Medical International | Dose counter and medication delivery device |
GB201118842D0 (en) * | 2011-11-01 | 2011-12-14 | Euro Celtique Sa | Dispenser cap arrangement |
US10576222B2 (en) * | 2014-05-07 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Container, indicator device with moveable piercing part, and nebulizer |
DK3139984T3 (en) * | 2014-05-07 | 2021-07-19 | Boehringer Ingelheim Int | Atomizer |
EP3668505A4 (en) | 2017-08-15 | 2021-05-12 | Nephron Pharmaceuticals Corporation | Aqueous nebulization composition |
CN110652632A (en) * | 2018-06-29 | 2020-01-07 | 上海英何医药包装技术有限公司 | Inhalation aerosol administration device |
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Also Published As
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UY28998A1 (en) | 2006-02-24 |
ZA200610423B (en) | 2008-01-08 |
JP4959559B2 (en) | 2012-06-27 |
IL180099A (en) | 2012-01-31 |
KR101247097B1 (en) | 2013-03-25 |
EP1765441A1 (en) | 2007-03-28 |
US8528545B2 (en) | 2013-09-10 |
EP1765441B1 (en) | 2018-05-16 |
NO20070520L (en) | 2007-03-22 |
TR201809758T4 (en) | 2018-07-23 |
ES2679101T3 (en) | 2018-08-22 |
JP4805923B2 (en) | 2011-11-02 |
AU2005260195C1 (en) | 2011-06-30 |
US20080060643A1 (en) | 2008-03-13 |
BRPI0512999B8 (en) | 2021-06-22 |
KR20070043771A (en) | 2007-04-25 |
JP2008504924A (en) | 2008-02-21 |
CA2570078C (en) | 2013-08-06 |
CA2570078A1 (en) | 2006-01-12 |
BRPI0512999A (en) | 2008-04-22 |
AR054295A1 (en) | 2007-06-20 |
JP2008504925A (en) | 2008-02-21 |
SE0401786D0 (en) | 2004-07-05 |
AU2005260195B2 (en) | 2008-10-30 |
MXPA06014658A (en) | 2007-02-12 |
AU2005260195A1 (en) | 2006-01-12 |
BRPI0512999B1 (en) | 2017-07-11 |
IL180099A0 (en) | 2007-05-15 |
CN101035582A (en) | 2007-09-12 |
NZ552104A (en) | 2009-12-24 |
CN102058921A (en) | 2011-05-18 |
TW200613019A (en) | 2006-05-01 |
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