WO2006007839A1 - Composition comprising minerals and uses thereof - Google Patents
Composition comprising minerals and uses thereof Download PDFInfo
- Publication number
- WO2006007839A1 WO2006007839A1 PCT/DK2005/000454 DK2005000454W WO2006007839A1 WO 2006007839 A1 WO2006007839 A1 WO 2006007839A1 DK 2005000454 W DK2005000454 W DK 2005000454W WO 2006007839 A1 WO2006007839 A1 WO 2006007839A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- coating
- calcium
- composition
- weight
- chewing gum
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 123
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 45
- 239000011707 mineral Substances 0.000 title claims abstract description 45
- 238000000576 coating method Methods 0.000 claims abstract description 181
- 239000011248 coating agent Substances 0.000 claims abstract description 176
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 153
- 229940112822 chewing gum Drugs 0.000 claims abstract description 146
- 238000000034 method Methods 0.000 claims abstract description 23
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 117
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 99
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 58
- 229960003563 calcium carbonate Drugs 0.000 claims description 56
- 235000010216 calcium carbonate Nutrition 0.000 claims description 56
- 235000010755 mineral Nutrition 0.000 claims description 43
- 239000000725 suspension Substances 0.000 claims description 41
- 239000000843 powder Substances 0.000 claims description 36
- 235000010356 sorbitol Nutrition 0.000 claims description 24
- 239000000600 sorbitol Substances 0.000 claims description 24
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 23
- 239000011230 binding agent Substances 0.000 claims description 23
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 22
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 22
- 229930003316 Vitamin D Natural products 0.000 claims description 20
- 235000019166 vitamin D Nutrition 0.000 claims description 20
- 239000011710 vitamin D Substances 0.000 claims description 20
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 20
- 229940046008 vitamin d Drugs 0.000 claims description 19
- -1 calcium carbonate Chemical compound 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229940088594 vitamin Drugs 0.000 claims description 15
- 229930003231 vitamin Natural products 0.000 claims description 15
- 235000013343 vitamin Nutrition 0.000 claims description 15
- 239000011782 vitamin Substances 0.000 claims description 15
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 14
- 239000011647 vitamin D3 Substances 0.000 claims description 14
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 12
- 239000011777 magnesium Substances 0.000 claims description 12
- 229910052749 magnesium Inorganic materials 0.000 claims description 12
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 11
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 11
- 229920005862 polyol Polymers 0.000 claims description 11
- 150000003077 polyols Chemical class 0.000 claims description 11
- 239000000811 xylitol Substances 0.000 claims description 11
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 11
- 229960002675 xylitol Drugs 0.000 claims description 11
- 208000001132 Osteoporosis Diseases 0.000 claims description 10
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 10
- 235000010449 maltitol Nutrition 0.000 claims description 8
- 239000000845 maltitol Substances 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- 229920000084 Gum arabic Polymers 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- 235000010489 acacia gum Nutrition 0.000 claims description 7
- 239000000205 acacia gum Substances 0.000 claims description 7
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 7
- 229940035436 maltitol Drugs 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
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- 210000000988 bone and bone Anatomy 0.000 claims description 4
- 235000010980 cellulose Nutrition 0.000 claims description 4
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- 235000015872 dietary supplement Nutrition 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 239000011653 vitamin D2 Substances 0.000 claims description 4
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims description 4
- 239000001828 Gelatine Substances 0.000 claims description 3
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims description 3
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 3
- 239000001354 calcium citrate Substances 0.000 claims description 3
- 229960004256 calcium citrate Drugs 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 159000000007 calcium salts Chemical class 0.000 claims description 3
- 229960002061 ergocalciferol Drugs 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 229960001855 mannitol Drugs 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 229960002920 sorbitol Drugs 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 3
- 235000001892 vitamin D2 Nutrition 0.000 claims description 3
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims description 2
- 239000004227 calcium gluconate Substances 0.000 claims description 2
- 235000013927 calcium gluconate Nutrition 0.000 claims description 2
- 229960004494 calcium gluconate Drugs 0.000 claims description 2
- 229940095618 calcium glycerophosphate Drugs 0.000 claims description 2
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims description 2
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 2
- 239000001527 calcium lactate Substances 0.000 claims description 2
- 235000011086 calcium lactate Nutrition 0.000 claims description 2
- 229960002401 calcium lactate Drugs 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 2
- 238000005115 demineralization Methods 0.000 claims description 2
- 150000004677 hydrates Chemical class 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 235000005282 vitamin D3 Nutrition 0.000 claims description 2
- 229940021056 vitamin d3 Drugs 0.000 claims description 2
- 241000978776 Senegalia senegal Species 0.000 claims 1
- LMVUZKNUWBMHQY-FJOGWHKWSA-L calcium (Z)-but-2-enedioate 2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Ca+2].[O-]C(=O)\C=C/C([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O LMVUZKNUWBMHQY-FJOGWHKWSA-L 0.000 claims 1
- 235000011116 calcium hydroxide Nutrition 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 description 57
- 239000003765 sweetening agent Substances 0.000 description 57
- 239000011575 calcium Substances 0.000 description 40
- 229910052791 calcium Inorganic materials 0.000 description 39
- 229960005069 calcium Drugs 0.000 description 39
- 235000001465 calcium Nutrition 0.000 description 39
- 239000000796 flavoring agent Substances 0.000 description 33
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- 235000002639 sodium chloride Nutrition 0.000 description 20
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- 235000013615 non-nutritive sweetener Nutrition 0.000 description 15
- 239000004615 ingredient Substances 0.000 description 14
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- 239000000047 product Substances 0.000 description 13
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- 235000013355 food flavoring agent Nutrition 0.000 description 9
- 238000004898 kneading Methods 0.000 description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 9
- 239000010452 phosphate Substances 0.000 description 9
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 6
- 239000013543 active substance Substances 0.000 description 6
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- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 6
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- NUFKRGBSZPCGQB-FLBSXDLDSA-N (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid;pentahydrate Chemical compound O.O.O.O.O.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C NUFKRGBSZPCGQB-FLBSXDLDSA-N 0.000 description 4
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- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000019809 paraffin wax Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical class OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 235000011197 perejil Nutrition 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000003075 phytoestrogen Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000007517 polishing process Methods 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- BLCXGBJMWQFERJ-UHFFFAOYSA-L sodium 4-hydroxy-3,3-dimethyl-2-oxidobutanoate iron(3+) Chemical compound [Na+].[Fe+3].CC(C)(CO)C([O-])C([O-])=O.CC(C)(CO)C([O-])C([O-])=O BLCXGBJMWQFERJ-UHFFFAOYSA-L 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- XWKBMOUUGHARTI-UHFFFAOYSA-N tricalcium;diphosphite Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])[O-].[O-]P([O-])[O-] XWKBMOUUGHARTI-UHFFFAOYSA-N 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/343—Products for covering, coating, finishing, decorating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/18—Chewing gum characterised by shape, structure or physical form, e.g. aerated products
- A23G4/20—Composite products, e.g. centre-filled, multi-layer, laminated
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2210/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing inorganic compounds or water in high or low amount
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the invention relates to the field of formulation of a pharmaceutical oral dosage form, in particular chewing gum formulations comprising high load of elemental calcium and/or high load of minerals.
- the invention also pertains to the field of treating and/or preventing diseases, which are associated with insufficient intake minerals such as e.g. osteoporosis.
- the required dose of calcium is rather high such as about 400-1000 mg per day dependent on the age.
- a chewing gum or the like which comprises a chewable inner core and a calcium-containing coating wherein the coating ingredients dissolves in the saliva except in the event where the calcium source is water-insoluble.
- chewing gum stimulates the production of saliva resulting in better conditions for swallowing the active substances and other excipients without the need of concurrent intake of water.
- chewing gum formulations with high load of active substances may be problematic to prepare without risking poor mouth feeling due to release of particles into the buccal cavity and/or low moisturising effect.
- Calcium has been used in chewing gum formulations.
- a pH-adjusting agent in respect of making the saliva slightly alkaline, which may increase buccal/lingual absorption of ingredients into the blood stream.
- WO 00/35298 relates to chewing gum formulations wherein the active agent level in the • composition is from about 25 ⁇ g to 250 mg per gram chewing gum product.
- EP 0 263 224 A2 relates to a chewing gum which contains a coating with sweeteners and mineral compounds. It is disclosed that the coating may contain from 5%-60% by weight mineral compounds. It is also disclosed that mineral compound concentrations greater than about 60% by weight are not useable since they result in a dry, chalky, gritty product and result in a flaked or peeled product.
- EP 0 228 999 A2 discloses a coated chewing gum wherein calcium carbonate is used as a drying agent in the coating.
- the document discloses unsuccessful attempts to prepare coated chewing gums wherein the coating contains a high load of calcium carbonate.
- the chewing gums having the highest calcium carbonate concentrations were found to be flaky and brittle and had an unsatisfactory overall quality.
- the present invention relates in its broadest sense to a composition comprising an inner core and a very high load of one or more minerals, e.g. elemental calcium, present in a coating that is partly of fully surrounding the inner core.
- minerals e.g. elemental calcium
- the requirements of high load of one or more minerals, such as elemental calcium, in products having therapeutically effect in preventing diseases, such as osteoporosis, is critical for the formulation of such products.
- incorporating sufficient amounts of other excipients without increasing the size of a unit dosage to an unacceptable extent and to meet the requirement of pleasant mouth feeling, such as a moist feeling in the mouth, and proper crunch properties of the product.
- compositions in the form of distinct dosage units for oral administration wherein a very high load of one or more minerals, e.g. elemental calcium, in a coating, i.e. one or more coating layers, which partly or fully surrounds the inner core of the composition.
- a very high load of one or more minerals e.g. elemental calcium
- the composition of the invention has maintained a pleasant mouth feeling and robustness of the coating, i.e. the coating does not flake or peel off during process and further handling of the composition.
- the inner core may in principle be made of any material provided that the inner core does not immediately disintegrate into a number of smaller particles, which need to be swallowed together with water.
- the exact nature of the coating may also be selected from a broad range of ingredients, which are mainly water-soluble.
- the load of the one or more minerals, e.g. elemental calcium, enclosed in the coating may preferably be more than 25% by weight of the coating.
- Calcium carbonate is a widely used calcium source because of its comprehensive properties. In using calcium carbonate as the source of calcium, the coating comprises at least 63% by weight of the coating.
- the invention provides in its first aspect a composition comprising a source of elemental calcium, the composition comprises two or more distinct fractions, namely i) an inner core, preferably an inner core comprising a continuous material such as a chewing gum core, a chewable tablet, a lozenge, a candy or a caramel and N) a coating wherein elemental calcium is enclosed in an amount of at least 25% by weight of the coating.
- An additional aspect of the present invention relates to a composition
- a composition comprising i) an inner core, preferably an inner core comprising a continuous material such as a chewing gum core, a chewable tablet, a lozenge, a candy or a caramel and ii) a coating wherein a one or more minerals, e.g. a source of elemental calcium, are present in an amount of at least 63% by weight of the coating.
- a one or more minerals e.g. a source of elemental calcium
- compositions comprising i) an inner core, preferably an inner core comprising a continuous material such as a chewing gum core, a lozenge, a candy or a caramel, and ii) a coating wherein a water-insoluble, particulate, inorganic material is present in an amount of at least 63% by weight of the coating.
- the coating may comprise the water-insoluble, particulate, inorganic material in an amount ranging between 63-90% by weight of the coating, preferably ranging between 70-90%, more preferably ranging between 75-90%, such as between 75-85%, most preferably ranging between 78-85% by weight of the coating.
- the invention provides a chewing gum comprising a high load of calcium carbonate.
- the invention encompasses a composition comprising a source of elemental calcium, the composition comprises i) an inner core comprising a chewing gum core; and ii) a coating, wherein the coating comprises calcium carbonate in an amount of at least 63% by weight of the coating.
- the composition may be further formulated in the form of individual dosage units intended for oral administration.
- Each dosage unit consists of the compositions mentioned herein in a unit weight between 1-6 g, preferably 2-4 g, such as 2.5-3.5 and 3 g.
- a particular aspect of the invention relates to a composition in the form of a dosage unit having a unit weight of about 2.5-3.5 g, the dosage unit comprises an inner core and a coating, wherein the coating comprises a dose of 100 mg to 2000 mg of elemental calcium, e.g. a dose of calcium carbonate of 250 mg to 5000 mg.
- the one or more minerals preferably comprise one or more inorganic compounds such as e.g. inorganic salts.
- a mineral may be a water-insoluble, inorganic compound.
- the mineral may e.g. be on particulate form such as a dry powder, when the mineral is applied to the composition according to the present invention.
- the one or more minerals comprises elemental calcium, e.g. in the form of calcium carbonate.
- the composition may comprise several minerals, e.g. 2, 3, 4, 5, 6, 7, 8, 9, 10 or even more minerals.
- the composition comprises minerals comprising both elemental calcium and elemental magnesium, such as e.g. calcium carbonate and magnesium carbonate.
- the coating of the composition may comprise the one or more minerals in an amount ranging between 60-90% by weight of the coating, preferably ranging between 63-90% such as 65-90%, 69-90%, 71-90%, or 73-90%, or e.g. ranging between 60-90%, such as between 60-85%, 60-80%, 60-75%, 63-85%, 63-80%, 63-75%, 65-85%, 65-80%, 65- 75% by weight of the coating.
- the coating may e.g. comprise the one or more minerals in an amount ranging between 70-90% by weight of the coating, preferably ranging between 72-90% such as 74-90%, 76-90%, or 78-90% by weight of the coating.
- source of elemental calcium or "calcium source” is meant to define any biological or synthetically source of elemental calcium.
- the source of elemental calcium may releases free ionised calcium upon being contacted with aqueous solution such as saliva from the buccal cavity and/or it may release free ionised calcium upon contact with the acidic environment of the stomach.
- Ionic calcium is mainly presented in the form of calcium(II) ions. Thus, intentionally the calcium is not covalently bound.
- sources of calcium encompass calcium salts such as calcium carbonate, calcium citrate, calcium gluconate, calcium glycerophosphate, calcium lactate, calcium tartrate, calcium malate, calcium malate-citrate, calcium levulinate, calcium phosphate, monobasic calcium phosphate, calcium hypophosphate, calcium succinate, calcium gluceptate, calcium sulfate, calcium chloride, calcium chelates, calcium amino acid chelate, anhydrous forms and/or hydrates thereof.
- Table 1 summarises the properties for useful calcium compounds and also presents useful magnesium compound, which use will be described in further detail below.
- the source of elemental calcium is a water-insoluble compound.
- a material or compound is considered water-insoluble if its solubility is at most 0.1 g material or compound per 100 g water at 25°C.
- Table 1 Physical and chemical properties of useful calcium and magnesium sources.
- the calcium source is calcium carbonate, calcium citrate or calcium malate-citrate of which calcium carbonate is more preferred because of the high amount of calcium per weight unit of calcium salt.
- the coating comprises elemental calcium in an amount of at least 25%, such as at least 28%, 30% and 32% by weight of the coating.
- the amount of elemental calcium ranges between 25-36% by weight of the coating, preferably between 28-35%, more preferably between 30-35% by weight of the coating.
- the coating comprises calcium carbonate in an amount ranging between 60-90% by weight of the coating, preferably ranging between 63-90% such as 65-90%, 69-90%, 71-90%, or 73-90%, or e.g. ranging between 60-90%, such as between 60-85%, 60-80%, 60-75%, 63-85%, 63-80%, 63- 75%, 65-85%, 65-80%, 65-75% by weight of the coating.
- the coating may e.g. comprise calcium carbonate in an amount ranging between 70-90% by weight of the coating, preferably ranging between 72-90% such as 74-90%, 76-90%, or 78-90% by weight of the coating.
- Calcium carbonate exists in several physical forms which each may affect the properties of the composition in terms of pleasant mouth feeling, ease of production and the maximum load of calcium in the coating.
- the calcium carbonate is micronised, either crystalline or amorphous.
- Calcium carbonate may also be defined in terms of its density.
- the specific gravity of the calcium carbonate may range between 2.5 -3 g/cm 3 such as e.g. 2.6-2.9 g/cm 3 .
- the specific gravity of the calcium carbonate may about 2.7 g/cm 3 .
- the bulk density of calcium carbonate powder may range between 0.3 - 1.5 g/cm 3 , such as e.g. 0.6-1.2 g/cm 3 .
- the bulk density of the calcium carbonate powder may about 1 g/cm 3 .
- the calcium carbonate has a mean diameter in the range of 0.1-200 micrometer, such as e.g. 0.1-50 micrometer, 1-50 micrometer, 1-150 micrometer, 5-100 micrometer, or 10-75 micrometer.
- At least 10% by weight of the calcium carbonate has a particle diameter of at most 2 ⁇ m, such as at least 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95%, such as at least 99% by weight of the calcium carbonate.
- the particle diameter may e.g. be measured by laser granulometry or by image analysis. Using the latter, the diameter of a particle is measured as the longest dimension of the particle.
- the calcium carbonate has a sieving residue at 45 ⁇ m of at most 500 mg per 100 g calcium carbonate powder, such as a sieving residue at 45 ⁇ m of at most 500 mg, 250 mg, 100 mg, 50 mg, 25 mg, 10 mg, 5 mg, 1 mg, or 0.1 mg per 100 g calcium carbonate powder.
- the calcium may be enclosed in the coating.
- additional amounts of elemental calcium may be comprised in the inner core, such as about 0.5% to 10% of the amount of elemental calcium in the coating may in addition be added to the inner core.
- the composition comprises an inner core comprising a water-insoluble gum base and a coating
- the coating comprises from about 65-90% of calcium carbonate and 10 to 30% of a sugar alcohol by weight of the coating, the sugar alcohol constitutes 5%-25% of the composition in total.
- the composition may furthermore comprise a magnesium compound such as organic and inorganic salts of magnesium wherein the anionic portion of the salt is acetate, carbonate hydroxide, chloride, citrate, dibasic citrate, hydroxide, lactate, oxide, phosphate monobasic, phosphate dibasic, trisilicate, sulfate as well as co- precipitated gel of aluminum hydroxide and magnesium carbonate, aluminum magnesium silicate, aluminum magnesium hydroxide, or mixtures thereof.
- Table 2 shows the useful daily dosage of elemental magnesium.
- elemental magnesium may be present in the composition, e.g. the chewing gum, in an amount in the range of 25-500 mg, such as 25-50 mg, 50-100 mg, 100-150 mg, or 150-400 mg.
- composition may furthermore comprise organic and inorganic salts of lithium wherein the anion is e.g. chloride, carbonate, citrate, sulfate, bromide, or mixtures thereof.
- compositions may furthermore comprise organic and inorganic salts of sodium wherein the anionic portion of the salt is acetate, ascorbate, bicarbonate, carbonate, chloride, 0 citrate, hypophosphite, lactate, phosphate monobasic, phosphate dibasic, phosphate tribasic, sulfate, tartarate, or mixtures thereof.
- Potassium is the important cationic constituent of the intracellular fluid. Potassium deficiency may result in kidney damage and vacuolization of the collection tubules. 5 Potassium deficiency is characterized by mental changes (hallucinations, loquacity) an animated facial expression and limpness of the extremities. The muscles become soft and weak.
- the composition may furthermore comprise inorganic and organic salts of potassium wherein the anionic portion of the salt is acetate, bicarbonate, bitartrate, bromide, carbonate, chloride, citrate, gluconate, phosphate monobasic, phosphate dibasic, phosphate tribasic, sulfate, tartrate, or mixtures thereof.
- the composition may furthermore comprise organic and inorganic salts of iron and chelates of iron such as reduced iron, ferrous sulfate, iron ammonium citrate, ferrous carbonate, ferrous chloride, ferrous fumarate, ferroglycine sulfate, ferronascin, ferrous carbonate mass, ferrous carbonate saccharated, ferrous citrate, ferrous gluconate, ferrous lactate, ferrous sulfate, ferrous succinate, iron chelates, iron chelate with magnesium trisilicate, or mixtures thereof.
- organic and inorganic salts of iron and chelates of iron such as reduced iron, ferrous sulfate, iron ammonium citrate, ferrous carbonate, ferrous chloride, ferrous fumarate, ferroglycine sulfate, ferronascin, ferrous carbonate mass, ferrous carbonate saccharated, ferrous citrate, ferrous gluconate, ferrous lactate, ferrous sulfate, ferrous succinate
- composition may furthermore comprise inorganic and organic salts of zinc wherein the anionic portion of the salt is e.g. carbonate, chloride, citrate, or mixtures thereof.
- composition may furthermore comprise phosphorous e.g. in the form of salts wherein the anionic portion is a phosphate and the cationic portion is sodium, potassium, magnesium, iron, calcium, lithium, zinc, or mixtures thereof.
- the one or more minerals are present in the coating of the composition.
- the inner core may be selected from a chewing gum core, a chewable tablet, a lozenge, a candy or a caramel.
- the inner core may e.g. be a chewable tablet, which is to be ingested after being chewed.
- the tablet to be chewed may e.g. be a compressed centre.
- the compressed centre may comprise one or more components selected from the group consisting of a filler, a bulk sweetener, a high intensity sweetener, a flavour, a lubricant and a binder.
- the compressed centre comprises a filler, a bulk sweetener, a flavour, a lubricant and a binder.
- the filler may e.g. be selected from the group consisting of calcium sulphate, dibasic calcium phosphate, starch, calcium carbonate, microcrystalline cellulose, or modified starch.
- the bulk sweetener may e.g. be selected from the group consisting of saccharose, sorbitol, xylitol, mannitol and maltitol.
- the high intensity sweetener may e.g. be selected from the group consisting of saccharin, saccharin sodium, saccharin calcium, aspartame, twinsweet, cyclamate, acesulfame-K, sucralose, neotame, alitame, neohesperidin DC, stevia, glycyrrhizin, thaumatin.
- the flavour may e.g. be selected from the group consisting of a natural flavour, a nature identical flavour and a synthetic flavour.
- the lubricant may e.g. be selected from the group consisting of magnesium stearate, calcium stearate, zinc stearate, hydrogenated vegetable oils, talc, and polyethylene glycol.
- the binder may e.g. be selected from the group consisting of starch, pregelatinized starch, polyvinylpyrrolidone, methylcellulose, sodium carboxymethylcellulose, ethylcellulose, and polyvinyl alcohol.
- the chewable tablet may be made by direct compression or include granulation and binders.
- the inner core comprises a chewing gum core.
- the composition of the present invention may be considered a coated chewing gum.
- the chewing gum core may comprise a water-insoluble gum base and optionally also a water-soluble portion and/or one or more flavouring agents.
- the water-insoluble gum base and the water-soluble portion will normally be mixed, e.g. via a kneading process or via compression of granulates.
- the water-soluble portion is released with a portion of the flavouring agent over a period of time during chewing.
- the water-insoluble gum base is preferably retained in the mouth throughout the chew.
- the chewing gum core comprises a water-insoluble gum base and a water-soluble portion.
- the water-insoluble gum base may e.g. comprise one or more components selected from the group consisting of an elastomer, an elastomer solvent, a softening agent, an emulsifier and a filler. 5
- the water-insoluble gum base may be a hydrophobic water-insoluble gum base or a hydrophilic water-insoluble gum base.
- a hydrophobic water-insoluble gum base may e.g. comprise a hydrophobic polymer. 10
- the hydrophobic polymer is elastic and/or rubbery at 37°C, such as for example an elastomer.
- the hydrophobic polymer comprises at least 10% by weight of the water-insoluble gum base of the chewing gum core, such as at least 20%, 15 30%, 40%, 50%, 60%, 70% 80% or 90%, such as at least 95% by weight of the water- insoluble gum base of the chewing gum core.
- the hydrophobic water-insoluble gum base may comprise hydrophobic polymer in range of 1-100% by weight of the water-insoluble gum base, such as in the range of 1-15%, 15%- 20 20%, 20%-30%, 30%-40%, 40%-50%, 50%-60%, 60%-70%, 70%-80% or 80%-90%, such as in the range of 90%-100%.
- the hydrophobic water-insoluble gum base comprises hydrophobic polymer in range of 1- 50% by weight of the water-insoluble gum base, such as e.g. 15- 30% by weight.
- the hydrophobic polymer may e.g. comprise an elastomer selected from the group of consisting of a styrene-butadiene rubber, a polyisobutulene rubber, a isobutylene-isoprene copolymer elastomers, a polyvinylacetate, styrene butadiene rubber and a natural gum.
- the natural gum could for example be jelutong, lechi caspi, perillo, massaranduba balata, massaranduba chocolate, nispero, rosindinha, chicle, gutta hang kang, or mixtures thereof.
- the elastomer can also be a mixture of such natural and synthetic elastomers. These elastomer mixtures can then be used with excellent results as the chewing gum core in the production of chewing gum.
- Elastomer used in chewing gum core may be categorized as hard elastomers or soft 35 elastomers.
- Hard elastomers which are most commonly butyl rubber and styrene butadiene rubber, generally have a high molecular weight, typically a Flory molecular weight over 200,000.
- a typical butyl rubber used in chewing gum core may have a Flory molecular weight of about 400,000.
- Hard elastomers are those which require high shear, dispersive mixing to be utilized in chewing gum core. Hard elastomers generally do not flow at room temperature, even over an extended period of time, and are not pumpable even when heated to temperatures just below which substantial degradation occurs.
- Soft elastomers have a lower molecular weight, typically a Flory molecular weight under 100,000. Polyisobutylene and polybutadiene are typically soft elastomers. A typical polyisobutylene used in chewing gum core has a Flory molecular weight of about 53,000. Soft elastomers are generally pumpable at temperatures normally used to make chewing gum core, and will flow at room temperature, though often very slowly.
- Stodinger molecular weights are generally 1/3 to 1/5 of Flory molecular weights.
- the polyisobutylene having a Flory molecular weight of 53,000 has a Stodinger molecular weight of about 12,000.
- number average or weight average molecular weights are reported, or the measurement method is not reported. In such instances, the above recitation of the functionality of the elastomer and how they are mixed in producing the chewing gum core can generally be used to classify the elastomer as hard or soft.
- a hydrophobic water-insoluble gum base may also comprise one or more additives selected from the group consisting of an elastomer solvent, a softening agent, an emulsifier and a filler.
- the chewing gum core comprises an elastomer solvent, a softening agent, an emulsifier and a filler.
- the elastomer solvent may constitute from about 0 to about 75 percent by weight of the hydrophobic water-insoluble gum base, preferably 5 to 45 percent by weight and most preferably 10 to 30 percent by weight.
- Elastomer solvents may include natural rosin esters such as glycerol ester of wood rosin, glycerol ester of partially hydrogenated rosin, glycerol ester of polymerized rosin, glycerol ester of partially dimerized rosin, glycerol ester of rosin, pentaerythritol esters of partially hydrogenated rosin, methyl and partially hydrogenated methyl esters of rosin, pentaerythritol ester of rosin, resin ester of glycerol abietate or mixtures thereof.
- Elastomer solvents may also include synthetics such as terpene resins derived from alpha-pinene, beta-pinene and/or d-limonene.
- Softening agents of hydrophobic water-insoluble gum bases may include oils, fats, waxes and emulsifiers.
- Oils and fats sometimes referred to as plasticizers, may include tallow, lard, hydrogenated and partially hydrogenated vegetable oils, such as soybean oil, cotton seed oil, palm oil, palm kernel oil, coconut oil, sunflower oil and corn oil, cocoa butter, and lipids made from triglycerides of fatty acids.
- Commonly employed waxes may include polywax, paraffin, microcrystalline and natural waxes such as candelilla, beeswax and carnauba. Paraffin waxes may be considered to be plasticizers.
- Microcrystalline waxes, especially those with a high degree of crystallinity may be considered as bodying agents or textural modifiers.
- Emulsifiers which also sometimes have plasticizing properties, include glycerol monostearate, lecithin, mono and diglycerides of fatty acids, glycerol mono and distearate, triacetin, acetylated monoglyceride, and glycerol triacetate.
- the filler of the hydrophobic water-insoluble gum base may e.g. be calcium carbonate, magnesium carbonate, talc, dicalcium phosphate or the like.
- the filler may e.g. comprise about 5% to about 60% by weight of the chewing gum core, such as e.g. 15-35% or 15- 20% by weight of the chewing gum core.
- the emulsifier and/or the filler need not be hydrophobic.
- the filler is typically an inorganic material with low water solubility.
- emulsifiers comprise both a polar part and a non-polar part of their molecular structure, which may render them partly soluble in both polar and non-polar media.
- the chewing gum core comprises a hydrophilic water-insoluble gum base, which comprises a hydrophilic polymer.
- the hydrophilic polymer is water-insoluble.
- the hydrophilic polymer may e.g. comprise polyvinyl acetate of various molecular weights, short and/or medium chain polyesters or polyamides, or short and medium side chain poly (vinyl esters) (e.g. polyvinyl butyrates, polyvinyl propionates).
- the hydrophilic water- insoluble gum base is typically essentially free of hydrophobic polymers such as natural and synthetic rubber elastomers, particularly butyl elastomers, polyisobutylene and styrene butadiene rubber elastomers.
- the water-insoluble gum base may be essentially free of elastomer solvents, such as terpene resins, ester gums and rosin esters.
- the hydrophilic water-insoluble gum base may comprise hydrophilic softeners/emulsifiers, but will be essentially free of hydrophobic softeners such as waxes.
- the hydrophilic water-insoluble gum base may e.g. be wax-free.
- the hydrophilic water-insoluble gum base can constitute about 5% to about 95% by weight of the chewing gum core, more commonly about 10% to about 50% of the gum or about 25% to 35% by weight of the chewing gum core.
- the chewing gum core of the present invention comprises about 20% to about 90% by weight hydrophilic polymers, about 4% to about 50% by weight filler, about 5% to about 35% by weight hydrophilic softeners/emulsifiers, and optional minor amounts (about 1% or less by weight) of miscellaneous ingredients such as colorants, antioxidants, etc.
- Fillers/texturizers may include magnesium and calcium carbonate, ground limestone, silicate types such as magnesium and aluminum silicate, clay, alumina, talc, titanium oxide, mono-, di- and tri-calcium phosphate, cellulose polymers, such as oat fiber, and combinations thereof.
- Hydrophilic softeners/emulsifiers may include glycerol monostearate, glycerol triacetate, lecithin, mono-, and diglycerides, and short and medium chain triglycerides, acetylated monoglycerides, and combinations thereof.
- Colorants and whiteners may include FD&C-type dyes and lakes, fruit and vegetable extracts, titanium dioxide, and combinations thereof.
- Softeners are added to the chewing gum in order to optimize the chewability and mouth feel of the gum.
- the softeners which are also known as plasticizers and plasticizing agents, generally constitute between approximately 0.5% to about 15% by weight of the chewing gum.
- the softeners may include glycerine, lecithin, and combinations thereof.
- Aqueous sweetener solutions such as those containing sorbitol, hydrogenated starch hydrolysates, corn syrup and combinations thereof, may also be used as softeners and binding agents in chewing gum.
- a chewing gum core having a hydrophilic water-insoluble gum base may comprise: a) about 20% to about 90% hydrophilic polymers; b) about 5% to about 35% hydrophilic softeners/emulsifiers; and c) about 4% to about 50% filler; d) the chewing gum core being essentially free of hydrophobic polymers, hydrophobic elastomer solvents, waxes and hydrophobic softeners.
- the water-insoluble gum base is not completely water insoluble but it looses a small fraction of its weight matter when chewed according to the standard described in The European Pharmacopoeia, 3rd Edition, 2001, published by the European Directorate of the Quality of Medicines within the Council of Europe, France.
- the standard method employs a chewing apparatus.
- the chewing apparatus comprises a chewing chamber of approximately 40 mL in the chewing gum core is artificially chewed by two horisontal pistons, which operate together at constant speed. At the end of a chew, 5 the pistons can rotate around their own axis in opposite directions to each other. In this way, the chewing gum core is subjected to maximum chewing.
- a third vertical piston simulating the tongue, operates alternately with the two horisontal pistons and makes sure that the chewing gum core stays in the right place during the chews.
- the pistons are driven by compressed air and all the materials in contact with the chewing gum core is 10 made of stainless steel.
- the temperature of the chewing chamber is adjusted to 36-37 degrees C, and 20 mL phosphate buffer of pH 7.4 is added to the chewing chamber.
- the chewing machine is started and runs for 2 minutes without
- any chewing gum core in there removes all the buffer by pipette and replace it by 20 mL fresh buffer.
- the buffer, which was removed, may be analysed as a control for the cleaning procedure of the chewing machine.
- a piece of chewing gum core having a weight of about 1 g (should weigh precisely before it is chewed) is put into the chewing chamber and the chewing machine is started. The chewing machine is allowed to run for 1 hour with a
- the remaining dry matter of chewing gum core should at least be 15% by weight of the original dry matter that was placed in the chewing chamber, such as at least
- the remaining dry matter of chewing gum core should be in the range of 10%-20% by weight of the original dry matter that was placed in the chewing chamber, such as in the range of 20%-30%, 30%-40%, 40%-
- the remaining dry matter of chewing gum core should be in the range of 10%-20% by weight of the original dry matter that was placed in the chewing chamber.
- the water-soluble portion of the chewing gum core may comprise one or more components selected from the group consisting of a softener, a bulk sweetener, a high intensity sweetener, and a flavouring agent.
- the water-soluble portion of the chewing gum core comprises a softener, a bulk sweetener, and a flavouring agent and in a further embodiment the water-soluble portion furthermore comprises a high intensity sweetener.
- a sweetener this may e.g. be a bulk sweetener or a high intensity sweetener.
- Bulk sweeteners may constitute between 5-95% by weight of the chewing gum core, more typically 20-80% by weight of the chewing gum core and most commonly 30-60% by weight of the chewing gum core. Bulk sweeteners may include both sugar and sugarless sweeteners.
- Sugar sweeteners may include saccharide containing components including but not limited to sucrose, dextrose, maltose, dextrin, dried invert sugar, fructose, levulose, galactose, corn syrup solids, and the like, alone or in combination.
- Sugarless sweeteners include components with sweetening characteristics but are devoid of the commonly known sugars.
- Sugarless sweeteners include but are not limited to sugar alcohols such as sorbitol, mannitol, xylitol, hydrogenated starch hydrolysates, maltitol, and the like, alone or in combination.
- the chewing gum core may comprise one or more high intensity sweeteners which are commonly used together with sugarless sweeteners.
- high intensity sweeteners typically constitute between 0.001-5% by weight of the chewing gum core, preferably between 0.01-1% by weight of the chewing gum core.
- high intensity sweeteners are at least 20 times sweeter than sucrose.
- sucralose aspartame, N-substituted APM derivatives such as neotame, salts of acesulfame, alitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizinate, dihydrochalcones, thaumatin, monellin, and the like, alone or in combination.
- sucralose aspartame
- N-substituted APM derivatives such as neotame, salts of acesulfame, alitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizinate, dihydrochalcones, thaumatin, monellin, and the like, alone or in combination.
- Combinations of sugar and/or sugarless sweeteners may be used in chewing gum core.
- the sweetener may also function in the chewing gum in whole or in part as a water-soluble bulking agent.
- a softener may provide additional sweetness such as with aqueous sugar or alditol solutions.
- Flavour may be present in the chewing gum in an amount within the range of about 0.1- 15% by weight of the chewing gum, preferably between about 0.2-5% by weight of the chewing gum core, most preferably between about 0.5-3% by weight of the chewing gum core.
- Flavouring agents may include essential oils, synthetic flavours or mixtures thereof including but not limited to oils derived from plants and fruits such as citrus oils, fruit essences, peppermint oil, spearmint oil, other mint oils, clove oil, oil of wintergreen, anise and the like. Artificial flavouring agents and components may also be used in the flavour ingredient of the invention. Natural and artificial flavouring agents may be combined in any senso ⁇ ally acceptable fashion.
- useful flavours may be selected from the group consisting of peppermint, periwinkle, eucalyptus, spearmint, anethol, menthol, powdered anise, and fruit flavours such as orange, lemon, mango, pineapple, lime, strawberry, cherry, black currant, blueberry, raspberry, wild berry, cranberry, apple, pear, banana, prune, and plum flavour, etc.
- the flavour may also be a plant extract which may be applied instead of or together with one or more of the above-mentioned flavour(s) are preferably selected among extracts of liquorice, coffee, tea, herbs such as sage, thyme, basil, bergamot, balm, valerian, camomile, lavender, aloe vera, and spices such as pepper, cinnamon, capsicum, paprika, tarragon, fennel, mustard, dill, caraway, parsley, tomato, etc.
- herbs such as sage, thyme, basil, bergamot, balm, valerian, camomile, lavender, aloe vera, and spices such as pepper, cinnamon, capsicum, paprika, tarragon, fennel, mustard, dill, caraway, parsley, tomato, etc.
- a humectant such as aqueous sorbitol or glycerine, may be added to the chewing gum core in manufacturing chewing gum.
- Softeners may be added to the chewing gum core in order to optimize the chewabihty and mouth feel of the chewing gum.
- the softeners which are also known as plasticizers or plasticizing agents, generally constitute between about 0.5-15% by weight of the chewing gum core.
- the softeners may include glycerine, lecithin, and combinations thereof.
- Aqueous sweetener solutions such as those containing sorbitol, hydrogenated starch hydrolysates, corn syrup and combinations thereof, may also be used as softeners and binding agents in a chewing gum core.
- Optional ingredients such as colours, emulsifiers, pharmaceutical agents and additional flavouring agents may also be included in chewing gum core.
- TiO 2 may e.g. be used to provide a white colour.
- the coating is meant one layer or the sum of several layers.
- the coating may be placed directly onto the inner core or onto one or more of other layers that may surround the inner core.
- the coating may comprise from 50% to 90% by weight of the entire composition, preferably from 55% to 80%, more preferably from 60% to 75% by weight of the composition.
- the coating comprises as its main constituent one or more minerals, such as a source of calcium, which in the case of calcium carbonate is water-insoluble.
- the source of calcium and/or the one or more minerals may be fully enclosed in the coating or it may be partly enclosed in the coating. Some of the source of calcium or the one or more minerals may only be partly enclosed by the coating, thus e.g. having air contact.
- the coating may fully surround the inner core or it may only partly surround the inner core. It is however preferred that at least 30% of the outer surface of the inner core is covered by the coating such as at least 50%, 75%, 90%, 95%, 99%, or 100% of the outer surface of the inner core is covered with the coating.
- the coating may comprise additionally components, preferably water-soluble ingredients.
- the coating may comprise one or more components selected from the group consisting of a bulk sweetener, a high intensity sweetener, a binder, a colour and an emulsifier.
- the coating comprises a bulk sweetener, a binder, an emulsifier and one or more minerals such as calcium carbonate.
- the coating may furthermore comprise a high intensity sweetener.
- the coating comprises a bulk sweetener, a high intensity sweetener, a binder, a colour and an emulsifier.
- Bulk sweeteners may include both sugar and sugarless sweeteners and components.
- Sugar sweeteners may include saccharide containing components including but not limited to sucrose, dextrose, maltose, dextrin, dried invert sugar, fructose, levulose, galactose, corn syrup solids, and the like, alone or in combination.
- Sugarless sweeteners include components with sweetening characteristics but are devoid of the commonly known sugars.
- Sugarless sweeteners include but are not limited to sugar alcohols such as sorbitol, mannitol, xylitol, hydrogenated starch hydrolysates, maltitol, isomalt and the like, alone or in combination.
- At least 50% by weight of the bulk sweetener is a sugar alcohol, such as at least 60%, 70%, 80%, 90%, or 95%, such as at least 99% of the bulk sweetener.
- essentially all the bulk sweetener is a sugar alcohol.
- the coating comprises sugarless sweeteners, such as the polyols.
- polyols are mannitol, sorbitol, xylitol and maltitol.
- the coating comprises sorbitol.
- the coating comprises at most 20% by weight xylitol, such as e.g. at most 15%, 10%, 7,5%, 5%, 2%, or at most 1%, such as at most 0.5% by weight xylitol. In an embodiment, the coating does not comprise xylitol.
- the coating comprises at most 40% by weight sugar alcohol, such as e.g. at most 35%, 30%, 25%, 20%, 15%, or at most 10%, such as at most 5% by weight sugar alcohol.
- the coating does not comprise xylitol.
- At least 50% by weight of the bulk sweetener is sorbitol, such as at least 60%, 70%, 80%, 90%, or 95%, such as at least 99% of the bulk sweetener. In a particular embodiment, essentially all the bulk sweetener is sorbitol.
- At least 50% by weight of the bulk sweetener is mannitol, such as at least 60%, 70%, 80%, 90%, or 95%, such as at least 99% of the bulk sweetener. In a particular embodiment, essentially all the bulk sweetener is mannitol.
- At least 50% by weight of the bulk sweetener is xylitol, such as at least 60%, 70%, 80%, 90%, or 95%, such as at least 99% of the bulk sweetener.
- essentially all the bulk sweetener is xylitol.
- At least 50% by weight of the bulk sweetener is maltitol, such as at least 60%, 70%, 80%, 90%, or 95%, such as at least 99% of the bulk sweetener.
- essentially all the bulk sweetener is maltitol.
- High intensity sweeteners may also be present in the coating and are commonly used with sugarless sweeteners. When used, high intensity sweeteners typically constitute between 0.001-5% by weight of the coating, preferably between 0.01-1% by weight of the coating. Typically, high intensity sweeteners are at least 20 times sweeter than sucrose.
- sucralose aspartame, salts of acesulfame such as acesulfame-K, alitame, saccharin and its salts such as saccharin sodium and saccharin calcium, cyclamic acid and its salts, neotame, alitame, neohesperidin DC, stevia, glycyrrhizin, dihydrochalcones, thaumatin, monellin, twinsweet and the like, alone or in combination. Combinations of sugar and/or sugarless sweeteners may also be used in the coating.
- acesulfame such as acesulfame-K
- saccharin and its salts such as saccharin sodium and saccharin calcium
- cyclamic acid and its salts such as saccharin sodium and saccharin calcium
- neotame alitame
- neohesperidin DC stevia
- glycyrrhizin dihydr
- the coating also comprises a binder such as gum arabic, gelatine, polyvinylpyrrolidone, starches or cellulose.
- a binder such as gum arabic, gelatine, polyvinylpyrrolidone, starches or cellulose.
- the coating comprises approximately 0.5-5% by weight binder, about 5-30% by weight sweetener and approximately 65% to about 90% by weight mineral.
- the coating comprises about 15-25% by weight sweetener, about 3-5% by weight binder and 75-80% by weight calcium source, such as calcium carbonate.
- Optional ingredients such as colours, emulsifiers, pharmaceutical agents and additional flavouring agents may also be included in chewing gum core.
- TiO 2 may e.g. be used to provide a white colour.
- the average thickness of the coating of a coated chewing gum is within the range of 50-5000 micrometer, such as e.g. 100-2000 micrometer, 200-1000 micrometer, and 250-750 micrometer.
- the weight of the coating of the composition may be within the range of 0.2-4 g, such as 0.8-3 g or 1.5-2.5 g.
- a coating suspension is distributed on the chewing gum cores.
- the coating suspension comprises water, sweetener and a binder.
- the solids typically account for 40-65% of the weight of the coating suspension.
- a portion of the powder is sprinkled on top of the chewing gum cores and sticks to the sticky layer of coating suspension.
- the chewing gum cores are dried and a further amount of coating suspension is applied and powder is supplied again. This process is continued until the necessary amount of coating suspension and powder have been applied to the exterior of the chewing gum cores, e.g., 5 to 50 coating layers or more are applied.
- the powder is dry when it is applied to the sticky layer of coating suspension on the chewing gum cores.
- the water content in the powder may e.g. be at most 10% such as e.g. at most 5%, 1% or 0.1% by weight of the powder.
- the coating suspension may also comprise suspended particles of the calcium source, e.g. calcium carbonate.
- elemental calcium may both be provided via the coating suspension and via the application of dry powder. If provided in the coating suspension the percentage of dry matter may be kept at the same level by lowering the concentration of the sweetener.
- further active agents such as one or more vitamins and/or minerals different from calcium may be added to the composition either as part of the inner core or the coating or both.
- Vitamins include vitamin A, beta carotene, B vitamins (B-I, B-2, B-6 or B-12), vitamin C, D, E or K, niacinamide, pantothenic acid, folic acid or biotin.
- Minerals include iron, lithium, magnesium, iodine, copper, phosphorous, zinc, manganese, potassium, sodium, chromium, molybdenum, selenium, zinc, tin, silicon, vanadium and boron.
- the further active ingredient is vitamin D or an analogue thereof, such as vitamin D 2 , ergocalciferol, vitamin D 3 , cholecalciferol, or a mixture thereof or active forms thereof.
- the further active ingredient is vitamin D 3 including the active form thereof in that vitamin D 3 enhances the absorption of calcium from the intestinal tract.
- a dosage unit of the invention such as a piece of chewing gum, comprises vitamin D 3 in range of 1-20 microgram, such as 3-5 microgram and 8-12 microgram.
- the ratio of calcium in elemental form to Vitamin D, expressed in mg of elemental calcium per IU of vitamin D may be in the range 1-5, such as e.g. 2-3.
- the dosage unit could for example comprise 500mg elemental Ca and 200 IU vitamin D.
- One microgram vitamin D corresponds to approximately 40 IU (International Units).
- the vitamin may be added in the form of a pre-mix.
- the vitamin may be encapsulated or spray-dried.
- the vitamin may be entrapped onto the surface of an inert carrier.
- the inert carrier may be the source of elemental calcium, e.g. calcium carbonate.
- the coating comprises a vitamin such as vitamin D 3 .
- Vitamin D 3 is preferably used in an encapsulated form.
- the composition further comprises active ingredients of relevance in reducing the risk of osteoporosis, such as estrogens, including the so-called phytoestrogens, parathyroidea hormone and analogues thereof, and/or vitamin K.
- active ingredients of relevance in reducing the risk of osteoporosis such as estrogens, including the so-called phytoestrogens, parathyroidea hormone and analogues thereof, and/or vitamin K.
- the process for the preparation of the composition may be performed as described below:
- the conventional chewing gum components are mixed in kneading kettles (mixers) with strong horizontally placed Z-shaped arms, which processes the raw materials and produces a homogeneous gum mass.
- the kneading kettles are heated to a temperature of 30-80 0 C, typically approx. 45°C.
- the mixing process starts with gum base quantities that have been weighed out, and the processing of these lasts for 1-20 minutes, typically approx. 10 minutes.
- one or more sweetener(s) in powder form or in liquid form is/are added.
- the dosage of sweeteners and the following processing last from 1 to 20 minutes, typically approx. 7 minutes.
- flavours and the remaining components are added and kneaded for a further 1 to 10 minutes, typically approx. 5 minutes.
- the admixture of flavours and the remaining components may also take place in the beginning of the kneading process, i.e. before the admixture of the sweeteners. It is also possible to add flavours in two or more portions during the kneading process.
- the kneading kettle is tipped, and the gum mass is taken out into carts, onto trays or the like.
- the next process is the forming of the chewing gum core.
- the chewing gum mass Before the forming can take place, the chewing gum mass, however, must be cooled. When taken out, the chewing gum mass has a temperature of 50-70 0 C, and in order to form the chewing gum core, the temperature must be reduced to 30-45 0 C.
- the cooling of the chewing gum core either takes place by storing the chewing gum mass in carts or on trays for quite a long time or by transporting a thin chewing gum carpet through a cooling tunnel.
- the forming of the chewing gum cores may take place by extrusion through a specially formed nozzle, or the chewing gum core may be formed after extrusion by means of rollers, punching machines, tentering wheels, and the like.
- the chewing gum core may be formed into cores of suitable shape, e.g. rectangular pellets/tablets, sticks, balls, cubes, cylinders, and many other shapes.
- the chewing gum core is frequently powdered with a powder, which may consist of i.a. icing sugar, talc, corn flour, and the like.
- the formed chewing gum cores can be cooled immediately to room temperature in a cooling tunnel or the cooling may take place on trays at a store for semi manufactured products at a controlled temperature and moisture.
- the formed and cooled chewing gum core is then treated by means coating and polishing processes before the packing.
- the coating of the chewing gum cores may take place in a tilted, round or horizon-tally placed cylindrical coating kettle that rotate during the whole process.
- the coating kettle may be made from copper, stainless steel or fiberglass-reinforced polyester, and are often equipped with a piping system that supplies and exhausts air and doses the coating suspension.
- the coating process may take place as described below. It should be noted that even though the process mentions a source of elemental calcium such as calcium carbonate, other mineral sources may be incorporated into the coating of by the same coating process, which has proved to be especially useful for obtaining high loads of water- insoluble mineral compounds in the coating:
- the coating suspension is heated up to a temperature in the range of 35-75°C depending on the sweetener, preferable for sorbitol in the range of 37-45°C, such as about 40 0 C.
- Air for drying the layers of coating suspension on the chewing gum cores is typically heated up to at least 35°C such as about 40 0 C.
- the coating suspension typically comprises a bulk sweetener, preferably a polyol, water and optionally also a binder.
- the coating suspension typically comprises 30-70% by weight bulk sweetener, e.g. polyol, preferably 40-60% by weight and even more preferably 50- 60% by weight such as 54-56% by weight.
- the coating suspension typically comprises 20-70% by weight water, preferably 30-50% by weight and even more preferably 35-45% by weight such as 38-42% by weight.
- the coating suspension may also comprise 0.5-10% by weight binder, preferably 2-8% by weight and even more preferably 3-6% by weight such as about 5% by weight.
- binder preferably 2-8% by weight and even more preferably 3-6% by weight such as about 5% by weight.
- binders of the coating are selected from the group consisting of gum arabic, gelatine, polyvinylpyrrolidone, starches, and cellulose. Gum arabic is particularly preferred as binder in the coating suspension.
- the coating suspension comprises 54-56% by weight polyol, e.g. sorbitol, 35-45% by weight water and 3-6% by weight binder.
- the coating suspension may furthermore comprise various additives such as emulsifiers, flavours and colorants, e.g. the emulsifiers, flavours and colorants described herein.
- the chewing gum cores are put into movement in the rotating coating kettles.
- the coating suspension is added in small portions that disperse evenly over the surfaces of the cores after some time to smooth out.
- the powder source of elemental calcium and optionally also vitamin D 3 is applied by sprinkling it freely over the tablets.
- the cores are stirred well to assure an even distribution of the powder and to smooth out the surface.
- the cores are dried by means of air.
- the operation is repeated up to 90 times, preferably approx. 30-40 times, until the correct amount of elemental calcium is added and the cores have the preferred measure and the preferred weight.
- Flavours might be added to the chewing gum tablets in addition to a small dosage of coating suspension.
- the addition of flavour might also be followed by addition of the powder source of elemental calcium as described.
- Preferable the flavour is added in different coating layers from the vitamin D 3 to avoid possible interactions.
- one or more active substance(s) in liquid form may be added.
- the coating can be finished by applying several small dosages of coating suspension without additional powder dosing and letting the tablets dry up without addition of airflow in between.
- polishing In order to achieve a shining surface of the chewing gum tablets with the completed coating, these may subsequently be subjected to a polishing.
- the polishing also takes place in rotating coating kettles in which a polishing suspension or a polishing powder is added to the coated cores in one or more portion(s).
- the polishing suspension often consists of wax, emulsifier, coating agent, gum arabic, water, etc.
- the polishing powder often consists of wax only, or of wax mixed with emulsifier, gum arabic or talc, etc.
- an aspect of the present invention relates to a process for the manufacturing of a composition, e.g. a coated chewing gum, comprising an inner core and a coating, wherein one or more minerals, e.g. elemental calcium, are present in an amount of at least 25% by weight of the coating, the process comprises the steps of:
- a coating suspension comprising a polyol and, optionally, also a binder
- the process also comprises a step of drying the layer of the suspension on the inner core.
- a step of drying the layer of the suspension on the inner core is preferably included as the last part of step iv) and/or in step v).
- the applied volume of coating suspension during one repetition of the step is typically in the range of 5-40 microL per inner core, preferably 10-30 microL, and even more preferred in the range of 15-25 microL.
- the amount of polyol which is applied during one repetition of step iv) is typically in the range of 1-20 microgram per inner core, preferably 5-15 microgram, and even more preferred in the range of 7-13 microgram per inner core.
- the applied amount of powdered mineral e.g. a source of calcium such as calcium carbonate, is typically in the range of 10-200 mg per inner core for one repetition of the step, preferably 25-100 mg, and even more preferred in the range of 40-60 mg.
- the invention relates to the use of a source of elemental calcium and optionally a vitamin D for the preparation of a medicament for the treatment of osteoporosis in a human, wherein said elemental calcium and vitamin D is provided in the form of a chewing gum that comprises i) an inner core comprising a chewing gum core; and ii) a coating comprising elemental calcium in an amount of at least 25% by weight of the coating; and wherein vitamin D is present in the inner core and/or in the coating.
- the invention relates to a method for treating osteoporosis comprising administering to a human an effective amount of elemental calcium and vitamin D provided in the form of a chewing gum that comprises i) an inner core comprising a chewing gum core; and ii) a coating comprising elemental calcium in an amount of at least 25% by weight of the coating; and wherein vitamin D is present in the inner core and/or the coating.
- the chewing gum may be a composition as described herein.
- the medicament is meant to be in the form of a chewing gum, which applies to the composition as defined herein.
- the compositions defined herein may be used in the prevention of bone demineralisation in a human, e.g. in the event wherein the composition as defined herein is used as a nutritional and/or dietary supplement or as a pharmaceutical product for preventing, relieving or treating symptoms associated with osteoporosis and/or bone- mineralisation in a mammal, such as in a female as well as a male.
- the mammal may e.g. be human.
- Another aspect of the present invention relates to method for preventing, relieving or treating symptoms associated with osteoporosis and/or bone-mineralisation in a mammal, such as in a female as well as a male, wherein said method comprises the step of administering the compositions defined herein to the mammal.
- the mammal may e.g. be human.
- this could be a composition comprising a chewing gum core having a hydrophobic water-insoluble gum base, said composition comprising a coating which includes sorbitol, calcium carbonate, vitamin D 3 , vitamin K and a magnesium compound.
- Chewing gum cores with a composition as described below were prepared by mixing the below ingredients into the gum base in a kneading kettle. A conventional hydrophobic gum base was used.
- composition of chewing gum cores is composition of chewing gum cores:
- flavour and calcium carbonate were added and kneaded for a approx. 5 minutes.
- the gum base mixture was cooled to a temperature of about 35°C and subsequently, the chewing gum cores having a weight of about 1 g per piece were formed using a punching machine.
- a Sorbitol suspension having ingredients as mentioned below was prepared by mixing the ingredients into the water at a temperature of 4O 0 C.
- Sorbitol syrup (70%) 2378 g
- coated chewing gum cores were polished in a rotating kettle using carnauba wax and 15 minutes rotation.
- the resulting coated chewing gum had an average weight of 2530 mg of which 1567 mg was coating. Of the 1567 mg coating, CaCO 3 accounted for 1204 mg corresponding to 76% by weight CaCO 3 in the coating.
- the coated chewing gums prepared according to Example 2 were inspected visually.
- the coated chewing gums were found to have uniform and robust coatings and did not display any tendency for peeling or flaking not even after 2 weeks storage at room temperature. All attempts to prepare high load calcium carbonate chewing gum reported in the prior art have been unsuccessful in obtaining a robust coatings for chewing gum having a calcium carbonate weight percent above 60% in the coating. Mouthfeel
- the coated chewing gums prepared according to Example 2 were tested with respect to mouthfeel, that is, sensations that the consumer feels in her mouth when chewing the chewing gum. Surprisingly, the coated chewing gums of Example 2 were found to be crunchy despite the concentration of calcium carbonate used in the coating. All attempts to prepare high load calcium carbonate chewing gums reported in the prior art have been unsuccessful in obtaining a crunchy coatings for chewing gum having a calcium carbonate weight percent above 60% in the coating.
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Abstract
Description
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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DKPA200401046 | 2004-07-01 | ||
DKPA200401046 | 2004-07-01 | ||
US58508704P | 2004-07-06 | 2004-07-06 | |
US60/585,087 | 2004-07-06 |
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WO2006007839A1 true WO2006007839A1 (en) | 2006-01-26 |
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Family Applications (1)
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PCT/DK2005/000454 WO2006007839A1 (en) | 2004-07-01 | 2005-07-01 | Composition comprising minerals and uses thereof |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012170339A (en) * | 2011-02-17 | 2012-09-10 | Asahi Food & Healthcare Ltd | Method for depressing reaction of vitamin c, and product such as vitamin c-containing food |
WO2014184704A1 (en) * | 2013-05-14 | 2014-11-20 | Activesignal Holding Limited | Device for the Treatment of Bone Conditions |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4786511A (en) * | 1986-01-07 | 1988-11-22 | Warner-Lambert Company | Coatings for chewing gums containing gum arabic and a soluble calcium salt |
US6569472B1 (en) * | 2000-09-01 | 2003-05-27 | Wm. Wrigley Jr. Company | Coated chewing gum products containing antacid and method of making |
US20030138518A1 (en) * | 2002-01-16 | 2003-07-24 | Kiefer Jesse John | Center-filled chewing gum containing a deliverable form of calcium |
DE10248632A1 (en) * | 2002-09-23 | 2004-04-01 | Sustech Gmbh & Co. Kg | Coated chewing gum |
-
2005
- 2005-07-01 WO PCT/DK2005/000454 patent/WO2006007839A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4786511A (en) * | 1986-01-07 | 1988-11-22 | Warner-Lambert Company | Coatings for chewing gums containing gum arabic and a soluble calcium salt |
US6569472B1 (en) * | 2000-09-01 | 2003-05-27 | Wm. Wrigley Jr. Company | Coated chewing gum products containing antacid and method of making |
US20030138518A1 (en) * | 2002-01-16 | 2003-07-24 | Kiefer Jesse John | Center-filled chewing gum containing a deliverable form of calcium |
DE10248632A1 (en) * | 2002-09-23 | 2004-04-01 | Sustech Gmbh & Co. Kg | Coated chewing gum |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012170339A (en) * | 2011-02-17 | 2012-09-10 | Asahi Food & Healthcare Ltd | Method for depressing reaction of vitamin c, and product such as vitamin c-containing food |
WO2014184704A1 (en) * | 2013-05-14 | 2014-11-20 | Activesignal Holding Limited | Device for the Treatment of Bone Conditions |
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