WO2006012765A1 - Device for the determination of functional values - Google Patents

Device for the determination of functional values Download PDF

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Publication number
WO2006012765A1
WO2006012765A1 PCT/CH2005/000446 CH2005000446W WO2006012765A1 WO 2006012765 A1 WO2006012765 A1 WO 2006012765A1 CH 2005000446 W CH2005000446 W CH 2005000446W WO 2006012765 A1 WO2006012765 A1 WO 2006012765A1
Authority
WO
WIPO (PCT)
Prior art keywords
values
conductivity
skin
distribution
measured values
Prior art date
Application number
PCT/CH2005/000446
Other languages
German (de)
French (fr)
Inventor
Fritz-Albert Popp
Yan Yu
John Swain
Original Assignee
Bühler AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bühler AG filed Critical Bühler AG
Priority to EP05760714A priority Critical patent/EP1776042A1/en
Publication of WO2006012765A1 publication Critical patent/WO2006012765A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/442—Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00875—Resistance or impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array

Definitions

  • the invention relates to a device for determining functional values, in particular the regulatory capacity of biological systems, in particular of the human body.
  • thermoregulatory diagnostics Procedures that attempt to include dynamic aspects are known as thermoregulatory diagnostics.
  • temperature values at various parts of the body are measured before and after a defined external influencing of the body.
  • Such measurements can be carried out by means of conventional infrared sensors, and the measured temperature differences of the measuring points before and after the influence are used to investigate the heat regulation capacity of the investigated system.
  • the reproducibility of the methods is low. It has therefore also been proposed, according to DE-A-10132549, to irradiate parts of the body surface with infrared and to determine the resulting photoemission in a time-dependent manner and subsequently to adjust the relaxation function with a hyperbolic function.
  • EP-A-1126271 a method for determining the malignancy and reactivity of tumor tissue is known (EP-A-1126271), in which suitable tissue treatment agents are selected on the basis of measured light emission values of the tissue.
  • the invention is based on the object of providing a device for determining functional values, in particular the regulatory capacity of biological systems, in particular to develop man's, which is easy and reliable applicable.
  • the object is achieved by the features of claim 1.
  • the invention is based on the recognition that the physiological values of healthy people are distributed according to a logarithmic normal distribution, which, however, is subject to a normal distribution by sick people who have lost their ability to be regulated.
  • Well-regulated and disregulating biological systems would therefore be easy to recognize in the distribution of measurements when a large number of measurements are carried out in a short time.
  • the conductivity of the skin is suitable as such a measured value, in particular with regard to electrical resistance values or conductivity values. Electrostatic resistance values and / or electrical conductivity values can be measured quickly and reliably at any number of skin locations. It is then only necessary to compare the actual regulatory capacity of a body with the ideal and the lost regulatory capacity and to conclude on a stage of disease and its development and also to assess a therapy in terms of their effect.
  • Characteristic are measuring electrodes that allow a large number of measured values, in particular the conductivity of the skin, to be determined and evaluated by at least one hand in a short time. Preferably, approximately 500 measured values should be determinable within 10 minutes.
  • Fig. 1 Frequency distribution of a relatively healthy subjects
  • Fig. 2 frequency distribution of a relatively ill subjects
  • Fig. 3 Frequency distribution of a nearly cured subjects
  • Fig. 5 an electrode matrix
  • the device for determining functional values comprises a plate with an electrode matrix 1 onto which a skin area 2, for example a hand, can be laid flat.
  • the electrode matrix 1 has a multiplicity of regularly arranged metal pins 3, which are received in guides 5 and whose upper end face is formed like a head half-round, while the lower end face terminates flatly.
  • the upper area of the metal pins 3 is surrounded between the head end and the electrode matrix 1 by a spring 4 which, in the untensioned state, causes the metal pins 3 to protrude from the upper surface of the metal matrix 1.
  • the metal pins 3 can be pressed against the resistance of the spring 4 so far and into the guides 5 that contact the lower end faces contact points 6 of a counter-plate 15 by electrical Lei ⁇ ter (bundle conductor 10) with a measuring device 11 and further with a reference electrode 13 are connected to another skin site of the measured body. Electro ⁇ denmatrix 1 and counter-plate 15 are spaced from each other by a holder 7 and fixed in position by means of screws 8 and nuts 9.
  • a circuit is built up by the body, the metal pin 3, the measuring device 11 and the reference electrode 13, and the conductivity at the respective home location which touches the metal pin (s) 3 is determined ⁇ measure.
  • the conductivity measurements at the home locations, which contact the metal pins 3, are carried out in sequence.
  • the measured values can then be stored in the EDP 12 and utilized, for example, at the regulation of diagnostics.
  • the spring constants and the geometry are selected so that preferably all the metal pins 3 produce the same back pressure when the contact points 6 are touched.
  • the distribution of the measured values of the conductivity of a subject's skin deviates more or less from the ideal lognormal distribution 2, 3 or 4 and the most unfavorable normal distribution 1.
  • about 500 measured values are recorded, evaluated and plotted in about 10 minutes.
  • a healthy Pro ⁇ band results in a good match to the logarithmic normal distribution 2 of the measured values, with a z.
  • a strong approximation of the distribution 3 to a normal distribution results in a frequency distribution 4 that resembles that of a healthy person.

Abstract

The invention relates to a device for the determination of functional values of biological systems, whereby in particular, the conductivity of the skin is recorded as a functional value. The measured values for the conductivity are determined using an electrode matrix (1) in a measuring device (11), whereby a current circuit to a reference electrode (13) is formed and the measured values are subsequently stored and analysed.

Description

Vorrichtung zur Ermittlung von Funktionswerten Device for determining functional values
Die Erfindung betrifft eine Vorrichtung zur Ermittlung von Funktionswerten, besonders der Regulationsfähigkeit biologischer Systemen, insbesondere des menschlichen Kör¬ pers.The invention relates to a device for determining functional values, in particular the regulatory capacity of biological systems, in particular of the human body.
Die Messung von Temperaturen lebender, biologischer Systeme, einschliesslich des menschlichen Körpers, ist ein bekanntes Mittel um die Regulierungsfähigkeit derartiger Systeme festzustellen. Solche Temperaturmessungen erfolgen statisch und die Pro¬ zessdynamik von Temperaturänderungen bleibt dabei unberücksichtigt.The measurement of temperatures of living biological systems, including the human body, is a well-known means of determining the regulatory capability of such systems. Such temperature measurements are static and the process dynamics of temperature changes remain unconsidered.
Verfahren, welche versuchen, dynamische Aspekte mit einzubeziehen, sind als Ther- moregulierungsdiagnose bekannt. Hierbei werden Temperaturwerte an verschiedenen Körperstellen vor und nach einer definierten äusseren Beeinflussung des Körpers ge¬ messen. Solche Messungen sind mittels üblicher Infrarotsensoren durchführbar und die gemessenen Temperaturdifferenzen der Messpunkte vor und nach der Beeinflussung werden zur Untersuchung der Wärmeregulationskapazität des untersuchten Systems verwendet. Neben den Unsicherheiten bei der Interpretation der Aussagen ist die Re¬ produzierbarkeit der Verfahren gering. Es wurde daher gemäss DE-A-10132549 auch vorgeschlagen, Teile der Körperoberfläche mit Infrarot zu bestrahlen und die resultie¬ rende Photoemission zeitabhängig zu ermitteln und die Relaxationsfunktion nachfol¬ gend mit einer hyperbolischen Funktion abzugleichen.Procedures that attempt to include dynamic aspects are known as thermoregulatory diagnostics. In this case, temperature values at various parts of the body are measured before and after a defined external influencing of the body. Such measurements can be carried out by means of conventional infrared sensors, and the measured temperature differences of the measuring points before and after the influence are used to investigate the heat regulation capacity of the investigated system. In addition to the uncertainties in the interpretation of the statements, the reproducibility of the methods is low. It has therefore also been proposed, according to DE-A-10132549, to irradiate parts of the body surface with infrared and to determine the resulting photoemission in a time-dependent manner and subsequently to adjust the relaxation function with a hyperbolic function.
Weiterhin ist ein Verfahren zur Bestimmung der Malignität und Reaktivität von Tumor¬ gewebe bekannt (EP-A-1126271 ), bei dem anhand gemessener Lichtemissionswerte des Gewebes geeignete Agenzien zur Gewebebehandlung ausgewählt werden.Furthermore, a method for determining the malignancy and reactivity of tumor tissue is known (EP-A-1126271), in which suitable tissue treatment agents are selected on the basis of measured light emission values of the tissue.
Der Erfindung liegt nun die Aufgabe zugrunde, eine Vorrichtung zur Ermittlung von Funktionswerten, besonders der Regulationsfähigkeit biologischer Systeme, insbeson- dere des Menschen zu entwickeln, welches einfach und zuverlässig anwendbar ist. Die Lösung der Aufgabe erfolgt mit den Merkmalen des Anspruchs 1.The invention is based on the object of providing a device for determining functional values, in particular the regulatory capacity of biological systems, in particular to develop man's, which is easy and reliable applicable. The object is achieved by the features of claim 1.
Die Erfindung geht von der Erkenntnis aus, dass die physiologischen Werte gesunder Menschen nach einer logarithmischen Normalverteilung verteilt sind, die von kranken Menschen, die ihre Regulationsfähigkeit verloren haben, jedoch nach einer Normalver¬ teilung unterliegen. Gut regulierte und disregulierende biologische Systeme wären demzufolge an der Messwertverteilung einfach zu erkennen, wenn eine Vielzahl von Messungen in kurzer Zeit ausgeführt wird. Als ein solcher Messwert bietet sich die Leit¬ fähigkeit der Haut an, insbesondere bezüglich elektrischer Widerstandswerte oder Leit¬ fähigkeitswerte. An beliebigen Hautstellen können schnell und sicher vielfach elektri¬ sche Widerstandswerte und/oder elektrische Leitfähigkeitswerte gemessen werden. Es ist dann lediglich erforderlich, die tatsächliche Regulationskapazität eines Körpers mit der idealen und der verloren gegangenen Regulationsfähigkeit zu vergleichen und daraus auf ein Krankheitsstadium und dessen Entwicklung zu schliessen und auch eine Therapie bezüglich ihrer Wirkung zu beurteilen.The invention is based on the recognition that the physiological values of healthy people are distributed according to a logarithmic normal distribution, which, however, is subject to a normal distribution by sick people who have lost their ability to be regulated. Well-regulated and disregulating biological systems would therefore be easy to recognize in the distribution of measurements when a large number of measurements are carried out in a short time. The conductivity of the skin is suitable as such a measured value, in particular with regard to electrical resistance values or conductivity values. Electrostatic resistance values and / or electrical conductivity values can be measured quickly and reliably at any number of skin locations. It is then only necessary to compare the actual regulatory capacity of a body with the ideal and the lost regulatory capacity and to conclude on a stage of disease and its development and also to assess a therapy in terms of their effect.
Kennzeichnend sind Messelektroden, die es gestatten, eine Vielzahl von Messwerten, insbesondere der Leitfähigkeit der Haut mindestens einer Hand in kurzer Zeit zu ermit- teln und auszuwerten. Bevorzugt sollten ca. 500 Messwerte innerhalb von 10 Minuten ermittelbar sein.Characteristic are measuring electrodes that allow a large number of measured values, in particular the conductivity of the skin, to be determined and evaluated by at least one hand in a short time. Preferably, approximately 500 measured values should be determinable within 10 minutes.
Die Erfindung wird nachfolgend in einem Ausführungsbeispiel anhand einer Zeichnung näher beschrieben. In der Zeichnung zeigen dieThe invention will be described below in an embodiment with reference to a drawing. In the drawing show the
Fig. 1 : Häufigkeitsverteilung eines relativ gesunden ProbandenFig. 1: Frequency distribution of a relatively healthy subjects
Fig. 2: Häufigkeitsverteilung eines relativ kranken ProbandenFig. 2: frequency distribution of a relatively ill subjects
Fig. 3: Häufigkeitsverteilung eines nahezu geheilten ProbandenFig. 3: Frequency distribution of a nearly cured subjects
Fig. 4: eine schematische Darstellung einer Vorrichtungsanordnung4 shows a schematic representation of a device arrangement
Fig. 5: eine ElektrodenmatrixFig. 5: an electrode matrix
Fig. 6: die Elektrodenmatrix im Querschnitt Die Vorrichtung zur Ermittlung von Funktionswerten umfasst eine Platte mit einer Elekt¬ rodenmatrix 1 , auf die ein Hautareal 2 zum Beispiel eine Hand flach auflegbar ist. Die Elektrodenmatrix 1 weist eine Vielzahl regelmässig angeordneter Metallstifte 3 auf, die in Führungen 5 aufgenommen sind und deren obere Stirnfläche kopfartig halbrund aus¬ gebildet ist, während die untere Stirnfläche flächig abschliesst. Der obere Bereich der Metallstifte 3 ist zwischen Kopfende und Elektrodenmatrix 1 von einer Feder 4umgeben, die im ungespannten Zustand dafür sorgt, dass die Metallstifte 3 aus der oberen Fläche der Metallmatrix 1 herausragen. Die Metallstifte 3 können gegen den Widerstand der Feder 4 leicht und soweit in die Führungen 5 hineingedrückt werden, das deren untere Stirnflächen Kontaktstellen 6 einer Gegenplatte 15 berühren, die durch elektrische Lei¬ ter (Bündelleiter 10) mit einem Messgerät 11 und weiter mit einer Referenzelektrode 13 an einer anderen Hautstelle des gemessenen Körpers angeschlossen sind. Elektro¬ denmatrix 1 und Gegenplatte 15 sind durch eine Halterung 7 voneinander beabstandet und mittels Schrauben 8 und Muttern 9 lagefixiert.Fig. 6: the electrode matrix in cross section The device for determining functional values comprises a plate with an electrode matrix 1 onto which a skin area 2, for example a hand, can be laid flat. The electrode matrix 1 has a multiplicity of regularly arranged metal pins 3, which are received in guides 5 and whose upper end face is formed like a head half-round, while the lower end face terminates flatly. The upper area of the metal pins 3 is surrounded between the head end and the electrode matrix 1 by a spring 4 which, in the untensioned state, causes the metal pins 3 to protrude from the upper surface of the metal matrix 1. The metal pins 3 can be pressed against the resistance of the spring 4 so far and into the guides 5 that contact the lower end faces contact points 6 of a counter-plate 15 by electrical Lei¬ ter (bundle conductor 10) with a measuring device 11 and further with a reference electrode 13 are connected to another skin site of the measured body. Electro¬ denmatrix 1 and counter-plate 15 are spaced from each other by a holder 7 and fixed in position by means of screws 8 and nuts 9.
Sobald ein Metallstift 3 auf eine Kontaktstelle 6 trifft, wird ein Stromkreis durch den Kör¬ per, den Metallstift 3, das Messgerät 11 und die Referenzelektrode 13 aufgebaut und die Leitfähigkeit an der betreffenden Haustelle, die den/die Metallstift(e) 3 berührt ge¬ messen. Die Leitfähigkeitsmessungen an den Haustellen, die die Metallstifte 3 berüh¬ ren, werden der Reihe nach durchgeführt. Die Messwerte können dann in der EDV 12 gespeichert und zum Beispiel na.ch der Regulationsdiagnostik verwertet. Die Federkon¬ stanten und die Geometrie sind so gewählt, dass bevorzugt alle Metallstifte 3 bei Berüh¬ rung der Kontaktstellen 6 den gleichen Gegendruck erzeugen.As soon as a metal pin 3 encounters a contact point 6, a circuit is built up by the body, the metal pin 3, the measuring device 11 and the reference electrode 13, and the conductivity at the respective home location which touches the metal pin (s) 3 is determined ¬ measure. The conductivity measurements at the home locations, which contact the metal pins 3, are carried out in sequence. The measured values can then be stored in the EDP 12 and utilized, for example, at the regulation of diagnostics. The spring constants and the geometry are selected so that preferably all the metal pins 3 produce the same back pressure when the contact points 6 are touched.
Die Verteilung der Messwerte der Leitfähigkeit der Haut eines Probanden weicht je nach Gesundheitszustand mehr oder weniger von der idealen Lognormalverteilung 2,3 oder 4 und der ungünstigsten Normalverteilung 1 ab. Hierbei werden ca. 500 Messwer¬ te in etwa 10 Minuten erfasst, ausgewertet und aufgetragen. Bei einem gesunden Pro¬ banden ergibt sich eine gute Übereinstimmung zur logarithmischen Normalverteilung 2 der Messwerte, bei einem z. B. Krebskranken eine starke Annäherung der Verteilung 3 an eine Normalverteilung. Bei erfolgreicher Behandlung der Erkrankung ergibt sich nach der Behandlung wieder eine Häufigkeitsverteilung 4, die der eines gesunden Menschen gleicht.Depending on the state of health, the distribution of the measured values of the conductivity of a subject's skin deviates more or less from the ideal lognormal distribution 2, 3 or 4 and the most unfavorable normal distribution 1. In this case, about 500 measured values are recorded, evaluated and plotted in about 10 minutes. In a healthy Pro¬ band results in a good match to the logarithmic normal distribution 2 of the measured values, with a z. As cancer patients a strong approximation of the distribution 3 to a normal distribution. Successful treatment of the disease results in a frequency distribution 4 that resembles that of a healthy person.
Mit diesem Verfahren ist es mit hoher Sicherheit (wenigstens 95%) und geringem Auf¬ wand möglich, z. B. Krebserkrankungen festzustellen. With this method, it is possible with high security (at least 95%) and low Auf¬ wall, z. B. cancers.
Bezugszeichenreference numeral
Elektrodenmatrixelectrode matrix
Hautarealskin area
Metallstiftmetal pin
Federfeather
Führungguide
Kontaktstellecontact point
Halterungbracket
Schraubescrew
Muttermother
Bündelleiterbundle conductors
Messgerätgauge
EDVit
Referenzelektrodereference electrode
Gegenplattecounterplate
Normalverteilung logarithmische NormalvertejlungNormal distribution logarithmic normal distribution
Verteilungdistribution
Häufigkeitsverteilung frequency distribution

Claims

Patentansprüche claims
1. Vorrichtung zur Ermittlung von Funktionswerten, besonders der Regulationsfähig¬ keit biologischer Systeme und insbesondere von deren elektrischen Widerstands¬ werten und7oder Leitfähigkeitswerten umfassend eine Elektrodenmatrix (1 ), in der bewegliche Metallstifte (3) beabstandet voneinander angeordnet sind, deren unte¬ re Stirnfläche sich über Kontaktstellen (6) befinden, die mittels elektrischer Leiter mit einem Messgerät (11 ) verbunden sind.1. Device for determining functional values, in particular the regulatory capability of biological systems and in particular their electrical resistance values and conductivity values, comprising an electrode matrix (1) in which movable metal pins (3) are arranged at a distance from one another, whose lower end face is located via contact points (6), which are connected by means of electrical conductors with a measuring device (11).
2. Vorrichtung nach Anspruch 1 , dadurch gekennzeichnet, dass das Messgerät mit einer Referenzelektrode zu einer anderen Stelle des biologischen Systems ver¬ bunden ist.2. Device according to claim 1, characterized in that the measuring device is ver¬ connected with a reference electrode to another point of the biological system.
3. Vorrichtung nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass die Metallstif¬ te (3) gleichmässig und regelmässig voneinander beabstandet sind.3. Apparatus according to claim 1 or 2, characterized in that the Metallstif¬ te (3) are uniformly and regularly spaced from each other.
4. Vorrichtung nach mindestens einem der Ansprüche 1 bis 3, dadurch gekennzeich¬ net, dass die Metallstifte (3J federnd geführt sind.4. Device according to at least one of claims 1 to 3, characterized gekennzeich¬ net, that the metal pins (3J are resiliently guided.
5. Verfahren zur Ermittlung von Funktionswerten, besonders der Regulationsfähigkeit biologischer Systeme, umfassend die Schritte5. A method for determining functional values, in particular the regulatory capacity of biological systems, comprising the steps
> Erfassung einer Vielzahl von Messwerten der Leitfähigkeit der Haut> Acquire a variety of measurements of the conductivity of the skin
> Ermittlung der Häufigkeitsverteilung der Messwerte> Determination of the frequency distribution of the measured values
> Vergleich der Häufigkeitsverteilung der Messwerte mit einer Normalverteilung (20) und einer logarithmischen Normalverteilung (21 ,22 oder 23).> Comparison of the frequency distribution of the measured values with a normal distribution (20) and a logarithmic normal distribution (21, 22 or 23).
6. Verfahren nach Anspruch 5, dadurch gekennzeichnet, dass die Leitfähigkeit der Haut mindestens einer Hand ermittelt wird. 6. The method according to claim 5, characterized in that the conductivity of the skin is determined at least one hand.
7. Verfahren nach Anspruch 5 oder 6, dadurch gekennzeichnet, dass ca. 500 Mess¬ werte in ca. 10 Minuten ermittelt werden.7. The method according to claim 5 or 6, characterized in that about 500 Mess¬ values are determined in about 10 minutes.
8. Verwendung einer Vorrichtung nach Anspruch 1 bis 4 zur Ermittlung der Leitfähig¬ keit von Hautgewebe.8. Use of a device according to claim 1 to 4 for determining the conductivity of skin tissue.
9. Anwendung eines Verfahrens nach den Ansprüchen 5 bis 7 zur Erkennung von Tumor- und Krebserkrankungen. 9. Application of a method according to claims 5 to 7 for the detection of tumors and cancers.
PCT/CH2005/000446 2004-08-02 2005-07-27 Device for the determination of functional values WO2006012765A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05760714A EP1776042A1 (en) 2004-08-02 2005-07-27 Device for the determination of functional values

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004037440A DE102004037440A1 (en) 2004-08-02 2004-08-02 Device for determining functional values
DE102004037440.6 2004-08-02

Publications (1)

Publication Number Publication Date
WO2006012765A1 true WO2006012765A1 (en) 2006-02-09

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DE (1) DE102004037440A1 (en)
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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006054509A1 (en) * 2006-11-20 2008-05-29 Dr.Röhr Medical Solutions GmbH Skin resistance distribution rising implementing device for e.g. human, has measuring head comprising sensor plate formed from non-conductive material, anti-pole provided as handle or sleeve, and probes applied/embedded on sensor plate
DE102006054508A1 (en) * 2006-11-20 2008-05-29 Dr.Röhr Medical Solutions GmbH Opto-electrical measurement device for specific skin resistance distributions in humans for detection of e.g. cancer disease, has central module for process control and data storage, and integrated unit for digital Kirlian photography
DE102010015608A1 (en) * 2010-04-19 2011-10-20 Ziaja Research Gmbh Organism i.e. patient, health statement making method, involves exerting time variable stimulus e.g. mechanical vibration, during measurements on organism, and determining change of statistical distribution with time
CN104414635A (en) * 2013-09-04 2015-03-18 上海帝仪科技有限公司 Dry electrode and manufacturing method thereof
DE102016001080A1 (en) 2015-02-09 2016-08-11 Stefan Liebelt Method and diagnostic device for the determination of cancer in the human body due to the higher iron concentration of malignant cells

Citations (4)

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Publication number Priority date Publication date Assignee Title
DE3025955A1 (en) * 1980-07-09 1982-01-21 Forschungsgesellschaft für Biomedizinische Technik, 5100 Aachen Skin contact electrode for bio-electric currents - has sprung pins fitting into hair to ensure contact with scalp
US4517983A (en) * 1980-12-31 1985-05-21 Yasuhiro Toyosu Electrode sets with resiliently mounted pin electrodes
EP0538739A1 (en) * 1991-10-23 1993-04-28 Reinhard, Max Method and device for determining the state of health of a living being
WO2003079896A1 (en) * 2002-03-25 2003-10-02 Christian Stockinger Measuring device and method for reducing measuring errors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3025955A1 (en) * 1980-07-09 1982-01-21 Forschungsgesellschaft für Biomedizinische Technik, 5100 Aachen Skin contact electrode for bio-electric currents - has sprung pins fitting into hair to ensure contact with scalp
US4517983A (en) * 1980-12-31 1985-05-21 Yasuhiro Toyosu Electrode sets with resiliently mounted pin electrodes
EP0538739A1 (en) * 1991-10-23 1993-04-28 Reinhard, Max Method and device for determining the state of health of a living being
WO2003079896A1 (en) * 2002-03-25 2003-10-02 Christian Stockinger Measuring device and method for reducing measuring errors

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EP1776042A1 (en) 2007-04-25
DE102004037440A1 (en) 2006-03-16

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