WO2006016913A2 - Method and apparatus for conducting raman spectroscopy - Google Patents
Method and apparatus for conducting raman spectroscopy Download PDFInfo
- Publication number
- WO2006016913A2 WO2006016913A2 PCT/US2005/014816 US2005014816W WO2006016913A2 WO 2006016913 A2 WO2006016913 A2 WO 2006016913A2 US 2005014816 W US2005014816 W US 2005014816W WO 2006016913 A2 WO2006016913 A2 WO 2006016913A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- raman
- light
- filter
- probe according
- specimen
- Prior art date
Links
- 238000001069 Raman spectroscopy Methods 0.000 title claims abstract description 247
- 238000000034 method Methods 0.000 title claims description 10
- 239000000523 sample Substances 0.000 claims abstract description 112
- 230000005284 excitation Effects 0.000 claims abstract description 79
- 239000013307 optical fiber Substances 0.000 claims abstract description 42
- 239000000835 fiber Substances 0.000 claims description 69
- 230000003287 optical effect Effects 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 10
- 238000004458 analytical method Methods 0.000 claims description 9
- 239000004065 semiconductor Substances 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 abstract description 4
- 238000010276 construction Methods 0.000 description 18
- 238000000576 coating method Methods 0.000 description 10
- 239000010409 thin film Substances 0.000 description 9
- 239000011248 coating agent Substances 0.000 description 7
- 238000013461 design Methods 0.000 description 7
- 230000005540 biological transmission Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000008707 rearrangement Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241001272720 Medialuna californiensis Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- -1 biotechnology Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0272—Handheld
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0291—Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
- G01J2003/1213—Filters in general, e.g. dichroic, band
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N2021/653—Coherent methods [CARS]
- G01N2021/656—Raman microprobe
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Spectrometry And Color Measurement (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05741216A EP1740914A2 (en) | 2004-04-30 | 2005-04-29 | Method and apparatus for conducting raman spectroscopy |
JP2007511017A JP2007535680A (en) | 2004-04-30 | 2005-04-29 | Method and apparatus for performing Raman spectroscopy |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56671304P | 2004-04-30 | 2004-04-30 | |
US60/566,713 | 2004-04-30 | ||
US60773504P | 2004-09-07 | 2004-09-07 | |
US60/607,735 | 2004-09-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006016913A2 true WO2006016913A2 (en) | 2006-02-16 |
WO2006016913A3 WO2006016913A3 (en) | 2007-11-15 |
Family
ID=35839687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/014816 WO2006016913A2 (en) | 2004-04-30 | 2005-04-29 | Method and apparatus for conducting raman spectroscopy |
Country Status (4)
Country | Link |
---|---|
US (3) | US7636157B2 (en) |
EP (1) | EP1740914A2 (en) |
JP (1) | JP2007535680A (en) |
WO (1) | WO2006016913A2 (en) |
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US10253346B2 (en) | 2013-08-07 | 2019-04-09 | Seraph Biosciences, Inc. | Hand-held micro-raman based detection instrument and method of detection |
US11698304B2 (en) | 2019-02-15 | 2023-07-11 | Wayne State University | Apparatuses, systems, and methods for detecting materials based on Raman spectroscopy |
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Also Published As
Publication number | Publication date |
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US20050248759A1 (en) | 2005-11-10 |
US8107069B2 (en) | 2012-01-31 |
JP2007535680A (en) | 2007-12-06 |
EP1740914A2 (en) | 2007-01-10 |
US20080024777A1 (en) | 2008-01-31 |
US20100002228A1 (en) | 2010-01-07 |
WO2006016913A3 (en) | 2007-11-15 |
US7636157B2 (en) | 2009-12-22 |
US7420672B2 (en) | 2008-09-02 |
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