WO2006020180A2 - Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders - Google Patents
Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders Download PDFInfo
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- WO2006020180A2 WO2006020180A2 PCT/US2005/025371 US2005025371W WO2006020180A2 WO 2006020180 A2 WO2006020180 A2 WO 2006020180A2 US 2005025371 W US2005025371 W US 2005025371W WO 2006020180 A2 WO2006020180 A2 WO 2006020180A2
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- substance
- reservoir
- barrier
- ostium
- implantable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
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- A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
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Definitions
- Patent Application Serial No. 10/829,917 entitled “Devices, Systems and Methods for Diagnosing and Treating Sinusitis and Other Disorders of the Ears,
- the present invention relates generally to medical devices and methods and more particularly to substance delivering implants and methods for treating a broad range of disorders including but not limited to sinusitis and other ear, nose and throat disorders.
- the paranasal sinuses are cavities formed within the bones of the face.
- the paranasal sinuses include frontal sinuses, ethmoid sinuses, sphenoidal sinuses and maxillary sinuses.
- the paranasal sinuses are lined with mucous- producing epithelial tissue. Normally, mucous produced by the linings of the paranasal sinuses slowly drains out of each sinus through an opening known as an ostium, and into the nasopharnyx. Disorders that interfere with drainage of mucous (e.g., occlusion of the sinus ostia) can result in a reduced ability of the paranasal sinuses to function normally.
- mucosal congestion within the paranasal sinuses results in mucosal congestion within the paranasal sinuses.
- Such mucosal congestion of the sinuses can cause damage to the epithelium that lines the sinus with subsequent decreased oxygen tension and microbial growth (e.g., a sinus infection).
- the nasal turbinates are three (or sometimes four) bony processes that extend inwardly from the lateral walls of the nose and are covered with mucosal tissue. These turbinates serve to increase the interior surface area of the nose and to impart warmth and moisture to air that is inhaled through the nose.
- the mucosal tissue that covers the turbinates is capable of becoming engorged with blood and swelling or becoming substantially devoid of blood and shrinking, in response to changes in physiologic or environmental conditions.
- the curved edge of each turbinate defines a passageway known as a meatus.
- the inferior meatus is a passageway that passes beneath the inferior turbinate.
- Ducts known as the nasolacrimal ducts, drain tears from the eyes into the nose through openings located within the inferior meatus.
- the middle meatus is a passageway that extends inferior to the middle turbinate.
- the middle meatus contains the semilunar hiatus, with openings or ostia leading into the maxillary, frontal, and anterior ethmoid sinuses.
- the superior meatus is located between the superior and medial turbinates.
- Nasal polyps are benign masses that grow from the lining of the nose or paranasal sinuses. Nasal polyps often result from chronic allergic rhinitis or other chronic inflammation of the nasal mucosa. Nasal polyps are also common in children who suffer from cystic fibrosis. In cases where nasal polyps develop to a point where they obstruct normal drainage from the paranasal sinuses, they can cause sinusitis.
- Sinusitis refers generally to any inflammation or infection of the paranasal sinuses. Sinusitis can be caused by bacteria, viruses, fungi (molds), allergies or combinations thereof.
- 2004/0116958A1 (Gopferich et al.) describes a tubular sheath or "spacer" formed of biodegradable or non-biodegradable polymer that, prior to insertion in the patient's body, is loaded with a controlled amount of an active substance, such as a corticosteroid or anti-proliferative agent. Surgery is performed to create a fenestration in a frontal sinus and the sheath is inserted into such fenestration.
- an active substance such as a corticosteroid or anti-proliferative agent
- the sheath which has been preloaded with the active substance is inserted into the surgically created fenestration where it a) deters closure of the surgically created fenestration, b) serves as a conduit to facilitate drainage from the sinus and d) delivers the active substance.
- the sheath of United States Patent Application Publication 2004/0116958A1 (Gopferich et al.) remains substantially in a single configuration (i.e., it does not transition between a collapsed configuration and an expanded configuration) although it may be coated with a material that swells when in contact with mucous or body fluid.
- the sheath is formed of multiple layers of polymeric material, one or more of which is/are loaded with the active substance and one or more of which is/are free of the active substance.
- the sheath has a "hollow body" which forms a reservoir system wherein the active substance is contained and a membrane which controls the release of the active substance from the reservoir.
- the sheath may be anchored by causing the end of the sheath that extends into the sinus to swell or otherwise enlarge.
- Group 2 received repeated intramuscular injections of ampicillin.
- 1.5 cm X 1.5 cm sheets of polylactic acid polymer (PLA) film containing ampicillin (0.326mg/sheet) were rolled up and inserted through the natural ostia into the infected sinuses. Thereafter, measurements of mucocilliary transport speed were made and the tissues lining the affected sinuses were examined histopathologically.
- the authors concluded that the therapeutic effect observed in the animals that had received intrasinus implants of PLA/Ampicillin film (Group 3) was significantly better that that observed in the untreated control animals (Groupi) or those that has received repeated intramuscular doses of ampicillin (Group 2).
- United States Patent No. 3,948,254 describes implantable drug delivery devices comprising a drug reservoir surrounded by a microporous wall.
- the reservoir may be formed of a solid drug carrier that is permeable to passage of the drug.
- the rate of passage of the drug through the wall may be slower than the rate at which the drug passes through the solid drug carrier that forms the reservoir.
- United States Patent No. 3,948,254 describes a number of applications for the implantable drug delivery devices including placement in a nasal passage. Specifically, United States Patent No.
- 3,948,254 claimed a nasal delivery device for dispensing a drug within a nasal passage at a controlled rate
- the nasal device is comprised of (a) a wall defining the device dimensioned for insertion and placement within a nasal passage, with the wall formed of a nasal acceptable microporous material, (b) a reservoir surrounded by the wall and comprised of a solid carrier permeable to drug and containing drug in an amount sufficient for the device to meter it at a continuous and controlled rate for a prolonged period of time from the device, (c) a liquid medium permeable to the passage of drug by diffusion charged in the micropores, and (d) wherein the device releases drug when in a nasal environment by passage of drug from the carrier and through the liquid to the exterior of the device to produce a useful result.
- DDR 26 (1976), 585-592 describes the placement of a resorbable drug delivery depot within the maxillary sinus for the purposes of eluting drugs, specifically Chloramphenicol.
- a water soluable gelatin was used as carrier and was mixed with the drug prior to application and introduced as a mass into the sinus. Since the substance had little mechanical integrity and dissolved in a relatively short timeframe, to achieve a therapeutic effect, the author suggested that it must be instilled every 2 to 3 days.
- An alternative to gelatin could be a sponge loaded with the therapeutic substance as suggested in 6,398,758 (Jacobsen, et al.).
- a hollow cylindrical sponge is loaded with drug and pressed against the wall. This allows the drug to contact the wall while sustaining blood flow within the center of the lumen. Further, a skin is provided to direct the drug into the walls of the blood vessel and prevent drug from flowing into the lumen. While sponges loaded with drug at the time of their application do permit some degree of sustained release, the time required to load them also correlates closely the time over which they will elute substance. Thus, if delivery is required for a longer period of time additional mechanisms must be employed to regulate their release. There are also several examples in the patent literature where various sustained release mechanisms have generally been proposed using systems with pre-incorporated drugs into matrices or polymers.
- a method and device for delivering a substance to a location within the body of a human or animal subject e.g., within the nose, paranasal sinus, ostium of a paranasal sinus, eustachian tube, etc.
- a disorder e.g., sinusitis or another disorder of the ear, nose or throat.
- this method comprises the steps of: A) providing an implantable substance delivery device that comprises i) a substance reservoir that may subsequently be loaded with a substance that is therapeutically effective to diagnose or treat the disorder and ii) a barrier that will limit the rate at which a substance will flow out of the reservoir; B) providing a substance that is useable to diagnose or treat the disorder; C) introducing a quantity of the substance into the reservoir; and D) implanting the device at a location within the subject's body such that the substance will be delivered by the implanted device to a location within the subject's body.
- the physician may load a desired therapeutic or diagnostic substance into the reservoir before the device is implanted in the subject's body.
- the physician may load a desired therapeutic or diagnostic substance into the reservoir after the device has been implanted in the subject's body.
- the device may be biodegradable or non-biodegradable and may or may not be removed from the body after it has remained implanted for a desired period of time.
- the barrier of the device may comprise an aperture, membrane (e.g., semi-permeable membrane) or other structure that allows one or more substances having certain key property or properties to pass through the barrier at approximately a known rate.
- Examples of the key properties that may determine a substance's ability to pass through the barrier at approximately the known rate include but are not limited to viscosity or a range of viscosities, molecular weight or range or molecular weights, osmolarity or range of osmolarities, osmolality or range of osmolalities, electrical charge, presence of a chemical group or atom, hydrophilic or hydrophibic properties, the size and/or shape of molecules, etc.
- a physician and/or pharmacist may, in some cases, select a barrier and select or specially formulate a substance that possess a particular key property relative to the selected barrier, such that the substance will be delivered through the barrier at an intended delivery rate.
- the reservoir of the device may comprise a hollow cavity, porous material (e.g., an absorptive polymer foam) or combination thereof.
- the barrier may comprise a membrane or opening that surrounds, substantially surrounds, partially surrounds or is located next to the reservoir such that substance contained within the reservoir will pass through the barrier at a controlled rate.
- the implantable substance delivery device may be configured such that, at least when the reservoir is loaded with the substance, the outer surface of the device will have peaks and valleys such that the peaks are in contact with adjacent tissues or other anatomical structure(s) and the valleys remain spaced away from adjacent tissues or other anatomical structures so as not to interfere with the physiological function of those tissues or other anatomical structures.
- Such embodiments of the device may be implanted in areas of the nose or paranasal sinuses lined with ciliated mucosal tissue and the surface(s) of the device within the valleys will remain far enough away from the adjacent ciliated mucosa as to not interfere with mucociliary transport by such tissue.
- the diameter or cross-sectional configuration of the device may vary along its length or may be shaped in a conical, frustoconical or curvilinear (e.g., hourglass) shape.
- the device may have region(s) of differing hardness (e.g., durometer), flexural properties (e.g., stiffness or flexibility) or compliance and such properties may change in response to the presence or absence of the therapeutic or diagnostic substance and/or contact or non-contact with body fluids (e.g., mucous) or other conditions present at the intended site of implantation.
- Figure 1 is a schematic cut-away showing of a human head having a catheter-based substance delivery system of the present invention inserted therein to deliver a substance delivery implant into the left frontal sinus.
- Figure 2 is a longitudinal sectional view of one embodiment of an implantable substance delivery device of the present invention having a generally round cross-sectional configuration and a self-sealing fill site.
- Figure 2A is a longitudinal sectional view of the device of Figure 2 as it is being filled with a substance.
- Figure 2B is a longitudinal sectional view of another embodiment of an implantable substance delivery device of the present invention having a fill tube that extends from its fill site.
- Figure 2C is a sectional view of a paranasal sinus having an implantable substance delivery device of the present invention implanted therein.
- Figure 3 is a perspective view of another embodiment of an implantable substance delivery device of the present invention having a cross-sectional configuration that provides discrete projections that contact the surrounding anatomical structure(s) while space remains between the remainder of the device and the surrounding anatomical structure(s).
- Figure 3A is a cross sectional view through line 3A-3A of Figure 3.
- Figure 4 is a perspective view of another embodiment of an implantable substance delivery device of the present invention having a frame, a porous core, an outer barrier layer and a cross-sectional configuration that provides for discrete areas of contact between the implanted substance delivery device and the surrounding anatomical structure(s).
- Figure 4A is an end view of the device of Figure 4.
- Figure 4B is a partial cross sectional view of an implantable substance delivery device having a frame, a porous core and an outer barrier layer, wherein the porous core is disposed within the frame and the barrier layer is subsequently applied over the frame.
- Figure 4C is a partial cross sectional view of an implantable substance delivery device having a frame, a porous core and an outer barrier layer, wherein the frame is integral of the porous core and the barrier layer is disposed on the outer surface of the porous core.
- Figure 5 is a perspective view of a screw-shaped substance delivery device of the present invention positioned within an anatomical passageway.
- Figure 5A is a cross sectional view through line 5A-5A of Figure 5.
- Figure 6A is a perspective view of a helical substance delivery device of the present invention positioned within an anatomical passageway.
- Figure 6B is a perspective view of another embodiment of a substance delivery device of the present invention comprising a plurality of substantially parallel substance eluting strut members.
- Figure 6C is a schematic diagram showing the device of Figure 6B implanted within a paranasal sinus.
- Figure 6D is a schematic diagram showing a modified version of the device of Figure 6B implanted within a paranasal sinus.
- Figure 7 is a side view of a substance delivery device of the present invention that is configured for implantation and retention within a paranasal sinus.
- Figure 7 A shows the substance delivery device of Figure 7 after it has been positioned within a paranasal sinus but before being loaded with therapeutic or diagnostic substance.
- Figure 7B shows the substance delivery device of Figure 7 after it has been positioned within a paranasal sinus and after it has been loaded with therapeutic or diagnostic substance.
- Figure 8A shows a fill tube for a substance delivery implant device of the present invention having a fill tube with a valve for preventing the substance from back-flowing out of the fill tube.
- Figure 8B shows a substance delivery implant device of the present invention having a fill tube with a clip for preventing the substance from back- flowing out of the fill tube.
- Figure 8C shows a substance delivery implant device of the present invention having a fill tube with a ligature for preventing the substance from back-flowing out of the fill tube.
- Figure 8D shows a substance delivery implant device of the present invention having a fill port with an adhesive applicator for applying adhesive to plug the fill port thereby preventing the substance from back-flowing out of the fill port.
- Figure 8E shows a substance delivery implant device of the present invention having a fill tube that is doubled over and clipped to prevent the substance from back-flowing out of the fill tube.
- Figure 9 is a longitudinal sectional view of another embodiment of an implantable substance delivery device according to the present invention.
- Figure 9A is a perspective view of a system comprising the implantable substance delivery device of Figure 9 in combination with a delivery catheter device that is useable for implantation of the implantable substance delivery device within the body of a human or animal subject.
- Figure 9B shows the system of Figure 9A after the delivery catheter device has been detached from the implanted substance delivery device.
- Figure 10A is an exploded view of a system for delivery and implantation of a substance eluting filament in accordance with the present invention.
- Figure 10B is a schematic diagram showing an example of a method by which the system of Figure 10A may be used to implant the substance eluting filament within a paranasal sinus.
- Figure 11A is a cut-away side view of a catheter system having a second lumen that is useable for implanting an implantable substance delivery device or drug eluting filament by tracking over a previously inserted guidewire.
- Figure 11 B is a cut-away side view of a catheter system adapted for over-the-wire delivery of an implantable substance delivery device or drug eluting filament that has a guidewire lumen extending longitudinally therethrough.
- Figures 12A-12F schematic diagrams showing steps in a procedure for a) access to and enlargement of the ostium of a paranasal sinus and b) implantation of an implantable substance delivery device of the present invention within the enlarged ostium and paranasal sinus.
- the human nose has right and left nostrils or nares which lead into separate right and left nasal cavities.
- the right and left nasal cavities are separated by the intranasal septum, which is formed substantially of cartilage and bone. Posterior to the intranasal septum, the nasal cavities converge into a single nasopharyngeal cavity.
- the right and left Eustachian tubes i.e., auditory tubes
- the nasopharynx extends inferiorly over the uvula and into the pharynx.
- paranasal sinuses are formed in the facial bones on either side of the face.
- the paranasal sinuses open, through individual openings or ostia, into the nasal cavities.
- the paranasal sinuses include frontal sinuses FS, ethmoid sinuses ES, sphenoidal sinuses SS and maxillary sinuses MS.
- the present invention provides implantable devices that may be positioned within a naturally occurring or man-made anatomical cavity or passageway such as a nostril, nasal cavity, meatus, ostium, interior of a sinus, etc. to deliver a diagnostic or therapeutic substance to tissues located adjacent to or near the implanted device.
- FIG. 1-12F Certain non-limiting examples of the present invention are shown in Figures 1-12F and described in detail herebelow. Although certain examples shown in these drawings are targeted to the paranasal sinuses and nasal cavities, the devices and methods of the present invention are useable in a wide range of applications in various area of the body, including but not limited to natural or man made orifices and passageways, subcutaneous locations, intravascular or intracardiac locations and locations within the gastrointestinal tract.
- diagnostic or therapeutic substance as used herein is to be broadly construed to include any feasible drugs, prodrugs, proteins, gene therapy preparations, cells, diagnostic agents, contrast or imaging agents, biologicals, etc. Such substances may be in bound or free form, liquid or solid, colloid or other suspension, solution or may be in the form of a gas or other fluid or nan-fluid.
- the substance delivered may comprise pharmaceutically acceptable salt or dosage form of an antimicrobial agent (e.g., antibiotic, antiviral, antiparacytic, antifungal, etc.), a corticosteroid or other anti ⁇ inflammatory (e.g., an NSAID), a decongestant (e.g., vasoconstrictor), a mucous thinning agent (e.g., an expectorant or mucolytic), an agent that prevents of modifies an allergic response (e.g., an antihistamine, cytokine inhibitor, leucotriene inhibitor, IgE inhibitor, immunomodulator), etc.
- an antimicrobial agent e.g., antibiotic, antiviral, antiparacytic, antifungal, etc.
- a corticosteroid or other anti ⁇ inflammatory e.g., an NSAID
- a decongestant e.g., vasoconstrictor
- a mucous thinning agent e.g., an expectorant or mu
- antimicrobial agents include acyclovir, amantadine, aminoglycosides (e.g., amikacin, gentamicin and tobramycin), amoxicillin, amoxicillin/clavulanate, amphotericin B, ampicillin, ampicillin/sulbactam, atovaquone, azithromycin, cefazolin, cefepime, cefotaxime, cefotetan, cefpodoxime, ceftazidime, ceftizoxime, ceftriaxone, cefuroxime, cefuroxime axetil, cephalexin, chloramphenicol, clotrimazole, ciprofloxacin, clarithromycin, clindamycin, dapsone, dicloxacillin, doxycycline, erythromycin, fluconazole, foscarnet, ganciclovir, atifloxacin, imipenem/cil
- the substances delivered in this invention may include various steroids or other anti-inflammatory agents (e.g., nonsteroidal anti-inflammatory agents or NSAIDS), analgesic agents or antipyretic agents.
- corticosteroids that have previously administered by intranasal administration may be used, such as beclomethasone (Vancenase® or Beconase®), flunisolide (Nasalide®), fluticasone proprionate (Flonase®), triamcinolone acetonide (Nasacort®), budesonide (Rhinocort Aqua®), loterednol etabonate (Locort) and mometasone (Nasonex®).
- beclomethasone Vancenase® or Beconase®
- flunisolide Nasalide®
- fluticasone proprionate Flonase®
- Triamcinolone acetonide Nasacort®
- steroids that may be useable in the present invention include but are not limited to aclometasone, desonide, hydrocortisone, betamethasone, clocortolone, desoximetasone, fluocinolone, flurandrenolide, mometasone, prednicarbate; amcinonide, desoximetasone, diflorasone, fluocinolone, fluocinonide, halcinonide, clobetasol, augmented betamethasone, diflorasone, halobetasol, prednisone, dexamethasone and methylprednisolone.
- COX inhibitors e.g., salicylic acid derivatives, aspirin, sodium salicylate, choline magnesium trisalicylate, salsalate, diflunisal, sulfasalazine and olsalazine; para-aminophenol derivatives such as acetaminophen; indole and indene acetic acids such as indomethacin and sulindac; heteroaryl acetic acids such as tolmetin, dicofenac and ketorolac; arylpropionic acids such as ibuprofen, naproxen, flurbiprofen, ketoprofen, fenoprofen and oxaprozin; anthranilic acids (fenamates) such as mefenamic acid and meloxicam; enolic acids such as the oxicams (piroxicam, meloxicam)
- COX inhibitors e.g., salicylic acid derivatives, aspirin, sodium
- the substances delivered in this invention may include a) various cytokine inhibitors such as humanized anti-cytokine antibodies, anti-cytokine receptor antibodies, recombinant (new cell resulting from genetic recombination) antagonists, or soluble receptors; b) various leucotriene modifiers such as zafirlukast, montelukast and zileuton; c) immunoglobulin E (IgE) inhibitors such as Omalizumab (an anti-lgE monoclonal antibody formerly called rhu Mab-E25) and secretory leukocyte protease inhibitor) and d) SYK Kinase inhibitoers such as an agent designated as "R-1 12" manufactured by Rigel Pharmaceuticals, Inc, or South San Francisco, California.
- various cytokine inhibitors such as humanized anti-cytokine antibodies, anti-cytokine receptor antibodies, recombinant (new cell resulting from genetic recombination) antagonists, or soluble receptors
- the substances delivered in this invention may include various vasoconstrictors for decongestant and or hemostatic purposes including but not limited to pseudoephedrine, xylometazoline, oxymetazoline, phenylephrine, epinephrine, etc.
- the substances delivered in this invention may include various mucolytics or other agents that modify the viscosity or consistency of mucous or mucoid secretions, including but not limited to acetylcysteine (MucomystTM, MucosilTM) and guaifenesin.
- the substance delivered by this invention comprises a combination of an anti-inflammatory agent (e.g. a steroid or an NSAID) and a mucolytic agent.
- the substances delivered in this invention may include various mast cell stabilizers or drugs which prevent the release of histamine such as cromolyn (e.g., Nasal Chrom®) and nedocromil.
- cromolyn e.g., Nasal Chrom®
- nedocromil e.g., nedocromil
- the substances delivered in this invention may include various antihistamines such as azelastine (e.g., Astylin ® ), diphenhydramine, loratidine, etc.
- azelastine e.g., Astylin ®
- diphenhydramine e.g., diphenhydramine, loratidine, etc.
- the substances delivered in this invention may include substances that weaken or modify bone and/or cartilage to facilitate other procedures of this invention wherein bone or cartilage is remodeled, reshaped, broken or removed.
- an agent such as a calcium chelator such as EDTA that could be injected or delivered in a substance delivery implant next to a region of bone that is to be remodeled or modified.
- a preparation consisting of or containing bone degrading cells such as osteoclasts.
- the substances delivered in this invention may include other classes of substances that are used to treat rhinitis, nasal polyps, nasal inflammation, and other disorders of the ear, nose and throat including but not limited to anti-cholinergic agents that tend to dry up nasal secretions such as ipratropium (Atrovent Nasal®), as well as other agents not listed here.
- CGN collagenase
- trypsin trypsin/EDTA
- hyaluronidase hyaluronidase
- TLCM tosyllysylchloromethane
- the substances delivered in this invention may include other classes of substances that are used to treat rhinitis, nasal polyps, nasal inflammation, and other disorders of the ear, nose and throat including but not limited to anti-cholinergic agents that tend to dry up nasal secretions such as ipratropium (Atrovent Nasal®), as well as other agents not listed here.
- the substances delivered in this invention may include locally or topically acting diuretics such as furosemide and/or hyperosmolar agents such as sodium chloride gel or other salt preparations that draw water from tissue or substances that directly or indirectly change the osmolar content of the mucous to cause more water to exit the tissue to shrink the polyps directly at their site.
- diuretics such as furosemide
- hyperosmolar agents such as sodium chloride gel or other salt preparations that draw water from tissue or substances that directly or indirectly change the osmolar content of the mucous to cause more water to exit the tissue to shrink the polyps directly at their site.
- the substances delivered in this invention may include antitumor agents (e.g., cancer chemotherapeutic agents, biological response modifiers, vascularization inhibitors, hormone receptor blockers, cryotherapeutic agents or other agents that destroy or inhibit neoplasia or tumorigenesis) such as; alkylating agents or other agents which directly kill cancer cells by attacking their DNA (e.g., cyclophosphamide, isophosphamide), nitrosoureas or other agents which kill cancer cells by inhibiting changes necessary for cellular DNA repair (e.g., carmustine (BCNU) and lomustine (CCNU)), antimetabolites and other agents that block cancer cell growth by interfering with certain cell functions, usually DNA synthesis (e.g., 6 mercaptopurine and 5-fluorouracil (5FU), antitumor antibiotics and other compounds that act by binding or intercalating DNA and preventing RNA synthesis
- antitumor agents e.g., cancer chemotherapeutic agents, biological response modifiers,
- biological response modifiers e.g., interferon, bacillus calmette-guerin (BCG), monoclonal antibodies, interluken 2, granulocyte colony stimulating factor (GCSF), etc.
- BCG Bacillus calmette-guerin
- GCSF granulocyte colony stimulating factor
- PGDF receptor antagonists herceptin, asparaginase, busulphan, carboplatin, cisplatin, carmustine, cchlorambucil, cytarabine, dacarbazine, etoposide, flucarbazine, flurouracil, gemcitabine, hydroxyurea, ifosphamide, irinotecan, lomustine, melphalan, mercaptopurine, methotrexate, thioguanine, thiotepa, tomudex, topotecan, treosulfan, vinblastine, vincristine, mitoazitrone, oxaliplatin,
- the substances delivered in this invention may include cells (mucosal cells, fibroblasts, stem cells or genetically engineered cells) as well as genes and gene delivery vehicles like plasmids, adenoviral vectors or naked DNA, mRNA, etc. injected with genes that code for anti-inflammatory substances, etc., and, as mentioned above, osteoclasts that modify or soften bone when so desired, cells that participate in or effect mucogenesis or ciliagenesis, etc.
- the device may be ideal to position the device in a specific location upstream in the mucous flow path (i.e. frontal sinus or ethmoid cells). This could allow the deposition of fewer drug releasing devices, and permit the "bathing" of all the downstream tissues with the desired drug.
- This utilization of mucous as a carrier for the drug may be ideal, especially since the concentrations for the drug may be highest in regions where the mucous is retained; whereas non-diseased regions with good mucous flow will be less affected by the drug. This could be particularly useful in chronic sinusitis, or tumors where bringing the concentration of drug higher at those specific sites may have greater therapeutic benefit.
- a solute such as a salt or other mucous soluble material may be positioned at a location whereby mucous will contact the substance and a quantity of the substance will become dissolved in the mucous thereby changing some property (e.g., pH, osmolarity, etc) of the mucous.
- this technique may be used to render the mucous hyperosmolar so that the flowing mucous will draw water and/or other fluid from polyps, edematous mucosal tissue, etc., thereby providing a drying or desiccating therapeutic effect.
- the nasal cavities provide unique access to the olfactory system and thus the brain. Any of the devices and methods described herein may also be used to deliver substances to the brain or alter the functioning of the olfactory system.
- Such examples include, the delivery of energy or the deposition of devices and/or substances and/or substance delivering implant(s) to occlude or alter olfactory perception, to suppress appetite or otherwise treat obesity, epilepsy (e.g., barbiturates such as phenobarbital or mephoobarbital; iminostilbenes such as carbamazepine and oxcarbazepine; succinimides such as ethylsuximide; valproic acid; benzodiazepines such as clonazepam, clorazepate, diazepam and lorazepam, gabapentin, lamotrigine, acetazolamide, felbamate, levetiraceam, tiagabine, topiramate, zonisamide, etc.), personality or mental disorders (e.g., antidepressants, antianxiety agents, antipsychotics, etc.) , chronic pain, Parkinson's disease (e.g., dopamine receptor
- the implantable substance delivery devices and methods of the present invention may satisfy one or more of the following objectives:
- the implantable substance delivery devices of this invention may be configured such that, when implanted in a nasal or perinasal passageway, they will allow at least a portion of the adjacent anatomical wall(s) to maintain muco-ciliary action.
- the devices may have discrete areas which contact the adjacent anatomical wall(s) and other areas that do not contact the adjacent anatomical wall(s) and/or they may incorporate an internal hollow lumen. While some embodiments of the invention include a central lumen, in most cases, it may be impossible or impracticable for mucous to flow through the lumen of the implanted device via gravity or sheer pressure.
- this central lumen may not be a usable structure to maintain patency of the anatomical passageway since in such cases fluids may more easily be conducted around the device.
- the device may comprise spaced apart struts or members which allow mucous to flow there-between, thus avoiding any need for the mucous to enter a lumen or bore within the device.
- the struts are relatively thin and the device in composed of an open- cellular structure such that the cilia are allowed to contact the inner lumen of the device directly. In these circumstance the clearing of mucous may be possible through the central lumen without relying on pressure or gravity.
- Sustained Effect Drug saturated gauze or sponges as may be used to deliver drugs in some intranasal/intrasinus applications, have little or no ability to regulate the dosage(s) of drug(s) delivered or the dispersion of those drug(s). Further, they may be either non-biodegradable or very quickly biodegradable. At least some embodiments of the devices of the present invention overcome these shortcomings by delivering predetermined dosages of drugs for a predetermined treatment duration and then, after conclusion of the predetermined treatment duration, may be removed or may biodegrade and be eliminated.
- Minimally Invasive Placement Many of the instruments currently used to perform sinus procedures require significant obliteration of or damage to tissues within the nose or sinus in order to gain access and place implants. However, the devices and methods of the present invention may be carried out with minimal iatrogenic damage to nasal and sinus tissues. Thus, the devices and methods described herein may permit swollen tissues and obstructed lumens to be reduced through the action of the drugs, and for infections to be controlled, thereby resulting in a resolution of symptoms without the need for invasive tissue-damaging therapy such as traditional sinus surgery.
- implantable substance delivery devices may be made of a material that is naturally antiinfective or may be coated with such a material. This may aid in avoidance of "toxic-shock" syndrome or other similar device related infections. Alternatively they may be removable or resistant to infection as a result of their mechanical structure or integrity.
- the implantable substance delivery devices of the present invention may be biodegradable and/or removable. In some applications, it will be desirable for the device to be biodegradable over a desired time period, yet be removable if conditions merit it's early removal (e.g., before sufficient time has elapsed to allow the device to fully biodegrade). To aid in the removability of the structure a tail, or suture/string attachment point may be provided to permit easy removal in the office.
- the device may contain two or more separated chambers that simultaneously or sequentially release drug(s).
- one other embodiment may include one or more drugs or substances that are pre-bound or pre-loaded within the device without being mixed with any additive or one or more drugs or substances may be added or mixed with other additives at the time of use.
- any material placed in the sinus should be designed of material such that adhesions or scarring may be minimized to allow for the continued patency of the channels in which they are placed. While simply having a mechanical barrier to adhesion may be useful, it is also important that the implant itself does not induce a tissue reaction. Inert materials should be used to avoid this condition. In other embodiments it may be necessary to release an agent capable of preventing the tissue response to the implant. Nominally, although a vast array of therapeutic substances may be used inside the device, it may also have utility simply as a spacer to maintain the passageway in which it is delivered, filled with an inert substance such as saline.
- the devices of the present invention can deliver therapeutic substances in a consistent or predictable manner over the course of the therapy, and if possible, this timing of delivery would be programmable based upon the material chosen. In some circumstances it may be ideal to allow the device to be refilled in situ, but in some embodiments the device may be capable of containing enough therapeutic substance so that refilling would not be necessary. To date there is no device proposed or available which can satisfy these needs and thus the need still exists for new devices and methods for delivering drugs and other therapeutic or diagnostic substances into paranasal sinuses or other locations within the body for the treatment of sinusitis or other diseases and disorders.
- the implantable substance delivery device may be delivered to or removed from the sinuses or other regions in the ear, nose, or throat via standard surgical techniques, it is of particular interest that the substance delivery device may also be delivered via minimally invasive means which may reduce bleeding, tissue removal, post-operative care, and other surgical issues.
- a catheter which may be malleable, deflectable, and/or have an appropriately shaped body and tip may be introduced into the nose and near or into the location of interest, such as the ostia of a sinus.
- the catheter may or may not be introduced through an access port located in the nostril.
- the guide may be positioned in the anatomy via such means, but not limited to: direct visualization, endoscopic imaging, fluoroscopic imaging, electro-magnetic sensing, etc.
- a guide wire may be advanced through the catheter and into a sinus cavity.
- the catheter tip may curve around the uncinate process (without the need to resect the uncinate) and enter through or point toward the appropriate sinus ostia.
- a guide wire can than be advanced into the sinus cavity. These maneuvers may be done under fluoroscopic, endoscopic, electro-magnetic sensing, etc. visualization methods. Appropriately shaped, deflectable, and/or malleable catheters may also be used to gain access to the frontal and sphenoidal sinuses.
- a balloon catheter may be introduced over the wire in order to enlarge the ostia of the sinus in question if it is deemed necessary.
- a second catheter may be advanced over the wire and through the access catheter. This second catheter may be used to exchange for a smaller guide wire - thus allowing for the use of smaller catheters that are compatible with the smaller guide wire.
- Access to the Sphenoid sinus may be accomplished similarly by advancing the access catheter medial to the middle turbinate and placing the catheter through or close to the ostium of the sinus. Similar techniques of advancing a guide wire into the sinus with subsequent balloon dilation prior to delivery of the substance delivery device may then follow.
- Access to the Ethmoid sinuses may be accomplished similarly by advancing the access catheter into or close to the retrobullar and suprabullar recesses, which provide entry into the ethmoid cells. Similar techniques of navigating and advancing a guide wire through and into the cells with subsequent balloon dilation prior to delivery of the substance delivery device may then follow.
- it may be desirable to advance a catheter near the anterior ethmoid e.g. Ethmoid Bulla
- a piercing member such as a needle or catheter may be advance through the access catheter, and through the walls of the anterior and posterior ethmoid cells.
- a guidewire may be advanced into the ethmoid cells via the needle or other catheter member. Balloon dilation of the pierced anterior and posterior ethmoid cells may be conducted, if desired, prior to placement of the substance delivery device. In general, minimally invasive access to the sinuses and their surrounding areas is a key element to delivering a substance delivery device.
- Figure 1 generally shows a diagram of the head of a human patient wherein a system 10 of the present invention is being employed to implant a substance delivery device 12 of the present invention within the left frontal sinus.
- this system 10 comprises a nasal access port device 14, a delivery catheter 16, an elongate member 18 and the implantable substance delivery device 12.
- the port device 14 is positioned within the nostril, as shown. Examples of nasal port devices that may be useable are described in detail in parent application Serial No. 10/829,917 entitled “Devices, Systems and Methods for Diagnosing and Treating Sinusitis and Other Disorders of the Ears, Nose and/or Throat,” which is incorporated herein by reference.
- the catheter 16 is advanced through the port device 14 and through the nasal cavity to a location within or very near the ostium to the left frontal sinus.
- the implantable substance delivery device 12 Prior to or after insertion of the catheter 16, the implantable substance delivery device 12 is loaded into the lumen of the delivery catheter 16 and the elongate member 18 is positioned in the lumen of the delivery catheter 16 proximal to the implantable substance delivery device 12.
- a separate guide catheter (not shown) may be advanced through port device 14 and to a position near the ostium of the left frontal sinus and thereafter the delivery catheter may be advanced through that guide catheter to a position where the distal end of the delivery catheter is in or immediately adjacent to the ostium of the left frontal sinus.
- the elongate member 18 may be advanced in the distal direction thereby pushing the implantable substance delivery device 12 out of the distal end of the delivery catheter 16.
- the distal end of the elongate member 18 may be positioned in contact with the proximal end of the drug delivery device 12 within the lumen of the delivery catheter 16 and, thereafter, the elongate member 18 may be held stationary while the delivery catheter 16 is retracted in the proximal direction so as to cause the implantable substance delivery device 12 to pass out of the distal end of the delivery catheter 16.
- the substance delivery device 12 will be positioned fully or partially within the frontal sinus and, thereafter, the port device 14, delivery catheter 16 and elongate member 18 may be removed.
- the implantable substance delivery device 12 may be constructed in various ways, examples of which are shown in Figures 2-12F and described herebelow. In any of the embodiments of this invention, the desired diagnostic or therapeutic substance may be loaded into the implantable substance delivery device 12 before and/or after the device 12 has been implanted within the body.
- Figures 2-2C show one embodiment of an implantable substance delivery device 12a which tube 20 having a lumen 22, a porous matrix 24 and an outer barrier 26.
- One end of the tube 20 protrudes through the outer barrier 26 and has a needle-penetrable, self-sealing cap 27 thereon.
- the other end of the tube 20 is closed such that the lumen 22 of the tube forms a hollow cavity within the approximate center of the porous matrix 24.
- a solution containing the desired therapeutic or diagnostic substance is introduced into the lumen 22 of the tube 20 by a syringe and needle 28, as shown in Figure 2A.
- the tube 20 is constructed of porous or permeable material such as expanded polytetrafluoroethylene (ePTFE)or a bioabsorbable material such as porous poly (L-lactic acid) (PLLA) or poly (L-glycolic acid) (PLGA,) etc. which allows the substance to pass through the wall of the tube 20 and into the porous matrix 24.
- ePTFE expanded polytetrafluoroethylene
- PLLA poly (L-lactic acid)
- PLGA poly (L-glycolic acid)
- the porous matrix may be formed of a biodegradable or non-biodegradable porous material such as a flexible or rigid polymer foam, cotton wadding, gauze, hydrogel, collagen etc.
- This device 12a may be fully or partially biodegradable or non-biodegradable.
- the tube 20, porous body 24 and outer barrier 26 may be formed of any suitable material, such as various commercially available biocompatible polymers including but not limited to silicone rubber, polyethylene terephthalate, ultra high molecular weight polyethylene, expanded polytetrafloroethylene, polypropylene, polycarbonate urethane, polyurethane, polyamides.
- any embodiment of this invention could incorporate a means for assisting the transport of a substance across the barrier.
- a device could take the form of a mechanical pump, an electro ⁇ mechanical pump, a nanotechnology pumping mechanism, or an electrical device that emits a current to drive the transport.
- This means could be incorporated into the barrier itself or into the porous matrix.
- a more specific example of a mechanical embodiment would be to mechanically change the reservoir size so that the volume of substance to be delivered is continually under positive pressure to drive its transport across the barrier. This mechanical change could be controlled via micro-electronics and could be pre ⁇ programmed or remotely controlled through various wireless communication technologies.
- a mechanical means to maintain pressure within the reservoir would be to incorporate a membrane barrier that contracts or shrinks as the drug volume diminishes such as an osmotic pump, or one activated by an internal chemical reaction. This contraction could be achieved by creating the membrane barrier from an elastic or shrinking polymer or by including movable filaments or sections that decrease the reservoir volume.
- the wall of any tube 22 or other cavity formed within or next to the porous matrix 24 may be constructed of material that controls the rate at which the substance passes from the lumen 22 of the tube 20 into the porous matrix 24.
- the outer barrier 26 may be constructed of material (e.g., a semi-permeable membrane or film) which will control the rate at which the substance will pass from the porous matrix 24 through the outer barrier 26 and out of the device 12.
- the substance delivery device that utilize multiple chambers within the device to contain multiple drugs.
- These chambers could be arranged in various configurations, including, but not limited to being arranged axially so that a strip of each chamber travels the length of the device but the cross- section shows multiple compartments, longitudinally so that the distal portion of the device could contain a different drug than the middle or proximal portions, or in layers (like an onion) such that the first drug that gets delivered may be different than the next drug to treat various afflictions at different times - i.e. first addressing inflammation, then after a predetermined period to begin releasing antimicrobials to combat infection.
- the dividing membranes may or may not be biodegradable.
- the device 12 of this invention may initially be provided without diagnostic or therapeutic substance contained in the device 12.
- a physician may then select or formulate a particular therapeutic or diagnostic substance or combination of such substances into the device 12 before the device is implanted in the subject's body.
- the physician may load a desired therapeutic or diagnostic substance or combination of such substances into the device 12 after the device has been implanted in the subject's body.
- the device may be accompanied by a data compilation for facilitating dilution of substance(s) and loading of the devices 12 such that desired dosage(s) of the substance(s) that have been loaded into the device 12 will be delivered by the implanted device 12.
- data compilation may be in the form of tabular data, algorithm(s) etc.
- Such data compilation may be provided in written form (e.g., as a table or list) as hard copy (e.g., a package insert or booklet) or stored in electronic form (e.g., on compact disc, accessible from a website, programmed into a computer or microprocessor device such as a hand held electronic dosage calculator that is programmed specifically for use in conjunction with the devices 12 of the present invention).
- the dosage of particular substance(s) delivered by the devices 12 will be determined rate(s) at which certain substances, preparations, mixtures or concentrations of solutes or substances having certain defined key properties will pass through the barriers 26 of the devices 12.
- the data compilation may include or comprise examples or lists of certain key properties for which specific barrier transition rates may be provided include a viscosity or a range of viscosities, molecular weight or range of molecular weights, an electrical charge, osmolarity or a range of osmolarities, osmolality or a range of osmolalities, presence of a certain chemical group or atom, relative hydrophilicity and/or hydrophobic properties, etc.
- An example of one type of data compilation that may be provided to facilitate preparation and loading of a device 12 of the present invention with specific steroid or steroid/antimicrobial formulations is a tabular presentation as shown in Table 1 below:
- the above-set-forth table shows several examples whereby a physician may use a starting preparation that contains one or more drugs (e.g., the preparations listed in the left column) to prepare different dilutions (e.g., concentrations X, Y or Z listed in the middle column) which will deliver different topical doses of the agents contained in the preparation (e.g., the daily dosages listed in the right column).
- the starting preparation e.g., the preparations listed in the left column
- the starting preparation (e.g., the preparations listed in the left column) may be a) packaged and/or provided along with the devices 12 of the present invention, b) obtained by the physician separately from the devices 12 of the present invention and/or c) pre-loaded in concentrated (e.g., dry or lyophilized form) within the devices 12 of the present invention, as described herein.
- the devices 12 may be provided with a dry (e.g, lyophilized or powdered) diagnostic or therapeutic substance (e.g., a drug preparation) contained in the device (e.g.
- the physician may subsequently inject a measured amount of a solvent (e.g., sterile water, 0.9 % NaCI solution, basic salt solution, etc.) to reconstitute or dissolve the substance and to expand or activate the device 12.
- a solvent e.g., sterile water, 0.9 % NaCI solution, basic salt solution, etc.
- the instructions or other information provided with the device 12 may include information for different concentrations of substance produced by injecting different amounts of solvent.
- the devices may be provided in an expanded state and need to be compressed or re ⁇ shaped for delivery then re-expanded fully, slightly, or not at all depending upon the desired implantation location.
- the starting preparation may be commercially available preparations.
- fluticasone proprionate referred to in the first 1 , 2 and 7 of Table 1 is commercially available as a preparation for intranasal spray administration as Flonase® nasal spray (Glaxo- SmithKline, Research Triangle Park, North Carolina).
- Fluticasone propionate the active component of Flonase ® nasal spray, is a synthetic corticosteroid having the chemical name S-(fluoromethyl)6(,9-difluoro-11®-17-dihydroxy-16(- methyl-3-oxoandrosta-1 ,4-diene-17®-carbothioate, 17-propionate. It is provided as an an aqueous suspension of microfine fluticasone propionate containing microcrystalline cellulose and carboxymethylcellulosesodium, dextrose, 0.02% w/w benzalkonium chloride, polysorbate 80, and 0.25% w/wphenylethyl alcohol, and having a pH between 5 and 7.
- This commercially available Flonase product may, in some cases, serve as the base preparation (left column of Table 1) which may be combined with one or more other substances and/or prepared in various dilutions (e.g., middle column of Table 1) prior to being loaded into the device 12 such that the device 12 will, when subsequently implanted in the subject's body, deliver a desired dosage of fluticasone propionate alone or in combination with other agent(s) (right column of Table 1).
- the suspension may be formulated such that it will remain stable within the implanted device 12 and the barrier 26 of the device 12 may comprise a membrane that has pores which are large enough to allow the particles (e.g., microparticles) of the suspension to pass through the barrier at the desired rate.
- triamcinolone acetonide referred to in rows 3 and 4 of Table 1 is commercially available as Nasacort ® AQ nasal spray (Aventis Pharmaceuticals, Inc., Bridgewater, New Jersey).
- Triamcinolone acetonide the active ingredient in Nasacort ® AQ nasal spray, is 9-Fluoro-11 ⁇ , 16 «, 17,21 - tetrahydroxypregna-1 ,4-diene-3,20-dione cyclic 16,17-acetal with acetone (C 24 H 31 FO 6 ). It is provided as a microcrystalline suspension of triamcinolone acetonide in an aqueous medium with microcrystalline cellulose, carboxymethylcellulose sodium, polysorbate 80, dextrose, benzalkonium chloride, and edetate disodium. Hydrochloric acid or sodium hydroxide may be added to adjust the pH to a target of 5.0 within a range of 4.5 and 6.0.
- preparations of the antifungal agent clotrimazole combined with the corticosteroid betamethasone dipropionate as referred to in row 5 of Table 1 are commercially available as Lotrisone ® lotion (Schering Corporation, Kenilworth, New Jersey) for topical application to treat fungal infections.
- Lotrisone ® lotion Schering Corporation, Kenilworth, New Jersey
- clotrimazole is 1-(a-Chloro, a, a-diphenylbenzyl) imid-azole, with the empirical formula C 22 H 17 CIN 2 and a molecular weight of 344.8.
- Clotrimazole is an odorless, white crystalline powder, insoluble in water and soluble in ethanol.
- Betamethasone dipropionate has the chemical name 9-Fluoro- 1 ,16, 17,21 -trihydroxy-16B-methylpregna-1 ,4-diene-3,20-dione-17,21- dipropionate, with the empirical formula C 2 8H37FO7 and a molecular weight of 504.6. Betamethasone dipropionate is a white to creamy white, odorless crystalline powder, insoluble in water.
- Each gram of Lotrisone ® lotion contains 10 mg clotrimazole and 0.643 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a hydrophilic base of purified water, mineral oil, white petrolatum, cetyl alcohol plus stearyl alcohol, ceteareth-30, propylene glycol, sodium phosphate monobasic monohydrate, and phosphoric acid; benzyl alcohol as a preservative.
- the base preparation may comprise low-viscosity forms of the Lotrisone ® lotion or may comprise a solution or suspension of microparticles containing the active ingredients of Lotrisone ® lotion absent the lotion base (e.g, excluding some or all of the mineral oil, white petrolatum, cetyl alcohol plus stearyl alcohol, ceteareth-30 and/or propylene glycol).
- mupirocin calcium is an antibiotic that is commercially available as Bactroban Nasal® ointment (Glaxo-SmithKline, Research Triangle Park, North Carolina) for intranasal application.
- Bactroban Nasal® ointment contains 2.15% w/w mupirocin calcium (equivalent to 2.0% pure mupirocin free acid) in a soft white ointment base that contains paraffin and a mixture of glycerin esters (Softisan® 649).
- the Mupirocin calcium is in the form of the dihydrate crystalline calcium hemi-salt of mupirocin.
- the base preparation (left column of Table 1 ) may comprise low-viscosity forms of the Bactroban Nasal® ointment or may comprise a solution or suspension of microparticles containing the active ingredients of Bactroban Nasal® ointment absent the ointment base (e.g, excluding some or all of the paraffin and/or glycerin esters (Softisan® 649)).
- Figure 2B shows a variant of the implantable substance delivery device
- this device 12b comprising the same components as the device 12a of Figures 2 and 2A but, instead of the needle-penetrable, self-sealing cap 27, this device 12b has a fill tube 32 connected to the exposed end of the inner tube 22 by way of a removable connector 30.
- a check valve 31 may be positioned in the lumen 22 just inside of the connector 30. This check valve may be a device or may simply be the function resulting from the elasticity of the materials chosen for its construction.
- a syringe or other substance injecting or infusing apparatus may be connected to the free end of the fill tube 32 and a diagnostic or therapeutic substance comprising or consisting of a fluid may be introduced through the fill tube 32, through check valve 31 and into the reservoir (i.e., in this embodiment the "reservoir” includes the lumen 22 as well as the adjacent porous matrix 24). Thereafter, the connector cap 30 and fill tube 32 may be removed.
- Check valve 31 will prevent the substance from backflowing out of the protruding end of the inner tube 20.
- the fill tube 32 may remain connected to the device 12 and may be closed (e.g., compressed, clamped, clipped, sealed, cut, doubled over, ligated or otherwise manipulated or sealed as shown in the examples of Figures 8A-8E and described herebelow).
- the outer barrier controls the rate at which the diagnostic or therapeutic substance will diffuse or pass out of the device 12a or 12b.
- the device 12a or 12b may be provided to a physician in an empty state (i.e., without diagnostic or therapeutic substance contained in lumen 22 or porous matrix 24). The physician may then select or self-formulate one or more diagnostic or therapeutic substances to be loaded into the device 12a, 12b before or after the device 12a, 12b has been implanted in the body.
- Figure 2C shows a general example where this implantable substance delivery device 12, 12a, 12b is implanted within the ostium OS of a paranasal sinus PS such that a portion of the device 12, 12a, 12b extends into the paranasal sinus PS.
- the physician may load the lumen 22 and porous matrix 24 with any drugs or other diagnostic or therapeutic substance that he or she deems suitable for treatment of the condition.
- the device 12, 12a, 12b may be loaded with a corticosteroid, such as one or more of those corticosteroids listed hereabove that have been approved for intranasal use (e.g., approved for topical application as a nasal spray or for intramucosal injection directly into the nasal turbinates or nasal mucosa).
- a corticosteroid such as one or more of those corticosteroids listed hereabove that have been approved for intranasal use (e.g., approved for topical application as a nasal spray or for intramucosal injection directly into the nasal turbinates or nasal mucosa).
- a corticosteroid such as one or more of those corticosteroids listed hereabove that have been approved for intranasal use (e.g., approved for topical application as a nasal spray or for intramucosal injection directly into the nasal turbinates or nasal mucosa).
- Flonase Glaxo-SmithKline
- the physician may then infuse the desired substance through the fill tube 32 and into the device 12b.
- the connector 30 may be disconnected and the fill tube 32 removed or, alternatively, the fill tube may be allowed to remain attached to the device 12b to facilitation subsequent in situ refilling of the device 12b.
- the fill tube is connected to a subcutaneous substance reservoir.
- the subcutaneous substance reservoir may comprise a pumping mechanism and is especially useful for chronic delivery of the substance.
- the subcutaneous drug reservoir may be refillable.
- FIGS 3-4C show additional embodiments of implantable substance delivery devices 12c and 12d.
- these embodiments 12c, 12d comprise at least a porous matrix 24 and an outer barrier 26, as described above.
- these embodiments 12c, 12d may also have an inner tube 20 or other hollow cavity formed within or next to the porous matrix 24.
- the outer surfaces of these devices 12c, 12d are shaped to define peaks 34 and valleys 36. When the device 12c, 12d is implanted in the body of a subject and loaded with the desired diagnostic or therapeutic substance, the peaks 34 will contact adjacent anatomical tissue and valleys 36 will remain a spaced distance away from adjacent anatomical tissue.
- the surface to surface contact of the device is minimized and normal flow of body fluids and/or function of anatomical tissues may continue in the areas adjacent to the valleys 36 of the device 12c, 12d.
- the peaks 34 will make firm abutting contact the mucosal tissue thereby holding the device 12c, 12d in place but the valleys 36 will remain a spaced distance away from the mucosal tissue so as not to substantially interfere with mucociliary transport by that tissue or mucous flow past the implanted device 12c, 12d.
- the implantable substance delivery devices 12c, 12d have a fill tube 38 that is connected to the device 12c, 12d.
- the diagnostic or therapeutic substance may be infused through the tube 38 such that it will be absorbed into porous matrix 24 and no closure or the tube or check valve will then be required as the substance will substantially remain within the porous matrix 24.
- the device 12c, 12d does have a hollow cavity (e.g., a tube 20 as shown in Figures 2-2B) within or next to the porous matrix 24, there may be a check valve or other means for closing the tube 38 (e.g., compressing, clamping, clipping, sealing, cutting, doubling over, ligating or otherwise manipulating or sealing the tube as shown in the examples of Figures 8A-8E and described herebelow) to prevent the substance from backflowing from the hollow cavity through the tube 38.
- a check valve or other means for closing the tube 38 e.g., compressing, clamping, clipping, sealing, cutting, doubling over, ligating or otherwise manipulating or sealing the tube as shown in the examples of Figures 8A-8E and described herebelow
- Figures 4-4C show an embodiment of the implantable substance delivery device 12d that further comprises a frame 40.
- Such frame may impart structural rigidity or a specific shape to all or any portion of the device 12d.
- such frame may act as a scaffold or support structure and/or may be self-expanding or pressure-expandable so as to exert outwardly directed force against an adjacent anatomical tissue or structure.
- Figure 4 shows a frame 40 that extends over the entire length of the device 12d, it is to be appreciated that the frame 40 may be confined to one or more specific region(s) of any device 12, such as in the example of Figures 12D-12E described herebelow.
- the frame 40 may be formed of any suitable material, including but not limited to wire, mesh, polymer, etc.
- the frame 40 comprises a self-expanding stent formed of wire members 42.
- the wire members 42 may be positioned on the outer surface of the porous matrix 24 within or inside of the outer barrier 26, as shown in Figure 4BA.
- Such embodiments may be manufactured by initially placing the porous matrix 24 (e.g. a sponge or mass of absorptive material) within the frame 40 and then dipping, spray-applying, applying by lay-up of a film or otherwise applying a polymer to from the outer barrier 26 encapsulating the porous matrix 24 and the frame 40, as shown in Figure 4B.
- such embodiments may be manufactured by forming (e.g., foaming in place) the porous matrix 24 about the frame 40 such that some or all of the frame members 42 are embedded within the porous matrix 24 as shown in Figure 4C.
- the outer barrier 26 may then be placed or formed (e.g., dip coated, sprayed on, applied by lay-up of a film, etc.) on the outer surface of the porous matrix 24 as further shown in Figure4C.
- another method of forming the device may include the initial creation of the barrier film within a mold cavity, and subsequently forming the foam within the film covered mold cavity.
- the device 12d comprises multiple, substantially non-intersecting ridges on its outer surface.
- the ridges enable only a portion of the device 12d to contact adjacent anatomical tissue while keeping bulk of the device 12d spaced a distance away from adjacent anatomical tissue.
- the ridges are designed to be substantially parallel to the direction of flow of fluids (e.g. mucous) along the walls of the adjacent anatomical tissue. This design enables reduced interfere with mucociliary transport by that tissue or the flow of fluids (e.g. mucous) past the device 12d.
- implantable substance delivery devices 12 of the present invention may be configured to define at lest one lumen of flow channel through which body fluid or extraneously introduced fluid may flow after the device 12 has been implanted in a natural or man made passageway of the body.
- Examples of this concept include devices 12c, 12d having peaks 34 and valleys 36 as shown in Figures 3 and 4, as well as 12e and 12f having other flow-facilitating configurations, examples of which are shown in Figures 5-6.
- the device 12e of Figures 5 and 5A comprises a porous matrix 24 covered with an outer barrier 26 and is in the shape of a helical strip (e.g., the shape of a screw or auger).
- this device 12e When loaded with the desired diagnostic or therapeutic substance and implanted in a body lumen or passageway, this device 12e defines a helical groove or flowpath 50 through which fluid (e.g., mucous, body fluid, etc.) may flow.
- the device 12e of Figure 5 also incorporates an optional grasping member 52 to facilitate grasping of the device 12e by forceps, by hand or by other instruments while removing, moving or manipulating the device 12e.
- the grasping member 52 comprises a strand of suture thread that extends from one end of the device 52 but it is to be appreciated that such grasping member 52 may be of any suitable design or construction and may be located over the entire length of the device.
- small threads or projections, a net or other graspable structure may be located at numerous location on the outer surface of the device so as to facilitate moving or removing the entire device or portion(s) of the device after the device has begun to break apart or biodegrade in situ.
- FIG. 6A shows an implantable substance delivery device 12f of the present invention that comprises a helical substance eluting filament.
- This helical structure defines a hollow lumen 54 through the center of the device 12f and open spaces 56 between individual convolutions of the helix, through which fluids (e.g., mucous or other body fluids) may flow.
- This helical filament may be formed of any suitable biodegradable or nonbiodegradable material.
- PLLA poly (L-lactic acid)
- PLGA poly (L-glycolic acid)
- PLA poly (L-glycolic acid)
- PLA polyglycolide
- poly-L-lactide poly-D-lactide
- poly(amino acids) polydioxanone
- polycaprolactone polygluconate
- polylactic acid-polyethylene oxide copolymers modified cellulose, collagen
- FIGS 6B-6D show in another embodiment of an implantable substance delivering device 12m which comprises a plurality of substance eluting struts 55 and may optionally include a spacing member 53.
- the struts 55 may be substantially parallel to the direction of flow of fluids (e.g.
- the device 12m can be placed both in anatomical cavities (e.g. nasal sinus cavities) and in anatomical passages (e.g. trachea, blood vessels etc.).
- the device 12m has a configuration that enables the struts 55 to substantially come into direct contact with the flow of fluids (e.g. mucous) past the stent.
- the device 12m may be delivered to the intended implantation site while in a collapsed configuration and may subsequently expand to an expanded configuration, as shown in the figures.
- This device 12m may be self expanding or pressure expandable (e.g., by inflation of a balloon within the collapsed device).
- the thickness of the struts 55 may vary along the length of the device 12m as shown in the example of Figure 6D.
- the diagnostic or therapeutic substance may be contained in and eluted from the thicker in regions 51 of the struts 55 and such substance may subsequently be carried or distributed by a natural flow of body fluid (e.g., mucous flow out of the paranasal sinus).
- the thinner regions of the struts 55 may be located near the drainage openings of the anatomical tissue (e.g. ostia of a nasal sinus) to minimize obstruction to fluid drainage.
- the device 12m may comprise a spacing member 53, such as a tubular or cylindrical hub, and such spacing member 53 may be positionable in an opening of the anatomical tissue (e.g. ostium of a nasal sinus as shown in Figure 6D).
- the spacing member 53 may or may not have drug eluting properties.
- the spacing member 53 may be configured to perform a scaffolding function such as to deter narrowing of a man made or natural an anatomical opening or passage in which it is positioned to ensure that fluid flow through the opening is not compromised.
- the device 12m may be biodegradable or bioabsorbable.
- FIGS 7-7B show an example of an implantable substance delivery device 12g of the present invention that is designed to be implanted and subsequently retained within a paranasal sinus.
- This device 12g may include the inner tube 20, porous matrix 24 and outer barrier 26 as shown in Figures 2 and 2A and described above. Additionally, this embodiment of the device 12g has an intrasinus portion 56 intended to be positioned within the paranasal sinus, an intraostial portion 58 intended to be positioned within the sinus ostium OS and an intranasal portion 60 intended to protrude into the nasal cavity.
- a fill tube 62 having a needle-penetrable, self-sealing cap 64 is positioned on the end of the fill tube.
- the intraostial portion 58 of device 12g has an annular groove formed therein. As may be appreciated from Figures 7A and 7B this annular groove is configured to receive the annulus of the ostium OS and frictionally engage the underlying bone B, thereby helping to position or seat and/or hold the device 12g in its intended implantation position. Initially, the device 12g is in a collapsed configuration wherein the device has a diameter or maximum cross dimension D1 that is small enough to be advanced through the ostium OS and into the paranasal sinus, as shown in Figures 7 and 7A.
- a syringe and needle 66 are used to inject a known volume of a solution containing the desired diagnostic or therapeutic substance 68 into the device 12g.
- the loading of the substance containing solution into the device 12g causes the intrasinus portion 56 to swell to a larger diameter D2, which is too large to pass through the ostium OS, thereby tending to retain the intrasinus portion 56 within the paranasal sinus, as shown in Figure 7B.
- FIGS 8A-8E show several non-limiting examples of the manner in which the implantable substance delivery devices 12 of this invention may be sealed or closed to prevent substantial backflow of the diagnostic or therapeutic substance from the device 12 after the device 12 has been loaded with substance.
- the device has a long fill tube 70 and a one way check valve 72 within the neck of the fill tube, immediately adjacent to the body of the device.
- the fill tube 70 may be cut to a desired length such that it will not protrude from the subject's body or interfere with the subject's daily activities.
- Figure 8B shows a device that has a fill tube 70 and a clip 74 which is useable to clip the fill tube 70 to prevent substance from backflowing out of the fill tube 70.
- Figure 8C shows a device that has a fill tube 70 and a ligature 76, such as a length of suture material or draw string which is useable to ligate the fill tube 70 to prevent substance from backflowing out of the fill tube 70.
- An annular indentation or groove may optionally be formed in the fill tube to receive and prevent longitudinal slippage of the ligature 76.
- Figure 8D shows a device that has a fill port 78 through which the substance is injected or otherwise loaded into device and an adhesive applicator 80 that may be used to apply an adhesive to the fill port 78 thereby sealing the fill port 78 such that substance will not backflow out of the fill port 78.
- Figure 8E shows a device that has a fill tube 70 that is doubled over and a clamp 82 that is useable to clamp the doubled over fill tube 70 to prevent substance from backflowing out of the fill tube 70.
- FIGS 9-9B are directed to another embodiment of an implantable substance delivery device 12h of the present invention.
- This device 12h comprises a container portion which comprises a container body 90 and a lid 92.
- the interior of the container portion is loaded with a desired diagnostic or therapeutic substance.
- the lid 92 has a permeable barrier 94 which allows the diagnostic or therapeutic substance to pass through the barrier 94 at approximately a known rate as described hereabove.
- An attachment portion 98 attaches the container portion to bone and/or soft tissue.
- Such attachment portion 98 may comprise any suitable type of attachment apparatus or substance such as an adhesive, barb(s), a screw, a suture or stitch, a clip, a suction apparatus, a stent, a self-expanding portion that grip the walls of the anatomical target etc.
- the device 12h may be mounted on a delivery catheter 100 which is useable to deliver the device 12h to its intended implantation location.
- the delivery catheter 100 has engagement members 102 that engage projections 96, 98 on the device 12h, as shown, to hold the device 12h on the end of the delivery catheter as it is advanced into the body to the desired implantation location.
- the proximal end of the delivery catheter 100 comprises a handpiece having a control knob 104.
- the engagement members 102 When the control knob 104 is retracted, the engagement members 102 will disengage the projections 96, 98, thereby releasing the device 12h and allowing the delivery catheter 100 to be retracted and removed as shown in Figure 9B.
- the attachment portion 98 comprises a screw
- the delivery catheter 100 may be braided or otherwise constructed in accordance with techniques well known in the art such that the catheter may be rotated to screw the screw into adjacent soft tissue or bone, before the device 12h is released from the delivery catheter 100.
- the substance may be loaded into this device 12h before or after the device 12h has been implanted within the subject's body.
- the device 12h is implanted in an anatomical location having a mucous flow in such a way that the eluted drug is distributed to a wider region by the mucous flow. This is especially helpful in the enhancing the efficacy of agents like mucolytics as they would accumulate at higher concentrations in regions of higher mucous density. This also enables the reduction in size of the substance delivery mechanism since it can be limited to deliver substances only to particular regions from where the drug can be distributed most efficiently.
- Figures 1OA and 10B show a system 110 for delivering another implantable substance delivery device which comprises a substance eluting filament 12j.
- This system 110 comprises the substance eluting filament 12j, a catheter 114, a pusher 116 and a connector 118.
- the substance eluting filament 12j is advanced into the lumen of the delivery catheter 114.
- the pusher 116 is advanced into the lumen of the delivery catheter 114 behind the substance eluting filament 12j and the connector 118 is connected to the proximal end of the delivery catheter 114.
- the delivery catheter 114 may then be advanced into the subject's body to a position where the distal end of the delivery catheter is within or near the location where the substance delivery device 12j is to be implanted (e.g., within or near the ostium of a paranasal sinus). Thereafter the pusher may be advanced in the distal direction or the pusher may be held stationary and the catheter 114 may be retracted in the proximal direction to push the substance delivery device 12j out of the end of distal end of the catheter and into the desired implantation site (e.g., paranasal sinus).
- the substance eluting filament may or may not be biased to a specific shape or coiled configuration.
- the substance eluting filament 12j assumes a random coiled shape within the implant location.
- the implantable substance delivery devices 12 of this invention and/or the delivery catheter or delivery devices used to deliver such devices 12 into the body may, in some instances, be configured for over-the-wire or rapid exchange delivery.
- Figure 11A shows an illustrative example of a rapid exchange embodiment of this invention and
- Figure 11B shows an illustrative example of an over-the-wire embodiment.
- the delivery catheter 120 has a first lumen within which the implantable substance delivery device 12k and elongate delivery member or pusher 126 are positioned.
- a side tube 124 having a second lumen 122 is located on a side of the delivery catheter 120, as shown.
- a guidewire GW may pass through the side lumen 122, thereby allowing the system to be advanced over a previously inserted guidewire.
- Figure 11 B shows an over-the-wire embodiment comprising a delivery catheter 130 having a lumen within which the implantable substance delivery device 121 and elongate delivery member or pusher 134 are positioned.
- the substance delivery device 121 and elongate delivery member or pusher 134 have lumens 132 and 136 extending longitudinally therethrough.
- a guidewire GW may pass through the lumens 132 and 136, thereby allowing the system to be advanced over a previously inserted guidewire.
- the substance delivery devices 12 of the present invention may have guidewire lumens or passageways extending therethrough.
- FIGS 12A-12E show one of many possible examples of procedures that may be performed using the implantable substance delivery devices 12 of the present invention.
- This particular example shows a method for treating sinusitis in a human or animal subject.
- the sinusitis is due at least in part to impaired drainage from the sinus as a result of an occlusion of the ostium OS that leads into the paranasal sinus.
- the ostium OS consists of thin bone B covered by mucosal tissue.
- a guidewire such as a Guidant Hi-Torque Supracore 35 Guide Wire is advanced through the ostium OS and into the paranasal sinus.
- a balloon catheter 200 such as the Guidant Agiltrac .035 Peripheral Dilatation Catheter having a balloon 202 formed of relatively strong material such as polyethylene teraphthalate is then advanced over the guidewire GW to a position where the balloon 202 is positioned within the ostium OS. Thereafter, as shown in Figure 12B, the balloon 202 is inflated so as to dilate the ostium OS possibly breaking bone B that surrounds the ostium OS and creating an enlarged ostium EOS. Thereafter, as shown in Figure 12C, the balloon 202 is deflated and the balloon catheter 200 is withdrawn and removed, leaving the guidewire GW in place.
- the balloon 202 is deflated and the balloon catheter 200 is withdrawn and removed, leaving the guidewire GW in place.
- a delivery catheter of any of the type described herein is advanced over the guidewire GW and to deliver an empty implantable substance delivery device 12i of the present invention within the enlarged ostium EOS such that a portion of the device 12i extends into the sinus, as shown in Figure 12D.
- the implantable substance delivery device 12i is an over the wire type device 12i having a fill tube 204, an intraostial portion 206 which includes a self-expanding frame 208 and intrasinus portion 210.
- the delivery catheter and guidewire GW are removed and a quantity of the desired diagnostic or therapeutic substance (e, g, a corticosteroid, anti-inflammatory, antimicrobial, mucous modifying or mucolytic agent, or other agent or substance effective to treat sinusitis) is infused through the fill tube 204 into the device 12i.
- the desired diagnostic or therapeutic substance e, g, a corticosteroid, anti-inflammatory, antimicrobial, mucous modifying or mucolytic agent, or other agent or substance effective to treat sinusitis
- this causes the intrasinus portion 210 of the device 12i to swell or expand to an enlarged configuration that will not pass out of the enlarged ostium EOS.
- the intraostial portion 206 and frame 208 will enlarge to an expanded configuration that exerts outward radial pressure against the enlarged ostium EOS for a period of time sufficient to allow the enlarged ostium OS and any broken bone BB therein to heal and remodel to the enlarged diameter.
- the substance(s) that was/were introduced into the device 12i will diffuse out of the device 12 into the sinus at a desired rate, thereby providing pharmacological treatment for the infection, inflammation and/or other aspects of the sinusitis. Thereafter the device 12i may biodegrade and/or may be removed and the enlarged ostium will remain facilitating normal drainage from the sinus thereafter.
- Another embodiment of the substance delivery device incorporates the addition of a micropump to one or all of the drug containing chambers.
- the micropump would assist in active transport of the drug across the membrane.
- the delivery rate of this pump could be programmed ahead of time or via remote electronics.
- Other methods of incorporating micromachinery or nanotechnology to enable pressure assisted transport could be added to the substance delivery device.
- Another example would include a semi-permeable membrane where the reservoir volume continuously shrinks as drug is eluted to maintain a certain driving pressure in the reservoir. This shrinkage could be due to elastic properties of the membrane or due to mechanically limiting and changing the space in the reservoir. These devices could be refillable.
- the abovementioned embodiments may be used as spacing devices after a open surgical, laparoscopic surgical or an interventional procedure. Further, these devices may be further coated with an anti-infective agent or may be constructed of a substance which is naturally bacteriostatic to reduce the likelihood of toxic-shock syndrome or other device related infections. Such a naturally bacteriostatic material would be a biodegradable substance which, through the process of biodegradation, undergoes hydrolysis, releasing bacteriostatic substances such as hydrogen peroxide.
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Abstract
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Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2005274794A AU2005274794B2 (en) | 2004-08-04 | 2005-07-18 | Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders |
EP05773189.5A EP1778335B1 (en) | 2004-08-04 | 2005-07-18 | Implantable devices for delivering drugs and other substances to treat sinusitis and other disorders |
JP2007524827A JP5306649B2 (en) | 2004-08-04 | 2005-07-18 | Implantable device that does not obstruct the flow of surrounding fluid |
CA2575361A CA2575361C (en) | 2004-08-04 | 2005-07-18 | Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders |
EP14181385.7A EP2845621B1 (en) | 2004-08-04 | 2005-07-18 | Implantable devices for delivering drugs and other substances to treat sinusitis and other disorders |
ES05773189T ES2427979T3 (en) | 2004-08-04 | 2005-07-18 | Implantable devices for the administration of drugs and other substances to treat sinusitis and other disorders |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/912,578 US7361168B2 (en) | 2004-04-21 | 2004-08-04 | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders |
US10/912,578 | 2004-08-04 |
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Publication Number | Publication Date |
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WO2006020180A2 true WO2006020180A2 (en) | 2006-02-23 |
WO2006020180A3 WO2006020180A3 (en) | 2006-06-15 |
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PCT/US2005/025371 WO2006020180A2 (en) | 2004-08-04 | 2005-07-18 | Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders |
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US (5) | US7361168B2 (en) |
EP (4) | EP2258440B1 (en) |
JP (2) | JP5306649B2 (en) |
AU (1) | AU2005274794B2 (en) |
CA (1) | CA2575361C (en) |
ES (3) | ES2427979T3 (en) |
WO (1) | WO2006020180A2 (en) |
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- 2005-07-18 AU AU2005274794A patent/AU2005274794B2/en not_active Ceased
- 2005-07-18 WO PCT/US2005/025371 patent/WO2006020180A2/en active Application Filing
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Also Published As
Publication number | Publication date |
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US20100114066A1 (en) | 2010-05-06 |
EP2263738A2 (en) | 2010-12-22 |
CA2575361A1 (en) | 2006-02-23 |
EP2845621B1 (en) | 2019-10-30 |
JP5306649B2 (en) | 2013-10-02 |
AU2005274794A1 (en) | 2006-02-23 |
US9039680B2 (en) | 2015-05-26 |
EP2263738A3 (en) | 2011-11-09 |
JP2008508938A (en) | 2008-03-27 |
US9039657B2 (en) | 2015-05-26 |
AU2005274794B2 (en) | 2012-01-19 |
US20050245906A1 (en) | 2005-11-03 |
US20090005763A1 (en) | 2009-01-01 |
JP5461628B2 (en) | 2014-04-02 |
EP2258440B1 (en) | 2014-08-20 |
US9084876B2 (en) | 2015-07-21 |
ES2523747T3 (en) | 2014-12-01 |
EP2258440A2 (en) | 2010-12-08 |
EP2263738B1 (en) | 2013-06-05 |
US20130281982A1 (en) | 2013-10-24 |
ES2425020T3 (en) | 2013-10-10 |
JP2012205930A (en) | 2012-10-25 |
EP2845621A3 (en) | 2015-04-08 |
ES2427979T3 (en) | 2013-11-05 |
EP1778335A2 (en) | 2007-05-02 |
US20150217097A1 (en) | 2015-08-06 |
CA2575361C (en) | 2015-06-30 |
EP2258440A3 (en) | 2011-11-02 |
EP1778335B1 (en) | 2013-06-12 |
US7361168B2 (en) | 2008-04-22 |
EP1778335A4 (en) | 2008-07-09 |
WO2006020180A3 (en) | 2006-06-15 |
EP2845621A2 (en) | 2015-03-11 |
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