WO2006020256B1 - Systems and methods for atraumatic implantation of bio-active agents - Google Patents

Systems and methods for atraumatic implantation of bio-active agents

Info

Publication number
WO2006020256B1
WO2006020256B1 PCT/US2005/025470 US2005025470W WO2006020256B1 WO 2006020256 B1 WO2006020256 B1 WO 2006020256B1 US 2005025470 W US2005025470 W US 2005025470W WO 2006020256 B1 WO2006020256 B1 WO 2006020256B1
Authority
WO
WIPO (PCT)
Prior art keywords
elongated member
tissue
bioactive agent
lumen
distal end
Prior art date
Application number
PCT/US2005/025470
Other languages
French (fr)
Other versions
WO2006020256A2 (en
WO2006020256A3 (en
Inventor
Mark C Bates
Original Assignee
Paragon Intellectual Propertie
Mark C Bates
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paragon Intellectual Propertie, Mark C Bates filed Critical Paragon Intellectual Propertie
Priority to JP2007522631A priority Critical patent/JP4774403B2/en
Priority to CA2573844A priority patent/CA2573844C/en
Priority to AU2005274775A priority patent/AU2005274775B2/en
Priority to EP20050773060 priority patent/EP1773441B1/en
Publication of WO2006020256A2 publication Critical patent/WO2006020256A2/en
Publication of WO2006020256A3 publication Critical patent/WO2006020256A3/en
Publication of WO2006020256B1 publication Critical patent/WO2006020256B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3478—Endoscopic needles, e.g. for infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00367—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like
    • A61B2017/00398—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like using powered actuators, e.g. stepper motors, solenoids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect
    • A61B2017/00871—Material properties shape memory effect polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3403—Needle locating or guiding means
    • A61B2017/3405—Needle locating or guiding means using mechanical guide means
    • A61B2017/3411—Needle locating or guiding means using mechanical guide means with a plurality of holes, e.g. holes in matrix arrangement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B2017/348—Means for supporting the trocar against the body or retaining the trocar inside the body
    • A61B2017/3482—Means for supporting the trocar against the body or retaining the trocar inside the body inside
    • A61B2017/3484—Anchoring means, e.g. spreading-out umbrella-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00351—Heart
    • A61B2018/00392—Transmyocardial revascularisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion

Abstract

Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter (31) and a needle (37) disposed within the catheter (31) and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle (37) may be configured to create a tissue space surrounding a distal or lateral surface of the needle (37), into which the bioactive agent to be infused.

Claims

received by the International Bureau on 16 November 2006 (16.11.2006)
+STATEMENT
What Is Claimed Is:
1. Apparatus for depositing a bioactive agent into a tissue mass, comprising: a catheter having a proximal end and a distal region and a lurnen extending therebetween; an elongated member disposed within the lumen of the catheter, the elongated member having a proximal end, a tissue-piercing distal end, and a lumen extending therebetween, the elongated member configured to atraumatically deliver the bioactive agent via the lumen into the tissue mass; and an actuator for selectively extending and retracting the tissue-piercing distal end of the elongated member into the tissue mass to form a needle track, wherein the bioactive agent is atraumatically delivered into the needle track during retraction of the tissue piercing distal end of the elongated member.
2. The apparatus of claim 1 wherein the elongated member is configured to deliver the bioactive agent using capillary action during retraction of the tissue-piercing distal end of the elongated member.
3. The apparatus of claim 2 further comprising a container holding a quantity of bioactive agent, the container coupled to the lumen of the elongated member, and a one-way valve that relieves negative pressure within the container.
4. The apparatus of claim 3 further comprising a valve that selectively couples the container to the lumen of the elongated member.
5. The apparatus of claim 1 wherein the tissue- piercing distal end of the elongated member
REPLACEMENT PAGE configured to be selectively extended beyond the lateral surface of the catheter.
17. Apparatus for depositing a bioactive agent into a tissue mass of a hollow organ, comprising: a catheter having a proximal end and a distal region and a lumen extending therebetween; an elongated member disposed within the lumen of the catheter, the elongated member having a proximal end, a tissue- piercing distal end, and a lumen extending therebetween, the elongated member configured to atraumatically deliver the bioactive agent via the lumen into the tissue mass; and means for stabilizing the catheter and elongated member within the hollow organ, wherein the bioactive agent is atraumatically delivered into a needle track formed during retraction of the tissue piercing distal end of the elongated member.
18. The apparatus of claim 17 further comprising an actuator for selectively extending and retracting the tissue- piercing distal end of the elongated member into the tissue mass to form a needle track.
19. The apparatus of claim 18 wherein the elongated member is configured to deliver the bioactive agent using capillary action during retraction of the tissue-piercing distal end of the elongated member.
20. The apparatus of claim 19 further comprising a container holding a quantity of bioactive agent, the container coupled to the lumen of the elongated member, and a one-way valve that relieves negative pressure within the container.
REPLACEMENT PAGE
PCT/US2005/025470 2004-07-19 2005-07-18 Systems and methods for atraumatic implantation of bio-active agents WO2006020256A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2007522631A JP4774403B2 (en) 2004-07-19 2005-07-18 System and method for non-invasive implantation of bioactive substances
CA2573844A CA2573844C (en) 2004-07-19 2005-07-18 Systems and methods for atraumatic implantation of bio-active agents
AU2005274775A AU2005274775B2 (en) 2004-07-19 2005-07-18 Systems and methods for atraumatic implantation of bio-active agents
EP20050773060 EP1773441B1 (en) 2004-07-19 2005-07-18 Systems and methods for atraumatic implantation of bio-active agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/894,810 2004-07-19
US10/894,810 US7632262B2 (en) 2004-07-19 2004-07-19 Systems and methods for atraumatic implantation of bio-active agents

Publications (3)

Publication Number Publication Date
WO2006020256A2 WO2006020256A2 (en) 2006-02-23
WO2006020256A3 WO2006020256A3 (en) 2006-12-28
WO2006020256B1 true WO2006020256B1 (en) 2007-01-25

Family

ID=35600417

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/025469 WO2006020255A2 (en) 2004-07-19 2005-07-18 Apparatus and methods for treating tissue using passive injection systems
PCT/US2005/025470 WO2006020256A2 (en) 2004-07-19 2005-07-18 Systems and methods for atraumatic implantation of bio-active agents

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2005/025469 WO2006020255A2 (en) 2004-07-19 2005-07-18 Apparatus and methods for treating tissue using passive injection systems

Country Status (7)

Country Link
US (5) US7632262B2 (en)
EP (4) EP1773440B1 (en)
JP (2) JP4934029B2 (en)
AT (1) ATE526054T1 (en)
AU (2) AU2005274775B2 (en)
CA (2) CA2573844C (en)
WO (2) WO2006020255A2 (en)

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Also Published As

Publication number Publication date
EP2340868B1 (en) 2017-03-29
US20110152833A1 (en) 2011-06-23
EP1773440A4 (en) 2010-08-04
AU2005274775B2 (en) 2011-07-21
EP1773440A2 (en) 2007-04-18
WO2006020255A3 (en) 2006-11-30
JP4934029B2 (en) 2012-05-16
US8377032B2 (en) 2013-02-19
JP2008506499A (en) 2008-03-06
JP2008506500A (en) 2008-03-06
AU2005274774A1 (en) 2006-02-23
US7632262B2 (en) 2009-12-15
CA2573844A1 (en) 2006-02-23
CA2574089C (en) 2013-12-31
EP1773440B1 (en) 2011-09-28
ATE526054T1 (en) 2011-10-15
JP4774403B2 (en) 2011-09-14
WO2006020256A2 (en) 2006-02-23
US20060015067A1 (en) 2006-01-19
US7862551B2 (en) 2011-01-04
WO2006020256A3 (en) 2006-12-28
AU2005274775A1 (en) 2006-02-23
CA2574089A1 (en) 2006-03-23
US20060015085A1 (en) 2006-01-19
EP2340868A1 (en) 2011-07-06
WO2006020255A2 (en) 2006-02-23
US20100331814A1 (en) 2010-12-30
EP2343099A1 (en) 2011-07-13
EP1773441A2 (en) 2007-04-18
EP1773441B1 (en) 2015-05-20
CA2573844C (en) 2014-11-25
US20080154201A1 (en) 2008-06-26
EP1773441A4 (en) 2010-07-28
AU2005274774B2 (en) 2011-05-12
US7338471B2 (en) 2008-03-04

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