WO2006029184A3 - Genes useful for diagnosing and monitoring inflammation related disorders - Google Patents

Genes useful for diagnosing and monitoring inflammation related disorders Download PDF

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Publication number
WO2006029184A3
WO2006029184A3 PCT/US2005/031806 US2005031806W WO2006029184A3 WO 2006029184 A3 WO2006029184 A3 WO 2006029184A3 US 2005031806 W US2005031806 W US 2005031806W WO 2006029184 A3 WO2006029184 A3 WO 2006029184A3
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WO
WIPO (PCT)
Prior art keywords
seq
diagnosing
monitoring
related disorders
inflammation related
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Application number
PCT/US2005/031806
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French (fr)
Other versions
WO2006029184A2 (en
Inventor
Jay Wohlgemuth
Darren Tayama
Dirk Walther
Lal G Preeti
Original Assignee
Expression Diagnostics Inc
Jay Wohlgemuth
Darren Tayama
Dirk Walther
Lal G Preeti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Expression Diagnostics Inc, Jay Wohlgemuth, Darren Tayama, Dirk Walther, Lal G Preeti filed Critical Expression Diagnostics Inc
Publication of WO2006029184A2 publication Critical patent/WO2006029184A2/en
Publication of WO2006029184A3 publication Critical patent/WO2006029184A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

Described herein is a system for monitoring gene expression for diagnosing and monitoring inflammation disorders, and for monitoring gene expression in inflammation disorders in response to a particular drug treatment reginmen. This system for detecting nucleic acid expression in a body fluid uses an isolated polynucleotide to detect expression of a nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 5; SEQ ID NO: 11; SEQ ID NO:17; and SEQ ID NO: 23. These nucleic acids are differentially expressed in body fluid in an individual with a disease criterion for a disease as listed in Table 1 as compared to an individual without the disease criterion.
PCT/US2005/031806 2004-09-08 2005-09-08 Genes useful for diagnosing and monitoring inflammation related disorders WO2006029184A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60840304P 2004-09-08 2004-09-08
US60/608,403 2004-09-08

Publications (2)

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WO2006029184A2 WO2006029184A2 (en) 2006-03-16
WO2006029184A3 true WO2006029184A3 (en) 2009-04-16

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PCT/US2005/031806 WO2006029184A2 (en) 2004-09-08 2005-09-08 Genes useful for diagnosing and monitoring inflammation related disorders

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WO (1) WO2006029184A2 (en)

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