WO2006031388A3 - Dentritic polymers, crosslinked gels, and their uses in orthopedic applications - Google Patents

Dentritic polymers, crosslinked gels, and their uses in orthopedic applications Download PDF

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Publication number
WO2006031388A3
WO2006031388A3 PCT/US2005/029915 US2005029915W WO2006031388A3 WO 2006031388 A3 WO2006031388 A3 WO 2006031388A3 US 2005029915 W US2005029915 W US 2005029915W WO 2006031388 A3 WO2006031388 A3 WO 2006031388A3
Authority
WO
WIPO (PCT)
Prior art keywords
capped
compound
dendritic
isocysteine
cysteine
Prior art date
Application number
PCT/US2005/029915
Other languages
French (fr)
Other versions
WO2006031388A2 (en
Inventor
Mark W Grinstaff
Michael A Carnahan
Original Assignee
Hyperbranch Medical Technology
Mark W Grinstaff
Michael A Carnahan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperbranch Medical Technology, Mark W Grinstaff, Michael A Carnahan filed Critical Hyperbranch Medical Technology
Publication of WO2006031388A2 publication Critical patent/WO2006031388A2/en
Publication of WO2006031388A3 publication Critical patent/WO2006031388A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Abstract

The present invention provides compositions, kits, and methods for repairing cartilaginous tissue. Certain methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine, cysteine, isocysteine residue or other nucleophilic group attached to their peripheries. Addition of a compound containing two or more electrophilic groups, such as aldehydes, activated esters, or acrylates, to the lysine-capped, cysteine-capped, or isocysteine-capped dendrimers produces a polymeric compound that can repair a cartilage defect.
PCT/US2005/029915 2004-08-20 2005-08-22 Dentritic polymers, crosslinked gels, and their uses in orthopedic applications WO2006031388A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60350204P 2004-08-20 2004-08-20
US60/603,502 2004-08-20
US60409704P 2004-08-23 2004-08-23
US60/604,097 2004-08-23

Publications (2)

Publication Number Publication Date
WO2006031388A2 WO2006031388A2 (en) 2006-03-23
WO2006031388A3 true WO2006031388A3 (en) 2006-10-12

Family

ID=36060499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029915 WO2006031388A2 (en) 2004-08-20 2005-08-22 Dentritic polymers, crosslinked gels, and their uses in orthopedic applications

Country Status (1)

Country Link
WO (1) WO2006031388A2 (en)

Cited By (14)

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US7943573B2 (en) 2008-02-07 2011-05-17 Biomimetic Therapeutics, Inc. Methods for treatment of distraction osteogenesis using PDGF
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US8114841B2 (en) 2004-10-14 2012-02-14 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US8492335B2 (en) 2010-02-22 2013-07-23 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8986730B2 (en) 2004-11-05 2015-03-24 Incept, Llc Methods for sealing a vascular puncture
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances

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US7799754B2 (en) 2004-10-14 2010-09-21 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
DE102005051334A1 (en) * 2005-10-25 2007-06-21 Degussa Gmbh Preparation, useful e.g. as a hardening agent and catalyst, and in cosmetics and medicines, comprises a low-molecular substance and a hyperbranched polymer having a hydrophilic core containing polyester unit and hydrophobic terminal group
JP5264492B2 (en) 2005-10-25 2013-08-14 エボニック デグサ ゲーエムベーハー Preparations containing hyperbranched polymers
CA2635374C (en) 2006-01-11 2015-12-08 Hyperbranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
WO2008005427A2 (en) 2006-06-30 2008-01-10 Biomimetic Therapeutics, Inc. Pdgf-biomatrix compositions and methods for treating rotator cuff injuries
US8262608B2 (en) 2007-01-25 2012-09-11 Hyperbranch Medical Technology, Inc. Applicators for multiple component formulations and the like, and methods of use thereof
US7862538B2 (en) 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
JP5684239B2 (en) 2009-05-04 2015-03-11 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ Ｌｌｃ Biomaterial for track and puncture closure
EP3960215A1 (en) 2009-12-15 2022-03-02 Incept, LLC Implants and biodegradable fiducial markers
CA2807537C (en) 2010-08-05 2018-09-18 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
CA2818612C (en) 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP4249059A3 (en) 2011-06-28 2023-11-29 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc Small molecule delivery with implantable therapeutic device
PL2755600T3 (en) 2011-09-16 2021-09-20 Forsight Vision4, Inc. Fluid exchange apparatus
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
WO2013086015A1 (en) 2011-12-05 2013-06-13 Incept, Llc Medical organogel processes and compositions
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
JP6581194B2 (en) 2014-07-15 2019-09-25 フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． Ocular implant delivery device and method
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
SG11201703726XA (en) 2014-11-10 2017-06-29 Forsight Vision4 Inc Expandable drug delivery devices and method of use
EP3229779B1 (en) 2014-12-10 2021-02-03 Incept, LLC Hydrogel drug delivery implants
AU2016261925B2 (en) 2015-05-12 2020-10-01 Incept, Llc Drug delivery from hydrogels
CN113069681B (en) 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 Method of manufacturing a therapeutic device for sustained drug delivery
US10420724B2 (en) 2015-11-25 2019-09-24 Incept, Llc Shape changing drug delivery devices and methods
CA3019822A1 (en) 2016-04-05 2017-10-12 Forsight Vision4, Inc. Implantable ocular drug delivery devices
CA3038075A1 (en) 2016-09-23 2018-03-29 Incept, Llc Intracameral drug delivery depots
WO2019103906A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
CN112203828B (en) * 2018-04-19 2023-06-09 聚合-医药有限公司 Macromers and compositions for use in a photocuring process
US20240042093A1 (en) * 2020-12-22 2024-02-08 Fluidx Medical Technology, Inc. In situ solidifying injectable compositions with transient contrast agents and methods of making and using thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642363B1 (en) * 1996-09-19 2003-11-04 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642363B1 (en) * 1996-09-19 2003-11-04 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114841B2 (en) 2004-10-14 2012-02-14 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US9386969B2 (en) 2004-11-05 2016-07-12 Incept, Llc Methods for sealing a vascular puncture
US8986730B2 (en) 2004-11-05 2015-03-24 Incept, Llc Methods for sealing a vascular puncture
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US7943573B2 (en) 2008-02-07 2011-05-17 Biomimetic Therapeutics, Inc. Methods for treatment of distraction osteogenesis using PDGF
US8349796B2 (en) 2008-02-07 2013-01-08 Biomimetic Therapeutics Inc. Methods for treatment of distraction osteogenesis using PDGF
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8492335B2 (en) 2010-02-22 2013-07-23 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof

Also Published As

Publication number Publication date
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