WO2006031879A1 - System and method for surgical implant - Google Patents
System and method for surgical implant Download PDFInfo
- Publication number
- WO2006031879A1 WO2006031879A1 PCT/US2005/032724 US2005032724W WO2006031879A1 WO 2006031879 A1 WO2006031879 A1 WO 2006031879A1 US 2005032724 W US2005032724 W US 2005032724W WO 2006031879 A1 WO2006031879 A1 WO 2006031879A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cannula
- guide element
- implant
- distal end
- incision
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0004—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse
- A61F2/0031—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra
- A61F2/0036—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra implantable
- A61F2/0045—Support slings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0482—Needle or suture guides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06004—Means for attaching suture to needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06066—Needles, e.g. needle tip configurations
- A61B17/06109—Big needles, either gripped by hand or connectable to a handle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0485—Devices or means, e.g. loops, for capturing the suture thread and threading it through an opening of a suturing instrument or needle eyelet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00805—Treatment of female stress urinary incontinence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06004—Means for attaching suture to needle
- A61B2017/06042—Means for attaching suture to needle located close to needle tip
Definitions
- This invention relates generally to systems and methods for placing surgical implants, and has particular application to placing implants for pelvic floor reconstructive surgery.
- United States Patent Publication No. 2003/0220538 which is incorporated herein by reference in its entirety, describes a standardized procedure and associated implant design that is designed for use in a variety of pelvic floor repair procedures. The described procedure eliminates the need for securing the implant by suturing by providing strap-like mesh extensions that pass through the sacrospinous ligament and/or obturator membrane.
- United States Patent Publication No. 2004/0039453 also describes a strap-based implant system for the treatment of a cystocele. Difficulties have been encountered, however, in pulling the strap-like mesh extensions through the pelvic cavity.
- the mesh extensions can cause tearing of tissue as they are pulled through, which can cause additional pain, bleeding, and/or nerve damage, but can also lead to improper positioning of the implant.
- the present invention provides an assembly for placement of a surgical implant having at least one implant extension portion.
- the assembly includes a guide element having a tissue penetrating distal end, a cannula having a proximal end, a distal end, and a channel extending therethrough within which the guide element can be slidably received such that the tissue penetrating tip of the guide element extends outward from the distal end of the cannula, and a retrieval device having a capture element at a distal end thereof for coupling with the implant extension portion of the surgical implant.
- the cannula When the cannula has the guide element slidably received therein, it is dimensioned to extend through a patient's pelvic cavity from an external incision and out through a vaginal incision, and the cannula channel is dimensioned allow passage therethrough of the retrieval device and coupled implant extension portion.
- the present invention also provides a method for placing a surgical implant including the steps of providing an assembly including a guide element having a tissue penetrating distal end, a cannula having a proximal end, a distal end, and a channel extending therethrough, and a retrieval device having a capture element at a distal end thereof.
- the method further includes the steps of slidably inserting the guide element into the cannula channel until the tissue penetrating tip extends out of the distal end of the cannula, passing the cannula and guide element through a first passage through a patient's pelvic cavity from an external incision until the distal ends of the guide element and cannula extend out through a vaginal incision, removing the guide element from the cannula by retracting it through the cannula channel, inserting the retrieval device through the cannula channel until the capture element passes out the distal end of the cannula, coupling the capture element to a first extension of the implant to be placed, retracting the retrieval device and coupled implant extension back through the cannula channel so that the implant extension extends through the cannula, and removing the cannula to thereby leave in place in the first passage the implant extension.
- the method may further include repeating the steps above on the opposite side of the patient's body to place a second implant extension. It may also further include the steps of slidably inserting the guide element into the cannula channel until the tissue penetrating tip extends out of the distal end of the cannula, passing the cannula and guide element through a second passage through a patient's pelvic cavity from a second external incision until the distal end of the guide element and cannula extend out through the vaginal incision, removing the guide element from the cannula by retracting it through the cannula channel, inserting the retrieval device through the cannula channel until the capture element passes out of the distal end of the cannula, coupling the capture element to a second extension of the implant, retracting the retrieval device and coupled second implant extension back through the cannula channel so that the implant extension extends through the cannula, and removing the cannula to thereby leave in place in the second passage the second implant extension.
- Figs. Ia-Ic illustrate exemplary meshes that can be placed using the system and method of the present invention.
- Fig. 2 illustrates the placement within the body of an exemplary mesh for treating a cystocele.
- Fig. 3 illustrates the placement within the body of an exemplary mesh for treating both a cystocele and a rectocele.
- Fig. 4 illustrates the placement within the body of an exemplary mesh for treating a rectocele.
- Fig. 5 illustrates an exemplary guide element of the assembly of the present invention.
- Fig. 6 illustrates an exemplary cannula of the assembly of the present invention.
- Figs. 6a and 6b illustrate alternative exemplary cross-sectional configurations of the cannula of Fig. 6.
- Fig. 7 illustrates an exemplary retrieval element of the assembly of the present invention.
- Fig. 8 illustrates the cannula of Fig. 6 inserted over the guide element of Fig. 5.
- Figs. 9a-9d illustrate various alternative cross- sectional configurations for the retrieval element of Fig. 7.
- Figs. 1Oa-IOd illustrate various embodiments of a capture element of a retrieval element of the present invention.
- Fig. 11 illustrates a retrieval element according to the present invention including a capture element having a pre-formed curve.
- Figs. 12a-12f illustrate various steps of a method for placing a surgical implant according to the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
- Figures Ia-Ic illustrate exemplary implants for use in pelvic floor repair that could be placed using the assemblies and methods described herein.
- Figure Ia illustrates a mesh suitable for use in anterior or cystocele repair.
- the central portion 3 of the implant 1 is designed to be placed under low or no tension between the patient's urinary bladder 5 and vagina 7, to thereby reinforce the fascia in between and prevent the bladder from pushing down into the vagina, as is illustrated in Fig. 2.
- the implant 1 includes a first set of strap-like implant extensions 9, 11 and a second set of strap-like implant extensions 13, 15 extending outwardly from opposite sides of the implant. As shown in Figs.
- both sets of implant extensions, 9, 11; 13, 15 are designed to pass from a location in proximity to the patient's arcus-tendineous fascia pelvis (ATFP) 17, through the obturator membrane and out of the body through the obturator foramen 19. Passage of the implant extensions through tissue along the passages described above anchors the implant in place by means of friction and ultimately tissue ingrowth into the implant.
- ATFP arcus-tendineous fascia pelvis
- FIG. Ib An exemplary implant for treating an apical, posterior/rectocele repair is shown in Fig. Ib.
- the implant 20 includes a central portion 22 that is designed to be placed under low or no tension between the patient's rectum 27 and vagina 7 (as shown in Fig. 4) , reinforcing the fascia therebetween and preventing the rectum from pushing up into the vagina.
- the implant 20 includes two strap-like implant extensions 24, 25 extending outwardly therefrom in opposite directions. These implant extensions are designed to extend through the patient's sacro-spinous ligaments 29 and exit the body through the gluteous maximus in the vicinity of the anus as shown in Fig. 3.
- Fig. Ic illustrates an implant that is suitable for both anterior and posterior repair when implanted as shown in Fig. 3.
- Each portion of the combination implant, the anterior portion 30 and the posterior portion 32, is substantially similar to that described above for separate implants.
- a suitable material for the implants described above is Gynecare's GYNEMESHTM PS, which is a knitted polypropylene mesh having a thickness of about 0.7 millimeters and which is manufactured by Ethicon, Inc., of Somerville, New Jersey. This material is approved by the FDA in the United States for implantation into the human body for a variety of uses.
- the present invention provides an improved assembly and method for doing so.
- the assembly consists of the components shown in Figs. 5- 7, and includes a guide element 52, a cannula 54, and a retrieval element 56.
- the guide element includes a handle 58 having any configuration suitable for grasping and manipulating the guide element, and a needle 60.
- the needle includes a tissue dissecting distal tip 62, which is preferably blunt but tapered, and preferably further includes a first substantially straight portion 66 extending from the handle, a curved transition portion 64 extending from the first substantially straight portion, and a second substantially straight portion 67 extending between the curved transitional portion and the distal tip 62.
- the length of the first substantially straight portion is approximately 75 mm
- the length of the second substantially straight portion is approximately 10.6 mm
- the length of the curved portion is approximately 111 mm.
- dimensions a and b shown in Fig. 5 are approximately 73 and 168 mm respectively, and the diameter of the needle is between 3 and 5 mm.
- the needle must be substantially rigid such that it can resist yielding under forces that are normally experienced in passing the needle through the body as described herein.
- Various stainless steel alloys or titanium are materials suitable for this purpose.
- Suitable materials for the handle include steel, aluminum, titanium, plastic, rubber etc.
- any standard manufacturing process can be used to form the handle, such as insert molding the handle to the needle, molding the handle in halves and press-fitting or using ultrasonic welding to connect the two handle pieces around the needle, etc.
- the cannula 54 is shown in Fig. 6, and preferably consists of a flexible or semi-rigid material and has a proximal end 68, a distal end 70 and a channel 72 extending therethrough between the proximal and distal ends.
- An enlarged hub portion 74 may exist at the proximal end, and may have one or more projections 76 extending outwardly therefrom.
- the hub and projections enable the surgeon to better handle the cannula and prevent the cannula from being pushed too far into the patient as will be described in greater detail below.
- the projections may also be designed in such a way that they secure the cannula in place within surrounding tissue.
- the cannula and guide element are dimensioned relative to one another so that the needle 60 of the guide element can be slidably received through the cannula channel 72 as shown in Fig. 8, with the tissue penetrating tip 62 of the guide element 52 extending outwardly from the distal end of the cannula.
- the distal end 70 of the cannula is preferably tapered so that there is a smooth transition from the distal tissue penetrating tip 62 of the guide element to the outer circumference 78 of the cannula as shown in Fig. 8. In this manner, trauma to surrounding tissue will be minimized during insertion of the cannula and guide element.
- the diameter of the distal end of the cannula channel is preferably slightly smaller than that of the rest of the channel, and even slightly smaller than the diameter of the guide needle so that it dilates with insertion of the needle to form a snug fit between the guide needle and cannula. This can be accomplished by reducing the diameter of the channel at the distal end by secondary operations, or by the addition of a second material after production.
- the cannula further includes a resilient end region 80 comprised of a resilient and sufficiently flexible material such that when the guide element is inserted within the cannula, the cannula assumes the configuration of the guide element as shown in Fig. 8.
- the resilient end region 80 returns to a configuration that is different from, and more curved than that of the corresponding portion of the guide needle, as is shown in Fig. 6.
- This aspect is important in aiding passage of the retrieval device, as will also be described in greater detail below.
- This feature can be achieved by exposure to heat either before or after formation of the cannula, or simply by mechanical manipulation of the cannula such as placing it on a spool of a desired curvature.
- the length of the hub portion 74 is approximately 18 mm
- the length of the substantially straight portion is approximately 155 mm
- the length m 3 of the resilient end region is approximately 35 mm with an angle A of approximately 80 degrees
- the length of the end region including the distal end is approximately 5 mm.
- the cannula preferably is comprised of PEBAXTM, which is a mixture of polyether and nylon, but may be constructed from or include various other materials such as polyethylene, Teflon, PVDF, PFE and Pebax.
- PEBAXTM polyethylene, Teflon, PVDF, PFE and Pebax.
- Other polymeric or non-polymeric materials with low coefficients of friction, such as flurorpolymers or hyluronic acid may also be used to coat the inner and/or outer surfaces of the cannula in order to reduce friction between the cannula and guide needle and/or tissue.
- This material may be reinforced with a wire coil, plastic coil, or braid to increase stiffness or provide kink resistance.
- the hub may be comprised of a different material, such as foam, but could also be any hard or soft plastic, or elastomeric material such as urethane, rubber or silicone.
- both the guide needle and cannula may each include a marking, bump or other feature 71a, 71b that are aligned with one another when the cannula is properly inserted over and oriented relative to the guide needle as shown in Fig. 8.
- the assembly may include a means for mechanically coupling the cannula and guide needle, such as a slot or notch in the needle or handle that mates with a corresponding element on the cannula.
- radio-opaque markings to enable visualization after placement using fluoroscopy or x-ray
- regularly spaced markings 73 along the length of the cannula to allow the user to determine how far the cannula has been inserted into the patient's body, and also to determine whether the cannula position has changed following its initial placement.
- the cannula preferably has a substantially circular cross-section with a single channel therethrough as shown in Fig. 6a, but may be of any other suitable cross- sectional configuration. It may alternatively have two or more lumens, with one lumen providing for passage of the guide needle and a second provision for passage of the retrieval line.
- the retrieval element 56 is a flexible or semi-rigid elongate instrument having a capture element 62 at the distal end 64 that is suitable for capturing or securing thereto an implant extension portion of a mesh to be implanted.
- the retrieval element is dimensioned so that it (and the attached mesh implant extension portion) can be drawn through the cannula channel as will be described below.
- the capture element is a simple loop through which the implant extension portion can be inserted so that it can be drawn through the cannula channel .
- Many other configurations for this capture element can also be envisioned, such as barb elements, various clips, cinching or lasso mechanisms etc., several of which are shown in Figs. 10a-d.
- the retrieval line may be made of any suitable material having sufficient rigidity such that it can be advanced through the cannula and out to a point where it is easily accessible by the surgeon.
- suitable material is a polypropylene material such as PROLENE ® (manufactured by Ethicon, Inc.) but many other semi-rigid plastics are suitable as well, such as acetal, ethylene tetrofluoroethylene, fluorinated ethylene propylene, high or low density polyethylene, nylon, polycarbonate, or polyurethane.
- stainless steel or nitinol are suitable as well .
- the retrieval element is a simple mono-filament extrusion having a substantially circular cross section as shown in Fig. 9a.
- the retrieval element could be a tubular extrusion, a multi-lumen extrusion (Fig. 9b) , a coiled wire similar to a stainless steel catheter guide wire, a braided configuration of plastic or stainless steel lines (Fig. 9c), or a single or multi-lumen extrusion having a cross-sectional shape other than substantially circular (Fig. 9d) .
- One or more of the above could also be combined, for example to create a plastic coated wire, a mesh-reinforced tubing (with metal or plastic braided mesh) , or dual extrusions with different plastics on different layers of extrusion.
- a preferred embodiment of the retrieval element is further illustrated in Fig. 10a, and includes a plastic tube 90 that is heat shrunk over a mono-filament loop 92 as described above.
- the mono-filament may simply be folded back on itself to form the loop and then welded together, or the mono-filament 94 can be inserted through a double lumen extrusion 96 (i.e., Fig. 10b) .
- the retrieval element could alternatively include any suitable form of cinching mechanism 98 or mechanical capture mechanism 99 such as those illustrated in Figs. 1Od and 10c respectively.
- the retrieval element also may include various features to render its use easier for the surgeon.
- the retrieval line may include a pre-formed curve 101 at its distal end (Fig. 11) , which is designed to point the retrieval line in a direction most easily accessible to the surgeon after it has been advanced through the cannula channel and has exited the vaginal incision. It may also include various features at the proximal end, such as graduated markings to indicate the degree of insertion, or handle features such as loops, balls etc. to facilitate grasping and holding of the proximal end of the retrieval line.
- the cannula could be a dual channel cannula having a cross-section such as that shown in Fig. 6b.
- the first channel 81 would be dimensioned to receive the guide needle as described above, and the second channel 82 dimensioned to receive the retrieval line.
- the full thickness of the anterior vaginal wall is incised as required and an appropriate associated lateral dissection is performed. .
- the cutaneous incision for the passage of mesh extension 13 is made in the skin over the anteromedial part of the obturator foramen, at the level of the urethral meatus . This incision should be approximately 4mm long in order to enable the guide element 52 and cannula 54 to pass through the skin without tearing.
- the cannula 54 is, or has previously been, inserted over the guide needle 52 as shown in Fig. 12a until the tissue penetrating tip extends out from the distal end of the cannula as shown in Fig. 8.
- the cannula and guide element are then inserted through the incision, through the obturator membrane, and directed in a relatively direct path that results in the tip exiting the previously dissected space in the proper location as shown in Figure 2..
- the guide element is withdrawn from the cannula as shown in Fig. 12b, leaving the cannula in place in the body.
- a second cutaneous incision is made at the level of the urethral meatus, approximately 3-4 cm below the preceding incision at the inferomedial part of the obturator foramen.
- the guide element and cannula are then inserted through the skin, through the obturator membrane on a path that allows it to emerge from the iliococcygeous muscle behind the ATFP approximately 1-1.5 cm from the ischial spine at the bottom of the paravesical fossa.
- retrieval elements are inserted through each of the placed cannulas, one at a time as shown in Fig. 12c, until the capture element exits the vaginal incision as shown in Fig. 12d.
- the retrieval line and the coupled implant extension are then retracted back through the cannula channel until the end of the implant extension exits the proximal end of the cannula as shown in Fig. 12f.
- final adjustments are made.
- the cannulas are removed from the body, leaving the implant extensions extending through the passageways formerly occupied by the cannulas.
- the implant extensions are then trimmed in close proximity to the incisions.
- the tissue surrounding the implant extensions will in essence collapse in on the implant extensions, securing them in place and leading to ingrowth therein.
- implant extensions 15, 11 are then repeated on the opposite side of the body to pass implant extensions 15, 11.
- the implant extensions are then trimmed in close proximity to the incisions in the upper leg and/or lower abdomen.
- the surgeon To place the posterior implant of Fig. Ib, the surgeon first performs an incision of the whole thickness of the posterior vaginal wall and an appropriate lateral dissection to expose the sacro-spinous ligament. Incisions are then made in the skin of the buttocks lateral to and below the anus and a cannula-loaded Guide is inserted into these incisions, exiting through the sacro-spinous ligament approximately 2 cm from the ischial spine. The guide is then removed and a retrieval line is installed and employed as described above for the anterior implant.
- the retrieval line may include a pre-formed curve 101 (Fig. 11) at the distal end.
- This pre-formed curve renders the retrieval line easier to access by the surgeon once it exits the vaginal incision, since the curve can be configured to extend from the incision in a direction toward the surgeon.
- the resilient end region 80 of the cannula may be configured so that, following removal of the guide needle, the resilient end region resumes a more curved configuration (i.e., Fig. 6) that points in a direction that facilitates passage of the retrieval line to the surgeon.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2005284836A AU2005284836B2 (en) | 2004-09-15 | 2005-09-14 | System and method for surgical implant |
PL05798476T PL1804715T3 (en) | 2004-09-15 | 2005-09-14 | System for surgical implant placement |
AT05798476T ATE446724T1 (en) | 2004-09-15 | 2005-09-14 | SYSTEM FOR INSERTING A SURGICAL IMPLANT |
DE602005017417T DE602005017417D1 (en) | 2004-09-15 | 2005-09-14 | SYSTEM FOR INSERTING A SURGICAL IMPLANT |
EP05798476A EP1804715B1 (en) | 2004-09-15 | 2005-09-14 | System for surgical implant placement |
DK05798476T DK1804715T3 (en) | 2004-09-15 | 2005-09-14 | System for placing a surgical implant |
JP2007532419A JP4767961B2 (en) | 2004-09-15 | 2005-09-14 | System and method for surgical implant placement |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/941,241 | 2004-09-15 | ||
US10/941,241 US7527588B2 (en) | 2004-09-15 | 2004-09-15 | System and method for surgical implant placement |
Publications (1)
Publication Number | Publication Date |
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WO2006031879A1 true WO2006031879A1 (en) | 2006-03-23 |
Family
ID=35464188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/032724 WO2006031879A1 (en) | 2004-09-15 | 2005-09-14 | System and method for surgical implant |
Country Status (12)
Country | Link |
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US (1) | US7527588B2 (en) |
EP (1) | EP1804715B1 (en) |
JP (1) | JP4767961B2 (en) |
AT (1) | ATE446724T1 (en) |
AU (1) | AU2005284836B2 (en) |
DE (1) | DE602005017417D1 (en) |
DK (1) | DK1804715T3 (en) |
ES (1) | ES2333142T3 (en) |
PL (1) | PL1804715T3 (en) |
PT (1) | PT1804715E (en) |
WO (1) | WO2006031879A1 (en) |
ZA (1) | ZA200703055B (en) |
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US20060058575A1 (en) | 2006-03-16 |
DE602005017417D1 (en) | 2009-12-10 |
PT1804715E (en) | 2009-11-23 |
EP1804715A1 (en) | 2007-07-11 |
JP2008513116A (en) | 2008-05-01 |
ZA200703055B (en) | 2009-03-25 |
AU2005284836A1 (en) | 2006-03-23 |
ES2333142T3 (en) | 2010-02-17 |
US7527588B2 (en) | 2009-05-05 |
JP4767961B2 (en) | 2011-09-07 |
DK1804715T3 (en) | 2010-01-04 |
AU2005284836B2 (en) | 2011-08-11 |
PL1804715T3 (en) | 2010-03-31 |
EP1804715B1 (en) | 2009-10-28 |
ATE446724T1 (en) | 2009-11-15 |
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