WO2006034156A3 - High succinate producing bacteria - Google Patents

High succinate producing bacteria Download PDF

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Publication number
WO2006034156A3
WO2006034156A3 PCT/US2005/033408 US2005033408W WO2006034156A3 WO 2006034156 A3 WO2006034156 A3 WO 2006034156A3 US 2005033408 W US2005033408 W US 2005033408W WO 2006034156 A3 WO2006034156 A3 WO 2006034156A3
Authority
WO
WIPO (PCT)
Prior art keywords
producing bacteria
succinate
succinate producing
anaerobic conditions
aerobic
Prior art date
Application number
PCT/US2005/033408
Other languages
French (fr)
Other versions
WO2006034156A2 (en
Inventor
Ka-Yiu San
George N Bennett
Henry Lin
Ailen Sanchez
Original Assignee
Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rice University filed Critical Rice University
Priority to EP05812424A priority Critical patent/EP1789569A2/en
Priority to JP2007532568A priority patent/JP2008513023A/en
Priority to BRPI0515273-9A priority patent/BRPI0515273A/en
Publication of WO2006034156A2 publication Critical patent/WO2006034156A2/en
Publication of WO2006034156A3 publication Critical patent/WO2006034156A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to a hybrid succinate production system that has a high capacity to produce succinate under aerobic and anaerobic conditions. The metabolic engineering of a hybrid bacterial succinate production system that can function under both aerobic and anaerobic conditions makes the production process more efficient, and the process control and optimization less difficult.
PCT/US2005/033408 2004-09-17 2005-09-16 High succinate producing bacteria WO2006034156A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05812424A EP1789569A2 (en) 2004-09-17 2005-09-16 High succinate producing bacteria
JP2007532568A JP2008513023A (en) 2004-09-17 2005-09-16 Highly succinic acid producing bacteria
BRPI0515273-9A BRPI0515273A (en) 2004-09-17 2005-09-16 modified bacteria, genetically engineered bacterial cell, and method for producing carboxic acids in a bacterial culture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61075004P 2004-09-17 2004-09-17
US60/610,750 2004-09-17

Publications (2)

Publication Number Publication Date
WO2006034156A2 WO2006034156A2 (en) 2006-03-30
WO2006034156A3 true WO2006034156A3 (en) 2006-08-24

Family

ID=36090558

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/033408 WO2006034156A2 (en) 2004-09-17 2005-09-16 High succinate producing bacteria

Country Status (7)

Country Link
US (1) US20060073577A1 (en)
EP (1) EP1789569A2 (en)
JP (1) JP2008513023A (en)
KR (1) KR20070065870A (en)
CN (1) CN101023178A (en)
BR (1) BRPI0515273A (en)
WO (1) WO2006034156A2 (en)

Cited By (7)

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US7833763B2 (en) 2003-07-09 2010-11-16 Mitsubishi Chemical Corporation Method for producing organic acid
US8691553B2 (en) 2008-01-22 2014-04-08 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US8993285B2 (en) 2009-04-30 2015-03-31 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
US9017983B2 (en) 2009-04-30 2015-04-28 Genomatica, Inc. Organisms for the production of 1,3-butanediol
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
US9260729B2 (en) 2008-03-05 2016-02-16 Genomatica, Inc. Primary alcohol producing organisms
US9562241B2 (en) 2009-08-05 2017-02-07 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid

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US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
US7244610B2 (en) * 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
US7223567B2 (en) * 2004-08-27 2007-05-29 Rice University Mutant E. coli strain with increased succinic acid production
US7569380B2 (en) * 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
US20070111294A1 (en) * 2005-09-09 2007-05-17 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US7335066B2 (en) * 2005-12-16 2008-02-26 James A. Carroll Network connector and connection system
JP5180060B2 (en) * 2006-02-24 2013-04-10 三菱化学株式会社 Organic acid producing bacteria and method for producing organic acid
EP2002009A4 (en) 2006-03-31 2012-01-04 Rice University Anaerobic fermentation of glycerol
KR100780324B1 (en) * 2006-07-28 2007-11-29 한국과학기술원 Novel engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same
US8236994B2 (en) * 2006-10-31 2012-08-07 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
US8673601B2 (en) * 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
DE102007019184A1 (en) * 2007-04-20 2008-10-23 Organo Balance Gmbh Microorganism for the production of succinic acid
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
AU2008307381B2 (en) * 2007-08-10 2014-02-20 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
WO2009024294A1 (en) 2007-08-17 2009-02-26 Basf Se Microbial succinic acid producer mannheimia succini producens ddl
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SG186646A1 (en) * 2007-12-13 2013-01-30 Glycos Biotechnologies Inc Microbial conversion of oils and fatty acids to high-value chemicals
CN103555643B (en) 2008-03-27 2016-08-10 基因组股份公司 For producing the microorganism of adipic acid and other compounds
CA2722680A1 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
WO2009155382A1 (en) * 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
WO2010006076A2 (en) * 2008-07-08 2010-01-14 Opx Biotechnologies Inc. Methods, compositions and systems for biosynthetic bio production of 1,4-butanediol
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
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AU2009327490A1 (en) * 2008-12-16 2011-07-28 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
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ES2560534T3 (en) 2008-12-23 2016-02-19 Basf Se Bacterial cells that show dehydrogenase activity for the manufacture of succinic acid
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US8673598B2 (en) 2009-02-16 2014-03-18 Basf Se Microbial succinic acid producers and purification of succinic acid
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EP2414505B1 (en) * 2009-04-02 2019-05-22 University of Florida Research Foundation, Inc. Engineering the pathway for succinate production
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US10385367B2 (en) * 2009-06-01 2019-08-20 Ginkgo Bioworks, Inc. Methods and molecules for yield improvement involving metabolic engineering
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7833763B2 (en) 2003-07-09 2010-11-16 Mitsubishi Chemical Corporation Method for producing organic acid
US8691553B2 (en) 2008-01-22 2014-04-08 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US9051552B2 (en) 2008-01-22 2015-06-09 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US9260729B2 (en) 2008-03-05 2016-02-16 Genomatica, Inc. Primary alcohol producing organisms
US8993285B2 (en) 2009-04-30 2015-03-31 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
US9017983B2 (en) 2009-04-30 2015-04-28 Genomatica, Inc. Organisms for the production of 1,3-butanediol
US9562241B2 (en) 2009-08-05 2017-02-07 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene

Also Published As

Publication number Publication date
BRPI0515273A (en) 2008-08-05
KR20070065870A (en) 2007-06-25
JP2008513023A (en) 2008-05-01
WO2006034156A2 (en) 2006-03-30
CN101023178A (en) 2007-08-22
EP1789569A2 (en) 2007-05-30
US20060073577A1 (en) 2006-04-06

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