WO2006034156A3 - High succinate producing bacteria - Google Patents

High succinate producing bacteria Download PDF

Info

Publication number
WO2006034156A3
WO2006034156A3 PCT/US2005/033408 US2005033408W WO2006034156A3 WO 2006034156 A3 WO2006034156 A3 WO 2006034156A3 US 2005033408 W US2005033408 W US 2005033408W WO 2006034156 A3 WO2006034156 A3 WO 2006034156A3
Authority
WO
WIPO (PCT)
Prior art keywords
producing bacteria
succinate
succinate producing
anaerobic conditions
aerobic
Prior art date
Application number
PCT/US2005/033408
Other languages
French (fr)
Other versions
WO2006034156A2 (en
Inventor
Ka-Yiu San
George N Bennett
Henry Lin
Ailen Sanchez
Original Assignee
Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rice University filed Critical Rice University
Priority to EP05812424A priority Critical patent/EP1789569A2/en
Priority to JP2007532568A priority patent/JP2008513023A/en
Priority to BRPI0515273-9A priority patent/BRPI0515273A/en
Publication of WO2006034156A2 publication Critical patent/WO2006034156A2/en
Publication of WO2006034156A3 publication Critical patent/WO2006034156A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

Abstract

The invention relates to a hybrid succinate production system that has a high capacity to produce succinate under aerobic and anaerobic conditions. The metabolic engineering of a hybrid bacterial succinate production system that can function under both aerobic and anaerobic conditions makes the production process more efficient, and the process control and optimization less difficult.
PCT/US2005/033408 2004-09-17 2005-09-16 High succinate producing bacteria WO2006034156A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05812424A EP1789569A2 (en) 2004-09-17 2005-09-16 High succinate producing bacteria
JP2007532568A JP2008513023A (en) 2004-09-17 2005-09-16 Highly succinic acid producing bacteria
BRPI0515273-9A BRPI0515273A (en) 2004-09-17 2005-09-16 modified bacteria, genetically engineered bacterial cell, and method for producing carboxic acids in a bacterial culture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61075004P 2004-09-17 2004-09-17
US60/610,750 2004-09-17

Publications (2)

Publication Number Publication Date
WO2006034156A2 WO2006034156A2 (en) 2006-03-30
WO2006034156A3 true WO2006034156A3 (en) 2006-08-24

Family

ID=36090558

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/033408 WO2006034156A2 (en) 2004-09-17 2005-09-16 High succinate producing bacteria

Country Status (7)

Country Link
US (1) US20060073577A1 (en)
EP (1) EP1789569A2 (en)
JP (1) JP2008513023A (en)
KR (1) KR20070065870A (en)
CN (1) CN101023178A (en)
BR (1) BRPI0515273A (en)
WO (1) WO2006034156A2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7833763B2 (en) 2003-07-09 2010-11-16 Mitsubishi Chemical Corporation Method for producing organic acid
US8691553B2 (en) 2008-01-22 2014-04-08 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US8993285B2 (en) 2009-04-30 2015-03-31 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
US9017983B2 (en) 2009-04-30 2015-04-28 Genomatica, Inc. Organisms for the production of 1,3-butanediol
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
US9260729B2 (en) 2008-03-05 2016-02-16 Genomatica, Inc. Primary alcohol producing organisms
US9562241B2 (en) 2009-08-05 2017-02-07 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
US7244610B2 (en) * 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
EP1781797B1 (en) * 2004-08-27 2016-10-19 Rice University Mutant e. coli strain with increased succinic acid production
WO2006069174A2 (en) * 2004-12-22 2006-06-29 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
CA2621562A1 (en) * 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US7335066B2 (en) * 2005-12-16 2008-02-26 James A. Carroll Network connector and connection system
EP1995308B1 (en) * 2006-02-24 2014-07-30 Mitsubishi Chemical Corporation Bacterium capable of producing organic acid, and method for production of organic acid
KR101390085B1 (en) * 2006-03-31 2014-04-28 라이스 유니버시티 Anaerobic fermentation of glycerol
KR100780324B1 (en) 2006-07-28 2007-11-29 한국과학기술원 Novel engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
BRPI0622099A2 (en) * 2006-10-31 2011-12-27 Metabolic Explorer Sa Process for the biological production of 1,3-propanediol from high yield glycerol
US8673601B2 (en) * 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
DE102007019184A1 (en) 2007-04-20 2008-10-23 Organo Balance Gmbh Microorganism for the production of succinic acid
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
WO2009045637A2 (en) * 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
EP2185682B1 (en) 2007-08-17 2016-05-18 Basf Se Carboxylic acid producing member of the pasteurellaceae
EP2241630B1 (en) * 2007-12-06 2016-06-01 Ajinomoto Co., Inc. A method for producing an organic acid
BRPI0820981A2 (en) * 2007-12-13 2014-10-14 Glycos Biotechnologies Inc MICROBIAN CONVERSION OF OILS AND FATTY ACIDS FOR HIGH VALUE CHEMICAL SUBSTANCES
CN102066551B (en) 2008-03-27 2013-10-09 基因组股份公司 Microorganisms for the production of adipic acid and other compounds
BRPI0911759A2 (en) 2008-05-01 2019-09-24 Genomatica Inc microorganism for the production of methacrylic acid
CA2725549A1 (en) * 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
US20110190513A1 (en) * 2008-07-08 2011-08-04 Lynch Michael D Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
MX2011003558A (en) 2008-10-03 2011-05-02 Metabolic Explorer Sa Method for purifying an alcohol from a fermentation broth using a falling film, a wiped film, a thin film or a short path evaporator.
US20100184173A1 (en) * 2008-11-14 2010-07-22 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
EP2373781A4 (en) * 2008-12-16 2012-10-10 Genomatica Inc Microorganisms and methods for conversion of syngas and other carbon sources to useful products
ES2559385T3 (en) 2008-12-23 2016-02-11 Basf Se Bacterial cells that have a glyoxylate derivative for the manufacture of succinic acid
EP2204443B1 (en) 2008-12-23 2015-11-25 Basf Se Bacterial cells exhibiting formate dehydrogenase activity for the manufacture of suc-cinic acid
FR2941959B1 (en) * 2009-02-12 2013-06-07 Roquette Freres PROCESSES FOR THE PRODUCTION OF SUCCINIC ACID
BRPI1008267B1 (en) 2009-02-16 2021-06-22 Basf Se PROCESS FOR THE FERMENTAL PRODUCTION OF SUCCINIC ACID
EP2233562A1 (en) * 2009-03-24 2010-09-29 Metabolic Explorer Method for producing high amount of glycolic acid by fermentation
CA2756705C (en) * 2009-04-02 2017-04-11 University Of Florida Research Foundation, Inc. Engineered bacterial cells for succinate production
KR102036265B1 (en) 2009-05-07 2019-10-24 게노마티카 인코포레이티드 Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
EP2429587A4 (en) * 2009-05-15 2014-10-08 Genomatica Inc Organisms for the production of cyclohexanone
US10385367B2 (en) * 2009-06-01 2019-08-20 Ginkgo Bioworks, Inc. Methods and molecules for yield improvement involving metabolic engineering
US8129169B2 (en) * 2009-06-04 2012-03-06 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
CN101613669B (en) * 2009-06-04 2012-01-25 山东大学 Colibacillus engineering strain for aerobic fermentation
WO2010144746A2 (en) * 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
MX2012003025A (en) 2009-09-09 2012-06-27 Genomatica Inc Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids.
US8377666B2 (en) 2009-10-13 2013-02-19 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
KR20120088753A (en) 2009-10-23 2012-08-08 게노마티카 인코포레이티드 Microorganisms for the production of aniline
WO2011063157A2 (en) 2009-11-18 2011-05-26 Myriant Technologies Llc Organic acid production in microorganisms by combined reductive and oxidative tricarboxylic acid cycle pathways
CN102666838B (en) 2009-11-18 2018-04-10 麦兰特公司 For efficiently producing the engineered microorganisms of chemicals
BR112012014062A2 (en) * 2009-12-10 2017-04-04 Genomatica Inc non-naturally occurring microbial organism and method for producing 1.3 bdo
WO2011083059A1 (en) * 2010-01-06 2011-07-14 Universiteit Gent Bacterial mutants and uses thereof in protein production
MX2012008738A (en) 2010-01-29 2012-08-31 Genomatica Inc Microorganisms and methods for the biosynthesis of p-toluate and terephthalate.
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) * 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
CN102812127B (en) 2010-03-09 2014-12-03 三菱化学株式会社 Method of producing succinic acid
KR20190006103A (en) 2010-05-05 2019-01-16 게노마티카 인코포레이티드 Microorganisms and methods for the biosynthsis of butadiene
US8962272B2 (en) 2010-06-21 2015-02-24 William Marsh Rice University Engineered bacteria produce succinate from sucrose
EP2607340B1 (en) 2010-07-26 2017-09-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
US20130130339A1 (en) 2010-07-31 2013-05-23 Myriant Corporation Fermentation process for the production of organic acids
CN102286387A (en) * 2011-06-21 2011-12-21 江南大学 Construction method and use of fumaric acid producing candida glabrata engineering strain
US9169486B2 (en) 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
WO2013089890A2 (en) * 2011-09-30 2013-06-20 Mascoma Corporation Engineering microorganisms to increase ethanol production by metabolic redirection
AU2012351501B2 (en) 2011-12-16 2018-06-14 Inbiose N.V. Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides
CN102618570B (en) * 2012-03-20 2014-04-09 南京工业大学 Method for constructing escherichia coli genetic engineering bacteria for producing fumaric acid
SG11201501013PA (en) 2012-08-10 2015-04-29 Opx Biotechnologies Inc Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP2015530121A (en) * 2012-10-02 2015-10-15 ザ ミシガン バイオテクノロジー インスティテュート Recombinant microorganisms for producing organic acids
BE1021047B1 (en) * 2013-01-18 2015-02-25 Man To Tree S.A. GENETICALLY MODIFIED SUCCINOGENIC ACTINOBACILLUS AND USE THEREOF FOR THE PRODUCTION OF SUCCINIC ACID
CN103981203B (en) 2013-02-07 2018-01-12 中国科学院天津工业生物技术研究所 5 amino-laevulic acid superior strains and its preparation method and application
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
CN104178442B (en) 2013-05-24 2017-10-31 中国科学院天津工业生物技术研究所 The Escherichia coli of lpdA genes containing mutation and its application
CN104178443B (en) * 2013-05-24 2017-04-12 中国科学院天津工业生物技术研究所 Recombinant escherichia coli producing succinic acid and application thereof
EP3022310B1 (en) 2013-07-19 2019-10-16 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP3129489B1 (en) * 2014-04-11 2021-10-13 String Bio Private Limited Production of succinic acid from organic waste or biogas or methane using recombinant methanotrophic bacterium
DE102015112882B4 (en) * 2014-09-01 2022-06-30 Uniwersytet Wrocławski Methods for controlling the course conditions for biological processes, reactor for implementation of this method and system for controlling the course conditions of processes in biological reactors
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN104651289B (en) * 2015-01-28 2017-09-26 江南大学 Acetic Acid Accumulation is to strengthen the genetic engineering bacterium and its construction method of L tryptophan yield in a kind of reduction fermentation process
US9970016B2 (en) 2015-11-12 2018-05-15 Industrial Technology Research Institute Genetic engineered bacteria and methods for promoting production of succinic acid or lactic acid
EP3577227A4 (en) 2017-02-02 2020-12-30 Cargill Inc. Genetically modified cells that produce c6-c10 fatty acid derivatives
KR102129379B1 (en) 2018-10-10 2020-07-02 한국과학기술원 A recombinant microorganism into which a high activity malate dehydrogenase for producing succinic acid and a method for producing succinic acid using the same
EP3880807A2 (en) 2018-12-28 2021-09-22 Braskem S.A. Modulation of carbon flux through the meg and c3 pathways for the improved production of monoethylene glycol and c3 compounds
EP3954756A4 (en) * 2019-04-12 2022-11-30 Green Earth Institute Co., Ltd. Genetically modified microorganism and method for producing target substance using same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869301A (en) * 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
KR19990013007A (en) * 1997-07-31 1999-02-25 박원훈 Transformed Escherichia Coli S373 (BTCC 8818 P) and Production Method of Succinic Acid Using the Same
WO1999053035A1 (en) * 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US20030087381A1 (en) * 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
US6159738A (en) * 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
US7256016B2 (en) * 2001-11-02 2007-08-14 Rice University Recycling system for manipulation of intracellular NADH availability
WO2004044210A2 (en) * 2002-11-06 2004-05-27 University Of Florida Materials and methods for the efficient production of acetate and other products
JP4275666B2 (en) * 2003-02-24 2009-06-10 財団法人地球環境産業技術研究機構 Highly efficient hydrogen production method using microorganisms
US20040199941A1 (en) * 2003-03-24 2004-10-07 Rice University Increased bacterial CoA and acetyl-CoA pools
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
US7244610B2 (en) * 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
US7326557B2 (en) * 2003-11-14 2008-02-05 Rice University Increasing intracellular NADPH availability in E. coli
US7262046B2 (en) * 2004-08-09 2007-08-28 Rice University Aerobic succinate production in bacteria
EP1781797B1 (en) * 2004-08-27 2016-10-19 Rice University Mutant e. coli strain with increased succinic acid production

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHATTERJEE ET AL.: "Mutation of the ptsG Gene Results in Increased Production of Succinate in Fermentation of Glucose by Escherichia coli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 67, no. 1, January 2001 (2001-01-01), pages 148 - 154, XP000996310 *
KIM ET AL.: "Effect of Overexpression of Actinobacillus succinogenes Phosphoenolpyruvate Carboxykinase on Succinate Production in Escherichia coli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 70, no. 2, February 2004 (2004-02-01), pages 1238 - 1241, XP002999937 *
MILLARD ET AL.: "Enhanced Production of Succinic Acid by Overexpression of Phosphoenolpyruvate Carboxylate in Escherichia coli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 62, no. 5, May 1996 (1996-05-01), pages 1808 - 1810, XP002296608 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7833763B2 (en) 2003-07-09 2010-11-16 Mitsubishi Chemical Corporation Method for producing organic acid
US8691553B2 (en) 2008-01-22 2014-04-08 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US9051552B2 (en) 2008-01-22 2015-06-09 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US9260729B2 (en) 2008-03-05 2016-02-16 Genomatica, Inc. Primary alcohol producing organisms
US8993285B2 (en) 2009-04-30 2015-03-31 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
US9017983B2 (en) 2009-04-30 2015-04-28 Genomatica, Inc. Organisms for the production of 1,3-butanediol
US9562241B2 (en) 2009-08-05 2017-02-07 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene

Also Published As

Publication number Publication date
KR20070065870A (en) 2007-06-25
WO2006034156A2 (en) 2006-03-30
EP1789569A2 (en) 2007-05-30
BRPI0515273A (en) 2008-08-05
JP2008513023A (en) 2008-05-01
US20060073577A1 (en) 2006-04-06
CN101023178A (en) 2007-08-22

Similar Documents

Publication Publication Date Title
WO2006034156A3 (en) High succinate producing bacteria
WO2002018617A3 (en) Carotenoid production by recombinant, c1-metabolizing methanothropic bacteria
MY170930A (en) L-glutamic acid-producing microorganism and a method for producing l-glutamic acid
MX345559B (en) Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors.
NZ589632A (en) Production of butanediol by anaerobic microbial fermentation
MX341513B (en) Fermentive production of four carbon alcohols.
EP1233068A3 (en) Method for producing L-glutamic acid
WO2009049274A3 (en) Microorganism engineered to produce isopropanol
MX2007007395A (en) Microbial biocementation.
WO2009006416A3 (en) Community driven program access system and method
MY139130A (en) Utilization of acetic acid reaction heat in other process plants.
WO2009081012A3 (en) Method for producing succinic acid
WO2008090770A1 (en) Microorganism capable of producing l-amino acid, and method for production of l-amino acid
WO2008126667A3 (en) Method for producing lactic acid
IN2004MU00201A (en)
WO2010131224A3 (en) Bioreactor process for production of hydrogen from biomass
WO2006130557A3 (en) Dual hydrogen production apparatus
WO2005118827A3 (en) Fermentation process
PL1751292T3 (en) A method to produce succinic acid from raw hydrolysates
WO2006130678A3 (en) Dual method of hydrogen production
GB0203307D0 (en) Method
WO2012009462A3 (en) Solid waste digestion system
WO2007110592A3 (en) Fermentation process for the production of ethanol
EP1233070A3 (en) Method for producing L-glutamic acid
TNSN08353A1 (en) Modulair continuous production of micro-organisms

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2007532568

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1020077004124

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2005812424

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200580031232.2

Country of ref document: CN

NENP Non-entry into the national phase

Ref country code: DE

WWP Wipo information: published in national office

Ref document number: 2005812424

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0515273

Country of ref document: BR