WO2006036936A3 - The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents - Google Patents
The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents Download PDFInfo
- Publication number
- WO2006036936A3 WO2006036936A3 PCT/US2005/034529 US2005034529W WO2006036936A3 WO 2006036936 A3 WO2006036936 A3 WO 2006036936A3 US 2005034529 W US2005034529 W US 2005034529W WO 2006036936 A3 WO2006036936 A3 WO 2006036936A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- indanyl
- phenylamino
- piperidine
- isomer
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61338604P | 2004-09-27 | 2004-09-27 | |
US60/613,386 | 2004-09-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006036936A2 WO2006036936A2 (en) | 2006-04-06 |
WO2006036936A3 true WO2006036936A3 (en) | 2006-10-19 |
Family
ID=36119520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/034529 WO2006036936A2 (en) | 2004-09-27 | 2005-09-27 | The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
Country Status (2)
Country | Link |
---|---|
US (2) | US7718674B2 (en) |
WO (1) | WO2006036936A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
US9393002B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2617637C (en) | 2005-08-02 | 2017-07-18 | Xbiotech Inc. | Diagnosis, treatment, and prevention of vascular disorders using il-1.alpha. autoantibodies |
US20110218218A1 (en) * | 2005-09-23 | 2011-09-08 | Bridge Pharma, Inc. | Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain |
US7943666B2 (en) * | 2006-07-24 | 2011-05-17 | Trinity Laboratories, Inc. | Esters of capsaicin for treating pain |
US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
US9044235B2 (en) | 2008-02-18 | 2015-06-02 | Covidien Lp | Magnetic clip for implant deployment device |
US9398944B2 (en) | 2008-02-18 | 2016-07-26 | Covidien Lp | Lock bar spring and clip for implant deployment device |
US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
US9034002B2 (en) | 2008-02-18 | 2015-05-19 | Covidien Lp | Lock bar spring and clip for implant deployment device |
US9833240B2 (en) | 2008-02-18 | 2017-12-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
US8034337B2 (en) | 2008-05-30 | 2011-10-11 | Xbiotech, Inc. | Interleukin-1α antibodies |
US8242074B2 (en) | 2008-09-12 | 2012-08-14 | Xbiotech, Inc. | Modulation of the amount or function of pathogenic CD14+CD16+ monocytes |
EP2792307B1 (en) | 2008-10-20 | 2017-10-04 | Covidien LP | A device for attaching a patch to a biological tissue |
RU2586212C2 (en) | 2008-12-08 | 2016-06-10 | Мандифарма Интернэшнл Корпорейшн Лимитед | Protein tyrosine kinase receptor inhibitor compositions |
US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
US9186334B2 (en) | 2009-05-04 | 2015-11-17 | Nuvo Research Inc. | Heat assisted lidocaine and tetracaine for transdermal analgesia |
US9186273B2 (en) * | 2009-05-04 | 2015-11-17 | Nuvo Research Inc. | Methods of treating pains associated with neuroma, nerve entrapment, and other conditions |
US8513259B2 (en) | 2009-07-03 | 2013-08-20 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US8263581B2 (en) | 2009-07-03 | 2012-09-11 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
AU2010286116B2 (en) | 2009-08-17 | 2014-06-26 | Covidien Lp | Means and method for reversibly connecting an implant to a deployment device |
AU2010286117B9 (en) | 2009-08-17 | 2014-07-10 | Covidien Lp | Articulating patch deployment device and method of use |
US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
US20110117175A1 (en) * | 2009-11-18 | 2011-05-19 | Rosenbaum Richard J | Sweet analgesic for use in medical procedures or treatments |
US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
CA2825986C (en) | 2010-06-18 | 2019-10-29 | Xbiotech Inc. | Arthritis treatment |
KR102314003B1 (en) | 2010-08-23 | 2021-10-19 | 얀센 바이오테크 인코포레이티드 | Treatment for neoplastic diseases |
US20120100125A1 (en) * | 2010-10-26 | 2012-04-26 | Kyphon Sarl | Local dehydration for carpal tunnel syndrome |
BR112013020874A2 (en) * | 2011-02-18 | 2019-05-21 | Endo Pharmaceuticals Inc. | compound, regimen, method for preparing said compound, and use of a compound |
US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
ES2695102T3 (en) | 2011-09-23 | 2019-01-02 | Xbiotech Inc | Treatment for cachexia |
US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
US8685418B2 (en) | 2011-10-24 | 2014-04-01 | Endo Pharmaceuticals Inc. | Cyclohexylamines |
US9259343B2 (en) | 2012-07-06 | 2016-02-16 | Newman Technologies LLC | Device for mitigating plantar fasciitis |
US9044482B2 (en) | 2012-08-15 | 2015-06-02 | Asana Biosciences, Llc | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis |
US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
US8999992B2 (en) | 2013-03-15 | 2015-04-07 | Vm Pharma Llc | Crystalline forms of tryosine kinase inhibitors and their salts |
EP3035903B1 (en) | 2013-08-20 | 2018-08-22 | Anutra Medical, Inc. | Syringe fill system and method |
US20180193462A1 (en) * | 2014-01-01 | 2018-07-12 | Real Time Imaging Technologies, Llc | Improved local anesthetic solution for dental and/or contrast media use |
USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
JP2017529356A (en) * | 2014-09-17 | 2017-10-05 | ムンディファーマ インターナショナル コーポレイション リミテッド | Crystal forms of tyrosine kinase inhibitors and salts thereof |
WO2016115117A1 (en) | 2015-01-12 | 2016-07-21 | Real Time Imaging Technologies, Llc | Low-dose x-ray imaging system |
WO2017066787A1 (en) * | 2015-10-17 | 2017-04-20 | Lebedyeva Iryna O | Compounds, compositions, and methods of making and using the same |
CN110382001A (en) | 2017-02-16 | 2019-10-25 | 埃克斯生物科技公司 | The treatment of suppurative hidradenitis |
CN111432807A (en) | 2017-10-06 | 2020-07-17 | 铸造疗法股份有限公司 | Implantable reservoir for controlled release of therapeutic agents |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923815A (en) * | 1972-11-06 | 1975-12-02 | Christiaens Sa A | Derivatives of 2-aminoindane thereof |
US6413987B1 (en) * | 1999-06-10 | 2002-07-02 | Bridge Pharma, Inc. | Dermal anesthetic agents |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE760018A (en) | 1969-12-19 | 1971-06-08 | Christiaens Sa A | NEW DERIVATIVES OF 2-AMINO-INDANE, THEIR PREPARATION AND THEIR USE |
US3923813A (en) | 1969-12-19 | 1975-12-02 | Christiaens Sa A | Derivatives of 2-aminoindanes |
AR206505A1 (en) | 1972-09-18 | 1976-07-30 | Christiaens Sa A | PROCEDURE TO OBTAIN NEW DERIVATIVES OF N-PHENYL-N-AMINOALKYL-2-AMINOINDANE |
GB1440440A (en) | 1972-10-06 | 1976-06-23 | Manuf Prod Pharma | Tetrahydronaphthalene derivatives |
GB1462036A (en) | 1973-02-05 | 1977-01-19 | Manuf Prod Pharma | Aminoindane derivatives |
AR208282A1 (en) | 1973-03-01 | 1976-12-20 | Christiaens Sa A | PROCEDURE FOR PREPARING DERIVATIVES OF 2- (N-PHENYL - (- AMINOALKYL) -AMINOINDANE |
IL44292A (en) | 1973-03-01 | 1977-04-29 | Christiaens Sa A | Preparation of 2-aminoindane derivatives |
GB1468347A (en) | 1973-03-02 | 1977-03-23 | Christiaens Sa A | Aminoindanes |
LU74197A1 (en) | 1976-01-16 | 1977-07-22 | ||
DE3226753A1 (en) | 1982-07-14 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Wound bandage to take up wound secretions |
US4942175A (en) | 1987-04-24 | 1990-07-17 | Schick Laboratories, Inc. | Composition for the treatment of substance abuse |
FI95572C (en) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt |
US4822597A (en) | 1987-07-13 | 1989-04-18 | Warner-Lambert Company | Anesthetic-containing chewing gum compositions |
US4888354A (en) | 1987-12-21 | 1989-12-19 | Theratech, Inc. | Skin penetration enhancement using free base and acid addition salt combinations of active agents |
US5446070A (en) | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5234957A (en) | 1991-02-27 | 1993-08-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5227165A (en) | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
US5061700A (en) | 1989-11-16 | 1991-10-29 | Gordon Jay Dow | Glyceryl acetate ointment vehicles |
JP2849950B2 (en) | 1990-11-30 | 1999-01-27 | 日東電工株式会社 | Transdermal formulation |
US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
IL101387A (en) | 1992-03-26 | 1999-11-30 | Pharmos Ltd | Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets |
US6113921A (en) | 1993-03-23 | 2000-09-05 | Pharmos Corp. | Topical and transdermal delivery system utilizing submicron oil spheres |
JPH07157424A (en) | 1993-12-03 | 1995-06-20 | Lintec Corp | Gel formulation for local anesthesia |
AU3726395A (en) | 1994-09-27 | 1996-04-19 | Virotex Corporation | Improved topical carriers for mucosal applications |
WO1996033706A1 (en) | 1995-04-28 | 1996-10-31 | Pharmetrix, Inc. | Compositions and methods for inducing dermal analgesia |
DE19524691A1 (en) | 1995-07-06 | 1997-01-09 | Liedtke Pharmed Gmbh | Method and composition of topical therapy for inner ear and labyrinth symptoms |
DE19526019A1 (en) | 1995-07-17 | 1997-01-23 | Liedtke Pharmed Gmbh | Method and composition of a topical therapy for headache |
DE19526031A1 (en) | 1995-07-17 | 1997-01-23 | Liedtke Pharmed Gmbh | Method and composition of a topical therapy for back pain and muscle tension |
US5968536A (en) | 1995-10-11 | 1999-10-19 | Godfrey; Marjorie M. | Device for applying topical anesthetic |
US5667799A (en) | 1995-10-30 | 1997-09-16 | Caldwell; Larry J. | Method for treating headache pain with topical local anesthetic compositions |
JP2791317B2 (en) | 1995-12-26 | 1998-08-27 | 株式会社三和化学研究所 | Multilayer film preparation |
SE9601421D0 (en) | 1996-04-12 | 1996-04-12 | Astra Ab | New composition |
US5863560A (en) | 1996-09-11 | 1999-01-26 | Virotex Corporation | Compositions and methods for topical application of therapeutic agents |
WO1998017263A1 (en) | 1996-10-25 | 1998-04-30 | Copley Pharmaceutical Inc. | Transdermal patch |
DE69815090T2 (en) | 1997-03-03 | 2004-02-19 | Eisai Co., Ltd. | USE OF CHOLINESTERASE INHIBITORS FOR TREATING CONCENTRATIONAL DISORDER |
US6103771A (en) | 1998-03-20 | 2000-08-15 | Caldwell Galer Incorporated | Method of treating neuroma pain |
US6075059A (en) | 1999-02-24 | 2000-06-13 | The Ohio State University | Compositions for dental anesthesia |
US6325993B1 (en) | 1999-03-03 | 2001-12-04 | Nitto Denko Corporation | Oral adhesive sheet and oral adhesive preparation |
US6299902B1 (en) | 1999-05-19 | 2001-10-09 | The University Of Georgia Research Foundation, Inc. | Enhanced transdermal anesthesia of local anesthetic agents |
US6762158B2 (en) | 1999-07-01 | 2004-07-13 | Johnson & Johnson Consumer Companies, Inc. | Personal care compositions comprising liquid ester mixtures |
US6528086B2 (en) | 1999-09-28 | 2003-03-04 | Zars, Inc. | Methods and apparatus for drug delivery involving phase changing formulations |
US6383511B1 (en) | 1999-10-25 | 2002-05-07 | Epicept Corporation | Local prevention or amelioration of pain from surgically closed wounds |
US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
ES2275670T3 (en) | 2000-03-03 | 2007-06-16 | EISAI R&D MANAGEMENT CO., LTD. | NEW METHODS USING CHOLESTERASE INHIBITORS. |
US6455066B1 (en) | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
US20020022052A1 (en) | 2000-04-06 | 2002-02-21 | Dransfield Charles William | Transdermal delivery system |
WO2001085139A2 (en) | 2000-05-11 | 2001-11-15 | Advanced Polymer Systems, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
GB0015617D0 (en) | 2000-06-26 | 2000-08-16 | Vectura Ltd | Improved preparations for dermal delivery of active substances |
JP4459414B2 (en) | 2000-08-24 | 2010-04-28 | 日東電工株式会社 | Oral patch preparation |
CA2446060A1 (en) | 2001-05-07 | 2002-11-14 | Corium International | Compositions and delivery systems for administration of a local anesthetic agent |
US20030082225A1 (en) | 2001-10-19 | 2003-05-01 | Mason Paul Arthur | Sterile, breathable patch for treating wound pain |
US20030124174A1 (en) | 2001-10-25 | 2003-07-03 | Endo Pharmaceuticals, Inc | Method for treating non-neuropathic pain |
US20030091619A1 (en) | 2001-11-14 | 2003-05-15 | Spencer Jamison R. | Temporomandibular joint patch |
US20030175328A1 (en) | 2002-03-06 | 2003-09-18 | Adi Shefer | Patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients into the skin |
DE60321572D1 (en) | 2002-06-20 | 2008-07-24 | Amnon Sintov | TRANSDERMAL DRUG ADMINISTRATION SYSTEM |
US7241456B2 (en) | 2002-10-25 | 2007-07-10 | Australian Importers Ltd. | Formulations for topical delivery of bioactive substances and methods for their use |
DE60325885D1 (en) | 2002-11-26 | 2009-03-05 | Endo Pharmaceuticals Inc | COMPOSITION AND ITS USE FOR TREATMENT |
-
2005
- 2005-09-27 WO PCT/US2005/034529 patent/WO2006036936A2/en active Application Filing
- 2005-09-27 US US11/236,263 patent/US7718674B2/en not_active Expired - Fee Related
-
2010
- 2010-03-04 US US12/717,526 patent/US20100179114A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923815A (en) * | 1972-11-06 | 1975-12-02 | Christiaens Sa A | Derivatives of 2-aminoindane thereof |
US6413987B1 (en) * | 1999-06-10 | 2002-07-02 | Bridge Pharma, Inc. | Dermal anesthetic agents |
Non-Patent Citations (1)
Title |
---|
BURGER A.: "Medicinal Chemistry", 1970, WILEY INTERSCIENCE, pages: 81 - 82 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
US9393002B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
Also Published As
Publication number | Publication date |
---|---|
US7718674B2 (en) | 2010-05-18 |
US20060079559A1 (en) | 2006-04-13 |
US20100179114A1 (en) | 2010-07-15 |
WO2006036936A2 (en) | 2006-04-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006036936A3 (en) | The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents | |
WO2006037047A3 (en) | The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents | |
WO2006049734A3 (en) | Quetiapine analogs and methods of use thereof | |
WO2005105110A3 (en) | Doxepin analogs and methods of use thereof | |
ZA200804030B (en) | Improved process for the preparation of 4-(benzimidazolylmethylamino)benzamides and the salts thereof | |
WO2005102335A3 (en) | Methods of treating sleep disorders | |
TWI370131B (en) | New hydrates and polymorphs of 4-[[(7r)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-mithoxy-n-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament | |
IL180371A0 (en) | Method of treating sjogren's syndrome | |
NO20050883L (en) | New Process for the Synthesis (IS) -4,5-Dimethoxy-1- (methylaminomethyl) -benzocyclobutane and Addition Salts thereof, and Use in the Synthesis of Ivabradine and Addition Salts thereof with a Pharmaceutically Acceptable Acid | |
ME01396B (en) | Process for the synthesis of ivabradine and its pharmaceutically acceptable acid addition salts | |
HK1171736A1 (en) | Substituted acids for the treatment of respiratory diseases | |
DE602005017503D1 (en) | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY RESTRICTIONS | |
WO2002074758A3 (en) | Novel amines as histamine-3 receptor ligands and their therapeutic applications | |
EA200400881A1 (en) | AZAARILPIPERAZINS | |
ATE448219T1 (en) | NEW HYDANTOIN DERIVATIVES FOR THE TREATMENT OF OBSTRUCTIVE AIRWAY DISEASES | |
JO3021B1 (en) | 4-[4-({[ 4- chloro-3- (trifluoromethyl) phenyl] carbamoyl}lamino)-3- fluoromethyl]-N-methylpyridine -2- carboxamide monohydrate | |
HK1080456A1 (en) | N-substituted hydromorphones and the use thereof | |
WO2005075450A3 (en) | Spiro-benzodioxoles and their use as cb1 antagonists | |
IL175032A0 (en) | Inhalable pharmaceutical formulations employing lactose anhydrate nad methods of administering the same | |
JP2007506758A5 (en) | 4- (1-benzofuran-3-yl-methylideneaminooxy-propoxy) -benzoic acid derivatives and related compounds as PAI-1 inhibitors for the treatment of disorders of fibrinolytic systems, thrombosis | |
MY139831A (en) | Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase i( ) | |
WO2004041272A3 (en) | Use of serotonin receptor antagonists for the treatment of sleep apnea | |
NO20050888D0 (en) | New Process for the Synthesis of 1,3,4,5-Tetrahydro-2H-3-Benzazepin-2-One Compounds, and Use in the Synthesis of Ivabradine and Addition Salts thereof with a Pharmaceutically Acceptable Acid | |
WO2004010936A3 (en) | Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders | |
WO2005016327A3 (en) | Treatment of sleep disorders with cholinesterase inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 05807636 Country of ref document: EP Kind code of ref document: A2 |