WO2006037105A3 - Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof - Google Patents

Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof Download PDF

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Publication number
WO2006037105A3
WO2006037105A3 PCT/US2005/035065 US2005035065W WO2006037105A3 WO 2006037105 A3 WO2006037105 A3 WO 2006037105A3 US 2005035065 W US2005035065 W US 2005035065W WO 2006037105 A3 WO2006037105 A3 WO 2006037105A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitric oxide
releasing
acrylonitrile
medical devices
compositions
Prior art date
Application number
PCT/US2005/035065
Other languages
French (fr)
Other versions
WO2006037105A2 (en
Inventor
Joseph A Hrabie
Michael L Citro
Frank Derosa
Larry K Keefer
Original Assignee
Us Health
Joseph A Hrabie
Michael L Citro
Frank Derosa
Larry K Keefer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Joseph A Hrabie, Michael L Citro, Frank Derosa, Larry K Keefer filed Critical Us Health
Priority to EP05802080.1A priority Critical patent/EP1794195B1/en
Priority to US11/576,012 priority patent/US7968664B2/en
Priority to CA2581939A priority patent/CA2581939C/en
Priority to AU2005289414A priority patent/AU2005289414B2/en
Publication of WO2006037105A2 publication Critical patent/WO2006037105A2/en
Publication of WO2006037105A3 publication Critical patent/WO2006037105A3/en
Priority to AU2011200972A priority patent/AU2011200972C1/en
Priority to US13/111,613 priority patent/US8093343B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups

Abstract

The invention described herein provides for novel nitric oxide-releasing polymers that comprise at least two adjacent units derived from acrylonitrile monomer units and containing at least one carbon-bound diazeniumdiolate. The diazeniumdiolated acrylonitrile-derived polymers can be used in medical devices therapeutically. Accordingly, the invention also provides a method of treating a biological disorder and a method of promoting angiogenesis that includes administering a medical device comprising a nitric oxide-releasing polymer comprising at least two adjacent units of acrylonitrile before exposure to nitric oxide and at least one nitric oxide releasing N2O2- group, wherein the N2O2- group is attached directly to the polyacrylonitrile backbone, to a specific location on or within the mammal in an amount effective to treat the biological disorder or promote angiogenesis.
PCT/US2005/035065 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof WO2006037105A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP05802080.1A EP1794195B1 (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
US11/576,012 US7968664B2 (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
CA2581939A CA2581939C (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
AU2005289414A AU2005289414B2 (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
AU2011200972A AU2011200972C1 (en) 2004-09-27 2011-03-04 Nitric oxide-releasing compounds and uses thereof
US13/111,613 US8093343B2 (en) 2004-09-27 2011-05-19 Nitric oxide-releasing diazeniumdiolated compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61325704P 2004-09-27 2004-09-27
US60/613,257 2004-09-27

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/576,012 A-371-Of-International US7968664B2 (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
US13/111,613 Division US8093343B2 (en) 2004-09-27 2011-05-19 Nitric oxide-releasing diazeniumdiolated compounds

Publications (2)

Publication Number Publication Date
WO2006037105A2 WO2006037105A2 (en) 2006-04-06
WO2006037105A3 true WO2006037105A3 (en) 2007-10-04

Family

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Family Applications (1)

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PCT/US2005/035065 WO2006037105A2 (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof

Country Status (5)

Country Link
US (2) US7968664B2 (en)
EP (1) EP1794195B1 (en)
AU (2) AU2005289414B2 (en)
CA (1) CA2581939C (en)
WO (1) WO2006037105A2 (en)

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US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same

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US7569559B2 (en) * 2004-02-09 2009-08-04 Noxilizer, Inc. Nitric oxide-releasing molecules
US20080241208A1 (en) * 2005-06-30 2008-10-02 Charles Shanley Methods, Compositions and Devices For Promoting Anglogenesis
ATE513568T1 (en) 2005-06-30 2011-07-15 Accord Biomaterials Inc NITROGEN OXIDE COATINGS FOR MEDICAL DEVICES
JP2009505727A (en) 2005-08-25 2009-02-12 メドトロニック ヴァスキュラー インコーポレイテッド Nitric oxide releasing biodegradable polymers useful as medical devices and their coatings
US20070053952A1 (en) * 2005-09-07 2007-03-08 Medtronic Vascular, Inc. Nitric oxide-releasing polymers derived from modified polymers
WO2007126344A1 (en) * 2006-04-27 2007-11-08 St. Jude Medical Ab Implantable medical device with releasing compound
US8241619B2 (en) 2006-05-15 2012-08-14 Medtronic Vascular, Inc. Hindered amine nitric oxide donating polymers for coating medical devices
US7811600B2 (en) 2007-03-08 2010-10-12 Medtronic Vascular, Inc. Nitric oxide donating medical devices and methods of making same
US8273828B2 (en) 2007-07-24 2012-09-25 Medtronic Vascular, Inc. Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation
US8852640B2 (en) * 2008-07-03 2014-10-07 Ecole Polytechnique Federale De Lausanne (Epfl) Micelles for delivery of nitric oxide
US8158187B2 (en) 2008-12-19 2012-04-17 Medtronic Vascular, Inc. Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices
US8709465B2 (en) 2009-04-13 2014-04-29 Medtronic Vascular, Inc. Diazeniumdiolated phosphorylcholine polymers for nitric oxide release
CN102695528B (en) 2009-08-21 2016-07-13 诺万公司 Wound dressing, its using method and forming method thereof
WO2012153331A2 (en) 2011-05-09 2012-11-15 Topical Therapeutic Agent (Tta) Ltd. Nitric oxide-sequestering topical formulations
US9017653B2 (en) 2012-06-14 2015-04-28 The Board Of Regents Of The University Of Texas System Nitric oxide-releasing compositions and methods
EP2875056B1 (en) 2012-07-17 2020-05-13 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing diazeniumdiolated polyvinylpyrrolidone-based polymers, and compositions, medical devices, and uses thereof
EP3180366B1 (en) * 2014-08-14 2018-09-26 Rohm and Haas Company Polymer with releasable gas
EP3347096A4 (en) 2015-09-09 2019-05-15 Advanced Inhalation Therapies (AIT) Ltd. Nitric oxide inhalation therapy for infants with bronchiolitis
CN107446096B (en) * 2017-09-01 2020-08-04 中车唐山机车车辆有限公司 Heavy metal ion porous adsorbent and preparation method and application thereof

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US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8956658B2 (en) 2005-05-27 2015-02-17 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
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US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same

Also Published As

Publication number Publication date
AU2011200972C1 (en) 2012-05-24
AU2011200972A1 (en) 2011-03-24
EP1794195B1 (en) 2014-12-17
AU2011200972B2 (en) 2012-01-12
US20110282060A1 (en) 2011-11-17
CA2581939A1 (en) 2006-04-06
US7968664B2 (en) 2011-06-28
AU2005289414B2 (en) 2010-12-09
WO2006037105A2 (en) 2006-04-06
EP1794195A2 (en) 2007-06-13
US8093343B2 (en) 2012-01-10
CA2581939C (en) 2013-01-08
US20070292471A1 (en) 2007-12-20
AU2005289414A1 (en) 2006-04-06

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