WO2006044856A3 - Use of a2a adenosine receptor agonists - Google Patents

Use of a2a adenosine receptor agonists Download PDF

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Publication number
WO2006044856A3
WO2006044856A3 PCT/US2005/037368 US2005037368W WO2006044856A3 WO 2006044856 A3 WO2006044856 A3 WO 2006044856A3 US 2005037368 W US2005037368 W US 2005037368W WO 2006044856 A3 WO2006044856 A3 WO 2006044856A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor agonists
adenosine receptor
myocardial imaging
adenosine
accomplished
Prior art date
Application number
PCT/US2005/037368
Other languages
French (fr)
Other versions
WO2006044856A2 (en
Inventor
Toufigh Gordi
Ann Walls Olmsted
Hsiao Dee Lieu
Luiz Belardinelli
Original Assignee
Cv Therapeuitics Inc
Toufigh Gordi
Ann Walls Olmsted
Hsiao Dee Lieu
Luiz Belardinelli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeuitics Inc, Toufigh Gordi, Ann Walls Olmsted, Hsiao Dee Lieu, Luiz Belardinelli filed Critical Cv Therapeuitics Inc
Priority to EP05815368A priority Critical patent/EP1802317A2/en
Priority to CA002583185A priority patent/CA2583185A1/en
Priority to MX2007004749A priority patent/MX2007004749A/en
Priority to JP2007537961A priority patent/JP2008517063A/en
Priority to AU2005295437A priority patent/AU2005295437B2/en
Publication of WO2006044856A2 publication Critical patent/WO2006044856A2/en
Publication of WO2006044856A3 publication Critical patent/WO2006044856A3/en
Priority to IL182645A priority patent/IL182645A0/en
Priority to NO20072540A priority patent/NO20072540L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Abstract

Myocardial imaging methods that are accomplished by administering doses of a pharmaceutical composition including regadenoson - an adenosine A2A receptor agonist - to a human undergoing myocardial imaging in an amount sufficient to achieve at least a minimal increase in average coronary peak flow velocity.
PCT/US2005/037368 2004-10-20 2005-10-19 Use of a2a adenosine receptor agonists WO2006044856A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP05815368A EP1802317A2 (en) 2004-10-20 2005-10-19 Use of a2a adenosine receptor agonists
CA002583185A CA2583185A1 (en) 2004-10-20 2005-10-19 Use of a2a adenosine receptor agonists
MX2007004749A MX2007004749A (en) 2004-10-20 2005-10-19 Use of a2a adenosine receptor agonists.
JP2007537961A JP2008517063A (en) 2004-10-20 2005-10-19 Use of A2A adenosine receptor agonist
AU2005295437A AU2005295437B2 (en) 2004-10-20 2005-10-19 Use of A2A adenosine receptor agonists
IL182645A IL182645A0 (en) 2004-10-20 2007-04-18 Use of a2a adenosine receptor agonists
NO20072540A NO20072540L (en) 2004-10-20 2007-05-18 Use of A2A adenosine receptor agonist

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62057704P 2004-10-20 2004-10-20
US60/620,577 2004-10-20

Publications (2)

Publication Number Publication Date
WO2006044856A2 WO2006044856A2 (en) 2006-04-27
WO2006044856A3 true WO2006044856A3 (en) 2006-07-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/037368 WO2006044856A2 (en) 2004-10-20 2005-10-19 Use of a2a adenosine receptor agonists

Country Status (13)

Country Link
US (3) US7655636B2 (en)
EP (1) EP1802317A2 (en)
JP (1) JP2008517063A (en)
KR (1) KR20070083714A (en)
CN (1) CN101076343A (en)
AU (1) AU2005295437B2 (en)
CA (1) CA2583185A1 (en)
IL (1) IL182645A0 (en)
MX (1) MX2007004749A (en)
NO (1) NO20072540L (en)
RU (1) RU2007114908A (en)
WO (1) WO2006044856A2 (en)
ZA (1) ZA200703229B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9045519B2 (en) 1999-06-22 2015-06-02 Gilead Sciences, Inc. N-pyrazole A2A receptor agonists
US9085601B2 (en) 2006-02-03 2015-07-21 Gilead Sciences, Inc. Process for preparing an A2A-adenosine receptor agonist and its polymorphs
US9163057B2 (en) 2000-02-23 2015-10-20 Gilead Sciences, Inc. Methods of myocardial perfusion imaging
US9289446B2 (en) 2002-07-29 2016-03-22 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
CA2492855C (en) * 2002-07-29 2012-09-18 Cv Therapeutics, Inc. Myocardial perfusion imaging using a2a receptor agonists
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
KR20070083714A (en) 2004-10-20 2007-08-24 씨브이 쎄러퓨틱스, 인코포레이티드 Use of a2a adenosine receptor agonists
JP2009541354A (en) * 2006-06-22 2009-11-26 シーブイ・セラピューティクス・インコーポレイテッド Use of A2A adenosine receptor agonists in the treatment of ischemia
WO2008028140A1 (en) * 2006-09-01 2008-03-06 Cv Therapeutics, Inc. Methods and compositions for increasing patient tolerability during myocardial imaging methods
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
JP2011502101A (en) * 2006-09-29 2011-01-20 ギリアード・パロ・アルト・インコーポレイテッド Myocardial imaging in patients with a history of lung disease
WO2008086096A2 (en) * 2007-01-03 2008-07-17 Cv Therapeutics, Inc. Myocardial perfusion imaging
KR20110063556A (en) * 2008-09-29 2011-06-10 길리애드 사이언시즈, 인코포레이티드 Combinations of a rate control agent and an a-2-alpha receptor antagonist for use in multidetector computed tomography methods
WO2014083580A2 (en) * 2012-11-30 2014-06-05 Leiutis Pharmaceuticals Pvt. Ltd. Pharmaceutical compositions of regadenoson
WO2017059302A1 (en) * 2015-09-30 2017-04-06 Cedars-Sinai Medical Center Robust myocardial blood oxygen level dependent magnetic resonance imaging with long-acting coronary vasodilators

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078779A2 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. N-pyrazole a2a receptor agonists
WO2001062979A2 (en) * 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Dentification of partial agonists of the a2a adenosine receptor
WO2004011010A1 (en) * 2002-07-29 2004-02-05 Cv Therapeutics, Inc. Myocardial perfusion imaging using a2a receptor agonists
WO2005082379A1 (en) * 2004-01-27 2005-09-09 Cv Therapeutics, Inc. Myocardial perfusion imaging using adenosine receptor agonists

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US9045519B2 (en) 1999-06-22 2015-06-02 Gilead Sciences, Inc. N-pyrazole A2A receptor agonists
US9163057B2 (en) 2000-02-23 2015-10-20 Gilead Sciences, Inc. Methods of myocardial perfusion imaging
US9289446B2 (en) 2002-07-29 2016-03-22 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
US9085601B2 (en) 2006-02-03 2015-07-21 Gilead Sciences, Inc. Process for preparing an A2A-adenosine receptor agonist and its polymorphs

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