WO2006049854A3 - Disruptions of genes encoding secreted proteins, compositions and methods relating thereto - Google Patents

Disruptions of genes encoding secreted proteins, compositions and methods relating thereto Download PDF

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Publication number
WO2006049854A3
WO2006049854A3 PCT/US2005/037291 US2005037291W WO2006049854A3 WO 2006049854 A3 WO2006049854 A3 WO 2006049854A3 US 2005037291 W US2005037291 W US 2005037291W WO 2006049854 A3 WO2006049854 A3 WO 2006049854A3
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WIPO (PCT)
Prior art keywords
disorders
disruptions
abnormalities
compositions
methods relating
Prior art date
Application number
PCT/US2005/037291
Other languages
French (fr)
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WO2006049854A2 (en
Inventor
Allison Anne Byers-Horner
Katherin Combs
Frederic Desauvage
Zhiyong Ding
Dorothy French
Lino Gonzalez
Erin Marie Massey
Laurie Jeanette Minze
Chuck Montgomery
Asja Praetor
Carolina Rangel
Zheng-Zheng Shi
Mary Jean Sparks
Joy Stala
Peter Vogel
Tracy Ellen Willis-Sevaux
Weilan Ye
Original Assignee
Genentech Inc
Lexicon Genetics Inc
Allison Anne Byers-Horner
Katherin Combs
Frederic Desauvage
Zhiyong Ding
Dorothy French
Lino Gonzalez
Erin Marie Massey
Laurie Jeanette Minze
Chuck Montgomery
Asja Praetor
Carolina Rangel
Zheng-Zheng Shi
Mary Jean Sparks
Joy Stala
Peter Vogel
Tracy Ellen Willis-Sevaux
Weilan Ye
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Lexicon Genetics Inc, Allison Anne Byers-Horner, Katherin Combs, Frederic Desauvage, Zhiyong Ding, Dorothy French, Lino Gonzalez, Erin Marie Massey, Laurie Jeanette Minze, Chuck Montgomery, Asja Praetor, Carolina Rangel, Zheng-Zheng Shi, Mary Jean Sparks, Joy Stala, Peter Vogel, Tracy Ellen Willis-Sevaux, Weilan Ye filed Critical Genentech Inc
Priority to CA002584297A priority Critical patent/CA2584297A1/en
Priority to AU2005301152A priority patent/AU2005301152A1/en
Priority to EP05837234A priority patent/EP1817335A2/en
Priority to US11/577,547 priority patent/US7947866B2/en
Priority to JP2007538976A priority patent/JP2008517625A/en
Publication of WO2006049854A2 publication Critical patent/WO2006049854A2/en
Publication of WO2006049854A3 publication Critical patent/WO2006049854A3/en
Priority to US13/082,706 priority patent/US20120210450A1/en

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    • A01K2267/035—Animal model for multifactorial diseases

Abstract

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
PCT/US2005/037291 2004-10-29 2005-10-18 Disruptions of genes encoding secreted proteins, compositions and methods relating thereto WO2006049854A2 (en)

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EP05837234A EP1817335A2 (en) 2004-10-29 2005-10-18 Disruptions of genes encoding secreted proteins, compositions and methods relating thereto
US11/577,547 US7947866B2 (en) 2004-10-29 2005-10-18 Gene disruptions, compositions and methods relating thereto
JP2007538976A JP2008517625A (en) 2004-10-29 2005-10-18 Disruption of genes encoding secreted proteins, and related compositions and methods
US13/082,706 US20120210450A1 (en) 2004-10-29 2011-04-08 Novel gene disruptions, compositions and methods relating thereto

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US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US9580483B2 (en) 2011-07-01 2017-02-28 Ngm Biopharmaceuticals, Inc. Methods of using compositions comprising variants and fusions of FGF19 polypeptides for treatment of diabetes

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US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases

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ZA200704338B (en) 2009-03-25
US20090196876A1 (en) 2009-08-06
ZA200806861B (en) 2009-07-29
ZA200806860B (en) 2009-07-29
ZA200806864B (en) 2009-07-29
US20120210450A1 (en) 2012-08-16
AU2005301152A1 (en) 2006-05-11
WO2006049854A2 (en) 2006-05-11
US7947866B2 (en) 2011-05-24
ZA200806862B (en) 2009-07-29
ZA200806863B (en) 2009-07-29
JP2008517625A (en) 2008-05-29

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