WO2006052551A3 - Micromachined bilayer unit of engineered tissues - Google Patents

Micromachined bilayer unit of engineered tissues Download PDF

Info

Publication number
WO2006052551A3
WO2006052551A3 PCT/US2005/039503 US2005039503W WO2006052551A3 WO 2006052551 A3 WO2006052551 A3 WO 2006052551A3 US 2005039503 W US2005039503 W US 2005039503W WO 2006052551 A3 WO2006052551 A3 WO 2006052551A3
Authority
WO
WIPO (PCT)
Prior art keywords
micromachined
engineered tissues
bilayer unit
bilayer
unit
Prior art date
Application number
PCT/US2005/039503
Other languages
French (fr)
Other versions
WO2006052551A2 (en
Inventor
Jeffrey T Borenstein
Eli Weinberg
Brian K Orrick
Eleanor M Pritchard
Edward J Barnard
Nicholas J Krebs
Theodore Marentis
Joseph P Vacanti
Mohammad Reza Kaazempur-Mofrad
Original Assignee
Gen Hospital Corp
Massachusetts Inst Technology
Draper Lab Charles S
Jeffrey T Borenstein
Eli Weinberg
Brian K Orrick
Eleanor M Pritchard
Edward J Barnard
Nicholas J Krebs
Theodore Marentis
Joseph P Vacanti
Mohammad Reza Kaazempur-Mofrad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Massachusetts Inst Technology, Draper Lab Charles S, Jeffrey T Borenstein, Eli Weinberg, Brian K Orrick, Eleanor M Pritchard, Edward J Barnard, Nicholas J Krebs, Theodore Marentis, Joseph P Vacanti, Mohammad Reza Kaazempur-Mofrad filed Critical Gen Hospital Corp
Publication of WO2006052551A2 publication Critical patent/WO2006052551A2/en
Publication of WO2006052551A3 publication Critical patent/WO2006052551A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1678—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.
PCT/US2005/039503 2004-11-05 2005-11-01 Micromachined bilayer unit of engineered tissues WO2006052551A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/983,213 2004-11-05
US10/983,213 US7776021B2 (en) 2000-04-28 2004-11-05 Micromachined bilayer unit for filtration of small molecules

Publications (2)

Publication Number Publication Date
WO2006052551A2 WO2006052551A2 (en) 2006-05-18
WO2006052551A3 true WO2006052551A3 (en) 2009-06-11

Family

ID=36336973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/039503 WO2006052551A2 (en) 2004-11-05 2005-11-01 Micromachined bilayer unit of engineered tissues

Country Status (2)

Country Link
US (2) US7776021B2 (en)
WO (1) WO2006052551A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314420B2 (en) 2005-10-26 2016-04-19 Jan-Eric Ahlfors Acellular bioabsorbable tissue regeneration matrices

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
WO2004065616A2 (en) 2003-01-16 2004-08-05 The General Hospital Corporation Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US7955504B1 (en) 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
US7790028B1 (en) * 2005-09-28 2010-09-07 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a cellularized nephron unit
JP4821466B2 (en) * 2006-07-03 2011-11-24 富士ゼロックス株式会社 Droplet discharge head
ES2614436T3 (en) 2007-04-12 2017-05-31 The General Hospital Corporation Biomimetic swing network and devices that use it
EP2200931B1 (en) 2007-09-19 2017-06-07 The Charles Stark Draper Laboratory, Inc. Microfluidic structures with circular cross-section
US8188416B2 (en) * 2008-01-14 2012-05-29 The Charles Stark Draper Laboratory, Inc. Engineered phantoms for perfusion imaging applications
WO2009102751A2 (en) * 2008-02-11 2009-08-20 The General Hospital Corporation System and method for in vitro blood vessel modeling
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
ES2635219T3 (en) * 2009-06-24 2017-10-02 Oregon State University Microfluidic devices for dialysis
US8801922B2 (en) 2009-06-24 2014-08-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialysis system
US9599407B2 (en) 2009-07-29 2017-03-21 Tokitae Llc System and structure for heating or sterilizing a liquid stream
US9930898B2 (en) * 2009-07-29 2018-04-03 Tokitae Llc Pasteurization system and method
EP2292284B1 (en) * 2009-09-04 2014-02-26 B. Braun Avitum AG Kidney substitution treatment machine
FR2950359B1 (en) * 2009-09-23 2011-12-02 Univ Compiegne Tech FILTRATION DEVICE AND SYSTEM
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
WO2011059786A1 (en) * 2009-10-29 2011-05-19 The Charles Stark Draper Laboratory, Inc. Microfluidic device for blood dialysis
US8753515B2 (en) 2009-12-05 2014-06-17 Home Dialysis Plus, Ltd. Dialysis system with ultrafiltration control
CA2786008C (en) * 2009-12-31 2018-02-06 Joseph L. Charest Microfluidic device facilitating gas exchange, and methods of use and manufacture thereof
US8580161B2 (en) 2010-05-04 2013-11-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluidic devices comprising photocontrollable units
JP2013534461A (en) 2010-05-26 2013-09-05 ザ チャールズ スターク ドレイパー ラボラトリー インク Micromachined artificial lung assist device and methods of use and manufacture thereof
US8501009B2 (en) 2010-06-07 2013-08-06 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluid purification system
US20130005660A1 (en) * 2011-04-27 2013-01-03 Orthobond, Inc. Plasma Activation of Biological Materials for Surface Modification
AU2012271341B2 (en) 2011-06-15 2017-07-13 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a biomimetic cellularized nephron unit
WO2013052680A2 (en) * 2011-10-07 2013-04-11 Home Dialysis Plus, Ltd. Heat exchange fluid purification for dialysis system
JP6395608B2 (en) 2011-12-05 2018-09-26 ザ チャールズ スターク ドレイパー ラボラトリー インク Method for reducing blood injection volume and membrane surface area in a microfluidic lung assist device
GB201213654D0 (en) 2012-08-01 2012-09-12 Univ Singapore Cell culture
US9353313B2 (en) 2012-08-09 2016-05-31 Auburn University Microdevices and methods of manufacture
US9421315B2 (en) * 2012-09-05 2016-08-23 The Charles Stark Draper Laboratory, Inc. Compact hydraulic manifold structure for shear sensitive fluids
US9656212B2 (en) 2013-01-08 2017-05-23 The Charles Stark Draper Laboratory, Inc. Compact hydraulic manifold structure for shear sensitive fluids
US10603419B2 (en) 2013-01-11 2020-03-31 The Charles Stark Draper Laboratories, Inc. Systems and methods for increasing convective clearance of undesired particles in a microfluidic device
US10342909B2 (en) 2013-01-11 2019-07-09 The Charles Stark Draper Laboratory Inc. Systems and methods for increasing convective clearance of undesired particles in a microfluidic device
US10478543B2 (en) 2013-01-11 2019-11-19 The Charles Stark Draper Laboratory, Inc. Systems and methods for increasing convective clearance of undesired particles in a microfluidic device
EP2953581B1 (en) 2013-02-05 2020-09-16 University of Utah Research Foundation Implantable devices for bone or joint defects
US9409139B2 (en) 2013-08-05 2016-08-09 Twist Bioscience Corporation De novo synthesized gene libraries
US9717835B2 (en) 2014-04-23 2017-08-01 The Charles Stark Draper Laboratory, Inc. Blood oxygenator
WO2015168280A1 (en) 2014-04-29 2015-11-05 Outset Medical, Inc. Dialysis system and methods
EP3220974A4 (en) 2014-11-19 2018-07-04 The Regents of The University of California Gas exchange composite membranes and methods of use thereof
WO2016126987A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
US10184102B2 (en) 2015-08-26 2019-01-22 EMULATE, Inc. Controlling pressure
AU2016324296A1 (en) 2015-09-18 2018-04-12 Twist Bioscience Corporation Oligonucleic acid variant libraries and synthesis thereof
US11512347B2 (en) 2015-09-22 2022-11-29 Twist Bioscience Corporation Flexible substrates for nucleic acid synthesis
CN115920796A (en) 2015-12-01 2023-04-07 特韦斯特生物科学公司 Functionalized surfaces and preparation thereof
US10758841B2 (en) * 2016-03-07 2020-09-01 Mcmaster University Laterally-fed membrane chromatography device
US10758840B2 (en) * 2016-03-07 2020-09-01 Mcmaster University Laterally-fed membrane chromatography device
US10759829B2 (en) * 2016-06-07 2020-09-01 Mcmaster University Chromatography device and method for filtering a solute from a fluid
EP3500317B1 (en) 2016-08-19 2022-02-23 Outset Medical, Inc. Peritoneal dialysis system and methods
CA3034769A1 (en) 2016-08-22 2018-03-01 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
WO2018057526A2 (en) 2016-09-21 2018-03-29 Twist Bioscience Corporation Nucleic acid based data storage
US10907274B2 (en) 2016-12-16 2021-02-02 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
CN110892485B (en) 2017-02-22 2024-03-22 特韦斯特生物科学公司 Nucleic acid-based data storage
EP3595674A4 (en) 2017-03-15 2020-12-16 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
WO2018227026A1 (en) * 2017-06-07 2018-12-13 Iviva Medical, Inc. Dialysate regeneration or enhancement component and methods of use thereof
US10696965B2 (en) 2017-06-12 2020-06-30 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
EP3681906A4 (en) 2017-09-11 2021-06-09 Twist Bioscience Corporation Gpcr binding proteins and synthesis thereof
GB2583590A (en) 2017-10-20 2020-11-04 Twist Bioscience Corp Heated nanowells for polynucleotide synthesis
KR20200106067A (en) 2018-01-04 2020-09-10 트위스트 바이오사이언스 코포레이션 DNA-based digital information storage
SG11202011467RA (en) 2018-05-18 2020-12-30 Twist Bioscience Corp Polynucleotides, reagents, and methods for nucleic acid hybridization
WO2020176680A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
KR20210143766A (en) 2019-02-26 2021-11-29 트위스트 바이오사이언스 코포레이션 Variant Nucleic Acid Libraries for the GLP1 Receptor
CA3144644A1 (en) 2019-06-21 2020-12-24 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907687A (en) * 1968-12-07 1975-09-23 Baxter Laboratories Inc Plate dialyzer
US4636310A (en) * 1982-12-07 1987-01-13 Bellhouse Brian John Transfer membrane apparatus
US5665596A (en) * 1995-07-31 1997-09-09 Becton, Dickinson And Company Device for cell co-culture and method for its use in culturing cells
US6139574A (en) * 1993-10-18 2000-10-31 Children's Medical Center Corporation Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6458275B1 (en) * 2000-06-05 2002-10-01 Harvard Apparatus, Inc. Multi-well equilibrium dialysis system

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3684097A (en) * 1970-07-02 1972-08-15 Gen Electric Blood component exchange device
US3839204A (en) * 1972-04-27 1974-10-01 Gen Electric Integral blood heat and component exchange device and two flow path membrane blood gas exchanger
FR2197565B1 (en) * 1972-08-30 1975-03-07 Rhone Poulenc Ind
US3892533A (en) * 1973-03-02 1975-07-01 Sci Med Oxygenator gas distribution header
NL7310808A (en) * 1973-08-06 1975-02-10 Josef Augustinus Elizabeth Spa DEVICE FOR EXCHANGE OF SUBSTANCES BETWEEN TWO ON EACH SIDE OF A MEMBRANE
US4008047A (en) * 1974-12-26 1977-02-15 North Star Research Institute Blood compatible polymers for blood oxygenation devices
DE2622684B2 (en) * 1976-05-21 1979-03-15 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt Membrane exchanger
WO1981000522A1 (en) * 1979-08-21 1981-03-05 V Gorun Gas-permeable membrane,method of making it and blood oxygenator based on the use thereof
US4980068A (en) 1983-08-15 1990-12-25 Lavender Ardis R System, apparatus and method for continuously fractionating blood in situ
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
JPH0342927Y2 (en) * 1987-02-09 1991-09-09
IT1202689B (en) * 1987-03-25 1989-02-09 Franco Maria Montevecchi PROCEDURE AND DEVICE FOR THE EXTRACORPOREAL BLOOD CIRCULATION AND FOR CARDIOVASCULAR ASSISTANCE
US5225161A (en) * 1988-10-20 1993-07-06 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger
US5316724A (en) * 1989-03-31 1994-05-31 Baxter International Inc. Multiple blood path membrane oxygenator
US5204055A (en) * 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5222982A (en) * 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
US5263924A (en) * 1991-09-25 1993-11-23 Baxter International Inc. Integrated low priming volume centrifugal pump and membrane oxygenator
US5549674A (en) * 1992-03-02 1996-08-27 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US5849553A (en) * 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
DE4320198C1 (en) * 1993-06-18 1994-07-14 Fresenius Ag Blood gas exchange appts.
US6200802B1 (en) * 1993-10-08 2001-03-13 Arch Development Corporation Human peroxisome proliferator activated receptor gamma: compositions and methods
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
US5626759A (en) * 1994-08-01 1997-05-06 Regents Of The University Of Colorado Blood treatment device with moving membrane
DE4433376C1 (en) 1994-09-20 1996-04-04 Peter M Prof Dr Kunz Process for removing rust from organic-based surfaces and process for producing the agent used
AT405288B (en) 1994-09-21 1999-06-25 Chemie Linz Gmbh FLAME-RESISTANT, GLASS FIBER-REINFORCED POLYAMIDE RESIN WITH MELAMINE OR MELEM-PHOSPHORIC ACID CONVERSION PRODUCTS AS A FLAME-RETARDANT
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US7008634B2 (en) * 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
BE1009306A5 (en) * 1995-04-28 1997-02-04 Baxter Int Bioreactor.
US6573063B2 (en) * 1995-10-04 2003-06-03 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
WO1997045533A1 (en) * 1996-05-28 1997-12-04 The Regents Of The University Of Michigan Engineering oral tissues
US6136212A (en) * 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
WO1999049807A2 (en) * 1997-01-16 1999-10-07 Yissum Research And Development Company Of The Hebrew University Of Jerusalem A device and method for performing a biological modification of a fluid
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6287558B1 (en) * 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
CA2227827A1 (en) 1998-01-23 1999-07-23 Unknown In vitro artificial cornea and sclera
WO1999047922A2 (en) * 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
JP2002511284A (en) 1998-04-09 2002-04-16 シャーロット−メクレンバーグ・ホスピタル・オーソリティ Creating a three-dimensional organization
AU3590199A (en) * 1998-05-01 1999-11-23 Queen's University At Kingston Method for diagnosing a vascular condition
US20020010550A1 (en) * 1998-09-14 2002-01-24 George M. Grass Pharmacokinetic-based drug design tool and method
US6547994B1 (en) * 1998-11-13 2003-04-15 Therics, Inc. Rapid prototyping and manufacturing process
US6165486A (en) * 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
IT1304503B1 (en) 1998-12-24 2001-03-19 In Te C S R L USE OF A SELECTIVE MEMBRANE IN A BIOMEDICAL DEVICE FOR THE EXTRA-BODY TREATMENT OF BLOOD AND OTHER ORGANIC LIQUIDS.
WO2000047129A2 (en) * 1999-02-11 2000-08-17 The General Hospital Corporation Microfabricated membranes and matrices
US20020090725A1 (en) * 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
JP2002542883A (en) * 1999-04-30 2002-12-17 マサチューセッツ ジェネラル ホスピタル Processing of neovascularized tissue using microfabricated two-dimensional mold
US20030129736A1 (en) * 1999-07-15 2003-07-10 Eduardo Mitrani Device and method for performing a biological modification of a fluid
IL147990A0 (en) 1999-08-05 2002-09-12 Mcl Llc Multipotent adult stem cells and methods for isolation
US6525242B1 (en) * 1999-11-02 2003-02-25 The University Of Connecticut Propagation of human hepatocytes in non-human mammals
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
CA2402413A1 (en) * 2000-03-14 2001-09-20 The University Of Western Ontario Compositions and methods for affecting osteogenesis
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
AU2001294671A1 (en) * 2000-09-25 2002-04-08 The Board Of Trustees Of The University Of Illinois Microfabrication of membranes for the growth of cells
US6607910B1 (en) * 2000-11-13 2003-08-19 Synthecon, Inc. Two chamber cell culture vessel
IL156113A0 (en) * 2000-11-28 2003-12-23 Art Of Xen Ltd Gas exchange
WO2002053193A2 (en) * 2001-01-02 2002-07-11 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
NL1017570C2 (en) 2001-03-12 2002-09-13 Stichting Hogeschool Van Utrec Blood treatment device.
CA2465262A1 (en) * 2001-10-31 2003-06-19 Bristol-Myers Squibb Company Methods of screening for toxicity of test compounds
AU2002340463A1 (en) * 2001-11-16 2003-06-10 Children's Medical Center Corporation Augmentation of organ function
US20030121594A1 (en) * 2001-12-28 2003-07-03 Brill Russell P. Method for manufacture of tubular multilayer structure from fiber-resin material
AU2003205241A1 (en) 2002-01-22 2003-09-02 The Penn State Research Foundation Drug candidate screening systems based on micropatterned hydrogels and microfluidic systems
DE10203237B4 (en) * 2002-01-28 2006-08-17 Siemens Ag Method for magnetic resonance imaging with automatic adjustment of the measuring field
WO2003104439A2 (en) * 2002-03-12 2003-12-18 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
WO2004006840A2 (en) * 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
US8129179B2 (en) 2002-08-27 2012-03-06 Vanderbilt University Bioreactors with an array of chambers and a common feed line
WO2004026115A2 (en) 2002-09-23 2004-04-01 The General Hospital Corporation Theree-dimensional construct for the design and fabrication of physiological fluidic networks
US20040147016A1 (en) * 2002-09-30 2004-07-29 Rowley Jonathan A. Programmable scaffold and methods for making and using the same
US7264723B2 (en) * 2002-11-01 2007-09-04 Sandia Corporation Dialysis on microchips using thin porous polymer membranes
AU2005294236A1 (en) * 2004-10-06 2006-04-20 Home Dialysis Plus, Ltd. Mecs dialyzer
US7955504B1 (en) * 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
US20070125489A1 (en) * 2005-09-08 2007-06-07 Oregon State University Microfluidic welded devices or components thereof and method for their manufacture
US8801922B2 (en) * 2009-06-24 2014-08-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialysis system
ES2635219T3 (en) * 2009-06-24 2017-10-02 Oregon State University Microfluidic devices for dialysis

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907687A (en) * 1968-12-07 1975-09-23 Baxter Laboratories Inc Plate dialyzer
US4636310A (en) * 1982-12-07 1987-01-13 Bellhouse Brian John Transfer membrane apparatus
US6139574A (en) * 1993-10-18 2000-10-31 Children's Medical Center Corporation Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5665596A (en) * 1995-07-31 1997-09-09 Becton, Dickinson And Company Device for cell co-culture and method for its use in culturing cells
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6458275B1 (en) * 2000-06-05 2002-10-01 Harvard Apparatus, Inc. Multi-well equilibrium dialysis system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314420B2 (en) 2005-10-26 2016-04-19 Jan-Eric Ahlfors Acellular bioabsorbable tissue regeneration matrices

Also Published As

Publication number Publication date
WO2006052551A2 (en) 2006-05-18
US20110056882A1 (en) 2011-03-10
US8491561B2 (en) 2013-07-23
US7776021B2 (en) 2010-08-17
US20050202557A1 (en) 2005-09-15

Similar Documents

Publication Publication Date Title
WO2006052551A3 (en) Micromachined bilayer unit of engineered tissues
EP1802245B8 (en) Ultrasonic surgical instrument
WO2007027788A3 (en) Analyte sensor introducer and methods of use
AU2003231022A1 (en) Improved membrane for use in sutured or sutureless surgical procedures
EP1945104A4 (en) Medical ultrasound system and handpiece and methods for making and tuning
EP1741390B8 (en) Ultrasonic diagnosis device
EP1810619A4 (en) Capacitive ultrasonic transducer and endo cavity ultrasonic diagnosis system using the same
EP1850779B8 (en) Electro-surgical needle apparatus
AU2003277243A1 (en) Tissue mimicking elastography phantoms
AU2003249176A1 (en) Multilayered tissue products
EP1781067A4 (en) CAPACITIVE MICROMACHINED ULTRASONIC TRANSDUCER (cMUT) AND ITS PRODUCTION METHOD
EP1875231B8 (en) Disposable test sensor cartridge
AU2003210867A1 (en) Forming system for the manufacture of thermoplastic nonwoven webs and laminates
AU2003282642A1 (en) Blood testing apparatus
GB2434105B (en) Fibronectin-modified ECM tissue graft constructs and methods for preparation and use thereof
WO2008030873A3 (en) Apparatus and method for pelvic organ prolapse repair
AU2003235155A1 (en) Medical anesthetic needle
EP1591069A4 (en) Surgical instrument, operation system, and anastomotic operation method using the surgical instrument
AU2003267668A1 (en) Medical apparatus
AU2013207571A1 (en) Medical tubing
AU2002951908A0 (en) Medical demonstration
AU2003284701A1 (en) Method of examining blood type and apparatus for examining blood type using the method.
EP1755866B8 (en) Process for the manufacture of a multi-layered polymer body
AU2003900260A0 (en) Ultrasonic transducer device
AU2003302887A1 (en) Solid bio-material for a sensor that detects bio-electric signals through the use of the characteristics and functions of bio-epidermal tissues and epidermal tissues of living organisms and the methods for producing the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05826051

Country of ref document: EP

Kind code of ref document: A2