WO2006055685A3 - Transplantation of human neural cells for treatment of neurodegenerative conditions - Google Patents
Transplantation of human neural cells for treatment of neurodegenerative conditions Download PDFInfo
- Publication number
- WO2006055685A3 WO2006055685A3 PCT/US2005/041631 US2005041631W WO2006055685A3 WO 2006055685 A3 WO2006055685 A3 WO 2006055685A3 US 2005041631 W US2005041631 W US 2005041631W WO 2006055685 A3 WO2006055685 A3 WO 2006055685A3
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- Prior art keywords
- neural
- stem cells
- transplantation
- neurons
- neural stem
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/148—Transforming growth factor alpha [TGF-a]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05851748.3A EP1814979B1 (en) | 2004-11-17 | 2005-11-17 | Transplantation of human neural cells for treatment of neurodegenerative conditions |
JP2007543219A JP5424559B2 (en) | 2004-11-17 | 2005-11-17 | Transplantation of human nerve cells to treat neurodegenerative conditions |
KR1020077012097A KR101429284B1 (en) | 2004-11-17 | 2005-11-17 | Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions |
ES05851748.3T ES2537004T3 (en) | 2004-11-17 | 2005-11-17 | Transplantation of human neural cells for the treatment of neurodegenerative conditions |
IN3629CHN2014 IN2014CN03629A (en) | 2004-11-17 | 2005-11-17 | |
EP15156823.5A EP2913393B8 (en) | 2004-11-17 | 2005-11-17 | Transplantation of human neural cells for treatment of neurodegenerative conditions |
KR1020137020263A KR101505347B1 (en) | 2004-11-17 | 2005-11-17 | Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions |
IL183092A IL183092A (en) | 2004-11-17 | 2007-05-09 | Human neural stem cells for use in treating neurodegenerative conditions |
NO20073078A NO340914B1 (en) | 2004-11-17 | 2007-06-15 | In vitro method of producing a population of nerve stem cells capable of generating neurons in a recipient's spinal cord. |
IL204356A IL204356A (en) | 2004-11-17 | 2010-03-08 | Method comprising use of poly-d-lysine for culturing human neural stem cells |
PH12015501195A PH12015501195A1 (en) | 2004-11-17 | 2015-05-28 | Transplantation of human neural cells for treatment of neurodegenerative conditions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62922004P | 2004-11-17 | 2004-11-17 | |
US62/629,220 | 2018-02-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006055685A2 WO2006055685A2 (en) | 2006-05-26 |
WO2006055685A3 true WO2006055685A3 (en) | 2007-03-15 |
Family
ID=36407743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/041631 WO2006055685A2 (en) | 2004-11-17 | 2005-11-17 | Transplantation of human neural cells for treatment of neurodegenerative conditions |
Country Status (13)
Country | Link |
---|---|
US (6) | US7691629B2 (en) |
EP (2) | EP1814979B1 (en) |
JP (3) | JP5424559B2 (en) |
KR (2) | KR101505347B1 (en) |
CN (2) | CN101084303A (en) |
ES (1) | ES2537004T3 (en) |
HK (1) | HK1202238A1 (en) |
IL (2) | IL183092A (en) |
IN (1) | IN2014CN03629A (en) |
NO (1) | NO340914B1 (en) |
PH (1) | PH12015501195A1 (en) |
RU (2) | RU2434636C2 (en) |
WO (1) | WO2006055685A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
Families Citing this family (41)
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US7838292B1 (en) * | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
KR101505347B1 (en) | 2004-11-17 | 2015-03-23 | 뉴럴스템, 인크. | Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions |
EP1855700B1 (en) * | 2005-03-07 | 2013-10-30 | SanBio, Inc. | Use of neuronal precursor cells for treatment of central nervous system lesions |
GB0822246D0 (en) | 2008-12-05 | 2009-01-14 | Reneuron Ltd | Composition |
EP2379087B1 (en) * | 2008-12-19 | 2014-08-20 | DePuy Synthes Products, LLC | Umbilical cord tissue derived cells for treating neuropathic pain and spasticity |
WO2010071864A1 (en) | 2008-12-19 | 2010-06-24 | Ethicon, Incorporated | Treatment of lung and pulmonary diseases and disorders |
GB0902034D0 (en) * | 2009-02-06 | 2009-03-11 | Reneuron Ltd | Method |
US10386360B2 (en) | 2009-03-13 | 2019-08-20 | University Of Central Florida Research Foundation, Inc. | Bio-microelectromechanical system transducer and associated methods |
BRPI1013409A2 (en) | 2009-03-26 | 2018-01-16 | Advanced Tech And Regenerative Medicine Llc | human umbilical cord tissue cells as therapy for alzheimer's disease |
US8815584B1 (en) | 2009-04-23 | 2014-08-26 | University Of Central Florida Research Foundation, Inc. | Method of co-culturing mammalian muscle cells and motoneurons |
US9163216B1 (en) | 2009-04-23 | 2015-10-20 | University Of Central Florida Research Foundation, Inc. | Method for culturing skeletal muscle for tissue engineering |
US8835168B2 (en) | 2009-04-23 | 2014-09-16 | University Of Central Florida Research Foundation, Inc. | Synthetic mammalian neuromuscular junction and method of making |
US8828721B1 (en) | 2009-05-28 | 2014-09-09 | University Of Central Florida Research Foundation, Inc. | Method of myelinating isolated motoneurons |
US9404140B1 (en) | 2009-11-03 | 2016-08-02 | The University Of Central Florida Research Foundation, Inc. | Patterned cardiomyocyte culture on microelectrode array |
EP2531910B1 (en) | 2010-02-05 | 2015-04-08 | University of Central Florida Research Foundation, Inc. | Methods for identifying points of action in electrically active cells |
KR101765980B1 (en) * | 2010-07-28 | 2017-08-07 | 뉴럴스템, 인크. | Methods for treating and/or reversing neurodegenerative diseases and/or disorders |
US9498554B2 (en) | 2012-07-24 | 2016-11-22 | S.C. Johnson & Son, Inc. | Dispensing device |
US10357517B1 (en) | 2012-10-01 | 2019-07-23 | University Of South Florida | Methods of treating epilepsy using neural stem cells that express nanog, SSEA-4, OCT-4, MIR-34B, MIR-34C and MIR-592 |
RU2515475C1 (en) * | 2012-11-15 | 2014-05-10 | Федеральное государственное бюджетное учреждение науки ИНСТИТУТ ЦИТОЛОГИИ РОССИЙСКОЙ АКАДЕМИИ НАУК | Method for stimulation of endometrial decidua formation experimentally |
US10694747B2 (en) | 2012-11-21 | 2020-06-30 | S. C. Johnson & Son, Inc. | Dispenser comprising only one single hinge |
WO2014120952A1 (en) | 2013-01-30 | 2014-08-07 | University Of Central Florida Research Foundation, Inc. | Devices and systems for mimicking heart function |
WO2014138003A1 (en) * | 2013-03-04 | 2014-09-12 | Neuralstem, Inc. | Compositions comprising an immunosuppressive drug and/or neural stem cells and methods of using same for the treatment of neurodegenerative diseases and/or disorders |
CA2910394A1 (en) | 2013-04-26 | 2014-10-30 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
CN104278008B (en) | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | Method, kit and application for preparing pluripotent stem cells through small molecule compound treatment |
KR101675123B1 (en) * | 2014-06-27 | 2016-11-14 | 연세대학교 산학협력단 | A Composition for Treating Ischemic Diseases or Neuroinflammatory Diseases Comprising PSA-NCAM-positive Neural Precursor Cells as Active Ingredient |
JP6889107B2 (en) * | 2014-06-27 | 2021-06-18 | アンジオクライン・バイオサイエンス・インコーポレイテッドAngiocrine Bioscience, Inc. | Nervous system cells expressing adenovirus E4ORF1, and methods for producing and using them. |
US10935541B2 (en) | 2014-08-07 | 2021-03-02 | University Of Central Florida Research Foundation, Inc. | Devices and methods comprising neuromuscular junctions |
EP3209306B1 (en) | 2014-10-20 | 2024-04-24 | Neuralstem, Inc. | Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof |
US10286009B2 (en) * | 2015-05-16 | 2019-05-14 | Asterias Biotherapeutics, Inc. | Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury |
JP6780870B2 (en) | 2015-08-13 | 2020-11-04 | 北昊干細胞与再生医学研究院有限公司Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. | Induced expanded pluripotent stem cells, how to make and use |
EP3384007B1 (en) | 2015-11-30 | 2024-03-27 | Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd. | Improved methods for reprograming non-pluripotent cells into pluripotent stem cells |
WO2017135753A1 (en) * | 2016-02-05 | 2017-08-10 | 경북대학교 산학협력단 | Pharmaceutical composition containing stem cell in which vascular endothelial growth factor is overexpressed as effective ingredient for preventing or treating neurodegenerative disease |
JP2019509744A (en) | 2016-03-30 | 2019-04-11 | アステリアス バイオセラピューティクス インコーポレイテッド | Oligodendrocyte progenitor cell composition |
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CN113474451A (en) | 2019-01-23 | 2021-10-01 | 阿斯特里亚斯生物疗法股份有限公司 | Back-derived oligodendrocyte precursor cells from human pluripotent stem cells |
CN111494422B (en) * | 2019-01-29 | 2022-04-29 | 中国科学院遗传与发育生物学研究所 | Product for treating spinal cord injury and application thereof |
CN115166260B (en) * | 2022-07-11 | 2023-06-13 | 东南大学 | Application of vitamin D binding protein in exosome derived from blood plasma brain cells in diagnosis of depression |
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