WO2006074351A3 - Reversible nucleotide terminators and uses thereof - Google Patents
Reversible nucleotide terminators and uses thereof Download PDFInfo
- Publication number
- WO2006074351A3 WO2006074351A3 PCT/US2006/000432 US2006000432W WO2006074351A3 WO 2006074351 A3 WO2006074351 A3 WO 2006074351A3 US 2006000432 W US2006000432 W US 2006000432W WO 2006074351 A3 WO2006074351 A3 WO 2006074351A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleotide terminators
- reversible nucleotide
- reversible
- terminators
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Abstract
The present invention provides nucleotide analogs which are useful in one or more DNA sequencing techniques.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007550492A JP2008526877A (en) | 2005-01-05 | 2006-01-05 | Reversible nucleotide terminator and use thereof |
EP06733635A EP1879906A4 (en) | 2005-01-05 | 2006-01-05 | Reversible nucleotide terminators and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64154905P | 2005-01-05 | 2005-01-05 | |
US60/641,549 | 2005-01-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006074351A2 WO2006074351A2 (en) | 2006-07-13 |
WO2006074351A3 true WO2006074351A3 (en) | 2007-01-18 |
Family
ID=36648200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/000432 WO2006074351A2 (en) | 2005-01-05 | 2006-01-05 | Reversible nucleotide terminators and uses thereof |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1879906A4 (en) |
JP (1) | JP2008526877A (en) |
WO (1) | WO2006074351A2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
US9228228B2 (en) | 2006-10-27 | 2016-01-05 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
US9334490B2 (en) | 2006-11-09 | 2016-05-10 | Complete Genomics, Inc. | Methods and compositions for large-scale analysis of nucleic acids using DNA deletions |
US9476054B2 (en) | 2005-06-15 | 2016-10-25 | Complete Genomics, Inc. | Two-adaptor library for high-throughput sequencing on DNA arrays |
US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2611671C (en) | 2005-06-15 | 2013-10-08 | Callida Genomics, Inc. | Single molecule arrays for genetic and chemical analysis |
JP5180845B2 (en) | 2006-02-24 | 2013-04-10 | カリダ・ジェノミックス・インコーポレイテッド | High-throughput genomic sequencing on DNA arrays |
US11940413B2 (en) | 2007-02-05 | 2024-03-26 | IsoPlexis Corporation | Methods and devices for sequencing nucleic acids in smaller batches |
US20090062132A1 (en) | 2007-08-29 | 2009-03-05 | Borner Scott R | Alternative nucleic acid sequencing methods |
CN105349647B (en) | 2007-10-30 | 2020-08-28 | 完整基因有限公司 | Methods for high throughput sequencing of nucleic acids |
EP2565279B1 (en) | 2007-12-05 | 2014-12-03 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
CA2765427A1 (en) | 2009-06-15 | 2010-12-23 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
KR101107315B1 (en) * | 2009-09-29 | 2012-01-20 | 한국과학기술연구원 | A DNA sequencing method using novel nucleoside triphosphates with a fluorescent 3'-O-blocking group as reversible terminators |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
PT2556171E (en) | 2010-04-05 | 2015-12-21 | Prognosys Biosciences Inc | Spatially encoded biological assays |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
HUE056246T2 (en) | 2011-09-23 | 2022-02-28 | Illumina Inc | Compositions for nucleic acid sequencing |
US10837879B2 (en) | 2011-11-02 | 2020-11-17 | Complete Genomics, Inc. | Treatment for stabilizing nucleic acid arrays |
EA034342B1 (en) * | 2012-09-04 | 2020-01-29 | КАБУСИКИ КАЙСЯ ДиЭнЭйФОРМ | Compound, nucleic acid, labeling substance, and detection method |
WO2014210223A1 (en) | 2013-06-25 | 2014-12-31 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
JP6261027B2 (en) * | 2013-07-23 | 2018-01-17 | 国立大学法人東京工業大学 | 2'-O-carbamoyl modified nucleoside triphosphates |
EP2876166B1 (en) * | 2013-11-20 | 2016-12-14 | Roche Diagnostics GmbH | New compound for sequencing by synthesis |
CN107532207B (en) | 2015-04-10 | 2021-05-07 | 空间转录公司 | Spatially differentiated, multiplexed nucleic acid analysis of biological samples |
EP3596099A4 (en) | 2017-03-06 | 2020-12-09 | Singular Genomics Systems, Inc. | Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps |
WO2019067635A1 (en) * | 2017-09-27 | 2019-04-04 | Ultima Genomics, Inc. | Methods and systems for nucleic acid sequencing |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5852182A (en) * | 1990-01-11 | 1998-12-22 | Isis Pharmaceuticals Inc. | Thiol-derivatized oligonucleosides |
US6265588B1 (en) * | 1997-01-28 | 2001-07-24 | Aventis Pharma Deutschland Gmbh | Isoxazole and crotonamide derivatives and their use as pharmaceuticals and diagnostics |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6087482A (en) * | 1990-07-27 | 2000-07-11 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5646269A (en) * | 1994-04-28 | 1997-07-08 | Gilead Sciences, Inc. | Method for oligonucleotide analog synthesis |
SE9500342D0 (en) * | 1995-01-31 | 1995-01-31 | Marek Kwiatkowski | Novel chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation |
ATE469699T1 (en) * | 1999-02-23 | 2010-06-15 | Caliper Life Sciences Inc | MANIPULATION OF MICROPARTICLES IN MICROFLUID SYSTEMS |
US6309836B1 (en) * | 1999-10-05 | 2001-10-30 | Marek Kwiatkowski | Compounds for protecting hydroxyls and methods for their use |
US7057026B2 (en) * | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
DE10214395A1 (en) * | 2002-03-30 | 2003-10-23 | Dmitri Tcherkassov | Parallel sequencing of nucleic acid segments, useful for detecting single-nucleotide polymorphisms, by single-base extensions with labeled nucleotide |
-
2006
- 2006-01-05 JP JP2007550492A patent/JP2008526877A/en active Pending
- 2006-01-05 WO PCT/US2006/000432 patent/WO2006074351A2/en active Application Filing
- 2006-01-05 EP EP06733635A patent/EP1879906A4/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5852182A (en) * | 1990-01-11 | 1998-12-22 | Isis Pharmaceuticals Inc. | Thiol-derivatized oligonucleosides |
US6265588B1 (en) * | 1997-01-28 | 2001-07-24 | Aventis Pharma Deutschland Gmbh | Isoxazole and crotonamide derivatives and their use as pharmaceuticals and diagnostics |
Non-Patent Citations (1)
Title |
---|
See also references of EP1879906A4 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9476054B2 (en) | 2005-06-15 | 2016-10-25 | Complete Genomics, Inc. | Two-adaptor library for high-throughput sequencing on DNA arrays |
US9228228B2 (en) | 2006-10-27 | 2016-01-05 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
US9334490B2 (en) | 2006-11-09 | 2016-05-10 | Complete Genomics, Inc. | Methods and compositions for large-scale analysis of nucleic acids using DNA deletions |
US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
Also Published As
Publication number | Publication date |
---|---|
EP1879906A4 (en) | 2009-07-22 |
WO2006074351A2 (en) | 2006-07-13 |
EP1879906A2 (en) | 2008-01-23 |
JP2008526877A (en) | 2008-07-24 |
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