WO2006075213A8 - Nmr mas probe with cryogenically cooled critical circuit components - Google Patents

Nmr mas probe with cryogenically cooled critical circuit components

Info

Publication number
WO2006075213A8
WO2006075213A8 PCT/IB2005/053854 IB2005053854W WO2006075213A8 WO 2006075213 A8 WO2006075213 A8 WO 2006075213A8 IB 2005053854 W IB2005053854 W IB 2005053854W WO 2006075213 A8 WO2006075213 A8 WO 2006075213A8
Authority
WO
WIPO (PCT)
Prior art keywords
tuning
zone
mas probe
cold zone
circuit
Prior art date
Application number
PCT/IB2005/053854
Other languages
French (fr)
Other versions
WO2006075213A3 (en
WO2006075213A2 (en
Inventor
David F Doty
Original Assignee
Doty Scient Inc
David F Doty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Doty Scient Inc, David F Doty filed Critical Doty Scient Inc
Publication of WO2006075213A2 publication Critical patent/WO2006075213A2/en
Publication of WO2006075213A3 publication Critical patent/WO2006075213A3/en
Publication of WO2006075213A8 publication Critical patent/WO2006075213A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/31—Temperature control thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
    • G01R33/3628—Tuning/matching of the transmit/receive coil
    • G01R33/3635—Multi-frequency operation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/43—Electric condenser making

Abstract

A novel MAS probe is disclosed for obtaining a substantial improvement in signal to noise (S/N) in triple-resonance high-resolution (HR) magic-angle-spinning (MAS) NMR of samples near room temperature (RT) in high field magnets, especially where the RT shim bore is less than 55 mm.  Critical circuit components other than the sample coils, including both high-power capacitors and inductors for one or more channels are located in a small, thermally insulated, cold zone immediately below the sample spinner assembly.  Cooling these components to 100 K allows their thermal noise power to be conveniently reduced by a factor of three or more.  Variable capacitors for fine tuning are located in an RT tuning zone below the cold zone.  The circuit is designed such that the currents, voltages, and standing wave ratio (SWR) in circuit tuning elements in the RT tuning zone are relatively low, so rf losses and noise contributions below the cold zone may be only a few percent.  The MAS probe is also compatible with magic angle gradients, automatic sample change, multi-nuclear tuning, variable temperature operation, field locking, and optical spin rate detection.
PCT/IB2005/053854 2005-01-12 2005-11-22 Nmr mas probe with cryogenically cooled critical circuit components WO2006075213A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59342205P 2005-01-12 2005-01-12
US60/593,422 2005-01-12
US10/906,379 2005-02-17
US10/906,379 US7151374B2 (en) 2005-01-12 2005-02-17 NMR MAS probe with cryogenically cooled critical circuit components

Publications (3)

Publication Number Publication Date
WO2006075213A2 WO2006075213A2 (en) 2006-07-20
WO2006075213A3 WO2006075213A3 (en) 2006-12-07
WO2006075213A8 true WO2006075213A8 (en) 2007-08-23

Family

ID=36652634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/053854 WO2006075213A2 (en) 2005-01-12 2005-11-22 Nmr mas probe with cryogenically cooled critical circuit components

Country Status (2)

Country Link
US (2) US7151374B2 (en)
WO (1) WO2006075213A2 (en)

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US7151374B2 (en) * 2005-01-12 2006-12-19 Doty Scientific, Inc. NMR MAS probe with cryogenically cooled critical circuit components
WO2006085261A2 (en) * 2005-02-10 2006-08-17 Doty Scientific, Inc. Nmr cryomas probe for high-field wide-bore magnets
DE102005030745B4 (en) * 2005-06-29 2008-05-29 Schleifring Und Apparatebau Gmbh RF coils for magnetic resonance imaging
US7456630B2 (en) * 2005-09-22 2008-11-25 U Chicago Argonne Llc NMR characterization of thin films
DE102006020774B3 (en) * 2006-05-03 2008-02-07 Bruker Biospin Ag Cooled, detachable NMR probe head
WO2008029408A1 (en) * 2006-09-08 2008-03-13 Arbel Medical Ltd. Method and device for combined treatment
WO2008087649A1 (en) * 2007-01-19 2008-07-24 Arbel Medical Ltd. Thermally insulated needles for dermatological applications
US20100162730A1 (en) * 2007-06-14 2010-07-01 Arbel Medical Ltd. Siphon for delivery of liquid cryogen from dewar flask
WO2009007963A1 (en) * 2007-07-09 2009-01-15 Arbel Medical Ltd. Cryosheath
WO2009066292A1 (en) * 2007-11-21 2009-05-28 Arbel Medical Ltd. Pumping unit for delivery of liquid medium from a vessel
US20110015624A1 (en) * 2008-01-15 2011-01-20 Icecure Medical Ltd. Cryosurgical instrument insulating system
WO2009128014A1 (en) 2008-04-16 2009-10-22 Arbel Medical Ltd Cryosurgical instrument with enhanced heat exchange
US20100281917A1 (en) * 2008-11-05 2010-11-11 Alexander Levin Apparatus and Method for Condensing Contaminants for a Cryogenic System
US7967814B2 (en) 2009-02-05 2011-06-28 Icecure Medical Ltd. Cryoprobe with vibrating mechanism
US8162812B2 (en) 2009-03-12 2012-04-24 Icecure Medical Ltd. Combined cryotherapy and brachytherapy device and method
US20100305439A1 (en) * 2009-05-27 2010-12-02 Eyal Shai Device and Method for Three-Dimensional Guidance and Three-Dimensional Monitoring of Cryoablation
US7967815B1 (en) 2010-03-25 2011-06-28 Icecure Medical Ltd. Cryosurgical instrument with enhanced heat transfer
JP5423605B2 (en) * 2010-04-02 2014-02-19 株式会社 Ｊｅｏｌ Ｒｅｓｏｎａｎｃｅ Sample tube for solid-state NMR and solid-state NMR measurement method
US7938822B1 (en) 2010-05-12 2011-05-10 Icecure Medical Ltd. Heating and cooling of cryosurgical instrument using a single cryogen
US8080005B1 (en) 2010-06-10 2011-12-20 Icecure Medical Ltd. Closed loop cryosurgical pressure and flow regulated system
TWI429935B (en) * 2010-08-09 2014-03-11 Shieh Yueh Yang Low magnetic field resonance system
DE212012000043U1 (en) * 2011-02-01 2013-09-06 Aspect Magnet Technologies Ltd. Low-field magnetic resonance system (LF-MRS) for generating a magnetic resonance image
FR2981442A1 (en) * 2011-10-17 2013-04-19 Bruker Biospin COLD GAS SUPPLY DEVICE AND NMR INSTALLATION COMPRISING SUCH A DEVICE
WO2014064550A1 (en) 2012-10-23 2014-05-01 Doty Scientific, Inc. Stabilizing control of a saturated cold gas stream
DE102015222935B3 (en) * 2015-11-20 2017-03-09 Bruker Biospin Ag Angle-adjustable measuring head of an NMR MAS apparatus
DE102016218772A1 (en) * 2016-09-28 2018-03-29 Bruker Biospin Gmbh Improved tempering of an NMR MAS rotor
JP6931565B2 (en) * 2017-07-24 2021-09-08 国立研究開発法人物質・材料研究機構 Magnetic resonance signal detection module
DE102019202001B3 (en) * 2019-02-14 2020-06-25 Bruker Biospin Gmbh MAS probe head with thermally insulated sample chamber
US11633224B2 (en) 2020-02-10 2023-04-25 Icecure Medical Ltd. Cryogen pump

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US7151374B2 (en) * 2005-01-12 2006-12-19 Doty Scientific, Inc. NMR MAS probe with cryogenically cooled critical circuit components
WO2006085261A2 (en) * 2005-02-10 2006-08-17 Doty Scientific, Inc. Nmr cryomas probe for high-field wide-bore magnets

Also Published As

Publication number Publication date
US7498812B2 (en) 2009-03-03
US7151374B2 (en) 2006-12-19
WO2006075213A3 (en) 2006-12-07
WO2006075213A2 (en) 2006-07-20
US20080136413A1 (en) 2008-06-12
US20060152221A1 (en) 2006-07-13

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