WO2006078242A1 - Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms - Google Patents
Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms Download PDFInfo
- Publication number
- WO2006078242A1 WO2006078242A1 PCT/US2005/001619 US2005001619W WO2006078242A1 WO 2006078242 A1 WO2006078242 A1 WO 2006078242A1 US 2005001619 W US2005001619 W US 2005001619W WO 2006078242 A1 WO2006078242 A1 WO 2006078242A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- flowable material
- core
- mold
- valve stem
- mold plate
- Prior art date
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- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 150000003657 tungsten Chemical class 0.000 description 1
- 229940072651 tylenol Drugs 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
- 239000002996 urinary tract agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/27—Sprue channels ; Runner channels or runner nozzles
- B29C45/278—Nozzle tips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/27—Sprue channels ; Runner channels or runner nozzles
- B29C45/28—Closure devices therefor
- B29C45/2806—Closure devices therefor consisting of needle valve systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/007—Marking tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/27—Sprue channels ; Runner channels or runner nozzles
- B29C2045/2766—Heat insulation between nozzle and mould
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/27—Sprue channels ; Runner channels or runner nozzles
- B29C45/278—Nozzle tips
- B29C2045/2787—Nozzle tips made of at least 2 different materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/27—Sprue channels ; Runner channels or runner nozzles
- B29C45/28—Closure devices therefor
- B29C45/2806—Closure devices therefor consisting of needle valve systems
- B29C2045/2858—Materials or coatings therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/03—Injection moulding apparatus
- B29C45/04—Injection moulding apparatus using movable moulds or mould halves
- B29C45/06—Injection moulding apparatus using movable moulds or mould halves mounted on a turntable, i.e. on a rotating support having a rotating axis parallel to the mould opening, closing or clamping direction
- B29C45/062—Injection moulding apparatus using movable moulds or mould halves mounted on a turntable, i.e. on a rotating support having a rotating axis parallel to the mould opening, closing or clamping direction carrying mould halves co-operating with fixed mould halves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/16—Making multilayered or multicoloured articles
- B29C45/1615—The materials being injected at different moulding stations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
- B29K2105/0035—Medical or pharmaceutical agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/677,984 US20050074514A1 (en) | 2003-10-02 | 2003-10-02 | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
PCT/US2005/001619 WO2006078242A1 (en) | 2003-10-02 | 2005-01-21 | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
BRPI0519796-1A BRPI0519796A2 (en) | 2005-01-21 | 2005-01-21 | zero-cycle molding systems, methods and apparatus for manufacturing dosage forms |
CA002594880A CA2594880A1 (en) | 2003-10-02 | 2005-01-21 | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
EP05711628A EP1843733A1 (en) | 2003-10-02 | 2005-01-21 | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/677,984 US20050074514A1 (en) | 2003-10-02 | 2003-10-02 | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
PCT/US2005/001619 WO2006078242A1 (en) | 2003-10-02 | 2005-01-21 | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006078242A1 true WO2006078242A1 (en) | 2006-07-27 |
Family
ID=40010489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/001619 WO2006078242A1 (en) | 2003-10-02 | 2005-01-21 | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
Country Status (4)
Country | Link |
---|---|
US (1) | US20050074514A1 (en) |
EP (1) | EP1843733A1 (en) |
CA (1) | CA2594880A1 (en) |
WO (1) | WO2006078242A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008155650A2 (en) * | 2007-06-21 | 2008-12-24 | Sinergetic S.R.L. | Method and means for moulding by injection or extrusion |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04002980A (en) * | 2001-09-28 | 2005-06-20 | Johnson & Johnson | Dosage forms having an inner core and outer shell with different shapes. |
US7404708B2 (en) * | 2004-12-07 | 2008-07-29 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
US7530804B2 (en) * | 2004-12-07 | 2009-05-12 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
US20060233882A1 (en) * | 2005-04-15 | 2006-10-19 | Sowden Harry S | Osmotic dosage form |
US8673352B2 (en) * | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
US20070048366A1 (en) * | 2005-08-26 | 2007-03-01 | Jen-Chi Chen | Gelatin-based coatings having improved durability |
DE102007026752A1 (en) * | 2007-06-09 | 2008-12-11 | Ivonne Silvester | Device for storage and administration of active ingredients |
EP2364143A1 (en) * | 2008-10-31 | 2011-09-14 | McNeil-PPC, Inc. | Osmotic tablet with a compressed outer coating |
EP2420374A1 (en) * | 2010-08-20 | 2012-02-22 | Nestec S.A. | An in-mould labelled container |
KR101359469B1 (en) | 2012-05-08 | 2014-02-13 | 창성소프트젤 주식회사 | A manufacturing equipment of vegetable gelatin capsule |
WO2012157933A2 (en) * | 2011-05-18 | 2012-11-22 | 창성소프트젤 주식회사 | Equipment for manufacturing a vegetable gelatin capsule |
US9550304B2 (en) * | 2013-01-07 | 2017-01-24 | The Procter & Gamble Company | Process for recycling multicompartment unit dose articles |
US20170354609A1 (en) * | 2016-06-10 | 2017-12-14 | Massachusetts Institute Of Technology | Pharmaceutical tablet coating process by injection molding process technology |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4406609A (en) * | 1981-07-15 | 1983-09-27 | Gellert Jobst U | Valve pin and method of manufacture |
US4576284A (en) | 1983-12-02 | 1986-03-18 | Warner-Lambert Company | Closing of filled capsules |
US4738817A (en) | 1983-11-17 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from hydrophilic polymers |
US4820524A (en) | 1987-02-20 | 1989-04-11 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US5228916A (en) | 1990-11-05 | 1993-07-20 | Mcneil-Ppc, Inc. | Apparatus for creating a gelatin coating |
US5415868A (en) | 1993-06-09 | 1995-05-16 | L. Perrigo Company | Caplets with gelatin cover and process for making same |
US5436026A (en) | 1990-11-05 | 1995-07-25 | Mcneil-Ppc, Inc. | Discharge and transfer system for apparatus for gelatin coating tablets |
US5538125A (en) | 1990-11-05 | 1996-07-23 | Mcneil-Ppc, Inc. | Indexing and feeding systems for apparatus for gelatin coating tablets |
US5679406A (en) | 1990-11-05 | 1997-10-21 | Mcneil-Ppc, Inc. | Tablet dipping systems for apparatus for gelatin coating tablets |
US6343922B1 (en) * | 1998-04-21 | 2002-02-05 | Synventive Molding Solutions | Manifold system having flow control using pressure transducers |
WO2003028619A2 (en) * | 2001-09-28 | 2003-04-10 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
WO2003045662A1 (en) * | 2001-11-26 | 2003-06-05 | S.I.P.A Societa' Industrializzazione Progettazione Automazione S.P.A. | Improvement in machines for injection-moulding of plastic material, and corresponding process of implementation |
US20030102595A1 (en) * | 2001-12-04 | 2003-06-05 | Puniello Paul A. | Method of forming golf balls from surface-roughened molds |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2307371A (en) * | 1941-08-13 | 1943-01-05 | Ray O Vac Co | Molding process |
GB972128A (en) * | 1960-01-21 | 1964-10-07 | Wellcome Found | Pellets for supplying biologically active substances to ruminants and the manufacture of such pellets |
US3832252A (en) * | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
US3726622A (en) * | 1971-08-20 | 1973-04-10 | Wolverine Pentronix | Compacting apparatus |
DE2157465C3 (en) * | 1971-11-19 | 1975-04-24 | Werner & Pfleiderer, 7000 Stuttgart | Filling device for a hydraulic block press |
US4230693A (en) * | 1975-04-21 | 1980-10-28 | Armour-Dial, Inc. | Antacid tablets and processes for their preparation |
GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
CA1086014A (en) * | 1977-04-29 | 1980-09-23 | Jobst U. Gellert | Thermal valve pin |
GB2030042A (en) * | 1978-09-21 | 1980-04-02 | Beecham Group Ltd | Antacid fondant |
US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
US4271206A (en) * | 1979-10-26 | 1981-06-02 | General Foods Corporation | Gasified candy having a predetermined shape |
US4273793A (en) * | 1979-10-26 | 1981-06-16 | General Foods Corporation | Apparatus and process for the preparation of gasified confectionaries by pressurized injection molding |
US4473526A (en) * | 1980-01-23 | 1984-09-25 | Eugen Buhler | Method of manufacturing dry-pressed molded articles |
US4289191A (en) * | 1980-04-02 | 1981-09-15 | United Technologies Corporation | Injection molding thermoplastic patterns having ceramic cores |
US4292017A (en) * | 1980-07-09 | 1981-09-29 | Doepel Wallace A | Apparatus for compressing tablets |
US4362757A (en) * | 1980-10-22 | 1982-12-07 | Amstar Corporation | Crystallized, readily water dispersible sugar product containing heat sensitive, acidic or high invert sugar substances |
US5002970A (en) * | 1981-07-31 | 1991-03-26 | Eby Iii George A | Flavor masked ionizable zinc compositions for oral absorption |
US4372942A (en) * | 1981-08-13 | 1983-02-08 | Beecham Inc. | Candy base and liquid center hard candy made therefrom |
DE3144678A1 (en) * | 1981-11-10 | 1983-05-19 | Eugen Dipl.-Ing. 8871 Burtenbach Bühler | METHOD AND DEVICE FOR THE PRODUCTION OF MOLDINGS FROM A GIANT CAPABILITY |
US4882167A (en) * | 1983-05-31 | 1989-11-21 | Jang Choong Gook | Dry direct compression compositions for controlled release dosage forms |
US4749575A (en) * | 1983-10-03 | 1988-06-07 | Bio-Dar Ltd. | Microencapsulated medicament in sweet matrix |
US4781714A (en) * | 1983-11-02 | 1988-11-01 | Alza Corporation | Dispenser for delivering thermo-responsive composition |
DE3404108A1 (en) * | 1984-02-07 | 1985-08-14 | Kilian & Co GmbH, 5000 Köln | TABLET PRESS |
US4518335A (en) * | 1984-03-14 | 1985-05-21 | Allied Corporation | Dilatant mold and dilatant molding apparatus |
JPS60217106A (en) * | 1984-04-12 | 1985-10-30 | 高橋 信之 | Inorganic-powder freezing molding method |
DK8603837A (en) * | 1985-08-13 | 1987-02-14 | ||
US5229164A (en) * | 1985-12-19 | 1993-07-20 | Capsoid Pharma Gmbh | Process for producing individually dosed administration forms |
IE58401B1 (en) * | 1986-06-20 | 1993-09-08 | Elan Corp Plc | Controlled absorption pharmaceutical composition |
US4757090A (en) * | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4762719A (en) * | 1986-08-07 | 1988-08-09 | Mark Forester | Powder filled cough product |
CA1290526C (en) * | 1986-11-07 | 1991-10-15 | Marianne Wieser | Mold and die operation |
US4813818A (en) * | 1987-08-25 | 1989-03-21 | Michael Sanzone | Apparatus and method for feeding powdered materials |
US4851226A (en) * | 1987-11-16 | 1989-07-25 | Mcneil Consumer Products Company | Chewable medicament tablet containing means for taste masking |
US4929446A (en) * | 1988-04-19 | 1990-05-29 | American Cyanamid Company | Unit dosage form |
DE3822095A1 (en) * | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | NEW MEDICAMENT FORMULATION AND METHOD FOR THE PRODUCTION THEREOF |
US4906478A (en) * | 1988-12-12 | 1990-03-06 | Valentine Enterprises, Inc. | Simethicone/calcium silicate composition |
CA1292848C (en) * | 1989-02-14 | 1991-12-10 | Jobst Ulrich Gellert | Injection molding system having a valve member with a ribbed insulative portion |
US5146730A (en) * | 1989-09-20 | 1992-09-15 | Banner Gelatin Products Corp. | Film-enrobed unitary-core medicament and the like |
DK469989D0 (en) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | PHARMACEUTICAL PREPARATION |
US5275822A (en) * | 1989-10-19 | 1994-01-04 | Valentine Enterprises, Inc. | Defoaming composition |
US5223266A (en) * | 1990-01-24 | 1993-06-29 | Alza Corporation | Long-term delivery device with early startup |
US4980169A (en) * | 1990-05-03 | 1990-12-25 | Warner-Lambert Company | Flavor enhancing and increasing efficacy of cough drops |
US5213738A (en) * | 1990-05-15 | 1993-05-25 | L. Perrigo Company | Method for making a capsule-shaped tablet |
US5089270A (en) * | 1990-05-15 | 1992-02-18 | L. Perrigo Company | Capsule-shaped tablet |
US5075114A (en) * | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
US5464631A (en) * | 1990-06-27 | 1995-11-07 | Warner-Lambert Company | Encapsulated dosage forms |
NZ241613A (en) * | 1991-02-27 | 1993-06-25 | Janssen Pharmaceutica Nv | Highlighting intagliations in tablets |
US5286497A (en) * | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
US5326570A (en) * | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
US5200191A (en) * | 1991-09-11 | 1993-04-06 | Banner Gelatin Products Corp. | Softgel manufacturing process |
US5200195A (en) * | 1991-12-06 | 1993-04-06 | Alza Corporation | Process for improving dosage form delivery kinetics |
US5317849A (en) * | 1992-08-07 | 1994-06-07 | Sauter Manufacturing Corporation | Encapsulation equipment and method |
US5391378A (en) * | 1993-02-22 | 1995-02-21 | Elizabeth-Hata International, Inc. | Two-part medicinal tablet and method of manufacture |
JP2524955B2 (en) * | 1993-04-22 | 1996-08-14 | トーワ株式会社 | Method and apparatus for resin sealing molding of electronic parts |
DK0621032T3 (en) * | 1993-04-23 | 2000-10-23 | Novartis Ag | Medicinal product with controlled release |
US5622719A (en) * | 1993-09-10 | 1997-04-22 | Fuisz Technologies Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
DE4341442C2 (en) * | 1993-12-04 | 1998-11-05 | Lohmann Therapie Syst Lts | Device for the controlled release of active substances and their use |
US5614578A (en) * | 1994-10-28 | 1997-03-25 | Alza Corporation | Injection-molded dosage form |
DK0824344T3 (en) * | 1995-05-09 | 2005-08-15 | Phoqus Pharmaceuticals Ltd | Powdered composition for electrostatic coating of pharmaceutical substrates |
US5578336A (en) * | 1995-06-07 | 1996-11-26 | Monte; Woodrow C. | Confection carrier for vitamins, enzymes, phytochemicals and ailmentary vegetable compositions and method of making |
US5614207A (en) * | 1995-06-30 | 1997-03-25 | Mcneil-Ppc, Inc. | Dry mouth lozenge |
US5824338A (en) * | 1996-08-19 | 1998-10-20 | L. Perrigo Company | Caplet and gelatin covering therefor |
FR2752523B1 (en) * | 1996-08-26 | 1998-10-02 | Oreal | KERATINIC FIBER DYEING COMPOSITIONS CONTAINING PYRAZOLO- (3,4-D) -THIAZOLES THEIR USE FOR DYEING AS COUPLERS, DYEING METHOD |
US5837301A (en) * | 1997-04-28 | 1998-11-17 | Husky Injection Molding Systems Ltd. | Injection molding machine having a high speed turret |
US6149939A (en) * | 1997-05-09 | 2000-11-21 | Strumor; Mathew A. | Healthful dissolvable oral tablets, and mini-bars |
US6103260A (en) * | 1997-07-17 | 2000-08-15 | Mcneil-Ppc, Inc. | Simethicone/anhydrous calcium phosphate compositions |
US5942034A (en) * | 1997-07-24 | 1999-08-24 | Bayer Corporation | Apparatus for the gelatin coating of medicaments |
US6365185B1 (en) * | 1998-03-26 | 2002-04-02 | University Of Cincinnati | Self-destructing, controlled release peroral drug delivery system |
US6103257A (en) * | 1998-07-17 | 2000-08-15 | Num-Pop, Inc. | System for delivering pharmaceuticals to the buccal mucosa |
US6200590B1 (en) * | 1998-08-10 | 2001-03-13 | Naphcare, Inc. | Controlled, phased-release suppository and its method of production |
DE19840256A1 (en) * | 1998-09-03 | 2000-03-09 | Basf Ag | Widely applicable, continuous method for preparing coated solid dosage forms, comprises extruding mixture of drug and thermoplastic binder then applying coating composition in liquid or vapor form |
US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
US6174547B1 (en) * | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
US6428305B2 (en) * | 1998-10-13 | 2002-08-06 | Husky Injection Molding Systems Ltd. | Injection molding nozzle tip insulator and injection molding device |
US6135757A (en) * | 1998-10-16 | 2000-10-24 | Husky Injection Systems Ltd. | Valve gated injection molding system |
US20010055613A1 (en) * | 1998-10-21 | 2001-12-27 | Beth A. Burnside | Oral pulsed dose drug delivery system |
US6270805B1 (en) * | 1998-11-06 | 2001-08-07 | Andrx Pharmaceuticals, Inc. | Two pellet controlled release formulation for water soluble drugs which contains an alkaline metal stearate |
US6248760B1 (en) * | 1999-04-14 | 2001-06-19 | Paul C Wilhelmsen | Tablet giving rapid release of nicotine for transmucosal administration |
US20020028240A1 (en) * | 2000-04-17 | 2002-03-07 | Toyohiro Sawada | Timed-release compression-coated solid composition for oral administration |
US7323192B2 (en) * | 2001-09-28 | 2008-01-29 | Mcneil-Ppc, Inc. | Immediate release tablet |
US6609902B1 (en) * | 2002-11-12 | 2003-08-26 | Husky Injection Molding Systems Ltd. | Injection molding nozzle |
US7189071B2 (en) * | 2003-02-12 | 2007-03-13 | Mold-Masters Limited | Telescopic manifold nozzle seal |
-
2003
- 2003-10-02 US US10/677,984 patent/US20050074514A1/en not_active Abandoned
-
2005
- 2005-01-21 CA CA002594880A patent/CA2594880A1/en not_active Abandoned
- 2005-01-21 EP EP05711628A patent/EP1843733A1/en not_active Withdrawn
- 2005-01-21 WO PCT/US2005/001619 patent/WO2006078242A1/en active Application Filing
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4406609A (en) * | 1981-07-15 | 1983-09-27 | Gellert Jobst U | Valve pin and method of manufacture |
US4738817A (en) | 1983-11-17 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from hydrophilic polymers |
US4576284A (en) | 1983-12-02 | 1986-03-18 | Warner-Lambert Company | Closing of filled capsules |
US4820524A (en) | 1987-02-20 | 1989-04-11 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US5436026A (en) | 1990-11-05 | 1995-07-25 | Mcneil-Ppc, Inc. | Discharge and transfer system for apparatus for gelatin coating tablets |
US5228916A (en) | 1990-11-05 | 1993-07-20 | Mcneil-Ppc, Inc. | Apparatus for creating a gelatin coating |
US5538125A (en) | 1990-11-05 | 1996-07-23 | Mcneil-Ppc, Inc. | Indexing and feeding systems for apparatus for gelatin coating tablets |
US5679406A (en) | 1990-11-05 | 1997-10-21 | Mcneil-Ppc, Inc. | Tablet dipping systems for apparatus for gelatin coating tablets |
US5415868A (en) | 1993-06-09 | 1995-05-16 | L. Perrigo Company | Caplets with gelatin cover and process for making same |
US6343922B1 (en) * | 1998-04-21 | 2002-02-05 | Synventive Molding Solutions | Manifold system having flow control using pressure transducers |
WO2003028619A2 (en) * | 2001-09-28 | 2003-04-10 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
WO2003045662A1 (en) * | 2001-11-26 | 2003-06-05 | S.I.P.A Societa' Industrializzazione Progettazione Automazione S.P.A. | Improvement in machines for injection-moulding of plastic material, and corresponding process of implementation |
US20030102595A1 (en) * | 2001-12-04 | 2003-06-05 | Puniello Paul A. | Method of forming golf balls from surface-roughened molds |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008155650A2 (en) * | 2007-06-21 | 2008-12-24 | Sinergetic S.R.L. | Method and means for moulding by injection or extrusion |
WO2008155650A3 (en) * | 2007-06-21 | 2009-02-12 | Sinergetic S R L | Method and means for moulding by injection or extrusion |
Also Published As
Publication number | Publication date |
---|---|
EP1843733A1 (en) | 2007-10-17 |
US20050074514A1 (en) | 2005-04-07 |
CA2594880A1 (en) | 2006-07-27 |
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