WO2006078519A3 - Control of electrical stimulation using heart rate variability - Google Patents

Control of electrical stimulation using heart rate variability Download PDF

Info

Publication number
WO2006078519A3
WO2006078519A3 PCT/US2006/000963 US2006000963W WO2006078519A3 WO 2006078519 A3 WO2006078519 A3 WO 2006078519A3 US 2006000963 W US2006000963 W US 2006000963W WO 2006078519 A3 WO2006078519 A3 WO 2006078519A3
Authority
WO
WIPO (PCT)
Prior art keywords
hrv
parameter
heart rate
pacing
rate variability
Prior art date
Application number
PCT/US2006/000963
Other languages
French (fr)
Other versions
WO2006078519A2 (en
Inventor
Joseph M Pastore
Rodney W Salo
Gerrard M Carlson
Andrew P Kramer
Jiang Ding
Yinghong Yu
Original Assignee
Cardiac Pacemakers Inc
Joseph M Pastore
Rodney W Salo
Gerrard M Carlson
Andrew P Kramer
Jiang Ding
Yinghong Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/037,723 external-priority patent/US7580745B2/en
Priority claimed from US11/037,309 external-priority patent/US7672725B2/en
Application filed by Cardiac Pacemakers Inc, Joseph M Pastore, Rodney W Salo, Gerrard M Carlson, Andrew P Kramer, Jiang Ding, Yinghong Yu filed Critical Cardiac Pacemakers Inc
Priority to JP2007552170A priority Critical patent/JP5036561B2/en
Priority to EP20060718078 priority patent/EP1846098B1/en
Publication of WO2006078519A2 publication Critical patent/WO2006078519A2/en
Publication of WO2006078519A3 publication Critical patent/WO2006078519A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36592—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by the heart rate variability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02405—Determining heart rate variability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4035—Evaluating the autonomic nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions

Abstract

A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value. In another embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode. In another embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
PCT/US2006/000963 2005-01-18 2006-01-12 Control of electrical stimulation using heart rate variability WO2006078519A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2007552170A JP5036561B2 (en) 2005-01-18 2006-01-12 Control of electrical stimulation using heart rate variability
EP20060718078 EP1846098B1 (en) 2005-01-18 2006-01-12 Control of electrical stimulation using heart rate variability

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11/037,723 2005-01-18
US11/037,308 2005-01-18
US11/037,723 US7580745B2 (en) 2005-01-18 2005-01-18 Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapy
US11/037,309 2005-01-18
US11/037,308 US7672724B2 (en) 2005-01-18 2005-01-18 Method and apparatus for optimizing electrical stimulation parameters using heart rate variability
US11/037,309 US7672725B2 (en) 2005-01-18 2005-01-18 Method and apparatus for using heart rate variability as a safety check in electrical therapies

Publications (2)

Publication Number Publication Date
WO2006078519A2 WO2006078519A2 (en) 2006-07-27
WO2006078519A3 true WO2006078519A3 (en) 2007-04-19

Family

ID=36215479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/000963 WO2006078519A2 (en) 2005-01-18 2006-01-12 Control of electrical stimulation using heart rate variability

Country Status (4)

Country Link
US (2) US7672724B2 (en)
EP (2) EP2554216B1 (en)
JP (2) JP5036561B2 (en)
WO (1) WO2006078519A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6678547B2 (en) * 2001-03-08 2004-01-13 Cardiac Pacemakers, Inc. Cardiac rhythm management system using time-domain heart rate variability indicia
US7580745B2 (en) 2005-01-18 2009-08-25 Cardiac Pacemakers, Inc. Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapy
US7672724B2 (en) * 2005-01-18 2010-03-02 Cardiac Pacemakers, Inc. Method and apparatus for optimizing electrical stimulation parameters using heart rate variability
US7672725B2 (en) 2005-01-18 2010-03-02 Cardiac Pacemakers, Inc. Method and apparatus for using heart rate variability as a safety check in electrical therapies
US7561923B2 (en) 2005-05-09 2009-07-14 Cardiac Pacemakers, Inc. Method and apparatus for controlling autonomic balance using neural stimulation
US20080091255A1 (en) * 2006-10-11 2008-04-17 Cardiac Pacemakers Implantable neurostimulator for modulating cardiovascular function
WO2008070189A2 (en) 2006-12-06 2008-06-12 The Cleveland Clinic Foundation Method and system for treating acute heart failure by neuromodulation
US8308649B2 (en) 2007-03-23 2012-11-13 St. Jude Medical Ab Implantable cardiac device and method for monitoring the status of a cardiovascular disease
US7751889B1 (en) * 2007-04-11 2010-07-06 Pacesetter, Inc. Closed loop programming for individual adjustment of electro-mechanical synchrony
US20080306564A1 (en) * 2007-06-11 2008-12-11 Cardiac Pacemakers, Inc Method and apparatus for short-term heart rate variability monitoring and diagnostics
JP5292416B2 (en) * 2008-03-13 2013-09-18 カーディアック ペースメイカーズ， インコーポレイテッド Autonomic balance monitoring to control intermittent therapy
US8532769B2 (en) * 2009-10-30 2013-09-10 Medtronic, Inc. Heart rate variability distinction
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection
EP2948217B1 (en) * 2013-01-25 2018-03-14 Cardiac Pacemakers, Inc. Systems to identify cardiac dysynchrony
GB2526249B (en) * 2014-03-20 2016-06-29 Branton Jakes Device for the automated non-invasive dynamically adaptive electrical stimulation of the vagus nerve
WO2015179634A2 (en) 2014-05-22 2015-11-26 CARDIONOMIC, Inc. Catheter and catheter system for electrical neuromodulation
EP3194017A1 (en) 2014-09-08 2017-07-26 Cardionomic, Inc. Methods for electrical neuromodulation of the heart
EP3242717B1 (en) 2015-01-05 2019-06-12 Cardionomic, Inc. Cardiac modulation facilitation systems
EP3426338A4 (en) 2016-03-09 2019-10-30 Cardionomic, Inc. Cardiac contractility neurostimulation systems and methods
EP3664703A4 (en) 2017-09-13 2021-05-12 Cardionomic, Inc. Neurostimulation systems and methods for affecting cardiac contractility
CA3107959A1 (en) 2018-08-13 2020-02-20 CARDIONOMIC, Inc. Systems and methods for affecting cardiac contractility and/or relaxation
US11890414B2 (en) * 2018-10-17 2024-02-06 Maquet Critical Care Ab Lung recruitment in mechanical ventilation
EP3648470A1 (en) * 2018-11-05 2020-05-06 GN Hearing A/S Hearing system with heart condition alert and related methods
CA3137307A1 (en) 2019-05-06 2020-11-12 CARDIONOMIC, Inc. Systems and methods for denoising physiological signals during electrical neuromodulation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540725A (en) * 1995-07-11 1996-07-30 Pacesetter, Inc. Upper rate response for implantable pacemaker based on atrial lock interval pacing
US6144878A (en) * 1995-12-11 2000-11-07 Intermedics Inc. Implantable medical device responsive to heart rate variability analysis
US6430438B1 (en) * 1999-05-21 2002-08-06 Cardiac Pacemakers, Inc. Cardiac rhythm management system with atrial shock timing optimization
US20040133247A1 (en) * 2001-10-31 2004-07-08 Stahmann Jeffrey E. Method for ischemia detection by implantable cardiac device
US20040193066A1 (en) * 2001-03-08 2004-09-30 Cardiac Pacemakers, Inc. Cardiac rhythm management system using time-domain heart rate variability indicia
US20040260348A1 (en) * 2003-06-19 2004-12-23 Bakken Earl E. Method and apparatus for temporarily varying a parameter in an implantable medical device

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5265617A (en) 1991-02-20 1993-11-30 Georgetown University Methods and means for non-invasive, dynamic tracking of cardiac vulnerability by simultaneous analysis of heart rate variability and T-wave alternans
US5437285A (en) * 1991-02-20 1995-08-01 Georgetown University Method and apparatus for prediction of sudden cardiac death by simultaneous assessment of autonomic function and cardiac electrical stability
US5842997A (en) * 1991-02-20 1998-12-01 Georgetown University Non-invasive, dynamic tracking of cardiac vulnerability by simultaneous analysis of heart rate variability and T-wave alternans
US5203326A (en) * 1991-12-18 1993-04-20 Telectronics Pacing Systems, Inc. Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy
IT1259358B (en) * 1992-03-26 1996-03-12 Sorin Biomedica Spa IMPLANTABLE DEVICE FOR DETECTION AND CONTROL OF THE SYMPATHIC-VAGAL TONE
US5291400A (en) * 1992-04-09 1994-03-01 Spacelabs Medical, Inc. System for heart rate variability analysis
US5891044A (en) * 1992-10-06 1999-04-06 Gw Scientific, Inc. Detection of abnormal and induction of normal heart rate variability
US5318591A (en) 1992-11-23 1994-06-07 Siemens Pacesetter, Inc. Implantable cardioverter-defibrillator having early charging capability
WO1995003739A1 (en) * 1993-08-03 1995-02-09 Peter Walter Kamen A method of measuring autonomic activity of a patient
US5522854A (en) * 1994-05-19 1996-06-04 Duke University Method and apparatus for the prevention of arrhythmia by nerve stimulation
US5549641A (en) 1994-10-31 1996-08-27 Incontrol, Inc. Atrial fibrillation type selective cardiovertor and method
US5466245A (en) * 1994-11-15 1995-11-14 Cardiac Pacemakers, Inc. Method and apparatus to continuously optimize the A-V delay in a dual chamber pacemaker
US5755671A (en) * 1995-10-05 1998-05-26 Massachusetts Institute Of Technology Method and apparatus for assessing cardiovascular risk
US5749900A (en) * 1995-12-11 1998-05-12 Sulzer Intermedics Inc. Implantable medical device responsive to heart rate variability analysis
US5603331A (en) * 1996-02-12 1997-02-18 Cardiac Pacemakers, Inc. Data logging system for implantable cardiac device
DE19609409C2 (en) 1996-03-04 2000-01-20 Biotronik Mess & Therapieg Therapy device
SE9603635D0 (en) * 1996-10-04 1996-10-04 Pacesetter Ab Implantable stimulator
US5893882A (en) * 1996-12-17 1999-04-13 Medtronic, Inc. Method and apparatus for diagnosis and treatment of arrhythmias
AU6673498A (en) * 1997-03-10 1998-09-29 Robin Medical Inc. Method and apparatus for the assessment and display of variability in mechanicalactivity of the heart, and enhancement of ultrasound contrast imaging by variab ility analysis
SE9701121D0 (en) * 1997-03-26 1997-03-26 Pacesetter Ab Implantable heart stimulator
US6042548A (en) * 1997-11-14 2000-03-28 Hypervigilant Technologies Virtual neurological monitor and method
ATE418286T1 (en) * 1998-03-17 2009-01-15 Univ Virginia METHOD AND DEVICE FOR THE EARLY DIAGNOSIS OF SUBACUTE, POTENTIALLY CATASTROPICAL ILLNESSES
US5941831A (en) * 1998-04-03 1999-08-24 Pacesetter, Inc. Method for diagnosing cardiac arrhythmias using interval irregularity
US6021351A (en) * 1998-05-11 2000-02-01 Cardiac Pacemakers, Inc. Method and apparatus for assessing patient well-being
US6026320A (en) * 1998-06-08 2000-02-15 Cardiac Pacemakers, Inc. Heart rate variability as an indicator of exercise capacity
US6301499B1 (en) * 1998-06-08 2001-10-09 Cardiac Pacemakers, Inc. Heart rate variability as an indicator of exercise capacity
US6370427B1 (en) 1998-07-23 2002-04-09 Intermedics, Inc. Method and apparatus for dual chamber bi-ventricular pacing and defibrillation
US6292693B1 (en) * 1998-11-06 2001-09-18 Impulse Dynamics N.V. Contractility enhancement using excitable tissue control and multi-site pacing
US6253107B1 (en) * 1998-12-09 2001-06-26 Cambridge Heart, Inc. Cardiac pacing to induce heart rate variability
JP2000166889A (en) * 1998-12-11 2000-06-20 Inst Of Physical & Chemical Res Heart rate fluctuation estimation method and device thereof
WO2000038782A1 (en) 1998-12-28 2000-07-06 Medtronic, Inc. Regularization of ventricular rate during atrial tachyarrhythmia
AU2977700A (en) 1999-01-29 2000-08-18 Evgueni N. Bogomolov Personal physiological monitor
US6358201B1 (en) * 1999-03-02 2002-03-19 Doc L. Childre Method and apparatus for facilitating physiological coherence and autonomic balance
US6508771B1 (en) * 1999-03-05 2003-01-21 Medtronic, Inc. Method and apparatus for monitoring heart rate
US6190324B1 (en) * 1999-04-28 2001-02-20 Medtronic, Inc. Implantable medical device for tracking patient cardiac status
US6341236B1 (en) 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
US6390986B1 (en) * 1999-05-27 2002-05-21 Rutgers, The State University Of New Jersey Classification of heart rate variability patterns in diabetics using cepstral analysis
US6314321B1 (en) 1999-06-30 2001-11-06 Cardiac Pacemakers, Inc. Therapy-selection methods for implantable heart monitors
US6450942B1 (en) * 1999-08-20 2002-09-17 Cardiorest International Ltd. Method for reducing heart loads in mammals
US7062314B2 (en) * 1999-10-01 2006-06-13 Cardiac Pacemakers, Inc. Cardiac rhythm management device with triggered diagnostic mode
US6480733B1 (en) * 1999-11-10 2002-11-12 Pacesetter, Inc. Method for monitoring heart failure
US7194305B1 (en) * 2000-04-07 2007-03-20 Cardiac Pacemakers, Inc. Cardiac rhythm management system with optimization of cardiac performance using heart rate
EP1172125B1 (en) * 2000-07-11 2005-03-09 SORIN BIOMEDICA CRM S.r.l. An implantable heart stimulation system with automatic mode switching controlled by sympatho-vagal balance
US6856829B2 (en) * 2000-09-07 2005-02-15 Denso Corporation Method for detecting physiological condition of sleeping patient based on analysis of pulse waves
US6628988B2 (en) * 2001-04-27 2003-09-30 Cardiac Pacemakers, Inc. Apparatus and method for reversal of myocardial remodeling with electrical stimulation
US7778703B2 (en) * 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
DE10151089A1 (en) * 2001-10-13 2003-04-17 Biotronik Mess & Therapieg Device for predicting tachyarrhythmias
US6973349B2 (en) * 2001-12-05 2005-12-06 Cardiac Pacemakers, Inc. Method and apparatus for minimizing post-infarct ventricular remodeling
US7123959B2 (en) * 2002-03-25 2006-10-17 Cardiac Pacemakers, Inc. Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation
US6922585B2 (en) * 2002-04-05 2005-07-26 Medtronic, Inc. Method and apparatus for predicting recurring ventricular arrhythmias
US7672724B2 (en) 2005-01-18 2010-03-02 Cardiac Pacemakers, Inc. Method and apparatus for optimizing electrical stimulation parameters using heart rate variability
US7580745B2 (en) * 2005-01-18 2009-08-25 Cardiac Pacemakers, Inc. Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapy
US7672725B2 (en) * 2005-01-18 2010-03-02 Cardiac Pacemakers, Inc. Method and apparatus for using heart rate variability as a safety check in electrical therapies

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540725A (en) * 1995-07-11 1996-07-30 Pacesetter, Inc. Upper rate response for implantable pacemaker based on atrial lock interval pacing
US6144878A (en) * 1995-12-11 2000-11-07 Intermedics Inc. Implantable medical device responsive to heart rate variability analysis
US20020068875A1 (en) * 1995-12-11 2002-06-06 Intermedics, Inc. Implantable medical device responsive to heart rate variability analysis
US6430438B1 (en) * 1999-05-21 2002-08-06 Cardiac Pacemakers, Inc. Cardiac rhythm management system with atrial shock timing optimization
US20040193066A1 (en) * 2001-03-08 2004-09-30 Cardiac Pacemakers, Inc. Cardiac rhythm management system using time-domain heart rate variability indicia
US20040133247A1 (en) * 2001-10-31 2004-07-08 Stahmann Jeffrey E. Method for ischemia detection by implantable cardiac device
US20040260348A1 (en) * 2003-06-19 2004-12-23 Bakken Earl E. Method and apparatus for temporarily varying a parameter in an implantable medical device

Also Published As

Publication number Publication date
EP1846098A2 (en) 2007-10-24
EP1846098B1 (en) 2015-04-22
JP5036561B2 (en) 2012-09-26
WO2006078519A2 (en) 2006-07-27
EP2554216B1 (en) 2014-03-26
US7672724B2 (en) 2010-03-02
US8805503B2 (en) 2014-08-12
EP2554216A1 (en) 2013-02-06
US20100137932A1 (en) 2010-06-03
JP2012071206A (en) 2012-04-12
JP5312619B2 (en) 2013-10-09
JP2008526456A (en) 2008-07-24
US20060161208A1 (en) 2006-07-20

Similar Documents

Publication Publication Date Title
WO2006078519A3 (en) Control of electrical stimulation using heart rate variability
US9101770B2 (en) Hypertension therapy device with longevity management
US6622041B2 (en) Treatment of congestive heart failure and autonomic cardiovascular drive disorders
US6738668B1 (en) Implantable cardiac stimulation device having a capture assurance system which minimizes battery current drain and method for operating the same
EP2440285B1 (en) Tissue oxygenation monitoring in heart failure
AU2008223498B2 (en) Closed-loop pacing system for intermittent cardiac stress augmentation
WO2003061759A8 (en) Methods and apparatus for detection and treatment of syncope
US8412326B2 (en) Pacemaker with vagal surge monitoring and response
JP2010505527A5 (en)
WO2003086531A3 (en) Method and apparatus for the treatment of sleep apnea using biventricular pacing
JP2009536558A5 (en)
WO2006083617A3 (en) Cardiac harness having electrodes and epicardial leads
US20080091248A1 (en) Percutaneous neurostimulator for modulating cardiovascular function
WO2004041354A8 (en) Respiratory nerve stimulation
WO2006118846A3 (en) Suppression of high rate pacing for reducing myocardial ischemic irritability
WO2009075750A3 (en) System for delivering neurostimulation from pulmonary artery
WO2011008747A3 (en) Remote sensing in an implantable medical device
US20150258341A1 (en) Visualization of biological environment impact on implanted therapy
WO2014088674A3 (en) Implantable stimulator with means for determining an impedance and for selecting a stimulation based on the impedance
EP2510973A3 (en) System for neurally-mediated anti-arrhythmic therapy
WO2008079840A3 (en) Rate adaptive cardiac pacing systems and methods
JP2010506618A5 (en)
WO2009114320A3 (en) Methods and apparatus for monitoring p-wave duration and end and qrs duration with an implantable medical device
ATE427134T1 (en) IMPLANTABLE MEDICAL DEVICE WITH VENTRICULAR PACEMAKER PROTOCOL
WO2010051425A3 (en) Implantable medical device crosstalk evaluation and mitigation

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2007552170

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006718078

Country of ref document: EP