WO2006085958A3 - Integration of direct binding sensors with mass spectrometry for functional and structural characterization of molecules - Google Patents
Integration of direct binding sensors with mass spectrometry for functional and structural characterization of molecules Download PDFInfo
- Publication number
- WO2006085958A3 WO2006085958A3 PCT/US2005/022719 US2005022719W WO2006085958A3 WO 2006085958 A3 WO2006085958 A3 WO 2006085958A3 US 2005022719 W US2005022719 W US 2005022719W WO 2006085958 A3 WO2006085958 A3 WO 2006085958A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- molecules
- mass spectrometry
- masses
- integration
- functional
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05857481A EP1769230A2 (en) | 2004-06-28 | 2005-06-28 | Integration of direct binding sensors with mass spectrometry for functional and structural characterization of molecules |
CA002572459A CA2572459A1 (en) | 2004-06-28 | 2005-06-28 | Integration of direct binding sensors with mass spectrometry for functional and structural characterization of molecules |
AU2005327173A AU2005327173A1 (en) | 2004-06-28 | 2005-06-28 | Integration of direct binding sensors with mass spectrometry for functional and structural characterization of molecules |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58356004P | 2004-06-28 | 2004-06-28 | |
US60/583,560 | 2004-06-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006085958A2 WO2006085958A2 (en) | 2006-08-17 |
WO2006085958A3 true WO2006085958A3 (en) | 2006-09-14 |
Family
ID=36649743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/022719 WO2006085958A2 (en) | 2004-06-28 | 2005-06-28 | Integration of direct binding sensors with mass spectrometry for functional and structural characterization of molecules |
Country Status (6)
Country | Link |
---|---|
US (1) | US20060003372A1 (en) |
EP (1) | EP1769230A2 (en) |
CN (1) | CN101057131A (en) |
AU (1) | AU2005327173A1 (en) |
CA (1) | CA2572459A1 (en) |
WO (1) | WO2006085958A2 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8111401B2 (en) * | 1999-11-05 | 2012-02-07 | Robert Magnusson | Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats |
US7167615B1 (en) * | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
US7094595B2 (en) | 2000-10-30 | 2006-08-22 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
US7371562B2 (en) * | 2000-10-30 | 2008-05-13 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
US7524625B2 (en) * | 2000-10-30 | 2009-04-28 | Sru Biosystems, Inc. | Real time binding analysis of antigens on a biosensor surface |
US7575939B2 (en) | 2000-10-30 | 2009-08-18 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US7927822B2 (en) | 2002-09-09 | 2011-04-19 | Sru Biosystems, Inc. | Methods for screening cells and antibodies |
US7309614B1 (en) | 2002-12-04 | 2007-12-18 | Sru Biosystems, Inc. | Self-referencing biodetection method and patterned bioassays |
US8298780B2 (en) | 2003-09-22 | 2012-10-30 | X-Body, Inc. | Methods of detection of changes in cells |
US20060065622A1 (en) * | 2004-09-27 | 2006-03-30 | Floyd Philip D | Method and system for xenon fluoride etching with enhanced efficiency |
ATE475886T1 (en) * | 2005-04-12 | 2010-08-15 | Sru Biosystems Inc | PROTEOLIPID MEMBRANE AND LIPID MEMBRANE BIOSENSOR |
JP2010525334A (en) * | 2007-04-19 | 2010-07-22 | エス アール ユー バイオシステムズ,インコーポレイテッド | Methods of using biosensors to detect small molecules that bind directly to an immobilized target |
JP2010532998A (en) | 2007-07-11 | 2010-10-21 | エス アール ユー バイオシステムズ,インコーポレイテッド | Method for identifying modulators of ion channels |
US9134307B2 (en) | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
US8257936B2 (en) | 2008-04-09 | 2012-09-04 | X-Body Inc. | High resolution label free analysis of cellular properties |
WO2010014903A1 (en) * | 2008-07-31 | 2010-02-04 | Massachusetts Institute Of Technology | Multiplexed olfactory receptor-based microsurface plasmon polariton detector |
US20100273185A1 (en) * | 2009-04-27 | 2010-10-28 | Sru Biosystems, Inc. | Detection of Biased Agonist Activation |
JP2012526998A (en) * | 2009-05-15 | 2012-11-01 | エス アール ユー バイオシステムズ,インコーポレイテッド | Detection of changes in cell populations and mixed cell populations |
JP5479314B2 (en) * | 2010-12-10 | 2014-04-23 | 日東電工株式会社 | SPR sensor cell and SPR sensor |
JP2013061301A (en) * | 2011-09-15 | 2013-04-04 | Nitto Denko Corp | Spr sensor cell and spr sensor |
CN102676494B (en) * | 2012-05-03 | 2013-10-30 | 天津大学 | Core-shell structure immobilized enzyme particle and preparation method thereof |
US20130330761A1 (en) | 2012-06-12 | 2013-12-12 | Celcuity, LLC | Whole cell assays and methods |
JP6029899B2 (en) * | 2012-09-07 | 2016-11-24 | 日東電工株式会社 | SPR sensor cell and SPR sensor |
WO2015089380A2 (en) | 2013-12-12 | 2015-06-18 | Celcuity Llc | Assays and methods for determining the responsiveness of an individual subject to a therapeutic agent |
CN103940752A (en) * | 2014-04-28 | 2014-07-23 | 上海理工大学 | Method for detecting antigen-antibody in 96-microplate in backside manner |
JP2016218963A (en) * | 2015-05-26 | 2016-12-22 | 富士通株式会社 | Information processing apparatus, input control program, and input control method |
AU2018239989A1 (en) | 2017-03-20 | 2019-08-08 | Celcuity Inc. | Methods of measuring signaling pathway activity for selection of therapeutic agents |
WO2020154598A1 (en) * | 2019-01-25 | 2020-07-30 | Regeneron Pharmaceuticals, Inc. | Protein a chromatography - electrospray ionization mass spectrometer |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998039632A1 (en) * | 1997-03-03 | 1998-09-11 | The Regents Of The University Of California | Direct colorimetric detection of biocatalysts |
WO2003064995A2 (en) * | 2002-01-28 | 2003-08-07 | Sru Biosystems, Llc | A guided mode resonant filter biosensor using a linear grating surface structure |
WO2004046164A2 (en) * | 2002-05-10 | 2004-06-03 | Engeneos, Inc. | Unique recognition sequences and methods of use thereof in protein analysis |
-
2005
- 2005-06-28 EP EP05857481A patent/EP1769230A2/en not_active Withdrawn
- 2005-06-28 CA CA002572459A patent/CA2572459A1/en not_active Abandoned
- 2005-06-28 CN CNA2005800218763A patent/CN101057131A/en active Pending
- 2005-06-28 US US11/168,155 patent/US20060003372A1/en not_active Abandoned
- 2005-06-28 WO PCT/US2005/022719 patent/WO2006085958A2/en active Application Filing
- 2005-06-28 AU AU2005327173A patent/AU2005327173A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998039632A1 (en) * | 1997-03-03 | 1998-09-11 | The Regents Of The University Of California | Direct colorimetric detection of biocatalysts |
WO2003064995A2 (en) * | 2002-01-28 | 2003-08-07 | Sru Biosystems, Llc | A guided mode resonant filter biosensor using a linear grating surface structure |
WO2004046164A2 (en) * | 2002-05-10 | 2004-06-03 | Engeneos, Inc. | Unique recognition sequences and methods of use thereof in protein analysis |
Non-Patent Citations (1)
Title |
---|
CUNNINGHAM B ET AL: "Colorimetric resonant reflection as a direct biochemical assay technique", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 81, no. 2-3, 5 January 2002 (2002-01-05), pages 316 - 328, XP004329915, ISSN: 0925-4005 * |
Also Published As
Publication number | Publication date |
---|---|
CA2572459A1 (en) | 2006-08-17 |
WO2006085958A2 (en) | 2006-08-17 |
AU2005327173A1 (en) | 2006-08-17 |
US20060003372A1 (en) | 2006-01-05 |
CN101057131A (en) | 2007-10-17 |
EP1769230A2 (en) | 2007-04-04 |
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