WO2006088476A3 - Carboranylporphyrins and uses thereof - Google Patents

Carboranylporphyrins and uses thereof Download PDF

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Publication number
WO2006088476A3
WO2006088476A3 PCT/US2005/017358 US2005017358W WO2006088476A3 WO 2006088476 A3 WO2006088476 A3 WO 2006088476A3 US 2005017358 W US2005017358 W US 2005017358W WO 2006088476 A3 WO2006088476 A3 WO 2006088476A3
Authority
WO
WIPO (PCT)
Prior art keywords
directed
methods
compounds
tumors
diagnosis
Prior art date
Application number
PCT/US2005/017358
Other languages
French (fr)
Other versions
WO2006088476A2 (en
Inventor
Haitao Wu
Michiko Miura
Original Assignee
Brookhaven Science Ass Llc
Haitao Wu
Michiko Miura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brookhaven Science Ass Llc, Haitao Wu, Michiko Miura filed Critical Brookhaven Science Ass Llc
Priority to NZ551732A priority Critical patent/NZ551732A/en
Priority to AU2005327597A priority patent/AU2005327597B2/en
Priority to EP05856727A priority patent/EP1753468A4/en
Priority to JP2007527402A priority patent/JP2008505983A/en
Priority to CA002567468A priority patent/CA2567468A1/en
Publication of WO2006088476A2 publication Critical patent/WO2006088476A2/en
Priority to IL179497A priority patent/IL179497A0/en
Priority to US11/606,864 priority patent/US20070093463A1/en
Priority to NO20065858A priority patent/NO20065858L/en
Publication of WO2006088476A3 publication Critical patent/WO2006088476A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents

Abstract

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20­-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.
PCT/US2005/017358 2004-05-20 2005-05-17 Carboranylporphyrins and uses thereof WO2006088476A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
NZ551732A NZ551732A (en) 2004-05-20 2005-05-17 Carboranylporphyrins and uses thereof
AU2005327597A AU2005327597B2 (en) 2004-05-20 2005-05-17 Carboranylporphyrins and uses thereof
EP05856727A EP1753468A4 (en) 2004-05-20 2005-05-17 Carboranylporphyrins and uses thereof
JP2007527402A JP2008505983A (en) 2004-05-20 2005-05-17 Carboranyl porphyrins and their use
CA002567468A CA2567468A1 (en) 2004-05-20 2005-05-17 Carboranylporphyrins and uses thereof
IL179497A IL179497A0 (en) 2004-05-20 2006-11-22 Carboranylporphyrins and uses thereof
US11/606,864 US20070093463A1 (en) 2004-05-20 2006-12-01 Radiation enhancement agent for X-ray radiation therapy and boron neutron-capture therapy
NO20065858A NO20065858L (en) 2004-05-20 2006-12-15 Carboranylforphyrins and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/848,741 2004-05-20
US10/848,741 US6995260B2 (en) 2004-05-20 2004-05-20 Carboranylporphyrins and uses thereof

Publications (2)

Publication Number Publication Date
WO2006088476A2 WO2006088476A2 (en) 2006-08-24
WO2006088476A3 true WO2006088476A3 (en) 2006-12-21

Family

ID=35375345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/017358 WO2006088476A2 (en) 2004-05-20 2005-05-17 Carboranylporphyrins and uses thereof

Country Status (11)

Country Link
US (1) US6995260B2 (en)
EP (1) EP1753468A4 (en)
JP (1) JP2008505983A (en)
KR (1) KR20070026552A (en)
CN (1) CN1968705A (en)
AU (1) AU2005327597B2 (en)
CA (1) CA2567468A1 (en)
IL (1) IL179497A0 (en)
NO (1) NO20065858L (en)
NZ (1) NZ551732A (en)
WO (1) WO2006088476A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2397067B (en) * 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
US20070093463A1 (en) * 2004-05-20 2007-04-26 Brookhaven Science Associates, Llc Radiation enhancement agent for X-ray radiation therapy and boron neutron-capture therapy
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
GB0427589D0 (en) 2004-12-16 2005-01-19 Psimei Pharmaceuticals Plc Process for the preparation of a substituted porphyrin
US8287839B2 (en) * 2006-12-04 2012-10-16 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
WO2008102669A1 (en) * 2007-02-19 2008-08-28 Rei Medical Co., Ltd. Novel sugar-linked chlorin derivative and process for production thereof
US8444953B2 (en) * 2007-03-22 2013-05-21 Brookhaven Science Associates, Llc Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof
US20080279781A1 (en) * 2007-05-10 2008-11-13 Brookhaven Science Associates, Llc Glycosylated Carboranylporphyrins and Uses Thereof
JP5745415B2 (en) * 2009-09-17 2015-07-08 国立大学法人九州大学 Porphyrin compounds
US8563712B2 (en) * 2009-10-28 2013-10-22 The University Of Hong Kong Hydroxy-substituted gold(III) porphyrin complexes as histone deacetylase inhibitors
CN102268003B (en) * 2011-06-16 2013-10-30 扬州大学 Unsymmetrical poly-substituted porphyrin gold (III) type anticancer compound and preparation method thereof
GB201221125D0 (en) * 2012-11-23 2013-01-09 Morex Dev Partners Llp Pharmaceutial formulations
KR20230011080A (en) * 2021-07-13 2023-01-20 삼성에스디아이 주식회사 Dye, composition compring the same, film, optical member and display device
CN114015066B (en) * 2021-11-12 2022-08-12 北京大学 Covalent organic framework materials, methods of making and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877165A (en) * 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
WO2001085736A1 (en) * 2000-05-09 2001-11-15 The Regents Of The University Of California Porphyrin-based neutron capture agents for cancer therapy

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783529A (en) * 1985-12-03 1988-11-08 Research Corporation Technologies Rapid synthesis of radiolabeled porphyrin complexes for medical application
US5162231A (en) * 1989-10-25 1992-11-10 Cole Dean A Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
US4959356A (en) * 1989-05-26 1990-09-25 The United States Of America As Represented By The United States Department Of Energy Porphyrins for boron neutron capture therapy
FR2656866B1 (en) * 1990-01-10 1992-05-15 Cis Bio Int PORPHYRIN DERIVATIVES AND METALLOPORPHYRINS POTENTIALLY COUPLED TO A BIOLOGICALLY ACTIVE MOLECULE, AND PHARMACEUTICAL COMPOSITION CONTAINING THEM.
US5654423A (en) * 1990-11-21 1997-08-05 Regents Of The University Of California Boronated metalloporphyrine and therapeutic methods
US5149801A (en) * 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5312896A (en) * 1992-10-09 1994-05-17 Sri International Metal ion porphyrin-containing poly(imide)
DE4305523A1 (en) * 1993-02-17 1994-08-18 Diagnostikforschung Inst Meso-tetraphenylporphyrin complexes, processes for their preparation and pharmaceutical compositions containing them
US5563132A (en) * 1994-06-21 1996-10-08 Bodaness; Richard S. Two-step cancer treatment method
US5648485A (en) * 1994-10-26 1997-07-15 University Of British Columbia β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US5955586A (en) * 1996-03-22 1999-09-21 Sessler; Jonathan L. Highly boronated derivatives of texaphyrins
WO1998030102A1 (en) * 1997-01-09 1998-07-16 Emory University Non-iron metalloporphyrins and methods of use
US6010805A (en) * 1998-05-26 2000-01-04 United States Of America As Represented By The Secretary Of The Air Force Ion conducting electrolyte material containing a lithium porphyrin complex
US6566517B2 (en) * 2001-06-06 2003-05-20 Brookhaven Science Associates, Llc Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
US7087214B2 (en) * 2002-02-01 2006-08-08 Zentaris Gmbh Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases
GB0222945D0 (en) * 2002-10-03 2002-11-13 Psimei Pharmaceuticals Plc Therapeutic compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877165A (en) * 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
WO2001085736A1 (en) * 2000-05-09 2001-11-15 The Regents Of The University Of California Porphyrin-based neutron capture agents for cancer therapy

Also Published As

Publication number Publication date
US6995260B2 (en) 2006-02-07
AU2005327597A1 (en) 2006-08-24
US20050260128A1 (en) 2005-11-24
IL179497A0 (en) 2011-08-01
EP1753468A2 (en) 2007-02-21
NZ551732A (en) 2011-03-31
AU2005327597B2 (en) 2011-02-24
WO2006088476A2 (en) 2006-08-24
NO20065858L (en) 2007-02-09
KR20070026552A (en) 2007-03-08
JP2008505983A (en) 2008-02-28
CN1968705A (en) 2007-05-23
CA2567468A1 (en) 2006-08-24
EP1753468A4 (en) 2010-05-26

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