WO2006089290A1 - Combinations and modes of administration of therapeutic agents and combination therapy - Google Patents
Combinations and modes of administration of therapeutic agents and combination therapy Download PDFInfo
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- WO2006089290A1 WO2006089290A1 PCT/US2006/006167 US2006006167W WO2006089290A1 WO 2006089290 A1 WO2006089290 A1 WO 2006089290A1 US 2006006167 W US2006006167 W US 2006006167W WO 2006089290 A1 WO2006089290 A1 WO 2006089290A1
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- albumin
- taxane
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- paclitaxel
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- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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Abstract
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US8828925B2 (en) | 2008-10-15 | 2014-09-09 | Angiochem Inc. | Etoposide and doxorubicin conjugates for drug delivery |
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US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
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US8921314B2 (en) | 2008-10-15 | 2014-12-30 | Angiochem, Inc. | Conjugates of GLP-1 agonists and uses thereof |
US8969310B2 (en) | 2005-07-15 | 2015-03-03 | Angiochem Inc. | Potentiation of anticancer agents |
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US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US9161988B2 (en) | 2009-07-02 | 2015-10-20 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
US9173891B2 (en) | 2009-04-20 | 2015-11-03 | Angiochem, Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
US9221867B2 (en) | 2003-01-06 | 2015-12-29 | Angiochem Inc. | Method for transporting a compound across the blood-brain barrier |
US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
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US9914754B2 (en) | 2008-12-05 | 2018-03-13 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
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Families Citing this family (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US20070116761A1 (en) * | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US20030133955A1 (en) * | 1993-02-22 | 2003-07-17 | American Bioscience, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
US20070092563A1 (en) * | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
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US20080280987A1 (en) * | 2006-08-31 | 2008-11-13 | Desai Neil P | Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases |
US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8168661B2 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
JP2010516625A (en) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | Polymer-drug conjugates with tether groups for controlled drug delivery |
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WO2008124823A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Method of treating melanoma |
CN101742910A (en) * | 2007-04-10 | 2010-06-16 | 美瑞德制药公司 | Method of treating brain cancer |
CA2720987A1 (en) * | 2007-04-10 | 2008-10-16 | Myrexis, Inc. | Dosages and methods for the treatment of cancer |
WO2008124826A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating cancer |
WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
EP3326630A3 (en) | 2007-05-03 | 2018-08-29 | Abraxis BioScience, LLC | Methods and compositions for treating pulmonary hypertension |
WO2008140751A1 (en) * | 2007-05-11 | 2008-11-20 | Champions Biotechnology, Inc. | Human leiosarcoma and non small cell lung cancer lung xenograft models |
US9545384B2 (en) * | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
NZ581589A (en) * | 2007-06-22 | 2012-10-26 | Scidose Llc | Solubilized sterile injectable formulation of docetaxel without Tween 80 |
US8558019B2 (en) * | 2007-11-08 | 2013-10-15 | Virginia Tech Intellectual Properties, Inc. | Thiolated paclitaxels for reaction with gold nanoparticles as drug delivery agents |
US9233078B2 (en) | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
JP2011516412A (en) * | 2008-03-05 | 2011-05-26 | ビカス セラピューティクス,エルエルシー | Compositions and methods for the treatment of cancer and mucositis |
WO2009126401A1 (en) * | 2008-04-10 | 2009-10-15 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
TW200951143A (en) * | 2008-05-27 | 2009-12-16 | Oncolytics Biotech Inc | Modulating interstitial pressure and oncolytic viral delivery and distribution |
UA104147C2 (en) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Pyrrolidine dicarboxylic acid derivative and use thereof in the treatment of proliferative diseases |
US20120128732A1 (en) | 2008-12-11 | 2012-05-24 | Vuong Trieu | Combinations and modes of administration of therapeutic agents and combination therapy |
WO2010105172A1 (en) * | 2009-03-13 | 2010-09-16 | Abraxis Bioscience, Llc | Combination therapy with thiocolchicine derivatives |
WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
JP2012522055A (en) * | 2009-03-30 | 2012-09-20 | セルリアン・ファーマ・インコーポレイテッド | Polymer-drug conjugates, particles, compositions, and related methods of use |
WO2010141956A2 (en) * | 2009-06-05 | 2010-12-09 | Caron Joan M | Methods and compositions for the treatment of cancer |
US9340697B2 (en) | 2009-08-14 | 2016-05-17 | Nano-C, Inc. | Solvent-based and water-based carbon nanotube inks with removable additives |
US20130045240A1 (en) | 2009-08-25 | 2013-02-21 | Abraxis Bioscience, Llc | Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors |
NZ598801A (en) * | 2009-09-18 | 2014-07-25 | Abraxis Bioscience Llc | Use of the sparc microenvironment signature in the treatment of cancer |
US20110092579A1 (en) * | 2009-10-19 | 2011-04-21 | Scidose Llc | Solubilized formulation of docetaxel |
US8541465B2 (en) * | 2009-10-19 | 2013-09-24 | Scidose, Llc | Docetaxel formulations with lipoic acid and/or dihydrolipoic acid |
US7772274B1 (en) | 2009-10-19 | 2010-08-10 | Scidose, Llc | Docetaxel formulations with lipoic acid |
US8912228B2 (en) | 2009-10-19 | 2014-12-16 | Scidose Llc | Docetaxel formulations with lipoic acid |
US20130115295A1 (en) * | 2009-11-22 | 2013-05-09 | Qiang Wang | Rare Earth-Doped Up-Conversion Nanoparticles for Therapeutic and Diagnostic Applications |
AU2011205343B2 (en) * | 2010-01-12 | 2015-08-13 | Nestec S.A. | Methods for predicting response of triple-negative breast cancer to therapy |
EP2555802A1 (en) * | 2010-04-08 | 2013-02-13 | Sanford-Burnham Medical Research Institute | Methods and compositions for enhanced delivery of compounds |
EP2382993A1 (en) | 2010-04-19 | 2011-11-02 | KTB Tumorforschungsgesellschaft mbH | Combination of drugs with protein-binding prodrugs |
JP2013530166A (en) | 2010-06-03 | 2013-07-25 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | Use of SPARC microenvironment signatures in cancer treatment |
KR101223484B1 (en) * | 2010-10-05 | 2013-01-17 | 한국과학기술연구원 | HUMAN SERUM ALBUMIN-siRNA NANO-SIZED CARRIER SYSTEM |
US8884027B2 (en) | 2010-10-22 | 2014-11-11 | University Of Rochester | Melampomagnolide B derivatives as antileukemic and cytotoxic agents |
RU2013127625A (en) * | 2010-11-18 | 2014-12-27 | Зе Дженерал Хоспитал Корпорейшен | NEW COMPOSITIONS AND APPLICATIONS OF ANTIHYPERTENSIVE MEDICINES FOR CANCER THERAPY |
AU2011336413B2 (en) | 2010-12-02 | 2015-01-22 | Oncolytics Biotech Inc. | Liquid viral formulations |
SG190419A1 (en) | 2010-12-02 | 2013-06-28 | Oncolytics Biotech Inc | Lyophilized viral formulations |
DK2766040T3 (en) * | 2011-10-14 | 2019-07-22 | Hoffmann La Roche | Pertuzumab, trastuzumab, docetaxel and carboplatin for the treatment of early breast cancer |
WO2013085902A1 (en) | 2011-12-05 | 2013-06-13 | The University Of Texas M.D. | Combination therapy methods for treating an inflammatory breast cancer |
EP2630971B8 (en) | 2012-02-21 | 2017-12-13 | Vergell Medical S.A. | Combinations of albumin-based drug delivery systems |
PT2833905T (en) | 2012-04-04 | 2018-08-06 | Halozyme Inc | Combination therapy with hyaluronidase and a tumor-targeted taxane |
WO2014026143A1 (en) * | 2012-08-09 | 2014-02-13 | Pono Corporation | Conjugated anti-microbial compounds and conjugated anti-cancer compounds and uses thereof |
EP3981408A1 (en) * | 2012-09-04 | 2022-04-13 | Novartis AG | Dabrafenib and trametinib in a method of adjuvant cancer treatment |
WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
TWI598341B (en) | 2012-11-12 | 2017-09-11 | 伊格尼塔公司 | Bendamustine derivatives and methods of using same |
EP2919759A4 (en) | 2012-11-14 | 2016-07-20 | Ohio State Innovation Foundation | Materials and methods useful for treating glioblastoma |
ES2689921T3 (en) | 2012-11-30 | 2018-11-16 | Novomedix, Llc | Substituted biarylsulfonamides and their uses |
AU2013353745A1 (en) * | 2012-12-04 | 2015-06-11 | Eisai R&D Management Co., Ltd. | Use of eribulin in the treatment of breast cancer |
CN104650113A (en) * | 2012-12-21 | 2015-05-27 | 百奥泰生物科技(广州)有限公司 | Maytansine derivative as well as preparation method and application thereof |
US20140199404A1 (en) * | 2013-01-11 | 2014-07-17 | Abraxis Bioscience, Llc | Method for treating cancer based on level of a nucleoside transporter |
US20140199405A1 (en) * | 2013-01-11 | 2014-07-17 | Abraxis Bioscience, Llc | Method for treating cancer based on mutation status of k-ras |
US9962452B2 (en) | 2013-02-04 | 2018-05-08 | Zhuhai Beihai Biotech Co., Ltd. | Soluble complexes of drug analogs and albumin |
NZ711948A (en) | 2013-03-13 | 2020-02-28 | Oncoceutics Inc | Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one |
US9376437B2 (en) | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
US9688679B2 (en) | 2013-03-13 | 2017-06-27 | Oncoceutics, Inc. | 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy |
US20160015817A1 (en) | 2013-03-13 | 2016-01-21 | Abraxis Bioscience, Llc | Methods of treatment of pediatric solid tumor |
WO2014165842A2 (en) * | 2013-04-05 | 2014-10-09 | Igdrasol | Nanoparticle formulations in biomarker detection |
KR101329646B1 (en) | 2013-05-02 | 2013-11-14 | 주식회사 지니스 | Targeting-enhancing anticancer nanoparticles and preparation method the same |
WO2015042234A1 (en) * | 2013-09-20 | 2015-03-26 | Igdrasol | Conditionally stable micelle compositions for cancer treatment including ovarian cancer |
US20170065723A1 (en) * | 2013-09-27 | 2017-03-09 | Cerulean Pharma Inc. | Treatment of cancer |
KR20160093609A (en) * | 2013-10-25 | 2016-08-08 | 머케이터 메드시스템즈, 인크. | Maintenance of bronchial patency by local delivery of cytotoxic, cytostatic, or anti-neoplastic agent |
CN106163524B (en) * | 2013-11-15 | 2019-11-08 | 昂克希尔迪克斯有限公司 | 7- benzyl -4- (2- methylbenzyl) -2,4,6,7,8,9- hexahydro imidazo [1,2-a] pyrido [3,4-e] pyrimidine -5 (1H) -one, its salt and application method |
FI20130341L (en) | 2013-11-19 | 2015-05-20 | Safemed Ltd Oy | Transport of poorly water-soluble pharmaceuticals with alpha-fetoprotein balanced by metal ions |
JP2016539149A (en) * | 2013-12-06 | 2016-12-15 | ノバルティス アーゲー | Alpha-isoform selective phosphatidylinositol 3-kinase inhibitor dosing regimen |
NO2699580T3 (en) | 2014-01-24 | 2018-02-24 | ||
US20150359810A1 (en) | 2014-06-17 | 2015-12-17 | Celgene Corporation | Methods for treating epstein-barr virus (ebv) associated cancers using oral formulations of 5-azacytidine |
WO2015200837A1 (en) | 2014-06-27 | 2015-12-30 | Fl Therapeutics Llc | Abiraterone derivatives and non-covalent complexes with albumin |
CN104434808A (en) | 2014-07-03 | 2015-03-25 | 石药集团中奇制药技术(石家庄)有限公司 | Therapeutic nanoparticles and preparation method thereof |
WO2016065139A1 (en) | 2014-10-24 | 2016-04-28 | Fl Therapeutics Llc | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin |
WO2016065283A1 (en) * | 2014-10-24 | 2016-04-28 | Bishop Alexander James Roy | Methods and compositions for enhancing chemotherapy |
AU2016211243B2 (en) | 2015-01-30 | 2020-09-10 | Oncoceutics, Inc. | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy |
US10669311B2 (en) | 2015-04-23 | 2020-06-02 | Sanford Burnham Prebys Medical Discovery Institute | Targeted delivery system and methods of use therefor |
TW201707725A (en) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | Carrier-antibody compositions and methods of making and using the same |
US11433136B2 (en) | 2015-12-18 | 2022-09-06 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
KR20180107257A (en) | 2016-02-19 | 2018-10-01 | 난트 홀딩스 아이피, 엘엘씨 | METHODS OF IMMUNOGENIC MODULATION |
KR20180117227A (en) | 2016-03-24 | 2018-10-26 | 난트셀, 인크. | Sequences and sequence arrangements for neo-epitope presentation |
AU2017273495B2 (en) | 2016-06-02 | 2023-01-12 | Innopharmax, Inc. | Metronomic oral gemcitabine for cancer therapy |
SG11201811074RA (en) | 2016-06-30 | 2019-01-30 | Nant Holdings Ip Llc | Nant cancer vaccine |
WO2018026965A1 (en) | 2016-08-02 | 2018-02-08 | Isi Life Sciences, Inc. | Compositions and methods for detecting cancer cells in a tissue sample |
MX2019001517A (en) | 2016-08-05 | 2019-07-12 | Mayo Found Medical Education & Res | Modified antibody-albumin nanoparticle complexes for cancer treatment. |
CN107714652B (en) * | 2016-08-12 | 2021-03-02 | 四川科伦药物研究院有限公司 | Tesirolimus albumin nano composition and freeze-dried preparation, preparation method and application thereof |
MX2019002430A (en) | 2016-08-31 | 2019-07-04 | Fujifilm Corp | Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit. |
AU2017362730B2 (en) | 2016-11-21 | 2021-04-08 | Nant Holdings Ip, Llc | Fractal combination therapy |
US20180169120A1 (en) * | 2016-11-21 | 2018-06-21 | Bexion Pharmaceuticals, Inc. | Combination therapy including sapc-dops for the treatment of pancreatic cancer |
BR112019012538A2 (en) * | 2016-12-21 | 2019-11-12 | Prometic Pharma Smt Ltd | methods and compositions for preventing or minimizing epithelial-mesenchymal transition |
AU2018219862B2 (en) | 2017-02-07 | 2020-09-17 | Nant Holding IP, LLC | Maximizing T-cell memory and compositions and methods therefor |
US20180235936A1 (en) * | 2017-02-17 | 2018-08-23 | University Of Notre Dame Du Lac | Cancer treatment methods |
SG11201909882SA (en) | 2017-04-24 | 2019-11-28 | Nantcell Inc | Targeted neoepitope vectors and methods therefor |
US10753942B2 (en) | 2017-05-15 | 2020-08-25 | Indicator Systems International, Inc. | Methods to detect remnant cancer cells |
CN111479571A (en) | 2017-07-21 | 2020-07-31 | 瓦里安医疗系统公司 | Methods of using ultra-high dose rate radiation and therapeutic agents |
SG11202001441WA (en) | 2017-08-18 | 2020-03-30 | Tragara Pharmaceuticals Inc | Polymorphic form of tg02 |
BR112020009055A2 (en) | 2017-11-06 | 2020-11-03 | Rapt Therapeutics, Inc. | chemokine receptor modulators for positive cancer treatment for epstein-Barr virus |
WO2019143606A1 (en) | 2018-01-17 | 2019-07-25 | Nantbio, Inc. | Enhanced immunogenicity for gpi-anchored antigens |
SG11202007130RA (en) | 2018-01-26 | 2020-08-28 | Univ California | Methods and compositions for treatment of angiogenic disorders using anti-vegf agents |
WO2019195350A1 (en) | 2018-04-03 | 2019-10-10 | Vaxess Technologies, Inc. | Microneedle comprising silk fibroin applied to a dissolvable base |
US11823773B2 (en) | 2018-04-13 | 2023-11-21 | Nant Holdings Ip, Llc | Nant cancer vaccine strategies |
WO2020112868A1 (en) * | 2018-11-30 | 2020-06-04 | Aileron Therapeutics, Inc. | Combination therapy of peptidomimetic macrocycles |
WO2021108255A1 (en) | 2019-11-25 | 2021-06-03 | The Regents Of The University Of California | Long-acting vegf inhibitors for intraocular neovascularization |
WO2022232420A1 (en) * | 2021-04-29 | 2022-11-03 | Insmed Incorporated | Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating cancer |
WO2023174210A1 (en) | 2022-03-14 | 2023-09-21 | Laekna Limited | Combination treatment for cancer |
WO2023250117A2 (en) | 2022-06-24 | 2023-12-28 | Vaxess Technologies, Inc. | Applicator for medicament patch |
WO2024044775A1 (en) * | 2022-08-26 | 2024-02-29 | Ideaya Biosciences, Inc. | Methods of treating uveal melanoma |
WO2024081674A1 (en) | 2022-10-11 | 2024-04-18 | Aadi Bioscience, Inc. | Combination therapies for the treatment of cancer |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5916596A (en) | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
WO2000064437A1 (en) | 1999-04-22 | 2000-11-02 | American Biosciences, Inc. | Long term administration of pharmacologically active agents |
WO2001089522A1 (en) | 2000-05-19 | 2001-11-29 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
US6506405B1 (en) | 1993-02-22 | 2003-01-14 | American Bioscience, Inc. | Methods and formulations of cremophor-free taxanes |
US6566405B2 (en) | 1998-04-16 | 2003-05-20 | Eurovita A/S | Synergistic compositions containing aromatic compounds and terpenoids present in alpinia galanga |
US20040143004A1 (en) | 2002-02-26 | 2004-07-22 | Joseph Fargnoli | Metronomic dosing of taxanes |
US20050004002A1 (en) | 2002-12-09 | 2005-01-06 | American Bioscience, Inc. | Compositions and methods of delivery of pharmacological agents |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206018A (en) * | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
US5470571A (en) | 1988-01-27 | 1995-11-28 | The Wistar Institute | Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425 |
FR2660556B1 (en) | 1990-04-06 | 1994-09-16 | Rhone Poulenc Sante | MICROSPHERES, THEIR PREPARATION PROCESS AND THEIR USE. |
IL98528A0 (en) * | 1990-06-21 | 1992-07-15 | Merck & Co Inc | Pharmaceutical compositions containing hybrid for killing bladder cancer cells |
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
JP3854306B2 (en) | 1991-03-06 | 2006-12-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Humanized and chimeric monoclonal antibodies |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6515009B1 (en) * | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
CA2086874E (en) * | 1992-08-03 | 2000-01-04 | Renzo Mauro Canetta | Methods for administration of taxol |
US6306421B1 (en) * | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
FR2697752B1 (en) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Antitumor compositions containing taxane derivatives. |
US6491938B2 (en) * | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5981568A (en) * | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5439686A (en) | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US6749868B1 (en) * | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US5997904A (en) * | 1993-02-22 | 1999-12-07 | American Bioscience, Inc. | Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof |
US20030133955A1 (en) * | 1993-02-22 | 2003-07-17 | American Bioscience, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
US6753006B1 (en) * | 1993-02-22 | 2004-06-22 | American Bioscience, Inc. | Paclitaxel-containing formulations |
US6528067B1 (en) | 1993-02-22 | 2003-03-04 | American Bioscience, Inc. | Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof |
US5665383A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of immunostimulating agents for in vivo delivery |
US20070116761A1 (en) * | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US5650156A (en) * | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
DK0693924T4 (en) | 1993-02-22 | 2008-08-04 | Abraxis Bioscience Inc | Process for (in vivo) delivery of biological materials and compositions suitable therefor |
US5362478A (en) | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US5665382A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of pharmaceutically active agents for in vivo delivery |
US20030068362A1 (en) * | 1993-02-22 | 2003-04-10 | American Bioscience, Inc. | Methods and formulations for the delivery of pharmacologically active agents |
US20030073642A1 (en) * | 1993-02-22 | 2003-04-17 | American Bioscience, Inc. | Methods and formulations for delivery of pharmacologically active agents |
DK0797988T3 (en) | 1993-07-19 | 2009-05-11 | Univ British Columbia | Anti-angiogenic compositions and methods for their use |
US5994341A (en) * | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
US6441026B1 (en) * | 1993-11-08 | 2002-08-27 | Aventis Pharma S.A. | Antitumor compositions containing taxane derivatives |
WO1995019171A1 (en) * | 1994-01-14 | 1995-07-20 | Cell Therapeutics, Inc. | Method for treating diseases mediated by cellular proliferation in response to pdgf, egf, fgf and vegf |
US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
US5534270A (en) | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
AU716005B2 (en) * | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
US5744460A (en) * | 1996-03-07 | 1998-04-28 | Novartis Corporation | Combination for treatment of proliferative diseases |
US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
NZ332234A (en) * | 1996-03-12 | 2000-06-23 | Pg Txl Company Lp | Water soluble paclitaxel prodrugs formed by conjugating paclitaxel or docetaxel with a polyglutamic acid polymer and use for treating cancer |
ATE340586T1 (en) * | 1996-07-30 | 2006-10-15 | Novartis Pharma Gmbh | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TRANSPLANT REJECTION AND AUTOIMMUNE OR INFLAMMATORY CONDITIONS |
US20070092563A1 (en) | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US5997899A (en) | 1996-10-01 | 1999-12-07 | Skyepharma Inc. | Method for producing liposomes with increased percent of compound encapsulated |
US6495579B1 (en) * | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
US6143276A (en) * | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
EP0973804B1 (en) | 1997-04-07 | 2006-12-27 | Genentech, Inc. | Anti-vegf antibodies |
US6884879B1 (en) * | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
IL133672A0 (en) | 1997-06-27 | 2001-04-30 | Vivorx Pharmaceuticals Inc | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
US6258084B1 (en) | 1997-09-11 | 2001-07-10 | Vnus Medical Technologies, Inc. | Method for applying energy to biological tissue including the use of tumescent tissue compression |
GB9800569D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
CA2362338A1 (en) * | 1998-07-30 | 2000-02-10 | Human Rt. | Pharmaceutically acceptable composition comprising an aqueous solution of paclitaxel and albumin |
US6682758B1 (en) * | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
US6740665B1 (en) | 1999-02-10 | 2004-05-25 | Ramachandran Murali | Tyrosine kinase inhibitors and methods of using the same |
US6537585B1 (en) * | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
WO2000071079A2 (en) | 1999-05-21 | 2000-11-30 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
BR0010794A (en) | 1999-05-24 | 2002-06-04 | Sonus Pharma Inc | Emulsion-vehicle for drugs with poor solubility |
WO2001034174A2 (en) | 1999-11-12 | 2001-05-17 | Entremed, Inc. | Methods for administration of therapeutic agents on an antiangiogenic schedule |
US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
IT1318401B1 (en) * | 2000-03-17 | 2003-08-25 | Indena Spa | N-DESACETYLTHIOCOLCHYCIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN. |
SK14452002A3 (en) | 2000-04-10 | 2003-07-01 | Teva Pharmaceutical Industries Ltd. | A composition for treating cancer |
ITMI20001107A1 (en) * | 2000-05-18 | 2001-11-18 | Acs Dobfar Spa | METHOD FOR TREATMENT OF SOLIC TUMORS BY INCORPORATING PACLITAXEL MICROPARTICLES OF ALBUMIN |
IL153111A0 (en) * | 2000-06-30 | 2003-06-24 | Glaxo Group Ltd | Quinazoline ditosylate salt compounds |
AU2001292548B2 (en) * | 2000-07-28 | 2005-06-16 | Sloan-Kettering Institute For Cancer Research | Methods for treating cell proliferative disorders and viral infections |
HUP0302599A3 (en) | 2000-09-22 | 2005-05-30 | Bristol Myers Squibb Co | Method for reducing toxicity of combined chemotherapic compositions |
ES2236481T3 (en) * | 2001-01-16 | 2005-07-16 | Glaxo Group Limited | PHARMACEUTICAL COMBINATION CONTAINING A 4-QUINAZOLINAMINE AND PACLITAXEL, CARBOPLATIN OR VINORELBINE FOR CANCER TREATMENT. |
JP2004523518A (en) | 2001-01-19 | 2004-08-05 | バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド | Cancer treatment method with more efficacy and less side effects |
US6548531B2 (en) * | 2001-02-09 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for cancer therapy |
GB0103668D0 (en) * | 2001-02-15 | 2001-03-28 | Biointeractions Ltd | Methods and clinical devices for the inhibition or prevention of mammalian cell growth |
WO2002069949A2 (en) * | 2001-03-06 | 2002-09-12 | Prendergast Patrick T | Combination therapy for reduction of toxycity of chemotherapeutic agents |
EE200300429A (en) | 2001-03-06 | 2003-12-15 | Bristol-Myers Squibb Company | Use of Tegafur, uracil, folinic acid, paclitaxel and carboplatin in the preparation of a pharmaceutical composition for the treatment of a tumor |
US6752922B2 (en) * | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
US7638161B2 (en) | 2001-07-20 | 2009-12-29 | Applied Materials, Inc. | Method and apparatus for controlling dopant concentration during BPSG film deposition to reduce nitride consumption |
US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
US7056338B2 (en) * | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
US20040033271A1 (en) * | 2001-12-03 | 2004-02-19 | Seth Lederman | Methods for contemporaneous administration of levamisole and 5-fluorouracil |
ITMI20020681A1 (en) | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | PROCEDURE FOR THE PRODUCTION OF PACLITAXEL AND ALBUMINA NANOPARTICLES |
ITMI20020680A1 (en) | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | IMPROVED ANTI-TUMOR COMPOSITION BASED ON PACLITAXEL AND METHOD FOR ITS OBTAINING |
US20040126400A1 (en) * | 2002-05-03 | 2004-07-01 | Iversen Patrick L. | Delivery of therapeutic compounds via microparticles or microbubbles |
US7794743B2 (en) * | 2002-06-21 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of making the same |
AU2003251955A1 (en) | 2002-07-16 | 2004-02-02 | Sonus Pharmaceuticals, Inc. | Platinum compound |
ATE502635T1 (en) | 2002-08-19 | 2011-04-15 | Pfizer | COMBINATION THERAPY AGAINST HYPERPROLIFERATIVE DISEASES |
US20040047835A1 (en) * | 2002-09-06 | 2004-03-11 | Cell Therapeutics, Inc. | Combinatorial drug therapy using polymer drug conjugates |
US20050158375A1 (en) * | 2002-11-15 | 2005-07-21 | Toshikiro Kimura | Pharmaceutical composition containing liposomes for treating cancer |
US20050095267A1 (en) * | 2002-12-04 | 2005-05-05 | Todd Campbell | Nanoparticle-based controlled release polymer coatings for medical implants |
KR20050095826A (en) * | 2002-12-09 | 2005-10-04 | 아메리칸 바이오사이언스, 인크. | Compositions and methods of delivery of pharmacological agents |
MXPA05007382A (en) * | 2003-01-10 | 2005-11-23 | Threshold Pharmaceuticals Inc | Treatment of cancer with 2-deoxyglucose. |
JP2006523235A (en) * | 2003-03-28 | 2006-10-12 | コーザン バイオサイエンシス インコーポレイテッド | Apparatus, method and composition for preventing restenosis |
US20060165744A1 (en) | 2003-05-22 | 2006-07-27 | Neopharm, Inc | Combination liposomal formulations |
MXPA05012723A (en) | 2003-05-30 | 2006-02-08 | Genentech Inc | Treatment with anti-vegf antibodies. |
US20050026893A1 (en) * | 2003-05-30 | 2005-02-03 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants |
AR046510A1 (en) * | 2003-07-25 | 2005-12-14 | Regeneron Pharma | COMPOSITION OF A VEGF ANTAGONIST AND AN ANTI-PROLIFERATIVE AGENT |
JP2007505938A (en) | 2003-09-23 | 2007-03-15 | ノバルティス アクチエンゲゼルシャフト | Combination of VEGF receptor inhibitor and chemotherapeutic agent |
DK2286794T3 (en) | 2003-10-15 | 2016-07-25 | Syncore Biotechnology Co Ltd | USE OF CATIONIC LIPOSOMES, WHICH INCLUDES paclitaxel |
US20080045559A1 (en) | 2003-10-29 | 2008-02-21 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
DE602004027936D1 (en) | 2003-10-29 | 2010-08-12 | Sonus Pharmaceutical Inc | TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUND |
US20050203174A1 (en) * | 2004-03-09 | 2005-09-15 | Kosan Biosciences, Inc. | Combination therapies using leptomycin B |
CA2560059A1 (en) | 2004-03-15 | 2005-09-29 | Sonus Pharmaceuticals, Inc. | Platinum carboxylate anticancer compounds |
WO2006001911A2 (en) * | 2004-05-06 | 2006-01-05 | Genentech, Inc. | Crystal structure of the hepatocyte growth factor beta chain and methods of use |
US8420603B2 (en) * | 2004-05-14 | 2013-04-16 | Abraxis Bioscience, Llc | SPARC and methods of use thereof |
EP1755653B1 (en) | 2004-05-14 | 2014-12-31 | Abraxis BioScience, LLC | Treatment methods utilizing albumin-binding proteins as targets |
NZ551180A (en) | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
CN1960732A (en) * | 2004-06-03 | 2007-05-09 | 霍夫曼-拉罗奇有限公司 | Treatment with gemcitabine and EGFR-inhibitor |
US20060051345A1 (en) | 2004-06-04 | 2006-03-09 | Genentech, Inc. | Method for treating multiple sclerosis |
SV2006002143A (en) | 2004-06-16 | 2006-01-26 | Genentech Inc | USE OF AN ANTIBODY FOR THE TREATMENT OF CANCER RESISTANT TO PLATINUM |
EP2301531B1 (en) | 2005-02-18 | 2018-06-06 | Abraxis BioScience, LLC | Combinations and modes of administration of therapeutic agents and combination therapy |
AU2006237613A1 (en) * | 2005-02-18 | 2006-10-26 | Abraxis Bioscience, Inc. | Q3 SPARC deletion mutant and uses thereof |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
US20070166388A1 (en) | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
WO2006117220A2 (en) | 2005-05-04 | 2006-11-09 | Medigene Ag | Method of administering a cationic liposomal preparation comprising paclitaxel |
US20080221135A1 (en) | 2005-05-13 | 2008-09-11 | Bristol-Myers Squibb Company | Combination therapy |
US8034765B2 (en) | 2005-08-31 | 2011-10-11 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
KR101420445B1 (en) | 2005-08-31 | 2014-07-16 | 아브락시스 바이오사이언스, 엘엘씨 | Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents |
WO2007059116A2 (en) | 2005-11-14 | 2007-05-24 | Abraxis Bioscience, Inc. | Geldanamycin derivatives and pharmaceutical compositions thereof |
CA2922029C (en) | 2006-03-22 | 2017-11-28 | Medigene Ag | A combination of a cationic liposomal preparation comprising an antimitotic agent and a non-liposomal preparation comprising an antimitotic agent |
US9037257B2 (en) * | 2006-04-07 | 2015-05-19 | Medtronic, Inc. | Resonance tuning module for implantable devices and leads |
SG136814A1 (en) | 2006-04-12 | 2007-11-29 | Tencube Pte Ltd | System for tracking mobile equipment and associated mobile subscribersæ identity |
US20080280987A1 (en) | 2006-08-31 | 2008-11-13 | Desai Neil P | Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases |
US20100112077A1 (en) | 2006-11-06 | 2010-05-06 | Abraxis Bioscience, Llc | Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer |
LT2117520T (en) | 2006-12-14 | 2018-12-10 | Abraxis Bioscience, Llc | Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane |
DK2481409T3 (en) | 2007-03-07 | 2018-08-06 | Abraxis Bioscience Llc | Nanoparticle comprising rapamycin and albumin as anticancer agent |
EP3326630A3 (en) | 2007-05-03 | 2018-08-29 | Abraxis BioScience, LLC | Methods and compositions for treating pulmonary hypertension |
US8927019B2 (en) | 2007-06-01 | 2015-01-06 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
WO2009009587A2 (en) | 2007-07-09 | 2009-01-15 | Board Of Regents Of The University Of Nebraska | Apoptosis-modulating protein therapy for proliferative disorders and nanoparticles containing the same |
WO2009126401A1 (en) | 2008-04-10 | 2009-10-15 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
US20120128732A1 (en) | 2008-12-11 | 2012-05-24 | Vuong Trieu | Combinations and modes of administration of therapeutic agents and combination therapy |
WO2010105172A1 (en) | 2009-03-13 | 2010-09-16 | Abraxis Bioscience, Llc | Combination therapy with thiocolchicine derivatives |
ES2788298T3 (en) | 2009-04-10 | 2020-10-21 | Abraxis Bioscience Llc | Nanoparticle formulations and their uses |
US20100297243A1 (en) | 2009-04-15 | 2010-11-25 | Desai Neil P | Prion free nanoparticle compositions and methods of making thereof |
US20130045240A1 (en) | 2009-08-25 | 2013-02-21 | Abraxis Bioscience, Llc | Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors |
BR112012024349A2 (en) | 2010-03-26 | 2016-05-24 | Abraxis Bioscience Llc | Hepatocellular carcinoma treatment methods |
WO2011123395A1 (en) | 2010-03-29 | 2011-10-06 | Abraxis Bioscience, Llc | Methods of treating cancer |
KR20130028727A (en) | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | Methods of enhancing drug delivery and effectiveness of therapeutic agents |
WO2011137114A1 (en) | 2010-04-26 | 2011-11-03 | Abraxis Bioscience, Llc | Sparc binding antibodies and uses thereof |
JP2013527232A (en) | 2010-06-02 | 2013-06-27 | アブラクシス バイオサイエンス, エルエルシー | How to treat bladder cancer |
NZ604031A (en) | 2010-06-04 | 2015-05-29 | Abraxis Bioscience Llc | Methods of treatment of pancreatic cancer |
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US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5916596A (en) | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US6506405B1 (en) | 1993-02-22 | 2003-01-14 | American Bioscience, Inc. | Methods and formulations of cremophor-free taxanes |
US6537579B1 (en) | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
US6566405B2 (en) | 1998-04-16 | 2003-05-20 | Eurovita A/S | Synergistic compositions containing aromatic compounds and terpenoids present in alpinia galanga |
WO2000064437A1 (en) | 1999-04-22 | 2000-11-02 | American Biosciences, Inc. | Long term administration of pharmacologically active agents |
WO2001089522A1 (en) | 2000-05-19 | 2001-11-29 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
US20040143004A1 (en) | 2002-02-26 | 2004-07-22 | Joseph Fargnoli | Metronomic dosing of taxanes |
US20050004002A1 (en) | 2002-12-09 | 2005-01-06 | American Bioscience, Inc. | Compositions and methods of delivery of pharmacological agents |
Non-Patent Citations (9)
Title |
---|
DESAI ET AL., EORTC-NCI-AACR, 2004 |
GRANT ET AL., INT. J. CANCER, 2003 |
LORENZ ET AL., AGENTS ACTIONS, vol. 7, 1987, pages 63 - 67 |
NAT. MED., vol. 5, no. 9, 1999, pages 1032 - 1038 |
NG ET AL., CANCER RES., vol. 64, 2004, pages 821 - 824 |
O'SHAUGHNESSY ET AL.: "Abstract #1122", SAN ANTONIO BREAST CANCER SYMPOSIUM, December 2003 (2003-12-01) |
O'SHAUGHNESSY J A ET AL: "Weekly nanoparticle albumin paclitaxel (Abraxane) results in long-term disease control in patients with taxane-refractory metastatic breast cancer.", BREAST CANCER RESEARCH AND TREATMENT, vol. 88, no. Suppl. 1, 2004, & 27TH ANNUAL CHARLES A COLTMAN SAN ANTONIO BREAST CANCER SYMPOSIUM; SAN ANTONIO, TX, USA; DECEMBER 08 -11, 2004, pages S65, XP009068641, ISSN: 0167-6806 * |
STINCHCOMBE T E ET AL: "Preliminary results of phase I trial of carboplatin (CP) in combination with ABI-007 administered weekly or every 3 weeks in patients (pts) with solid tumors.", BREAST CANCER RESEARCH AND TREATMENT, vol. 94, no. Suppl. 1, 2005, & 28TH ANNUAL SAN ANTONIO BREAST CANCER SYMPOSIUM; SAN ANTONIO, TX, USA; DECEMBER 08 -11, 2005, pages S71, XP009068639, ISSN: 0167-6806 * |
WEISS ET AL., J. CLIN. ONCOL., vol. 8, 1990, pages 1263 - 1268 |
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RU2483714C2 (en) * | 2007-03-07 | 2013-06-10 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи. | Nanoparticle, containing rapamycin and albumin as anti-cancer agent |
AU2015271950B2 (en) * | 2007-03-07 | 2017-09-28 | Abraxis Bioscience, Llc | Nanoparticle comprising rapamycin and albumin as anticancer agent |
CN104814930A (en) * | 2007-03-07 | 2015-08-05 | 阿布拉科斯生物科学有限公司 | Nanoparticle comprising rapamycin and albumin as anticancer agent |
JP2014015487A (en) * | 2007-03-07 | 2014-01-30 | Abraxis Bioscience Llc | Nanoparticle comprising rapamycin and albumin as anticancer agent |
WO2008109163A1 (en) * | 2007-03-07 | 2008-09-12 | Abraxis Bioscience, Llc. | Nanoparticle comprising rapamycin and albumin as anticancer agent |
US20100183728A1 (en) * | 2007-03-07 | 2010-07-22 | Desai Neil P | Nanoparticle comprising rapamycin and albumin as anticancer agent |
EP2481402A3 (en) * | 2007-03-07 | 2012-10-17 | Abraxis BioScience, LLC | Nanoparticle comprising rapamycin and albumin as anticancer agent |
JP2018150381A (en) * | 2007-03-07 | 2018-09-27 | アブラクシス バイオサイエンス, エルエルシー | Nanoparticle comprising rapamycin and albumin as anticancer agent |
AU2008223334B2 (en) * | 2007-03-07 | 2014-05-08 | Abraxis Bioscience, Llc | Nanoparticle comprising rapamycin and albumin as anticancer agent |
US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
AU2008260447B2 (en) * | 2007-06-01 | 2013-10-10 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
US8927019B2 (en) | 2007-06-01 | 2015-01-06 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
JP2016172777A (en) * | 2007-06-01 | 2016-09-29 | アブラクシス バイオサイエンス, エルエルシー | Method and composition for treating recurrent cancer |
JP2014185186A (en) * | 2007-06-01 | 2014-10-02 | Abraxis Bioscience Llc | Methods and compositions for treating recurrent cancer |
WO2008150532A1 (en) * | 2007-06-01 | 2008-12-11 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
JP2010529025A (en) * | 2007-06-01 | 2010-08-26 | アブラクシス バイオサイエンス, エルエルシー | Methods and compositions for the treatment of recurrent cancer |
JP2011507840A (en) * | 2007-12-19 | 2011-03-10 | アーデニア・インベストメンツ・リミテッド | Drug delivery system for administering water-soluble, cationic and amphiphilic pharmaceutically active substances |
WO2009127072A1 (en) | 2008-04-18 | 2009-10-22 | Angiochem Inc. | Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use |
EP2279008A4 (en) * | 2008-04-18 | 2013-09-04 | Angiochem Inc | Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use |
EP2279008A1 (en) * | 2008-04-18 | 2011-02-02 | Angiochem Inc. | Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use |
US8710013B2 (en) | 2008-04-18 | 2014-04-29 | Angiochem Inc. | Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use |
US8846628B2 (en) | 2008-05-15 | 2014-09-30 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
US10220050B2 (en) | 2008-05-15 | 2019-03-05 | Celgene Corporation | Isotopologues of 5-azacytidine |
US11571436B2 (en) | 2008-05-15 | 2023-02-07 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
US10463683B2 (en) | 2008-05-15 | 2019-11-05 | Celgene Corporation | Isotopologues of 5-azacytidine |
US10646503B2 (en) | 2008-05-15 | 2020-05-12 | Celgene Corporation | Isotopologues of 5-azacytidine |
US8828925B2 (en) | 2008-10-15 | 2014-09-09 | Angiochem Inc. | Etoposide and doxorubicin conjugates for drug delivery |
US8921314B2 (en) | 2008-10-15 | 2014-12-30 | Angiochem, Inc. | Conjugates of GLP-1 agonists and uses thereof |
US9914754B2 (en) | 2008-12-05 | 2018-03-13 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
US10206887B2 (en) | 2009-04-15 | 2019-02-19 | Abraxis Bioscience, Llc | Prion free nanoparticle compositions and methods of making thereof |
US9446003B2 (en) | 2009-04-15 | 2016-09-20 | Abraxis Bioscience, Llc | Prion free nanoparticle compositions and methods of making thereof |
US9173891B2 (en) | 2009-04-20 | 2015-11-03 | Angiochem, Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
US9161988B2 (en) | 2009-07-02 | 2015-10-20 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
US9370494B2 (en) | 2010-03-26 | 2016-06-21 | Abraxis Bioscience, Llc | Methods for treating hepatocellular carcinoma |
RU2589513C2 (en) * | 2010-03-29 | 2016-07-10 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Methods of treating oncological diseases |
US9393318B2 (en) | 2010-03-29 | 2016-07-19 | Abraxis Bioscience, Llc | Methods of treating cancer |
AU2016202000B2 (en) * | 2010-03-29 | 2017-11-16 | Abraxis Bioscience, Llc | Methods of treating cancer |
EP2552415B1 (en) | 2010-03-29 | 2016-09-07 | Abraxis BioScience, LLC | Methods of treating cancer |
WO2011123395A1 (en) | 2010-03-29 | 2011-10-06 | Abraxis Bioscience, Llc | Methods of treating cancer |
US10660965B2 (en) | 2010-03-29 | 2020-05-26 | Abraxis Bioscience, Llc | Methods of enhancing drug delivery and effectiveness of therapeutic agents |
EP3141245A1 (en) * | 2010-03-29 | 2017-03-15 | Abraxis BioScience, LLC | Methods of treating cancer |
US9597409B2 (en) | 2010-03-29 | 2017-03-21 | Abraxis Bioscience, Llc | Methods of treating cancer |
AU2011261684B2 (en) * | 2010-06-02 | 2016-09-15 | Abraxis Bioscience, Llc | Methods of treating bladder cancer |
RU2621640C2 (en) * | 2010-06-02 | 2017-06-06 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Methods for bladder cancer treatment |
WO2011153009A1 (en) * | 2010-06-02 | 2011-12-08 | Abraxis Bioscience, Llc | Methods of treating bladder cancer |
RU2576609C2 (en) * | 2010-06-04 | 2016-03-10 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Methods of treating pancreatic cancer |
WO2011153010A1 (en) * | 2010-06-04 | 2011-12-08 | Abraxis Biosciences, Llc | Methods of treatment of pancreatic cancer |
US9399072B2 (en) | 2010-06-04 | 2016-07-26 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
US9399071B2 (en) | 2010-06-04 | 2016-07-26 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
US9820949B2 (en) | 2010-06-04 | 2017-11-21 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
AU2011261685B2 (en) * | 2010-06-04 | 2016-02-11 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
AU2016202815B2 (en) * | 2010-06-04 | 2018-02-08 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
AU2011264590B2 (en) * | 2010-06-07 | 2016-12-15 | Abraxis Bioscience, Llc | Combination therapy methods for treating proliferative diseases |
EP3056201A1 (en) * | 2010-06-07 | 2016-08-17 | Abraxis BioScience, LLC | Combination therapy methods for treating proliferative diseases |
WO2011156119A1 (en) * | 2010-06-07 | 2011-12-15 | Abraxis Bioscience, Llc | Combination therapy methods for treating proliferative diseases |
RU2577278C2 (en) * | 2010-06-07 | 2016-03-10 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Methods for combination therapy of proliferative diseases |
EP2575774A1 (en) * | 2010-06-07 | 2013-04-10 | Abraxis BioScience, LLC | Combination therapy methods for treating proliferative diseases |
EP2575774A4 (en) * | 2010-06-07 | 2014-01-22 | Abraxis Bioscience Llc | Combination therapy methods for treating proliferative diseases |
US10258565B2 (en) | 2011-04-28 | 2019-04-16 | Abraxis Bioscience, Llc | Intravascular delivery of nanoparticle compositions and uses thereof |
US9884013B2 (en) | 2011-04-28 | 2018-02-06 | Abraxis Bioscience, Llc | Intravascular delivery of nanoparticle compositions and uses thereof |
US9061014B2 (en) | 2011-04-28 | 2015-06-23 | Abraxis Bioscience, Llc | Intravascular delivery of nanoparticle compositions and uses thereof |
US10765741B2 (en) | 2011-05-09 | 2020-09-08 | Mayo Foundation For Medical Education And Research | Methods for treating VEGF-expressing cancer using preformed nanoparticle complexes comprising albumin-bound paclitaxel and bevacizumab |
WO2013067043A1 (en) * | 2011-11-01 | 2013-05-10 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
US9693987B2 (en) | 2011-11-01 | 2017-07-04 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
AU2012318239B2 (en) * | 2011-11-01 | 2015-07-09 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
US9125884B2 (en) | 2011-11-01 | 2015-09-08 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
US10076501B2 (en) | 2011-12-14 | 2018-09-18 | Abraxis Bioscience, Llc | Use of polymeric excipients for lyophilization or freezing of particles |
US9585960B2 (en) | 2011-12-14 | 2017-03-07 | Abraxis Bioscience, Llc | Use of polymeric excipients for lyophilization or freezing of particles |
US10555912B2 (en) | 2011-12-14 | 2020-02-11 | Abraxis Bioscience, Llc | Use of polymeric excipients for lyophilization or freezing of particles |
GB2513050A (en) * | 2011-12-20 | 2014-10-15 | European Molecular Biology Lab Embl | Detection and treatment of breast cancer |
WO2013093489A3 (en) * | 2011-12-20 | 2013-08-15 | The European Molecular Biology Laboratory | Detection and treatment of breast cancer |
US10376579B2 (en) | 2012-10-01 | 2019-08-13 | Mayo Foundation For Medical Education And Research | Nanoparticle complexes of albumin, paclitaxel, and anti-VEGF antibody for treatment of cancer |
US10668151B2 (en) | 2012-10-01 | 2020-06-02 | Mayo Foundation For Medical Education And Research | Nanoparticle complexes of albumin, paclitaxel, and panitumumab for treatment of cancer |
US10279036B2 (en) | 2012-10-01 | 2019-05-07 | Mayo Foundation For Medical Education And Research | Antibody-albumin nanoparticle complexes comprising albumin, bevacizumab, and paclitaxel, and methods of making and using the same |
US11648311B2 (en) | 2012-10-01 | 2023-05-16 | Mayo Foundation For Medical Education And Research | Cancer treatments |
US10307482B2 (en) | 2012-10-01 | 2019-06-04 | Mayo Foundation For Medical Education And Research | Nanoparticle complexes of paclitaxel, cetuximab, and albumin |
US10493150B2 (en) | 2012-10-01 | 2019-12-03 | Mayo Foundation For Medical Education And Research | Nanoparticle complexes of paclitaxel, alemtuzumab, and albumin |
US10507243B2 (en) | 2012-10-01 | 2019-12-17 | Mayo Foundation For Medical Education And Research | Nanoparticle complexes of rituximab, albumin and pacltaxel |
US10478495B2 (en) | 2012-10-01 | 2019-11-19 | Mayo Foundation For Medical Education And Research | Methods for treating cancer using nanoparticle complexes of paclitaxel, cetuximab, and albumin |
US10376580B2 (en) | 2012-10-01 | 2019-08-13 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with antibody-albumin nanoparticle complexes comprising albumin, trastuzumab, and paclitaxel |
US10441656B2 (en) | 2012-10-01 | 2019-10-15 | Mayo Foundation For Medical Education And Research | Nanoparticle complexes of paclitaxel, cetuximab, and albumin, and methods of making the same |
US10279035B2 (en) | 2012-10-01 | 2019-05-07 | Mayo Foundation For Medical Education And Research | Nanoparticle complexes of paclitaxel, trastuzumab, and albumin |
US10406224B2 (en) | 2012-10-01 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Nanoparticle complexes of paclitaxel, trastuzumab, and albumin |
US10413606B2 (en) | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
US10471145B2 (en) | 2012-10-01 | 2019-11-12 | Mayo Foundation For Medical Education And Research | Methods for treating cancer using nanoparticle complexes of paclitaxel, rituximab, and albumin |
US10420839B2 (en) | 2012-10-01 | 2019-09-24 | Mayo Foundation For Medical Education And Research | Methods for treating CD52-expressing cancers using compositions comprising nanoparticle complexes of paclitaxel, alemtuzumab, and albumin |
AU2016202111B2 (en) * | 2012-11-09 | 2018-03-29 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US10328031B2 (en) | 2013-01-11 | 2019-06-25 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
US9855220B2 (en) | 2013-01-11 | 2018-01-02 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
WO2014123612A1 (en) * | 2013-02-11 | 2014-08-14 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US10744110B2 (en) | 2013-03-12 | 2020-08-18 | Abraxis Bioscience, Llc | Methods of treating lung cancer |
US9962373B2 (en) | 2013-03-14 | 2018-05-08 | Abraxis Bioscience, Llc | Methods of treating bladder cancer |
US10413531B2 (en) | 2013-03-14 | 2019-09-17 | Abraxis Bioscience, Llc | Methods of treating bladder cancer |
US10842969B2 (en) | 2013-10-25 | 2020-11-24 | Mercator Medsystems, Inc. | Systems and methods of treating malacia by local delivery of hydrogel to augment tissue |
CN106132927A (en) * | 2014-03-27 | 2016-11-16 | 因德纳有限公司 | The activity of nitrogen-based thiocolchicine derivatives of amorphous form |
US10213513B2 (en) | 2014-06-16 | 2019-02-26 | Mayo Foundation For Medical Education And Research | Treating myelomas |
US11285221B2 (en) | 2014-06-16 | 2022-03-29 | Mayo Foundation For Medical Education And Research | Treating myelomas |
US10610484B2 (en) | 2014-10-06 | 2020-04-07 | Mayo Foundation For Medical Education And Research | Methods of using albumin-CD20 paclitaxel nanoparticle complex compositions for treating cancer |
US10993912B2 (en) | 2014-10-06 | 2021-05-04 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
US10993911B2 (en) | 2014-10-06 | 2021-05-04 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
US11433023B2 (en) | 2014-10-06 | 2022-09-06 | Mayo Foundation For Medical Education And Research | Albumin-PD-1 paclitaxel nanoparticle complex compositions and methods of making and using the same |
US10966923B2 (en) | 2014-10-06 | 2021-04-06 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
US10596112B2 (en) | 2014-10-06 | 2020-03-24 | Mayo Foundation For Medical Education And Research | Methods of using albumin-antibody nanoparticle complex compositions for treating cancer |
US10596111B2 (en) | 2014-10-06 | 2020-03-24 | Mayo Foundation For Medical Education And Research | Methods of making lyophilized compositions comprising albumin-VEGF paclitaxel nanoparticle complexes |
US10322084B2 (en) | 2014-10-06 | 2019-06-18 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
US10391055B2 (en) | 2014-10-06 | 2019-08-27 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
US10624846B2 (en) | 2014-10-06 | 2020-04-21 | Mayo Foundation For Medical Education And Research | Lyophilized compositions comprising albumin-antibody paclitaxel nanoparticle complexes |
US10772833B2 (en) | 2014-10-06 | 2020-09-15 | Mayo Foundation For Medical Education And Research | Albumin-CTLA-4 paclitaxel nanopartilce complex compositions and methods of making and using the same |
US10780050B2 (en) | 2014-10-06 | 2020-09-22 | Mayo Foundation For Medical Education And Research | Lyophilized compositions comprosing albumin-EGFR paclitaxel nanoparticle complexes |
US10780049B2 (en) | 2014-10-06 | 2020-09-22 | Mayo Foundation For Medical Education And Research | Lyophilized compositions comprising albumin-rankl or albumin-GD2 paclitaxel nanoparticle complexes |
US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
US10900951B1 (en) | 2015-03-05 | 2021-01-26 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
US10527604B1 (en) | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
US11320416B1 (en) | 2015-03-05 | 2022-05-03 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
US10980892B2 (en) | 2015-06-15 | 2021-04-20 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
US10973806B2 (en) | 2015-06-29 | 2021-04-13 | Abraxis Bioscience, Llc | Methods of treating epithelioid cell tumors comprising administering a composition comprising nanoparticles comprising an mTOR inhibitor and an albumin |
US11660339B2 (en) | 2015-10-06 | 2023-05-30 | Mayo Foundation For Medical Education And Research | Methods of treating cancer using compositions of antibodies and carrier proteins with antibody pretreatment |
US10561726B2 (en) | 2015-10-06 | 2020-02-18 | Vavotar Life Sciences LLC | Methods of treating cancer using compositions of antibodies and carrier proteins with antibody pretreatment |
US11571469B2 (en) | 2016-01-07 | 2023-02-07 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon wherein the cancer cells are HLA negative or have reduced HLA expression |
US11351254B2 (en) | 2016-02-12 | 2022-06-07 | Mayo Foundation For Medical Education And Research | Hematologic cancer treatments |
US11878061B2 (en) | 2016-03-21 | 2024-01-23 | Mayo Foundation For Medical Education And Research | Methods for improving the therapeutic index for a chemotherapeutic drug |
US11305020B2 (en) | 2016-03-21 | 2022-04-19 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
US11655301B2 (en) | 2016-04-06 | 2023-05-23 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
US11160876B2 (en) | 2016-09-01 | 2021-11-02 | Mayo Foundation For Medical Education And Research | Methods and compositions for targeting t-cell cancers |
US11548946B2 (en) | 2016-09-01 | 2023-01-10 | Mayo Foundation For Medical Education And Research | Carrier-PD-L1 binding agent compositions for treating cancers |
US11427637B2 (en) | 2016-09-06 | 2022-08-30 | Mayo Foundation For Medical Education And Research | Methods of treating PD-L1 expressing cancer |
US11590098B2 (en) | 2016-09-06 | 2023-02-28 | Mayo Foundation For Medical Education And Research | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
RU2756892C2 (en) * | 2016-09-06 | 2021-10-06 | Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч | Compositions with paclitaxel, albumin and binding agent and methods for their use and preparation |
KR102486055B1 (en) | 2016-09-06 | 2023-01-09 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | Paclitaxel-albumin-binder compositions and methods of use and preparation thereof |
US11872205B2 (en) | 2016-09-06 | 2024-01-16 | Mayo Foundation For Medical Education And Research | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
WO2018048958A1 (en) * | 2016-09-06 | 2018-03-15 | Mayo Foundation For Medical Education And Research | Paclitaxel-albumin-binding agent compositions and methods for using and making the same |
KR20190053204A (en) * | 2016-09-06 | 2019-05-17 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | Paclitaxel-Albumin-Binder Composition and Methods for its Use and Preparation |
US11311631B2 (en) | 2016-09-06 | 2022-04-26 | Mayo Foundation For Medical Education And Research | Paclitaxel-albumin-binding agent compositions and methods for using and making the same |
EP3512560A4 (en) * | 2016-09-13 | 2020-05-27 | Rasna Research Inc. | Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
US10973773B2 (en) | 2016-09-13 | 2021-04-13 | Tiziana Life Sciences Plc | Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
US11944708B2 (en) | 2018-03-20 | 2024-04-02 | Abraxis Bioscience, Llc | Methods of treating central nervous system disorders via administration of nanoparticles of an mTOR inhibitor and an albumin |
EP3858846A4 (en) * | 2018-09-30 | 2023-08-09 | Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. | Nucleic acid nanocarrier medicament, preparation method therefor, pharmaceutical composition thereof, and use thereof |
EP3926047A4 (en) * | 2018-10-16 | 2023-08-09 | Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. | Nucleic acid nano-carrier drug, preparation method therefor, and pharmaceutical composition and application thereof |
RU2706347C1 (en) * | 2019-07-24 | 2019-11-18 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ ИМЕНИ АКАДЕМИКА А.М. ГРАНОВА" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ / ФГБУ "РНЦРХТ им. ак. А.М. Гранова" Минздрава России | Method of treating operable pancreatic head adenocarcinoma |
US11497737B2 (en) | 2019-10-28 | 2022-11-15 | Abraxis Bioscience, Llc | Pharmaceutical compositions of albumin and rapamycin |
RU2774032C1 (en) * | 2021-12-02 | 2022-06-14 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Method for increasing the effectiveness of ionizing radiation on melanoma |
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