WO2006091774A3 - Transdermal electrotransport drug delivery systems with reduced abuse potential - Google Patents

Transdermal electrotransport drug delivery systems with reduced abuse potential Download PDF

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Publication number
WO2006091774A3
WO2006091774A3 PCT/US2006/006525 US2006006525W WO2006091774A3 WO 2006091774 A3 WO2006091774 A3 WO 2006091774A3 US 2006006525 W US2006006525 W US 2006006525W WO 2006091774 A3 WO2006091774 A3 WO 2006091774A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
delivery systems
transdermal electrotransport
electrotransport drug
abuse potential
Prior art date
Application number
PCT/US2006/006525
Other languages
French (fr)
Other versions
WO2006091774A2 (en
Inventor
Michel J N Cormier
Rama V Padmanabhan
Original Assignee
Alza Corp
Michel J N Cormier
Rama V Padmanabhan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp, Michel J N Cormier, Rama V Padmanabhan filed Critical Alza Corp
Priority to AU2006216634A priority Critical patent/AU2006216634A1/en
Priority to EP06735974A priority patent/EP1858584A2/en
Publication of WO2006091774A2 publication Critical patent/WO2006091774A2/en
Publication of WO2006091774A3 publication Critical patent/WO2006091774A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

Abstract

A transdermal electrotransport drug delivery system having reduced potential for abuse. The system uses ion barrier (112, 124, 130, 140, 162, 168), preferentially ion exchange material to separate the drug (110, 122, 136, 148, 154, 170) from an antagonist and provides for the release of the antagonist (116, 128, 132, 138, 164) with the agonist when the system is subject to abuse. In a preferred embodiment, the barrier has a weak area which breaks when under stress or placed in solvent. In another preferred embodiment, the barrier is a dialysis membrane.
PCT/US2006/006525 2005-02-24 2006-02-24 Transdermal electrotransport drug delivery systems with reduced abuse potential WO2006091774A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2006216634A AU2006216634A1 (en) 2005-02-24 2006-02-24 Transdermal electrotransport drug delivery systems with reduced abuse potential
EP06735974A EP1858584A2 (en) 2005-02-24 2006-02-24 Transdermal electrotransport drug delivery systems with reduced abuse potential

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65618105P 2005-02-24 2005-02-24
US60/656,181 2005-02-24

Publications (2)

Publication Number Publication Date
WO2006091774A2 WO2006091774A2 (en) 2006-08-31
WO2006091774A3 true WO2006091774A3 (en) 2008-01-10

Family

ID=36649078

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/006525 WO2006091774A2 (en) 2005-02-24 2006-02-24 Transdermal electrotransport drug delivery systems with reduced abuse potential

Country Status (7)

Country Link
US (1) US20060211980A1 (en)
EP (1) EP1858584A2 (en)
CN (1) CN101309724A (en)
AU (1) AU2006216634A1 (en)
RU (1) RU2007135188A (en)
TW (1) TW200640526A (en)
WO (1) WO2006091774A2 (en)

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US7590444B2 (en) * 2004-12-09 2009-09-15 Tti Ellebeau, Inc. Iontophoresis device
JP4731931B2 (en) * 2005-02-03 2011-07-27 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
JP4793806B2 (en) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
US8386030B2 (en) 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US8295922B2 (en) 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
JPWO2007023907A1 (en) * 2005-08-24 2009-02-26 Ｔｔｉ・エルビュー株式会社 Electrode structure for frozen iontophoresis
WO2007031973A2 (en) * 2005-09-15 2007-03-22 Visible Assets, Inc. Active low frequency radio tag and patch drug delivery system
CN101321554A (en) * 2005-09-30 2008-12-10 Tti优而美株式会社 Transdermal drug delivery systems, devices, and methods employing opioid agonist and/or opioid antagonist
US20080154230A1 (en) * 2006-12-20 2008-06-26 Janardhanan Anand Subramony Anode for electrotransport of cationic drug
US8838229B2 (en) 2009-05-04 2014-09-16 University Of Florida Research Foundation, Inc. Method and device for electromotive delivery of macromolecules into tissue
CN104383634A (en) * 2014-12-09 2015-03-04 沈阳药科大学 Percutaneous iontophoresis drug-delivery system and preparation method thereof
CN114768045A (en) * 2022-03-28 2022-07-22 重庆师范大学 Hemodialysis tube and antibacterial method thereof

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US6049733A (en) * 1994-04-08 2000-04-11 Alza Corporation Electrotransport system with ion exchange material competitive ion capture
US6216033B1 (en) * 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US20040013716A1 (en) * 2002-04-23 2004-01-22 Gale Robert M. Transdermal analgesic systems with reduced abuse potential
US20040219196A1 (en) * 2003-04-30 2004-11-04 3M Innovative Properties Company Abuse-resistant transdermal dosage form
US20040241218A1 (en) * 2001-05-01 2004-12-02 Lino Tavares Abuse resistant opioid containing transdermal systems

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Publication number Priority date Publication date Assignee Title
US6049733A (en) * 1994-04-08 2000-04-11 Alza Corporation Electrotransport system with ion exchange material competitive ion capture
WO1997004835A1 (en) * 1995-07-28 1997-02-13 Novartis Ag Transdermal system
US6216033B1 (en) * 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US20040241218A1 (en) * 2001-05-01 2004-12-02 Lino Tavares Abuse resistant opioid containing transdermal systems
US20040013716A1 (en) * 2002-04-23 2004-01-22 Gale Robert M. Transdermal analgesic systems with reduced abuse potential
US20040219196A1 (en) * 2003-04-30 2004-11-04 3M Innovative Properties Company Abuse-resistant transdermal dosage form

Also Published As

Publication number Publication date
CN101309724A (en) 2008-11-19
AU2006216634A1 (en) 2006-08-31
US20060211980A1 (en) 2006-09-21
RU2007135188A (en) 2009-03-27
WO2006091774A2 (en) 2006-08-31
TW200640526A (en) 2006-12-01
EP1858584A2 (en) 2007-11-28

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