WO2006091921A3 - Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications - Google Patents

Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications Download PDF

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Publication number
WO2006091921A3
WO2006091921A3 PCT/US2006/006790 US2006006790W WO2006091921A3 WO 2006091921 A3 WO2006091921 A3 WO 2006091921A3 US 2006006790 W US2006006790 W US 2006006790W WO 2006091921 A3 WO2006091921 A3 WO 2006091921A3
Authority
WO
WIPO (PCT)
Prior art keywords
sparger
epsilon
caprolactone
super
structures
Prior art date
Application number
PCT/US2006/006790
Other languages
French (fr)
Other versions
WO2006091921A2 (en
Inventor
Andrew Darling
Lauren Shor
Wei Sun
Selcuk Guceri
Original Assignee
Univ Drexel
Andrew Darling
Lauren Shor
Wei Sun
Selcuk Guceri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Drexel, Andrew Darling, Lauren Shor, Wei Sun, Selcuk Guceri filed Critical Univ Drexel
Publication of WO2006091921A2 publication Critical patent/WO2006091921A2/en
Priority to US11/842,796 priority Critical patent/US20080020049A1/en
Publication of WO2006091921A3 publication Critical patent/WO2006091921A3/en
Priority to US12/877,818 priority patent/US8735117B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A microcarrier bead having a porous three-dimensional core having at least 99% interconnected pores and an outer protective layer for growing cells in a bioreactor using higher sparging rates than cells would ordinary withstand. A method of making an artificial scaffold wherein a scaffolding material is extruded into a coolant and thereby creating a porous material.
PCT/US2006/006790 2005-02-25 2006-02-24 Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications WO2006091921A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/842,796 US20080020049A1 (en) 2005-02-25 2007-08-21 Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications
US12/877,818 US8735117B2 (en) 2005-02-25 2010-09-08 Method for making artificial scaffold having porous three-dimensional body comprising cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65650505P 2005-02-25 2005-02-25
US65625805P 2005-02-25 2005-02-25
US60/656,505 2005-02-25
US60/656,258 2005-02-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/842,796 Continuation-In-Part US20080020049A1 (en) 2005-02-25 2007-08-21 Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications

Publications (2)

Publication Number Publication Date
WO2006091921A2 WO2006091921A2 (en) 2006-08-31
WO2006091921A3 true WO2006091921A3 (en) 2007-12-27

Family

ID=36928102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/006790 WO2006091921A2 (en) 2005-02-25 2006-02-24 Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications

Country Status (1)

Country Link
WO (1) WO2006091921A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9458431B2 (en) 2008-03-17 2016-10-04 Agency For Science, Technology And Research Microcarriers for stem cell culture
WO2009116951A2 (en) 2008-03-17 2009-09-24 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8691569B2 (en) 2008-03-17 2014-04-08 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8828720B2 (en) 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
SG174471A1 (en) 2009-03-20 2011-10-28 Agency Science Tech & Res Culture of pluripotent and multipotent cells on microcarriers
KR101067827B1 (en) 2010-03-19 2011-09-27 포항공과대학교 산학협력단 Three-dimensional scaffold and fabrication method for the same
US20160083690A1 (en) * 2013-04-10 2016-03-24 Agency For Science, Technology And Research Microcarriers for stem cell culture and fabrication thereof
EP3623136B1 (en) * 2018-09-14 2023-11-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for producing three-dimensional hydrogel structures and device for the layerwise building-up of such hydrogel structures
WO2020204777A1 (en) * 2019-03-29 2020-10-08 Akira Science Ab Scaffolds for use in tissue engineering and method for preparing scaffolds
CN110124103B (en) * 2019-05-08 2021-07-23 上海交通大学 Active substance sustained-release material system for tissue repair and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073491A (en) * 1988-12-23 1991-12-17 Hoffman-La Roche Inc. Immobilization of cells in alginate beads containing cavities for growth of cells in airlift bioreactors
US20040010320A1 (en) * 2000-05-11 2004-01-15 Huckle James William Tissue regrafting
WO2004012782A1 (en) * 2002-07-30 2004-02-12 Bionethos Holding Method and device for culturing cells
US20060154365A1 (en) * 2004-08-30 2006-07-13 Anthony Ratcliffe Cultured three dimensional tissues and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073491A (en) * 1988-12-23 1991-12-17 Hoffman-La Roche Inc. Immobilization of cells in alginate beads containing cavities for growth of cells in airlift bioreactors
US20040010320A1 (en) * 2000-05-11 2004-01-15 Huckle James William Tissue regrafting
WO2004012782A1 (en) * 2002-07-30 2004-02-12 Bionethos Holding Method and device for culturing cells
US20050221485A1 (en) * 2002-07-30 2005-10-06 Augustinus Bader Method and device for culturing cells
US20060154365A1 (en) * 2004-08-30 2006-07-13 Anthony Ratcliffe Cultured three dimensional tissues and uses thereof

Also Published As

Publication number Publication date
WO2006091921A2 (en) 2006-08-31

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