WO2006101885A3 - Soft tissue processing - Google Patents

Soft tissue processing Download PDF

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Publication number
WO2006101885A3
WO2006101885A3 PCT/US2006/009286 US2006009286W WO2006101885A3 WO 2006101885 A3 WO2006101885 A3 WO 2006101885A3 US 2006009286 W US2006009286 W US 2006009286W WO 2006101885 A3 WO2006101885 A3 WO 2006101885A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
soft tissue
fascia
dermis
human
Prior art date
Application number
PCT/US2006/009286
Other languages
French (fr)
Other versions
WO2006101885A2 (en
Inventor
Katherine Gomes Truncale
Carl Alexander Depaula
Jeffrey Stuart Cartmell
David J Gocke
Carina Syring
Versen Ruediger Von
Original Assignee
Musculoskeletal Transplant
Katherine Gomes Truncale
Carl Alexander Depaula
Jeffrey Stuart Cartmell
David J Gocke
Carina Syring
Versen Ruediger Von
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Musculoskeletal Transplant, Katherine Gomes Truncale, Carl Alexander Depaula, Jeffrey Stuart Cartmell, David J Gocke, Carina Syring, Versen Ruediger Von filed Critical Musculoskeletal Transplant
Priority to CA002602100A priority Critical patent/CA2602100A1/en
Priority to AU2006227711A priority patent/AU2006227711A1/en
Priority to EP06738359A priority patent/EP1858319A2/en
Publication of WO2006101885A2 publication Critical patent/WO2006101885A2/en
Publication of WO2006101885A3 publication Critical patent/WO2006101885A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0215—Disinfecting agents, e.g. antimicrobials for preserving living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Abstract

The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps: (1) isolating from a suitable donor a desired soft tissue sample of the biological material; (2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water; (3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same; (4) processing the tissue by cutting the tissue to size and perforating the tissue; and (5) dipping the tissue in 70% ethanol and packaging the tissue.
PCT/US2006/009286 2005-03-16 2006-03-15 Soft tissue processing WO2006101885A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002602100A CA2602100A1 (en) 2005-03-16 2006-03-15 Soft tissue processing
AU2006227711A AU2006227711A1 (en) 2005-03-16 2006-03-15 Soft tissue processing
EP06738359A EP1858319A2 (en) 2005-03-16 2006-03-15 Soft tissue processing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66207805P 2005-03-16 2005-03-16
US60/662,078 2005-03-16

Publications (2)

Publication Number Publication Date
WO2006101885A2 WO2006101885A2 (en) 2006-09-28
WO2006101885A3 true WO2006101885A3 (en) 2009-04-16

Family

ID=37024354

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/009286 WO2006101885A2 (en) 2005-03-16 2006-03-15 Soft tissue processing

Country Status (5)

Country Link
US (2) US7723108B2 (en)
EP (1) EP1858319A2 (en)
AU (1) AU2006227711A1 (en)
CA (1) CA2602100A1 (en)
WO (1) WO2006101885A2 (en)

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Also Published As

Publication number Publication date
AU2006227711A1 (en) 2006-09-28
EP1858319A2 (en) 2007-11-28
US20060275377A1 (en) 2006-12-07
US8557581B2 (en) 2013-10-15
WO2006101885A2 (en) 2006-09-28
US7723108B2 (en) 2010-05-25
US20100304487A1 (en) 2010-12-02
CA2602100A1 (en) 2006-09-28

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