WO2006102533A3 - Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates - Google Patents

Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates Download PDF

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Publication number
WO2006102533A3
WO2006102533A3 PCT/US2006/010638 US2006010638W WO2006102533A3 WO 2006102533 A3 WO2006102533 A3 WO 2006102533A3 US 2006010638 W US2006010638 W US 2006010638W WO 2006102533 A3 WO2006102533 A3 WO 2006102533A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleoside
lipid
methods
pharmaceutically active
based formulation
Prior art date
Application number
PCT/US2006/010638
Other languages
French (fr)
Other versions
WO2006102533A2 (en
Inventor
Jia-Ai Zhang
Sydney Ugwu
Lan Ma
Moghis U Ahmad
Shoukath M Ali
Abdul R Khan
Imran Ahmad
Original Assignee
Neopharm Inc
Jia-Ai Zhang
Sydney Ugwu
Lan Ma
Moghis U Ahmad
Shoukath M Ali
Abdul R Khan
Imran Ahmad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neopharm Inc, Jia-Ai Zhang, Sydney Ugwu, Lan Ma, Moghis U Ahmad, Shoukath M Ali, Abdul R Khan, Imran Ahmad filed Critical Neopharm Inc
Publication of WO2006102533A2 publication Critical patent/WO2006102533A2/en
Publication of WO2006102533A3 publication Critical patent/WO2006102533A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

Novel formulations of nucleoside-lipid conjugates, the methods of preparing them and the methods for administering them are provided. More particularly, methods for making liposomal formulations of nucleoside-cardiolipin and analogues thereof are provided. By encapsulating nucleoside prodrugs, drugs are protected from degradation, thereby extending the drugs' plasma half-life and intracellular release. In addition, compositions that demonstrate greater efficacy and higher cytotoxicity are produced. Accordingly, nucleoside-lipid conjugates that demonstrate greater in-vitro and in-vivo activity are produced.
PCT/US2006/010638 2005-03-23 2006-03-23 Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates WO2006102533A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66460105P 2005-03-23 2005-03-23
US60/664,601 2005-03-23

Publications (2)

Publication Number Publication Date
WO2006102533A2 WO2006102533A2 (en) 2006-09-28
WO2006102533A3 true WO2006102533A3 (en) 2007-12-13

Family

ID=37024639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/010638 WO2006102533A2 (en) 2005-03-23 2006-03-23 Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates

Country Status (1)

Country Link
WO (1) WO2006102533A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20053519L (en) * 2005-07-18 2007-01-19 Thia Medica As Use of compounds comprising fatty acids
WO2011084610A1 (en) * 2009-12-16 2011-07-14 Children Medical Center Corporation Liposomes for preventing the spread of hiv
CN102144981B (en) * 2011-04-07 2013-02-27 海南锦瑞制药股份有限公司 Gemcitabine hydrochloride lyophilized powder injection and preparation method thereof
JP2015517087A (en) * 2012-02-15 2015-06-18 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ Means and methods for assessing bone disorders
CA3182565A1 (en) 2015-03-06 2016-09-15 Atea Pharmaceuticals, Inc. .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
PT3512863T (en) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc 2'-substituted-n6-substituted purine nucleotides for rna virus treatment
CA3197567A1 (en) 2017-02-01 2018-08-09 Atea Pharmaceuticals, Inc. Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus
CN112351799A (en) 2018-04-10 2021-02-09 阿堤亚制药公司 Treatment of HCV infected patients with cirrhosis
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017944A1 (en) * 2002-08-23 2004-03-04 Neopharm, Inc. Liposomal gemcitabine compositions for better drug delivery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017944A1 (en) * 2002-08-23 2004-03-04 Neopharm, Inc. Liposomal gemcitabine compositions for better drug delivery

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALI ET AL.: "Synthesis and biological evaluation of gemicitabine-lipid conjugate (NEO6002)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 2005, pages 2571 - 2574, XP004866838 *
IMMORDINO ET AL.: "Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing liposomes containing lipophilic gemicitabine prodrugs", JOURNAL OF CONTROLLED RELEASE, vol. 100, no. 3, 2004, pages 331 - 346, XP004656456 *

Also Published As

Publication number Publication date
WO2006102533A2 (en) 2006-09-28

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