WO2006103056A2 - Topical product containing betaine for preventing and treating nappy rash - Google Patents

Topical product containing betaine for preventing and treating nappy rash Download PDF

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Publication number
WO2006103056A2
WO2006103056A2 PCT/EP2006/002859 EP2006002859W WO2006103056A2 WO 2006103056 A2 WO2006103056 A2 WO 2006103056A2 EP 2006002859 W EP2006002859 W EP 2006002859W WO 2006103056 A2 WO2006103056 A2 WO 2006103056A2
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WO
WIPO (PCT)
Prior art keywords
topical product
esp
diaper
product according
concentrations
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PCT/EP2006/002859
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German (de)
French (fr)
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WO2006103056A3 (en
Inventor
Gerhard Sauermann
Christian Sauermann
Original Assignee
Gerhard Sauermann
Christian Sauermann
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Filing date
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Priority claimed from DE102005014870A external-priority patent/DE102005014870A1/en
Application filed by Gerhard Sauermann, Christian Sauermann filed Critical Gerhard Sauermann
Publication of WO2006103056A2 publication Critical patent/WO2006103056A2/en
Publication of WO2006103056A3 publication Critical patent/WO2006103056A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Definitions

  • Urine and faeces cause contact with the skin, reinforced by an environment under diaper pads, diaper rash, as it occurs esp. In children in the first year of life, or even in elderly, bedridden patients who diapers are applied, as in Alzheimer's patients and Patients with other new rodegenerativen diseases is the case. Diaper dermatitis is a cumbersome condition that is still treated with zinc oxide containing wound creams or ointments, especially baby wipes or ointments.
  • the object of the invention was to provide a means for preventing, alleviating and curing diaper dermatitis, with a preventive treatment in the foreground.
  • Such a product contains betaines, which are to be understood as meaning trimethylglycine and / or choline and / or lecithin, a precursor of betaine, with particular preference being given to betaine source as beetroot molasses.
  • betaines which are to be understood as meaning trimethylglycine and / or choline and / or lecithin
  • betaine source as beetroot molasses.
  • betaine into such a topical product can be carried out in a manner known per se, as is known, for example, for creams, ointments, pastes, lotions or sprays. Emulsions are particularly suitable for this, wherein the betaine is preferably incorporated in its oil phase. But also the equipment of e.g. a carrier, such as diapers or wipes, with betaines or a betaine containing preparation is suitable.
  • Some embodiments are particularly advantageous (all in wt .-%).
  • the concentration of betaine in such a topical product is advantageously 0.000001-20%, especially 0.01-5%, especially 0.05-1%.
  • such a topical product advantageously contains folic acid, in particular in concentrations of 0.0001-10%, preferably 0.2-1%.
  • such a topical product advantageously contains vitamin B6, in particular in concentrations of 0.0001-10%, preferably 0.2-1%.
  • such a topical product advantageously contains vitamin B2, in particular in concentrations of from 0.0001 to 10%, preferably from 0.1 to 0.5%.
  • such a topical product advantageously contains zinc in the form of zinc salts and / or zinc oxide, in particular in concentrations of from 0.0001 to 20%, preferably from 0.2 to 2%.
  • Such a topical product is advantageously present in the form of a dermatological preparation, in particular as a cream, ointment, paste, lotion or spray, if appropriate on a carrier, such as a diaper or a cleaning cloth.
  • the invention further relates to the use of such a topical product for the treatment of diaper dermatitis, esp. But for the prevention of diaper dermatitis.
  • the po and genital area is preferably provided with a preparation according to the invention in each diaper change, unless the diaper or the cleaning cloth used itself is equipped accordingly. Treated in this way, diarrhea does not lead to otherwise easily developing diaper dermatitis.
  • This emulsion is prepared in a manner known per se, is extremely skin compatible and is effective in both the preventive and the curative treatment of diaper dermatitis.
  • This ointment is prepared in a manner known per se, is extremely skin-friendly and is effective in both the preventive and the curative treatment of diaper dermatitis.
  • Diaper with strongly water-binding polymers impregnated with an emulsion according to Example 1.
  • the emulsion content of the soaked diaper is 2 wt .-%.
  • This diaper is designed in a manner known per se and is effective in both the preventive and the curative treatment of diaper dermatitis, both in small children and in older patients.

Abstract

The invention relates to a topical product containing betaine for preventing and treating nappy rash.

Description

Topisches Produkt zur Vorbeugung und Behandlung von Topical product for the prevention and treatment of
Windeldermatitisnappy rash
Urin und Kot verursachen bei Kontakt mit der Haut, verstärkt durch ein Milieu unter Windelauflagen, Windeldermatitis, wie sie insb. bei Kindern im ersten Lebensjahr vorkommt, oder auch bei älteren, bettlägerigen Patienten, denen Windeln angelegt werden, wie dies bei Alzheimer-Patienten und Patienten mit anderen neu rodegenerativen Erkrankungen der Fall ist. Windeldermatitis ist ein beschwerlicher Zustand, der nach wie vor mit Zinkoxid enthaltenden Wundcremes oder -salben, insb. Babywundcremes oder - salben behandelt wird.Urine and faeces cause contact with the skin, reinforced by an environment under diaper pads, diaper rash, as it occurs esp. In children in the first year of life, or even in elderly, bedridden patients who diapers are applied, as in Alzheimer's patients and Patients with other new rodegenerativen diseases is the case. Diaper dermatitis is a cumbersome condition that is still treated with zinc oxide containing wound creams or ointments, especially baby wipes or ointments.
Zu einer Windeldermatitis kommt es oftmals ohne ersichtlichen Anlass. Zwar geht gelegentlich einer Windeldermatitis eine Diarrhöe voraus, insb. eine Diarrhöe eines Kleinkindes, ggf. auch eine Diarrhöe der stillenden Mutter, ohne dass jedoch darin ein kausaler Zusammenhang gesehen werden kann. Bei älteren Patienten, aber auch bei Kleinkindern, liegt eine mögliche Ursache einer Windeldermatitis auch in einem zu seltenen Wechsel der Windeln. - Eine wissenschaftlichen Ansprüchen gerecht werdende Erklärung für die Entstehung und für eine angemessene heilende oder vorbeugende Behandlung einer Windeldermatitis gibt es jedoch nicht.Diaper dermatitis often occurs without apparent cause. Although diarrhea is sometimes preceded by diaper rash, in particular diarrhea of an infant, or even diarrhea by the breastfeeding mother, this does not mean that a causal relationship can be seen. In older patients, but also in infants, is a possible cause of diaper dermatitis in too rare a change of diapers. - However, there is no scientific explanation for the emergence and for an appropriate healing or preventive treatment of diaper dermatitis.
Aufgabe der Erfindung war es, ein Mittel zur Verhinderung, zur Linderung und Heilung von Windeldermatitis zu schaffen, wobei eine vorbeugende Behandlung im Vordergrund steht.The object of the invention was to provide a means for preventing, alleviating and curing diaper dermatitis, with a preventive treatment in the foreground.
Gelöst wir diese Aufgabe durch ein topisches Produkt, wie dies näher in den Ansprüchen gekennzeichnet ist. Ein solches Produkt enthält Betaine, worunter Trimethylglyzin und/oder Cholin und/oder Lecithin, einer Vorstufe von Betain, verstanden werden soll, wobei als Betain-Quelle besonders Rote-Beete- Melasse geeignet ist. Denn der Erfindung liegt die Erkenntnis zugrunde, dass ein Mangel an Betainen insb. in den hier betroffenen Hautbereichen (Anal- und Genitalbereich) die Entstehung einer Windeldermatitis begünstigt und deren Abheilung erschwert. Der gezielte Einsatz von Betainen zur Linderung und Heilung, insb. aber zur vorbeugenden Behandlung von Windeldermatitis ist damit Kern dieser Erfindung.Solving this problem by a topical product as more fully characterized in the claims. Such a product contains betaines, which are to be understood as meaning trimethylglycine and / or choline and / or lecithin, a precursor of betaine, with particular preference being given to betaine source as beetroot molasses. For the invention is based on the finding that a lack of Betainen esp. In the affected skin areas (anal and genital area) favors the emergence of diaper dermatitis and hampers their healing. The targeted use of betaines for relief and healing, esp. But for the preventive treatment of diaper rash is thus core of this invention.
Die Einarbeitung von Betain in ein solches topisches Produkt kann in an sich bekannterWeise erfolgen, wie dies beispielsweise für Cremes, Salben, Pasten, Lotionen oder Sprays bekannt ist. Besonders geeignet sind dafür Emulsionen, wobei das Betain bevorzugt in deren Öl-Phase eingearbeitet wird. Aber auch die Ausrüstung von z.B. einem Träger, wie Windeln oder Reinigungstüchern, mit Betainen oder einem Betaine enthaltenden Präparat ist geeignet.The incorporation of betaine into such a topical product can be carried out in a manner known per se, as is known, for example, for creams, ointments, pastes, lotions or sprays. Emulsions are particularly suitable for this, wherein the betaine is preferably incorporated in its oil phase. But also the equipment of e.g. a carrier, such as diapers or wipes, with betaines or a betaine containing preparation is suitable.
Einige Ausgestaltungen sind dabei besonders vorteilhaft (alles in Gew.-%).Some embodiments are particularly advantageous (all in wt .-%).
Die Konzentration an Betain in einem solchen topischen Produkt beträgt vorteilhaft 0,000001 - 20 %, insb. von 0,01 - 5 %, ganz besonders 0,05 - 1 %.The concentration of betaine in such a topical product is advantageously 0.000001-20%, especially 0.01-5%, especially 0.05-1%.
Zusätzlich enthält ein solches topisches Produkt vorteilhaft Folsäure, insb. in Konzentrationen von 0,0001 - 10 %, bevorzugt von 0,2 - 1 %.In addition, such a topical product advantageously contains folic acid, in particular in concentrations of 0.0001-10%, preferably 0.2-1%.
Zusätzlich enthält ein solches topisches Produkt vorteilhaft Vitamin B6, insb. in Konzentrationen von 0,0001 - 10 %, bevorzugt von 0,2 - 1 %.In addition, such a topical product advantageously contains vitamin B6, in particular in concentrations of 0.0001-10%, preferably 0.2-1%.
Zusätzlich enthält ein solches topisches Produkt vorteilhaft Vitamin B2, insb. in Konzentrationen von 0,0001 - 10 %, bevorzugt von 0,1 - 0,5 %.In addition, such a topical product advantageously contains vitamin B2, in particular in concentrations of from 0.0001 to 10%, preferably from 0.1 to 0.5%.
Diese bevorzugten Co-Komponenten gehen einher mit der der Erfindung zugrunde liegenden Erkenntnis über die Auswirkungen eines Mangel an Betainen insb. in den hier betroffenen Hautbereichen, indem bei einem solchen Mangel die Natur sich auf einem sog. Redundandenweg selbst Abhilfe zu schaffen sucht; erfindungsgemäß gilt es, dies durch entsprechende Co-Komponenten zu unterstützen.These preferred co-components are associated with the underlying recognition of the invention on the effects of a lack of Betainen esp. In the skin areas affected here, by nature in such a deficiency on a so-called. Redundandenweg itself Seeks to remedy the situation; According to the invention, this is to be supported by corresponding co-components.
Zusätzlich enthält ein solches topisches Produkt vorteilhaft Zink in Form von Zinksalzen und/oder Zinkoxid, insb. in Konzentrationen von 0,0001 - 20 %, bevorzugt von 0,2 - 2 %.In addition, such a topical product advantageously contains zinc in the form of zinc salts and / or zinc oxide, in particular in concentrations of from 0.0001 to 20%, preferably from 0.2 to 2%.
Ein solches topisches Produkt liegt vorteilhaft in Form eines dermatologischen Präparats vor, insb. als Creme, Salbe, Paste, Lotion oder Spray, ggf. auf einem Träger, wie einer Windel oder einem Reinigungstuch.Such a topical product is advantageously present in the form of a dermatological preparation, in particular as a cream, ointment, paste, lotion or spray, if appropriate on a carrier, such as a diaper or a cleaning cloth.
Die Erfindung betrifft weiterhin die Verwendung eines solchen topischen Produkts zur Behandlung von Windeldermatitis, insb. aber zur Vorbeugung von Windeldermatitis.The invention further relates to the use of such a topical product for the treatment of diaper dermatitis, esp. But for the prevention of diaper dermatitis.
Bei der erfindungsgemäßen Anwendung zeigt sich eine hervorragende Verträglichkeit. Auf der zu behandelnden Haut im Anal- und Genitalbereich kommt es zu keinerlei Irritationen, auch bei Behandlung über längere Zeit. Dabei wird bevorzugt bei jedem Windelwechsel der Po- und Genitalbereich mit einem erfindungsgemäßen Präparat versehen, sofern nicht die Windel oder das verwendete Reinigungstuch selbst entsprechend ausgerüstet ist. So behandelt führt auch eine Diarrhöe nicht zu einer sonst leicht entstehenden Windeldermatitis.In the application according to the invention shows an excellent compatibility. On the skin to be treated in the anal and genital area, there are no irritations, even when treated for a long time. In this case, the po and genital area is preferably provided with a preparation according to the invention in each diaper change, unless the diaper or the cleaning cloth used itself is equipped accordingly. Treated in this way, diarrhea does not lead to otherwise easily developing diaper dermatitis.
Auch die Behandlung einer bereits bestehenden Windeldermatitis wird erfindungsgemäß begünstigt, wobei dazu ein zusätzlicher Gehalt an Zink in Form von Zinksalzen und/oder Zinkoxid in dem topischen Produkt von Vorteil ist. Demgemäss ist für diese Anwendung eine neben Betainen zusätzlich Zinkoxid enthaltende Wundcreme oder -salbe besonders geeignet.The treatment of an existing diaper dermatitis is favored according to the invention, to which an additional content of zinc in the form of zinc salts and / or zinc oxide in the topical product is advantageous. Accordingly, in addition to betaines additionally containing zinc oxide wound cream or ointment is particularly suitable for this application.
Als nicht geeignet hat sich hingegen eine zusätzliche Behandlung mit einem Antibiotikum gezeigt. Im folgenden soll die Erfindung anhand von Ausführungsbeispielen beschrieben werden, ohne sie dadurch aber unnötig einschränken zu wollen.By contrast, an additional treatment with an antibiotic has not proved suitable. In the following, the invention will be described with reference to exemplary embodiments, without thereby limiting it unnecessarily.
Beispiel 1example 1
Emulsion bestehend ausConsisting of emulsion
Gew.-%Wt .-%
Glyzerylstearat 3Glyceryl stearate 3
Cetylalkohol 3Cetyl alcohol 3
PEG-40-Stearat 3,5PEG-40 stearate 3,5
Paraffin liqu. 5Paraffin liqu. 5
Cyclomethicone 5Cyclomethicone 5
Glyzerin 2Glycerin 2
Trimethylglyzin 1Trimethylglycine 1
Cholin 1Choline 1
ZnO 2,0ZnO 2.0
Wasser ad 100,0Water ad 100.0
Diese Emulsion wird in an sich bekannter Weise bereitet, ist außerordentlich hautverträglich und ist wirksam sowohl bei der vorbeugenden als auch der heilenden Behandlung einer Windeldermatitis.This emulsion is prepared in a manner known per se, is extremely skin compatible and is effective in both the preventive and the curative treatment of diaper dermatitis.
Beispiel 2Example 2
Salbe bestehend ausOintment consisting of
Gew.-%Wt .-%
Cetylalkohol 2,4Cetyl alcohol 2,4
Steareth-21 1 ,2Steareth-21 1, 2
Steareth-2 2,4Steareth-2 2,4
Paraffin liqu. 15Paraffin liqu. 15
Xanthan Gum 0,2Xanthan gum 0.2
Glyzerin 10Glycerol 10
Betain 10Betaine 10
Folsäure 1 Wasser ad 100,0Folic acid 1 Water ad 100.0
Diese Salbe wird in an sich bekannter Weise bereitet, ist außerordentlich hautverträglich und ist wirksam sowohl bei der vorbeugenden als auch der heilenden Behandlung einer Windeldermatitis.This ointment is prepared in a manner known per se, is extremely skin-friendly and is effective in both the preventive and the curative treatment of diaper dermatitis.
Beispiel 3Example 3
Windel mit stark wasserbindenden Polymeren, getränkt mit einer Emulsion gemäß Beispiel 1. Der Emulsionsanteil der so getränkten Windel beträgt 2 Gew.-%.Diaper with strongly water-binding polymers, impregnated with an emulsion according to Example 1. The emulsion content of the soaked diaper is 2 wt .-%.
Diese Windel ist im übrigen in an sich bekannter Weise ausgestaltet und ist wirksam sowohl bei der vorbeugenden als auch der heilenden Behandlung einer Windeldermatitis, sowohl bei Kleinkindern als auch bei älteren Patienten. This diaper, moreover, is designed in a manner known per se and is effective in both the preventive and the curative treatment of diaper dermatitis, both in small children and in older patients.

Claims

Ansprüche claims
1. Topisches Produkt zur Vorbeugung und Behandlung von Windeldermatitis, enthaltend Betaine.1. Topical product for the prevention and treatment of diaper dermatitis containing betaines.
2. Topisches Produkt nach Anspruch 1 , dadurch gekennzeichnet, dass Betaine in Konzentrationen von 0,000001 - 20 %, insb. von 0,01 - 5 %, ganz besonders von 0,05 - 1 % enthalten sind.2. Topical product according to claim 1, characterized in that betaines are contained in concentrations of 0.000001 - 20%, esp. Of 0.01 - 5%, especially of 0.05 - 1%.
3. Topisches Produkt nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, dass zusätzlich Folsäure enthalten ist, insb. in Konzentrationen von 0,0001 - 10 %, bevorzugt von 0,2 - 1 %.3. Topical product according to one of claims 1 or 2, characterized in that folic acid is additionally contained, esp. In concentrations of 0.0001 - 10%, preferably from 0.2 to 1%.
4. Topisches Produkt nach einem der Ansprüche 1 - 3, dadurch gekennzeichnet, dass zusätzlich Vitamin B6 enthalten ist, insb. in Konzentrationen von 0,0001 - 10 %, bevorzugt von 0,2 - 1 %.4. Topical product according to one of claims 1 - 3, characterized in that in addition vitamin B6 is contained, esp. In concentrations of 0.0001 - 10%, preferably from 0.2 to 1%.
5. Topisches Produkt nach einem der Ansprüche 1 - 4, dadurch gekennzeichnet, dass zusätzlich Vitamin B2 enthalten ist, insb. in Konzentrationen von 0,0001 - 10 %, bevorzugt von 0,1 - 0,5 %.5. Topical product according to one of claims 1 - 4, characterized in that in addition vitamin B2 is contained, esp. In concentrations of 0.0001 - 10%, preferably from 0.1 - 0.5%.
6. Topisches Produkt nach einem der Ansprüche 1 - 5, dadurch gekennzeichnet, dass zusätzlich Zink in Form von Zinksalzen und/oder Zinkoxid enthalten ist, insb. in Konzentrationen von 0,0001 - 20 %, bevorzugt von 0,2 - 2 %.6. Topical product according to any one of claims 1-5, characterized in that additionally zinc in the form of zinc salts and / or zinc oxide is contained, esp. In concentrations of 0.0001 - 20%, preferably from 0.2 to 2%.
7. Topisches Produkt nach einem der Ansprüche 1 - 6, in Form eines dermatologischen Präparats, insb. als Creme, Salbe, Paste, Lotion oder Spray, ggf. auf einem Träger, wie einer Windel oder Reinigungstuch.7. Topical product according to one of claims 1 - 6, in the form of a dermatological preparation, esp. As a cream, ointment, paste, lotion or spray, optionally on a support, such as a diaper or cleaning cloth.
8. Verwendung eines topischen Produkts nach einem der Ansprüche 1 - 7 zur Vorbeugung und Behandlung von Windeldermatitis. 8. Use of a topical product according to any one of claims 1-7 for the prevention and treatment of diaper dermatitis.
PCT/EP2006/002859 2005-03-30 2006-03-29 Topical product containing betaine for preventing and treating nappy rash WO2006103056A2 (en)

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DE102005014870A DE102005014870A1 (en) 2004-03-30 2005-03-30 Blade mold design program and method
DE102005014370.9 2005-03-30

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010043769A2 (en) * 2008-10-15 2010-04-22 Danisco A/S Use of betaine

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3567820A (en) * 1969-04-09 1971-03-02 George S Sperti Compositions and treatment for the alleviation of diaper rash
WO1995022898A1 (en) * 1994-02-28 1995-08-31 Cox James P Sulfur and oxygen deodorant compositions
WO1999026610A1 (en) * 1997-11-26 1999-06-03 The Procter & Gamble Company Skin care composition
DE19857492A1 (en) * 1998-12-14 2000-06-15 Hans Lautenschlaeger Cosmetic or dermatological skin-protective compositions, containing saturated phosphatidyl choline to give good barrier stabilizing and active agent penetrating effects
WO2003053485A1 (en) * 2001-12-20 2003-07-03 Kimberly-Clark Worldwide, Inc. Products for controlling microbial generated odors
DE20312369U1 (en) * 2003-08-08 2004-03-18 Eckardt, Rainer, Dr.med. Dermatological ointment, useful for therapeutic treatment of dry, inflamed and damaged skin, contains pumpkin seed oil, fluid lecithin, oily fragrance and ointment base
WO2004026295A2 (en) * 2002-09-17 2004-04-01 Phenion Gmbh & Co. Kg Use of skin-protecting substances

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5860068A (en) * 1981-10-01 1983-04-09 花王株式会社 Surface modifier of nonwoven fabric for sanitary material
JPH0832915B2 (en) * 1987-03-23 1996-03-29 ピジヨン株式会社 Detergent composition for diapers

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3567820A (en) * 1969-04-09 1971-03-02 George S Sperti Compositions and treatment for the alleviation of diaper rash
WO1995022898A1 (en) * 1994-02-28 1995-08-31 Cox James P Sulfur and oxygen deodorant compositions
WO1999026610A1 (en) * 1997-11-26 1999-06-03 The Procter & Gamble Company Skin care composition
DE19857492A1 (en) * 1998-12-14 2000-06-15 Hans Lautenschlaeger Cosmetic or dermatological skin-protective compositions, containing saturated phosphatidyl choline to give good barrier stabilizing and active agent penetrating effects
WO2003053485A1 (en) * 2001-12-20 2003-07-03 Kimberly-Clark Worldwide, Inc. Products for controlling microbial generated odors
WO2004026295A2 (en) * 2002-09-17 2004-04-01 Phenion Gmbh & Co. Kg Use of skin-protecting substances
DE20312369U1 (en) * 2003-08-08 2004-03-18 Eckardt, Rainer, Dr.med. Dermatological ointment, useful for therapeutic treatment of dry, inflamed and damaged skin, contains pumpkin seed oil, fluid lecithin, oily fragrance and ointment base

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch, Week 198320 Derwent Publications Ltd., London, GB; Class A60, AN 1983-47979K XP002396716 & JP 58 060068 A (KAO CORP) 9. April 1983 (1983-04-09) *
DATABASE WPI Section Ch, Week 198845 Derwent Publications Ltd., London, GB; Class D16, AN 1988-318229 XP002396715 & JP 63 234096 A (PIGEON KK) 29. September 1988 (1988-09-29) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010043769A2 (en) * 2008-10-15 2010-04-22 Danisco A/S Use of betaine
WO2010043769A3 (en) * 2008-10-15 2011-01-20 Danisco A/S Use of betaine
JP2012505869A (en) * 2008-10-15 2012-03-08 ダニスコ エイ／エス Use of betaine

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