WO2006105359A3 - Methods for stimulating hair growth by administering bmps - Google Patents

Methods for stimulating hair growth by administering bmps Download PDF

Info

Publication number
WO2006105359A3
WO2006105359A3 PCT/US2006/011799 US2006011799W WO2006105359A3 WO 2006105359 A3 WO2006105359 A3 WO 2006105359A3 US 2006011799 W US2006011799 W US 2006011799W WO 2006105359 A3 WO2006105359 A3 WO 2006105359A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
bmps
administering
hair growth
stimulating hair
Prior art date
Application number
PCT/US2006/011799
Other languages
French (fr)
Other versions
WO2006105359A2 (en
Inventor
Kieron Leslie
Alexandre Valentin
John Wozney
Edward Kilbourne
Original Assignee
Wyeth Corp
Kieron Leslie
Alexandre Valentin
John Wozney
Edward Kilbourne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Kieron Leslie, Alexandre Valentin, John Wozney, Edward Kilbourne filed Critical Wyeth Corp
Priority to EP06740137A priority Critical patent/EP1863518A2/en
Priority to CA002601436A priority patent/CA2601436A1/en
Priority to JP2008504403A priority patent/JP2008534607A/en
Priority to BRPI0609504-6A priority patent/BRPI0609504A2/en
Priority to AU2006230434A priority patent/AU2006230434A1/en
Priority to MX2007011591A priority patent/MX2007011591A/en
Publication of WO2006105359A2 publication Critical patent/WO2006105359A2/en
Publication of WO2006105359A3 publication Critical patent/WO2006105359A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

Methods and compositions for stimulating hair growth and inhibiting immune system activity by administering BMPs are provided. The methods and compositions can be used for treating or preventing disorders resulting in loss of hair, as well as a wide range of autoimmune disorders.
PCT/US2006/011799 2005-03-30 2006-03-30 Methods for stimulating hair growth by administering bmps WO2006105359A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06740137A EP1863518A2 (en) 2005-03-30 2006-03-30 Methods for stimulating hair growth by administering bmps
CA002601436A CA2601436A1 (en) 2005-03-30 2006-03-30 Methods for stimulating hair growth by administering bmps
JP2008504403A JP2008534607A (en) 2005-03-30 2006-03-30 Method for stimulating hair growth by administering BMP
BRPI0609504-6A BRPI0609504A2 (en) 2005-03-30 2006-03-30 methods to stimulate hair growth by administering bone morphogenetic proteins (bmps)
AU2006230434A AU2006230434A1 (en) 2005-03-30 2006-03-30 Methods for stimulating hair growth by administering BMPs
MX2007011591A MX2007011591A (en) 2005-03-30 2006-03-30 Methods for stimulating hair growth by administering bmps.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66617205P 2005-03-30 2005-03-30
US60/666,172 2005-03-30

Publications (2)

Publication Number Publication Date
WO2006105359A2 WO2006105359A2 (en) 2006-10-05
WO2006105359A3 true WO2006105359A3 (en) 2006-12-07

Family

ID=36648737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/011799 WO2006105359A2 (en) 2005-03-30 2006-03-30 Methods for stimulating hair growth by administering bmps

Country Status (9)

Country Link
US (1) US20060239951A1 (en)
EP (1) EP1863518A2 (en)
JP (1) JP2008534607A (en)
CN (1) CN101309698A (en)
AU (1) AU2006230434A1 (en)
BR (1) BRPI0609504A2 (en)
CA (1) CA2601436A1 (en)
MX (1) MX2007011591A (en)
WO (1) WO2006105359A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100047299A1 (en) * 2007-01-25 2010-02-25 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Use of gdf-5 for the improvement or maintenance of dermal appearance
CN101301467B (en) * 2008-04-22 2012-01-25 同济大学 Uses of BMP-7 in preparing medicament for preventing and/or treating liver fibrosis
IT1392903B1 (en) * 2008-07-29 2012-04-02 Marino Salin COMPOSITION INCLUDING AN ASSOCIATION OF ACTIVE PRINCIPLES FOR USE IN THE TOPIC TREATMENT OF CALVIZIE
WO2010029343A2 (en) * 2008-09-10 2010-03-18 University Of Bradford Compositions and methods
PT2344198T (en) * 2008-09-27 2020-12-04 Jina Pharmaceuticals Inc Lipid based pharmaceutical preparations for oral and topical application; their compositions, methods, and uses thereof
EP3693014A1 (en) * 2008-11-13 2020-08-12 The General Hospital Corporation Methods and compositions for regulating iron homeostasis by modulation bmp-6
WO2010059861A1 (en) * 2008-11-20 2010-05-27 University Of Southern California Compositions and methods to modulate hair growth
KR101355809B1 (en) 2012-03-13 2014-01-28 우리들생명과학 주식회사 Composition for inducing a bone differentiation and method for enhancing a bone differentiation using the same
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
US9445980B2 (en) * 2012-04-18 2016-09-20 Mark Laney Methods for stimulating hair growth
WO2014052393A2 (en) 2012-09-25 2014-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for the diagnosis and treatment of sjögren's syndrome
CN112933223A (en) * 2012-10-24 2021-06-11 细胞基因公司 Methods for treating anemia
US20140315803A1 (en) * 2013-04-17 2014-10-23 Mark Laney Methods for stimulating hair growth
KR20150000242A (en) * 2013-06-24 2015-01-02 고려대학교 산학협력단 Compositions Containing BMP6 for Preventing or Treating Psoriasis and Health Foods Containing BMP6 for Preventing or Improving Psoriasis
US9937117B2 (en) * 2015-07-09 2018-04-10 Galderma S.A. Method of reducing hair loss associated with chemotherapy
CN108129572B (en) * 2018-01-04 2021-01-29 河南大学 Application of human GDF11-Fc fusion protein in treating ulcerative colitis
CN110237237A (en) * 2019-06-10 2019-09-17 上海交通大学医学院附属上海儿童医学中心 Application of the BMP4 albumen as preparation treatment autoimmune disease drug
CN110638833A (en) * 2019-11-15 2020-01-03 西安圣德生物科技有限公司 Composition for promoting hair growth and method of use thereof
US20210315834A1 (en) * 2020-04-12 2021-10-14 Sol-Gel Technologies Ltd. Treatment of alopecia
KR102553476B1 (en) * 2020-10-30 2023-07-11 (의료)길의료재단 Pharmaceutical composition for preventing or treating metabolic diseases comprising bone morphogenetic protein 10
CN114699506A (en) * 2021-12-30 2022-07-05 北京百华百汇生物科技有限公司 Use of recombinant calreticulin for growing hair, protecting hair or preventing alopecia and related products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005002068A (en) * 2003-06-13 2005-01-06 Lion Corp Method for growing and restoring hair, hair growing and restoring agent and method for screening hair growing and restoring agent

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215893A (en) * 1985-10-03 1993-06-01 Genentech, Inc. Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US6432919B1 (en) * 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5631142A (en) * 1986-07-01 1997-05-20 Genetics Institute, Inc. Compositions comprising bone morphogenetic protein-2 (BMP-2)
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5939388A (en) * 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5457092A (en) * 1987-07-30 1995-10-10 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Methods of promoting bone growth in mammals comprising administration of modified parathyroid hormone
US6586388B2 (en) * 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5457038A (en) * 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
WO1990010067A1 (en) * 1989-02-23 1990-09-07 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Dna sequences coding for pth variants, pth variants, expression vector, bacterial host, use and therapeutic composition
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
WO1991000103A1 (en) * 1989-06-29 1991-01-10 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US5218090A (en) * 1990-06-12 1993-06-08 Warner-Lambert Company EGF receptor truncates
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
US6287816B1 (en) * 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
DK0592562T3 (en) * 1991-06-25 1999-08-30 Genetics Inst BMP-9 compositions
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5306307A (en) * 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
JP3504263B2 (en) * 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Recombinant bone morphogenetic protein heterodimers, compositions and uses
ATE208217T1 (en) * 1992-02-28 2001-11-15 Cohesion Tech Inc INJECTABLE CERAMIC COMPOUNDS AND METHOD FOR THEIR PRODUCTION AND USE
AU3920693A (en) * 1992-03-18 1993-10-21 General Hospital Corporation, The Four novel receptors of the TGF-beta receptor family
IT1259100B (en) * 1992-05-20 1996-03-11 Lanfranco Callegaro USE OF HYDROGELS FOR THE LOCKING OF PROSTHETIC SYSTEMS
US5420243A (en) * 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
DE69432815T2 (en) * 1993-03-19 2003-12-11 Univ Johns Hopkins Med GROWTH FACTOR-8
GB9308060D0 (en) * 1993-04-19 1993-06-02 Cancer Res Campaign Tech Stem cell inhibitor
US5637480A (en) * 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
DE69433530T2 (en) * 1993-05-12 2005-01-05 Genetics Institute, LLC, Cambridge BMP-11 COMPOSITIONS
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
ATE326234T1 (en) * 1993-08-26 2006-06-15 Genetics Inst Llc HUMAN BONE MORPHOGENETIC PROTEINS FOR USE IN NEURONAL REGENERATION
US5455041A (en) * 1993-09-13 1995-10-03 Research Foundation Of State University Of New York At Buffalo Method for inducing periodontal tissue regeneration
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
AU8095694A (en) * 1993-10-28 1995-05-22 Thm Biomedical, Inc. Improved process and device for treating and healing a bone void
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
ES2255059T3 (en) * 1993-12-07 2006-06-16 Genetics Institute, Llc BMP-12, BMP-13 AND YOUR INDUCTION COMPOSITIONS OF TENDON.
US6027919A (en) * 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
US5556767A (en) * 1993-12-22 1996-09-17 Human Genome Sciences, Inc. Polynucleotide encoding macrophage inflammatory protein γ
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5545616A (en) * 1994-09-22 1996-08-13 Genentech, Inc. Method for predicting and/or preventing preterm labor
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
AU699918B2 (en) * 1995-06-05 1998-12-17 Genetics Institute, Llc Methods and compositions for healing and repair of connective tissue attachment
US5674292A (en) * 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
JP3521164B2 (en) * 1995-10-02 2004-04-19 ヤマハ発動機株式会社 Exhaust system for motorcycle
JP2000501966A (en) * 1995-12-18 2000-02-22 デグッサ アクチエンゲゼルシャフト Medical implant
CA2256400A1 (en) * 1996-05-28 1997-12-04 Brown University Research Foundation Hyaluronan based biodegradable scaffolds for tissue repair
US5813411A (en) * 1996-08-20 1998-09-29 Menlo Care, Inc. Method of deforming tissue with a swollen hydrogel
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
BR9713348A (en) * 1996-11-12 2000-08-08 Dov Tamarkin Method for treating dermatological disorders
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US5972368A (en) * 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
IT1302534B1 (en) * 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl INJECTABLE, BIOCOMPATIBLE AND BIODEGRADABLE COMPOSITIONS INCLUDING AT LEAST A DERIVATIVE OF HYALURONIC ACID, CHONDROGENIC CELLS, FOR
KR100748297B1 (en) * 2000-02-29 2007-08-09 알콘, 인코퍼레이티드 Diagnostics and therapeutics for glaucoma
JP2004525930A (en) * 2001-03-23 2004-08-26 バイオファーム・ゲゼルシャフト・ツア・バイオテクノロジシェン・エントヴィックルング・フォン・ファーマカ・ミット・ベシュレンクテル・ハフツング Use of TGF-β superfamily cytokines for the treatment and diagnosis of skin related diseases
ATE393573T1 (en) * 2001-06-01 2008-05-15 Wyeth Corp COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENESIS PROTEINS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005002068A (en) * 2003-06-13 2005-01-06 Lion Corp Method for growing and restoring hair, hair growing and restoring agent and method for screening hair growing and restoring agent

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANNALI ITALIANI DI DERMATOLOGIA CLINICA E SPERIMENTALE, vol. 41, no. 4, 1987, pages 383 - 391, ISSN: 0365-169X *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1987, SBANO E ET AL: "MINOXIDIL-CYCLOSPORIN A ASSOCIATION IN THE TREATMENT OF ALOPECIA UNIVERSALIS CLINICAL AND IMMUNOLOGICAL OBSERVATIONS", XP002391212, Database accession no. PREV198886062188 *
DATABASE WPI Section Ch Week 200507, Derwent World Patents Index; Class B04, AN 2005-061576, XP002390695 *
LESLIE K S ET AL: "Alopecia universalis treated with bone morphogenetic protein?", BRITISH JOURNAL OF DERMATOLOGY, vol. 154, no. 1, January 2006 (2006-01-01), pages 190 - 191, XP002390573, ISSN: 0007-0963 *
MIDORIKAWA T ET AL: "Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis", JOURNAL OF DERMATOLOGICAL SCIENCE, ELSEVIER SCIENCE PUBLISHERS, SHANNON, IR, vol. 36, no. 1, October 2004 (2004-10-01), pages 25 - 32, XP004603014, ISSN: 0923-1811 *
WILSON N ET AL: "The role of BMP-2 and BMP-4 in follicle initiation and the murine hair cycle.", EXPERIMENTAL DERMATOLOGY. AUG 1999, vol. 8, no. 4, August 1999 (1999-08-01), pages 367 - 368, XP008066794, ISSN: 0906-6705 *

Also Published As

Publication number Publication date
CA2601436A1 (en) 2006-10-05
MX2007011591A (en) 2007-12-10
CN101309698A (en) 2008-11-19
AU2006230434A1 (en) 2006-10-05
US20060239951A1 (en) 2006-10-26
WO2006105359A2 (en) 2006-10-05
JP2008534607A (en) 2008-08-28
BRPI0609504A2 (en) 2010-04-13
EP1863518A2 (en) 2007-12-12

Similar Documents

Publication Publication Date Title
WO2006105359A3 (en) Methods for stimulating hair growth by administering bmps
WO2006138418A3 (en) Improvement of cognitive performance with sirtuin activators
WO2001012199A3 (en) Methoxyamine potentiation of temozolomide anti-cancer activity
WO2005123116A3 (en) Compositions and methods for treating or preventing oxalate-related disease
WO2007140002A3 (en) Method for treating non-hodgkin's lymphoma
WO2013142124A8 (en) Solid forms of a thiophosphoramidate nucleotide prodrug
WO2006105527A3 (en) Amylin and amylin agonists for treating psychiatric diseases and disorders
GB2463833A (en) Methods and compositions for the treatment of neurological disorders
WO2005063232A8 (en) Obesity and metabolic syndrome treatment with tanshinone derivatives which increase metabolic activity
WO2008067389A3 (en) Modulation of sod protein synthesis for the treatment of neurodegenerative diseases
WO2006003388A3 (en) Compositions and methods for treating inflammatory disorders
WO2007081710A3 (en) Treatment modalities for autoimmune diseases
IL178390A0 (en) Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
WO2005091853A3 (en) Methods and compositions for treating il-13 related pathologies
TW200519110A (en) Substituted tetrahydro-1H-pyrazolo [3, 4-c] pyridines, compositions comprising them, and use
WO2007146965A3 (en) Compounds for the treatment of periodontal disease
WO2007058850A3 (en) Inhibitors of akt activity
PL1761266T3 (en) Compounds, formulations, and methods for treating or preventing inflammatory skin disorders
WO2008148074A3 (en) Inhibitors of mtor and methods of treatment using same
WO2005118609A3 (en) Small molecule stimulators of neuronal growth
WO2010004197A3 (en) Pyridino-pyridinone derivatives, preparation thereof, and therapeutic use thereof
WO2007092496A3 (en) 7,9-dihydro-purin-8-one and related analogs as hsp90-inhibitors
WO2010088450A3 (en) Arylamide derivatives useful in the treatment of diseases associated with serca activity
WO2006113837A3 (en) Inhibitors of akt activity
WO2006034035A3 (en) Treatment of ischemia

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680010142.X

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006740137

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2601436

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006230434

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/011591

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2008504403

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2006230434

Country of ref document: AU

Date of ref document: 20060330

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 3968/KOLNP/2007

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: RU

ENP Entry into the national phase

Ref document number: PI0609504

Country of ref document: BR

Kind code of ref document: A2