WO2006119645B1 - Marker device for x-ray, ultrasound and mr imaging - Google Patents
Marker device for x-ray, ultrasound and mr imagingInfo
- Publication number
- WO2006119645B1 WO2006119645B1 PCT/CA2006/000782 CA2006000782W WO2006119645B1 WO 2006119645 B1 WO2006119645 B1 WO 2006119645B1 CA 2006000782 W CA2006000782 W CA 2006000782W WO 2006119645 B1 WO2006119645 B1 WO 2006119645B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- animal
- tissue
- marker
- difference
- compared
- Prior art date
Links
- 239000003550 marker Substances 0.000 title claims abstract 15
- 238000002604 ultrasonography Methods 0.000 title claims 4
- 238000003384 imaging method Methods 0.000 title abstract 5
- 239000011159 matrix material Substances 0.000 claims abstract 5
- 239000011521 glass Substances 0.000 claims abstract 3
- 210000001519 tissue Anatomy 0.000 claims 9
- 210000005013 brain tissue Anatomy 0.000 claims 7
- 210000000481 breast Anatomy 0.000 claims 7
- 210000005003 heart tissue Anatomy 0.000 claims 7
- 238000002513 implantation Methods 0.000 claims 3
- 238000002595 magnetic resonance imaging Methods 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 238000002310 reflectometry Methods 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 2
- 239000000919 ceramic Substances 0.000 claims 1
- 239000002923 metal particle Substances 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 4
- 239000004005 microsphere Substances 0.000 abstract 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052782 aluminium Inorganic materials 0.000 abstract 2
- 229910052742 iron Inorganic materials 0.000 abstract 2
- 238000001574 biopsy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
- A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3995—Multi-modality markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/12—Devices for detecting or locating foreign bodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
Abstract
An imaging marker comprised of glass and iron-containing aluminum microspheres in a gel matrix which shows uniformly good contrast with MR, US and X-Ray imaging The maiker is small and can be easily introduced into tissue through a 12-gauge biopsy needle The concentration of glass microspheres and the size dictate the contrast for US imaging The contrast seen m MRI resulting from susceptibility losses is dictated by the number of iron-containmg aluminum microspheres, while the artifact of the marker also depends on its shape, orientation and echo time By optimizing the size, iron concentration and gel binding, an implantable tissue marker is created which is clearly visible with all three imaging modalities.
Claims
1. An implantable image marker supported in a matrix for enabling non-invasive viewing of the marker subsequent to implantation, the marker comprising a surface of an artifact that has at least 10% difference in ultrasound reflectivity as compared to at least one animal tissue a material that has at least 10% difference in relaxivity at a field strength used for magnetic resonance imaging as compared to at least one of animal breast tissue, animal brain tissue, and animal heart tissue, respectively, and a composition that has at least 10% difference in attenuation of X-rays from at least one of animal breast tissue, animal brain tissue, and animal heart tissue, respectively.
2. The implantable marker of claim 1 wherein at least two distinct particles supported in a matrix are used to provide the surface of an artifact that has at least 10% difference in ultrasound reflectivity as compared to at least one of animal breast tissue, animal brain tissue, and animal heart tissue, the material that has at least 10% difference in relaxivity at the magnetic resonance imaging field strength as compared to at least one of animal breast tissue, animal brain tissue, and animal heart tissue, respectively, and the composition that has at least 10% difference in attenuation of X-rays from at least one of animal breast tissue, animal brain tissue, and animal heart tissue, respectively.
3. An implantable image marker supported in a matrix for enabling non-invasive viewing of the marker subsequent to implantation, the marker comprising a surface of an artifact that has at least 10% difference in ultrasound reflectivity as compared to at least one animal tissue a material that has at least 10% difference in relaxivity at a field strength used for magnetic resonance imaging as compared to at least one of animal breast tissue, animal brain tissue, and animal heart tissue, respectively, and a composition that has at least 10% difference in attenuation of X-rays from at least one of animal breast tissue, animal brain tissue, and animal heart tissue, respectively, wherein the marker comprises a) a glass or ceramic particle and b) a metal particle.
4. An implantable image marker supported in a matrix for enabling non-invasive viewing of the marker subsequent to implantation, the marker comprising a surface of an
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002579914A CA2579914A1 (en) | 2005-05-12 | 2006-05-12 | Marker device for x-ray, ultrasound and mr imaging |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/128,013 | 2005-05-12 | ||
US11/128,013 US20060293581A1 (en) | 2005-05-12 | 2005-05-12 | Marker device for X-ray, ultrasound and MR imaging |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006119645A1 WO2006119645A1 (en) | 2006-11-16 |
WO2006119645B1 true WO2006119645B1 (en) | 2006-12-28 |
Family
ID=37396164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2006/000782 WO2006119645A1 (en) | 2005-05-12 | 2006-05-12 | Marker device for x-ray, ultrasound and mr imaging |
Country Status (3)
Country | Link |
---|---|
US (1) | US20060293581A1 (en) |
CA (1) | CA2579914A1 (en) |
WO (1) | WO2006119645A1 (en) |
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-
2005
- 2005-05-12 US US11/128,013 patent/US20060293581A1/en not_active Abandoned
-
2006
- 2006-05-12 WO PCT/CA2006/000782 patent/WO2006119645A1/en active Application Filing
- 2006-05-12 CA CA002579914A patent/CA2579914A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2006119645A1 (en) | 2006-11-16 |
US20060293581A1 (en) | 2006-12-28 |
CA2579914A1 (en) | 2006-11-16 |
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