WO2006122183A3 - Injectable hydrogels and methods of making and using same - Google Patents

Injectable hydrogels and methods of making and using same Download PDF

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Publication number
WO2006122183A3
WO2006122183A3 PCT/US2006/018067 US2006018067W WO2006122183A3 WO 2006122183 A3 WO2006122183 A3 WO 2006122183A3 US 2006018067 W US2006018067 W US 2006018067W WO 2006122183 A3 WO2006122183 A3 WO 2006122183A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel
making
methods
same
sec
Prior art date
Application number
PCT/US2006/018067
Other languages
French (fr)
Other versions
WO2006122183A2 (en
Inventor
William G Hubbard
Original Assignee
Cytophil Inc
William G Hubbard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytophil Inc, William G Hubbard filed Critical Cytophil Inc
Priority to EP06759483A priority Critical patent/EP1893174A2/en
Publication of WO2006122183A2 publication Critical patent/WO2006122183A2/en
Publication of WO2006122183A3 publication Critical patent/WO2006122183A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

A biocompatible hydrogel and method for augmenting soft and hard tissue, wherein the hydrogel comprises at least one gel former and the hydrogel is used to augment tissue when introduced into a desired tissue site. The hydrogel may comprise at least one of a carbomer, a poloxamer and a combination thereof. The hydrogel may have a yield strength of about 300 gm/cm-sec to about 12,000 gm/cm-sec and require less than about 10 lbf to extrude the hydrogel from a 1 cc syringe having a 25 gauge 1/2' length needle at a rate of 2 inches per minute.
PCT/US2006/018067 2005-05-10 2006-05-10 Injectable hydrogels and methods of making and using same WO2006122183A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06759483A EP1893174A2 (en) 2005-05-10 2006-05-10 Injectable hydrogels and methods of making and using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67952305P 2005-05-10 2005-05-10
US60/679,523 2005-05-10

Publications (2)

Publication Number Publication Date
WO2006122183A2 WO2006122183A2 (en) 2006-11-16
WO2006122183A3 true WO2006122183A3 (en) 2007-12-06

Family

ID=37309131

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/018067 WO2006122183A2 (en) 2005-05-10 2006-05-10 Injectable hydrogels and methods of making and using same

Country Status (3)

Country Link
US (1) US20060257488A1 (en)
EP (1) EP1893174A2 (en)
WO (1) WO2006122183A2 (en)

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Also Published As

Publication number Publication date
WO2006122183A2 (en) 2006-11-16
EP1893174A2 (en) 2008-03-05
US20060257488A1 (en) 2006-11-16

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