WO2006122318A3 - Directed intranasal administration of pharmaceutical agents - Google Patents
Directed intranasal administration of pharmaceutical agents Download PDFInfo
- Publication number
- WO2006122318A3 WO2006122318A3 PCT/US2006/018612 US2006018612W WO2006122318A3 WO 2006122318 A3 WO2006122318 A3 WO 2006122318A3 US 2006018612 W US2006018612 W US 2006018612W WO 2006122318 A3 WO2006122318 A3 WO 2006122318A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- intranasal
- intranasal administration
- pharmaceutical agents
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/008—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised by squeezing, e.g. using a flexible bottle or a bulb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/361—Phantom sensations, e.g. tinnitus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M19/00—Local anaesthesia; Hypothermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/048—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0681—Sinus (maxillaris)
Abstract
The invention includes methods, kits, compositions, and apparatus for intranasal administration of a compound such as a pharmaceutically active agent in a targeted manner. Such compounds can be delivered preferentially to a component of the central nervous system (CNS) such as the brain, the spinal cord, or cerebrospinal fluid. Such compounds can alternatively be administered preferentially to the systemic circulation of a human patient. The compound can be administered to either side of the blood-brain barrier by directing administration of the compound to portions of the nasal epithelium that overlie or are near an intranasal nerve structure, and intranasal blood vessel, or both.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/126,475 | 2005-05-11 | ||
US11/126,475 US20050281751A1 (en) | 1997-07-21 | 2005-05-11 | Directed intranasal administration of pharmaceutical agents |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006122318A2 WO2006122318A2 (en) | 2006-11-16 |
WO2006122318A3 true WO2006122318A3 (en) | 2007-04-19 |
Family
ID=37397348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/018612 WO2006122318A2 (en) | 2005-05-11 | 2006-05-11 | Directed intranasal administration of pharmaceutical agents |
Country Status (2)
Country | Link |
---|---|
US (1) | US20050281751A1 (en) |
WO (1) | WO2006122318A2 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
US8105611B2 (en) * | 2005-06-17 | 2012-01-31 | Allergan, Inc. | Treatment of autoimmune disorder with a neurotoxin |
US9511210B2 (en) * | 2006-05-19 | 2016-12-06 | The Foundry, Llc | Apparatus for toxin delivery to the nasal cavity |
US10052465B2 (en) | 2005-07-22 | 2018-08-21 | The Foundry, Llc | Methods and systems for toxin delivery to the nasal cavity |
WO2007014003A2 (en) | 2005-07-22 | 2007-02-01 | The Foundry Inc. | Systems and methods for delivery of a therapeutic agent |
GB0605799D0 (en) | 2006-03-23 | 2006-05-03 | Optinose As | Nasal delivery devices |
CA2755492A1 (en) * | 2008-03-21 | 2009-09-24 | Paindure Ltd. | Solid dosage form for treating headaches |
US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
NL2001698C2 (en) * | 2008-06-18 | 2009-12-22 | Nasophlex B V | Cardioverter / defibrillator. |
US8231588B2 (en) * | 2008-08-01 | 2012-07-31 | Tian Xia | Methods for ameliorating pain and devices for delivering a medicament |
US8905980B2 (en) * | 2008-08-01 | 2014-12-09 | Tian Xia | Devices for delivering a medicament and methods for ameliorating pain |
US8690839B2 (en) | 2008-08-01 | 2014-04-08 | Tian Xia | Devices for delivering a medicament and connector for same |
US20100057048A1 (en) | 2008-09-04 | 2010-03-04 | Stephen Eldredge | Apparatus, System, and Method for Treating Atypical Headaches |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
WO2011084507A1 (en) * | 2009-12-15 | 2011-07-14 | Ira Sanders | Treatment of nasal and sinus disorders |
CN103874481B (en) | 2011-07-13 | 2016-09-28 | 铸造有限责任公司 | For delivering the method and device of therapeutic agent to mucous membrane of nasopharynx target |
EP2731654B1 (en) | 2011-07-13 | 2018-12-26 | The Foundry, LLC | Delivery devices for nasopharyngeal mucosa targets |
US20160030408A1 (en) * | 2013-03-15 | 2016-02-04 | Bhl Patent Holdings Llc | Materials and methods for treating neuropathies and related disorders including those involving a keystone nerve |
US20150100042A1 (en) * | 2013-10-07 | 2015-04-09 | Impel Neuropharma Inc. | Muroid Family Nasal Device |
AU2014352997B2 (en) * | 2013-11-21 | 2017-11-30 | Jet Medical, Inc. | System for facilitating intranasal guidance |
US9510743B2 (en) | 2013-12-17 | 2016-12-06 | Biovision Technologies, Llc | Stabilized surgical device for performing a sphenopalatine ganglion block procedure |
US9516995B2 (en) | 2013-12-17 | 2016-12-13 | Biovision Technologies, Llc | Surgical device for performing a sphenopalatine ganglion block procedure |
US9694163B2 (en) | 2013-12-17 | 2017-07-04 | Biovision Technologies, Llc | Surgical device for performing a sphenopalatine ganglion block procedure |
US10016580B2 (en) | 2013-12-17 | 2018-07-10 | Biovision Technologies, Llc | Methods for treating sinus diseases |
US20150290439A1 (en) * | 2014-04-14 | 2015-10-15 | Stephen Eldredge | Methods for bilateral central autonomic neuromodulation |
CN204446844U (en) * | 2015-03-03 | 2015-07-08 | 苏州同力生物医药有限公司 | Disposable per nasal brain-targeted drug delivery device |
CN104667391B (en) * | 2015-03-03 | 2017-08-25 | 苏州同力生物医药有限公司 | A kind of disposable intranasal brain-targeted drug delivery device |
CN115887456A (en) | 2015-03-26 | 2023-04-04 | 杰奎琳·M·艾弗森 | Methods and compositions for inhibiting symptoms associated with hangover |
US10300220B2 (en) | 2015-09-03 | 2019-05-28 | Franklyn R. GERGITS | Surgery needle support member |
WO2017217967A1 (en) * | 2016-06-13 | 2017-12-21 | Noveome Biotherapeutics, Inc. | Novel methods for delivering therapeutic agents to the eye via nasal passages |
BR112020013750A8 (en) | 2018-01-05 | 2022-10-18 | Impel Neuropharma Inc | INTRANASAL DISPENSE OF OLANZAPINE BY PRECISION OLFATIVE DEVICE |
JP2021520266A (en) * | 2018-04-12 | 2021-08-19 | ロケット サイエンス ヘルス コープ. | Intranasal drug delivery devices, systems, and processes |
WO2020005910A1 (en) | 2018-06-28 | 2020-01-02 | Sandler Scientific, Llc | Sino-nasal rinse delivery device with agitation, flow-control and integrated medication management system |
US20210161808A1 (en) * | 2018-07-24 | 2021-06-03 | Zenvision Pharma Llp | Nasal Drug Delivery System of Brivaracetam or Salt Thereof |
US20210338946A1 (en) * | 2020-04-30 | 2021-11-04 | Migraine Solutions, LLC | Device for Dispensing Medication for Medical Treatment |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410046B1 (en) * | 1996-11-19 | 2002-06-25 | Intrabrain International Nv | Administering pharmaceuticals to the mammalian central nervous system |
US6432986B2 (en) * | 1997-07-21 | 2002-08-13 | Bruce H. Levin | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches |
US20030133877A1 (en) * | 1997-07-21 | 2003-07-17 | Levin Bruce H. | Apparatus for directed intranasal administration of a composition |
US20030206866A1 (en) * | 2002-05-02 | 2003-11-06 | Wei Edward T. | 1,2,3,6-Tetrahydropyrimidine-2-one compositions, articles and therapeutic methods for upper airway breathing disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4886493A (en) * | 1987-10-22 | 1989-12-12 | Jordan Yee | Medical applicator process |
US5696093A (en) * | 1994-10-28 | 1997-12-09 | Crc For Biopharmaceutical Research Pty Limited | Method of treating nasal congestion using neuropeptide Y Y2 agonist peptides |
US6678553B2 (en) * | 1995-11-21 | 2004-01-13 | Intraabrain International Nv | Device for enhanced delivery of biologically active substances and compounds in an organism |
-
2005
- 2005-05-11 US US11/126,475 patent/US20050281751A1/en not_active Abandoned
-
2006
- 2006-05-11 WO PCT/US2006/018612 patent/WO2006122318A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410046B1 (en) * | 1996-11-19 | 2002-06-25 | Intrabrain International Nv | Administering pharmaceuticals to the mammalian central nervous system |
US6432986B2 (en) * | 1997-07-21 | 2002-08-13 | Bruce H. Levin | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches |
US20030133877A1 (en) * | 1997-07-21 | 2003-07-17 | Levin Bruce H. | Apparatus for directed intranasal administration of a composition |
US20030206866A1 (en) * | 2002-05-02 | 2003-11-06 | Wei Edward T. | 1,2,3,6-Tetrahydropyrimidine-2-one compositions, articles and therapeutic methods for upper airway breathing disorders |
Also Published As
Publication number | Publication date |
---|---|
WO2006122318A2 (en) | 2006-11-16 |
US20050281751A1 (en) | 2005-12-22 |
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