WO2006123113A3 - Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors - Google Patents

Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors Download PDF

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Publication number
WO2006123113A3
WO2006123113A3 PCT/GB2006/001760 GB2006001760W WO2006123113A3 WO 2006123113 A3 WO2006123113 A3 WO 2006123113A3 GB 2006001760 W GB2006001760 W GB 2006001760W WO 2006123113 A3 WO2006123113 A3 WO 2006123113A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazolylaminopyrimidine
tyrosine kinase
kinase inhibitors
derivatives useful
novel compounds
Prior art date
Application number
PCT/GB2006/001760
Other languages
French (fr)
Other versions
WO2006123113A2 (en
Inventor
Bin Wang
Tao Wang
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Bin Wang
Tao Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008511776A priority Critical patent/JP2008540622A/en
Priority to NZ564317A priority patent/NZ564317A/en
Priority to EP06727105A priority patent/EP1899323A2/en
Priority to MX2007014328A priority patent/MX2007014328A/en
Priority to AU2006248780A priority patent/AU2006248780B2/en
Priority to US11/914,492 priority patent/US20080287437A1/en
Priority to CA002608009A priority patent/CA2608009A1/en
Priority to BRPI0610184-4A priority patent/BRPI0610184A2/en
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Bin Wang, Tao Wang filed Critical Astrazeneca Ab
Priority to UY29530A priority patent/UY29530A1/en
Publication of WO2006123113A2 publication Critical patent/WO2006123113A2/en
Publication of WO2006123113A3 publication Critical patent/WO2006123113A3/en
Priority to IL186845A priority patent/IL186845A0/en
Priority to NO20075647A priority patent/NO20075647L/en
Priority to US12/713,777 priority patent/US8114989B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
PCT/GB2006/001760 2005-05-16 2006-05-12 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors WO2006123113A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CA002608009A CA2608009A1 (en) 2005-05-16 2006-05-12 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
EP06727105A EP1899323A2 (en) 2005-05-16 2006-05-12 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
MX2007014328A MX2007014328A (en) 2005-05-16 2006-05-12 Chemical compounds.
AU2006248780A AU2006248780B2 (en) 2005-05-16 2006-05-12 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
US11/914,492 US20080287437A1 (en) 2005-05-16 2006-05-12 Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
JP2008511776A JP2008540622A (en) 2005-05-16 2006-05-12 Compound
BRPI0610184-4A BRPI0610184A2 (en) 2005-05-16 2006-05-12 compound, pharmaceutically acceptable salt of a compound, process for preparing a compound or a pharmaceutically acceptable salt thereof, use of a compound or a pharmaceutically acceptable salt thereof, methods for inhibiting trk activity, for cancer treatment or prophylaxis and for producing an antiproliferative effect on a warm-blooded animal, and, pharmaceutical composition
NZ564317A NZ564317A (en) 2005-05-16 2006-05-12 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
UY29530A UY29530A1 (en) 2005-05-16 2006-05-15 CHEMICAL COMPOUNDS
IL186845A IL186845A0 (en) 2005-05-16 2007-10-22 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
NO20075647A NO20075647L (en) 2005-05-16 2007-11-06 Chemical connections
US12/713,777 US8114989B2 (en) 2005-05-16 2010-02-26 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68151505P 2005-05-16 2005-05-16
US60/681,515 2005-05-16
US72228205P 2005-09-30 2005-09-30
US60/722,282 2005-09-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/914,492 A-371-Of-International US20080287437A1 (en) 2005-05-16 2006-05-12 Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
US12/713,777 Continuation US8114989B2 (en) 2005-05-16 2010-02-26 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
WO2006123113A2 WO2006123113A2 (en) 2006-11-23
WO2006123113A3 true WO2006123113A3 (en) 2007-01-04

Family

ID=37087720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001760 WO2006123113A2 (en) 2005-05-16 2006-05-12 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors

Country Status (15)

Country Link
US (2) US20080287437A1 (en)
EP (1) EP1899323A2 (en)
JP (1) JP2008540622A (en)
KR (1) KR20080015409A (en)
AR (1) AR056354A1 (en)
AU (1) AU2006248780B2 (en)
BR (1) BRPI0610184A2 (en)
CA (1) CA2608009A1 (en)
IL (1) IL186845A0 (en)
MX (1) MX2007014328A (en)
NO (1) NO20075647L (en)
NZ (1) NZ564317A (en)
TW (1) TW200716606A (en)
UY (1) UY29530A1 (en)
WO (1) WO2006123113A2 (en)

Cited By (2)

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US11851434B2 (en) 2017-01-18 2023-12-26 Array Biopharma Inc. Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors
US11964988B2 (en) 2018-09-10 2024-04-23 Array Biopharma Inc. Fused heterocyclic compounds as RET kinase inhibitors

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EP2155742A1 (en) * 2007-04-18 2010-02-24 AstraZeneca AB 5-aminopyrazol-3-yl-3h-imidazo [4,5-b]pyridine derivatives and their use for the treatment of cancer
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