WO2006124431A3 - Systems and methods of blood-based therapies having a microfluidic membraneless exchange device - Google Patents

Systems and methods of blood-based therapies having a microfluidic membraneless exchange device Download PDF

Info

Publication number
WO2006124431A3
WO2006124431A3 PCT/US2006/018008 US2006018008W WO2006124431A3 WO 2006124431 A3 WO2006124431 A3 WO 2006124431A3 US 2006018008 W US2006018008 W US 2006018008W WO 2006124431 A3 WO2006124431 A3 WO 2006124431A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
blood
removal
sample fluid
systems
Prior art date
Application number
PCT/US2006/018008
Other languages
French (fr)
Other versions
WO2006124431A2 (en
Inventor
Edward F Leonard
Alan C West
Nina C Shapley
Zhongliang Tang
Original Assignee
Univ Columbia
Edward F Leonard
Alan C West
Nina C Shapley
Zhongliang Tang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Edward F Leonard, Alan C West, Nina C Shapley, Zhongliang Tang filed Critical Univ Columbia
Publication of WO2006124431A2 publication Critical patent/WO2006124431A2/en
Publication of WO2006124431A3 publication Critical patent/WO2006124431A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3482—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/243—Dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/243—Dialysis
    • B01D61/244—Dialysis comprising multiple dialysis steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/28—Apparatus therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/11—Laminar flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4005—Concentrating samples by transferring a selected component through a membrane
    • G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of 'small' molecules, 'middle' molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
PCT/US2006/018008 2005-05-12 2006-05-09 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device WO2006124431A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/127,905 US20060076295A1 (en) 2004-03-15 2005-05-12 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US11/127,905 2005-05-12

Publications (2)

Publication Number Publication Date
WO2006124431A2 WO2006124431A2 (en) 2006-11-23
WO2006124431A3 true WO2006124431A3 (en) 2007-09-27

Family

ID=37431837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/018008 WO2006124431A2 (en) 2005-05-12 2006-05-09 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device

Country Status (2)

Country Link
US (3) US20060076295A1 (en)
WO (1) WO2006124431A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8496606B2 (en) 2008-02-04 2013-07-30 The Trustees Of Columbia University In The City Of New York Fluid separation devices, systems and methods

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060076295A1 (en) * 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
ATE510605T1 (en) * 2003-03-14 2011-06-15 Univ Columbia SYSTEMS AND METHODS FOR BLOOD BASED THERAPY USING A MEMBRANELESS MICROFLUID EXCHANGE DEVICE
FR2882939B1 (en) * 2005-03-11 2007-06-08 Centre Nat Rech Scient FLUIDIC SEPARATION DEVICE
JP5114702B2 (en) * 2005-07-29 2013-01-09 国立大学法人 東京大学 Method and apparatus for forming bilayer film by contact with amphiphilic monolayer
WO2007044938A2 (en) * 2005-10-13 2007-04-19 The Regents Of The University Of California Microfluidic samplers and methods for making and using them
CN101534917A (en) 2006-05-22 2009-09-16 纽约市哥伦比亚大学理事会 Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
EP2109909B1 (en) 2006-12-21 2016-07-06 Arizona Board of Regents, acting for and on behalf of, Arizona State University Fuel cell with transport flow across gap
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
WO2009067071A1 (en) * 2007-11-19 2009-05-28 Carl Tyren Method and device for differentiation of substances
WO2009079383A1 (en) * 2007-12-14 2009-06-25 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for blood treatment
US8309259B2 (en) * 2008-05-19 2012-11-13 Arizona Board Of Regents For And On Behalf Of Arizona State University Electrochemical cell, and particularly a cell with electrodeposited fuel
JP5608943B2 (en) * 2009-03-31 2014-10-22 マイクロ化学技研株式会社 Plasma separation apparatus and method
US8709356B2 (en) * 2009-04-10 2014-04-29 Canon U.S. Life Sciences, Inc. Systems and methods for minimization or elimination of diffusion effects in a microfluidic system
CN102498602A (en) * 2009-09-18 2012-06-13 流体公司 Rechargeable electrochemical cell system with a charging electrode charge/discharge mode switching in the cells
CN202721244U (en) 2010-06-24 2013-02-06 流体股份有限公司 Electrochemical battery provided with step-shaped bracket fuel anode
CN105206789B (en) 2010-09-16 2018-09-07 流体公司 Electrochemical cell system with progressive analysis oxygen electrode/fuel electrode
US9105946B2 (en) 2010-10-20 2015-08-11 Fluidic, Inc. Battery resetting process for scaffold fuel electrode
JP5908251B2 (en) 2010-11-17 2016-04-26 フルイディック，インク．Ｆｌｕｉｄｉｃ，Ｉｎｃ． Multi-mode charging of hierarchical anode
US8641659B2 (en) 2011-02-17 2014-02-04 Medtronic, Inc. Method and device to treat kidney disease
US9017277B2 (en) 2011-05-02 2015-04-28 Medtronic, Inc. System and implantable device for treating chronic kidney disease
US9541480B2 (en) 2011-06-29 2017-01-10 Academia Sinica Capture, purification, and release of biological substances using a surface coating
JP6001660B2 (en) 2011-08-02 2016-10-05 メドトロニック，インコーポレイテッド Hemodialysis system having a flow path with controlled follow-up volume
EP2744537B1 (en) 2011-08-16 2018-01-24 Medtronic, Inc. Modular hemodialysis system
EP2800592B1 (en) 2012-01-04 2019-03-06 Medtronic Inc. Multi-staged filtration system for blood fluid removal
US9414752B2 (en) 2012-11-09 2016-08-16 Elwha Llc Embolism deflector
US9623164B2 (en) 2013-02-01 2017-04-18 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US10543052B2 (en) 2013-02-01 2020-01-28 Medtronic, Inc. Portable dialysis cabinet
US10850016B2 (en) 2013-02-01 2020-12-01 Medtronic, Inc. Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection
US9144640B2 (en) 2013-02-02 2015-09-29 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
WO2015153816A2 (en) 2014-04-01 2015-10-08 Academia Sinica Methods and systems for cancer diagnosis and prognosis
US10112198B2 (en) 2014-08-26 2018-10-30 Academia Sinica Collector architecture layout design
US10098993B2 (en) 2014-12-10 2018-10-16 Medtronic, Inc. Sensing and storage system for fluid balance
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
US10874787B2 (en) 2014-12-10 2020-12-29 Medtronic, Inc. Degassing system for dialysis
US20160238506A1 (en) * 2015-02-02 2016-08-18 Derek Oberreit Ice nucleii counter technology
US10786615B2 (en) * 2016-03-02 2020-09-29 Exthera Medical Corporation Method for treating drug intoxication
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
BR112019000713B1 (en) 2016-07-22 2023-04-25 Nantenergy, Inc ELECTROCHEMICAL CELL AND METHOD OF CONSERVING MOISTURE INSIDE AN ELECTROCHEMICAL CELL
US11278654B2 (en) 2017-12-07 2022-03-22 Medtronic, Inc. Pneumatic manifold for a dialysis system
US11033667B2 (en) 2018-02-02 2021-06-15 Medtronic, Inc. Sorbent manifold for a dialysis system
US11110215B2 (en) 2018-02-23 2021-09-07 Medtronic, Inc. Degasser and vent manifolds for dialysis
EP3787794A1 (en) * 2018-04-30 2021-03-10 United Therapeutics Corporation Apparatus and method for controlling fluid flow
CN109012775B (en) * 2018-10-09 2024-01-26 深圳亘流科技有限公司 Universal inertial focusing micro-fluidic chip
CN109954525B (en) * 2019-04-08 2021-07-20 广东药科大学 Three-phase layer micro-fluidic chip for simultaneously detecting concentration of free drug and total concentration of blood drug in blood and detection method
WO2020231718A1 (en) 2019-05-10 2020-11-19 Nantenergy, Inc. Nested annular metal-air cell and systems containing same
WO2020243016A1 (en) * 2019-05-24 2020-12-03 United Therapeutics Corporation Systems and methods for exchanging small molecules with fluid
CN111185029A (en) * 2020-01-09 2020-05-22 昆明理工大学 Multi-metal ion extraction device and method based on micro-fluidic chip and extraction rate calculation method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040225249A1 (en) * 2003-03-14 2004-11-11 Leonard Edward F. Systems and methods of blood-based therapies having a microfluidic membraneless exchange device

Family Cites Families (205)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2885782A (en) * 1956-06-11 1959-05-12 James R Groves Vacuum ejector for dental debris
US3388803A (en) * 1965-04-16 1968-06-18 Applied Biolog Sciences Lab In Wearable dialysis apparatus
US3799873A (en) * 1968-04-19 1974-03-26 Hydronautics Artificial kidney
US3506126A (en) * 1968-05-03 1970-04-14 Milton Roy Co Closed recirculating hemodialysis system
US3619423A (en) 1970-04-20 1971-11-09 Us Health Education & Welfare Cascade dialysis apparatus and method
DE2239254C2 (en) 1970-12-30 1983-08-04 Organon Teknika Corp., Oklahoma City, Okla. "Column for regenerating a circulating dialysate solution and using this column".
BE788759A (en) * 1971-09-14 1973-01-02 Atomic Energy Commission COMPACT DIALYZER FOR BLOOD DIALYSIS AND OTHER APPLICATIONS
BE792314A (en) * 1971-12-06 1973-06-05 Rhone Poulenc Sa DEVELOPMENT IN ARTIFICIAL KIDNEYS
US3994799A (en) 1973-04-17 1976-11-30 Yao Shang J Blood and tissue detoxification apparatus
US3884808A (en) * 1973-06-20 1975-05-20 Res Dev Systems Inc Wearable, self-regenerating dialysis appliance
DE2444524A1 (en) * 1974-09-18 1976-04-08 Oeser Henning Dr METHOD AND DEVICE FOR EXPLORATION OF HUMAN BLOOD PLASMA COMPONENTS
US4083786A (en) * 1975-03-20 1978-04-11 Asahi Kasei Kogyo Kabushiki Kaisha Apparatus for treating ascites
US4153554A (en) * 1977-02-22 1979-05-08 American Micro-Bionics Corp. Apparatus for use in artificial kidney system
US4094775A (en) * 1977-02-28 1978-06-13 California Institute Of Technology Dialysis system
FR2385406A1 (en) * 1977-03-28 1978-10-27 Akzo Nv ARTIFICIAL KIDNEY
US4300565A (en) 1977-05-23 1981-11-17 American Cyanamid Company Synthetic polyester surgical articles
US4243775A (en) * 1978-11-13 1981-01-06 American Cyanamid Company Synthetic polyester surgical articles
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4166800A (en) 1977-08-25 1979-09-04 Sandoz, Inc. Processes for preparation of microspheres
US4181983A (en) * 1977-08-29 1980-01-08 Kulkarni R K Assimilable hydrophilic prosthesis
DE2843963A1 (en) 1978-10-09 1980-04-24 Merck Patent Gmbh BODY-RESORBABLE SHAPED MATERIAL BASED ON COLLAGEN AND THEIR USE IN MEDICINE
IT1174707B (en) * 1978-05-03 1987-07-01 Bonomini Vittorio PORTABLE ARTIFICIAL KIDNEY FOR DIALYSIS
US4390519A (en) * 1978-05-19 1983-06-28 Sawyer Philip Nicholas Bandage with hemostatic agent and methods for preparing and employing the same
US4212742A (en) 1978-05-25 1980-07-15 United States Of America Filtration apparatus for separating blood cell-containing liquid suspensions
DE2838414C2 (en) * 1978-09-02 1984-10-31 Fresenius AG, 6380 Bad Homburg Device for hemodialysis and for withdrawing ultrafiltrate
FR2439003A1 (en) * 1978-10-20 1980-05-16 Anvar NEW OSTEOSYNTHESIS PARTS, THEIR PREPARATION AND THEIR APPLICATION
US4247393A (en) * 1979-01-11 1981-01-27 Wallace Richard A Hemodialysis assist device
JPS6032505B2 (en) 1979-03-19 1985-07-29 株式会社吉野工業所 liquid sprayer
US4321192A (en) * 1980-01-10 1982-03-23 Ionics Incorporated Fractionation of protein mixtures by salt addition followed by dialysis treatment
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US5366734A (en) 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4585797A (en) * 1981-04-13 1986-04-29 Seton Company Cosmetic and pharmaceutical sheet material containing polypeptides
US4431019A (en) * 1981-06-25 1984-02-14 Baxter Travenol Laboratories, Inc. Fluid flow control device
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4443333A (en) * 1981-09-24 1984-04-17 Mahurkar Sakharam D Portable dialysis system and pump therefor
US4409332A (en) 1982-01-12 1983-10-11 Jefferies Steven R Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same
US4450449A (en) * 1982-02-25 1984-05-22 Honeywell Inc. Patch array antenna
US4538603A (en) 1982-04-22 1985-09-03 E. R. Squibb & Sons, Inc. Dressings, granules, and their use in treating wounds
DE3221365C1 (en) * 1982-06-05 1983-12-22 Chemie Und Filter Gmbh, Verfahrenstechnik Kg, 6900 Heidelberg Device for regulating a size by feeding an additive into a medium
US4539981A (en) 1982-11-08 1985-09-10 Johnson & Johnson Products, Inc. Absorbable bone fixation device
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4765899A (en) 1983-10-11 1988-08-23 E. I. Du Pont De Nemours And Company Apparatus for continuous separation of leukocyte/platelet-enriched fraction from whole blood
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US5197977A (en) * 1984-01-30 1993-03-30 Meadox Medicals, Inc. Drug delivery collagen-impregnated synthetic vascular graft
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4623588A (en) 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4578384A (en) * 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
CA1295796C (en) 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US4765907A (en) 1984-03-28 1988-08-23 Research Development Systems, Inc. Wearable, continuously internally operable and externally regenerable dialysis device
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4663049A (en) * 1984-07-05 1987-05-05 University Of Utah Process for therapeutic dissociation of immune complexes and removal of antigens
US4678566A (en) 1984-07-20 1987-07-07 Terumo Kabushiki Kaisha Apparatus for separating proteins from blood plasma
US4661246A (en) * 1984-10-01 1987-04-28 Ash Medical Systems, Inc. Dialysis instrument with dialysate side pump for moving body fluids
JPH0662679B2 (en) 1985-06-21 1994-08-17 新田ゼラチン株式会社 Tissue-friendly collagen and its manufacturing method
US4741337A (en) * 1985-07-17 1988-05-03 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
US4889119A (en) 1985-07-17 1989-12-26 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
DE3684446D1 (en) * 1985-12-28 1992-04-23 Sumitomo Pharma MEDICINAL PRODUCTS WITH DELAYED RELEASED RELEASE.
US5133755A (en) 1986-01-28 1992-07-28 Thm Biomedical, Inc. Method and apparatus for diodegradable, osteogenic, bone graft substitute device
US4968422A (en) 1986-06-23 1990-11-06 Runge Thomas M Pulsatile flow hemodialysis
US4877864A (en) 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
ZA874681B (en) 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US4839130A (en) * 1986-07-17 1989-06-13 United States Surgical Corporation Process of making an absorbable surgical device
US4744365A (en) * 1986-07-17 1988-05-17 United States Surgical Corporation Two-phase compositions for absorbable surgical devices
JPS6368155A (en) * 1986-09-11 1988-03-28 グンゼ株式会社 Bone bonding pin
US5227157A (en) 1986-10-14 1993-07-13 Board Of Regents, The University Of Texas System Delivery of therapeutic agents
FI80605C (en) * 1986-11-03 1990-07-10 Biocon Oy Bone surgical biocomposite material
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5051272A (en) 1988-07-19 1991-09-24 United States Surgical Corporation Method for improving the storage stability of a polymeric article susceptible to hydrolytic degradation and resulting article
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US4844854A (en) 1987-09-22 1989-07-04 United States Surgical Corporation Process for making a surgical device using two-phase compositions
US4822278A (en) * 1987-10-16 1989-04-18 The Wilkinson Dental Manufacturing Company, Inc. Dental veneer instrument
GB8724914D0 (en) * 1987-10-23 1987-11-25 Research Corp Ltd Blood purification apparatus
FR2623402B1 (en) * 1987-11-19 1994-04-29 Solvay ARTICLE OF LACTIC ACID POLYMER FOR USE IN PARTICULAR AS A BIODEGRADABLE PROSTHESIS AND METHOD FOR THE PRODUCTION THEREOF
US4916193A (en) * 1987-12-17 1990-04-10 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US4961707A (en) 1987-12-22 1990-10-09 University Of Florida Guided periodontal tissue regeneration
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US4968590A (en) 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
DE3825211A1 (en) * 1988-07-25 1990-02-01 Henkel Kgaa IMPROVED BODY RESORBONABLE WAXES (III)
US5250584A (en) 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
DE3837498A1 (en) * 1988-11-04 1990-05-17 Fresenius Ag METHOD AND DEVICE FOR ULTRAFILTRATION IN HAEMODIALYSIS
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
ES2051968T3 (en) 1988-12-22 1994-07-01 American Cyanamid Co METHOD FOR THE TREATMENT OF PERIODONTAL DISEASE THROUGH THE CONTINUOUS RELEASE OF A THERAPEUTIC AGENT TO THE PERIODONTAL BAG; COMPOSITION OF THE SAME MATTER AND APPARATUS FOR ITS ADMINISTRATION.
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US5460803A (en) 1989-05-24 1995-10-24 American Dental Association Health Foundation Methods and compositions for mineralizing and fluoridating calcified tissues
US5534244A (en) 1989-05-24 1996-07-09 Tung; Ming S. Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds
US6000341A (en) 1989-05-24 1999-12-14 American Dental Association Health Foundation Methods and composition for mineralizing and fluoridating calcified tissues
US5037639A (en) 1989-05-24 1991-08-06 American Dental Association Health Foundation Methods and compositions for mineralizing calcified tissues
US6056930A (en) * 1989-05-24 2000-05-02 American Dental Association Health Foundation Methods and compositions for mineralizing and fluoridating calcified tissues
US5077049A (en) 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5268178A (en) 1989-09-25 1993-12-07 The Board Of Regents, The University Of Texas System Biodegradable antibiotic implants and methods of their use in treating and preventing infections
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5193688A (en) * 1989-12-08 1993-03-16 University Of Utah Method and apparatus for hydrodynamic relaxation and sample concentration NIN field-flow fraction using permeable wall elements
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
US5350580A (en) 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
JP3359919B2 (en) 1990-05-16 2002-12-24 サザン・リサーチ・インスティテュート Controlled release dopamine and uses for stimulating nerve fiber growth
US5080665A (en) * 1990-07-06 1992-01-14 American Cyanamid Company Deformable, absorbable surgical device
US5324307A (en) * 1990-07-06 1994-06-28 American Cyanamid Company Polymeric surgical staple
US5081106A (en) * 1990-07-16 1992-01-14 The Oregon Health Sciences University Wound dressing protocol utilizing collagen gelatin formed with iodine
US5128136A (en) 1990-07-16 1992-07-07 The Oregon Health Sciences University Wound healing kit comprised of gelable collagen
US5231169A (en) 1990-10-17 1993-07-27 Norian Corporation Mineralized collagen
US5114932A (en) * 1990-11-30 1992-05-19 Runge Thomas M Hyperosmolar oxyreplete hemosubstitute
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5320624A (en) * 1991-02-12 1994-06-14 United States Surgical Corporation Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5149691A (en) 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
US5284559A (en) * 1992-06-16 1994-02-08 Rhode Island Hospital Preparative electrophoresis device and method
US5281419A (en) * 1992-09-28 1994-01-25 Thomas Jefferson University Biodegradable drug delivery system for the prevention and treatment of osteomyelitis
US5284470A (en) * 1992-11-02 1994-02-08 Beltz Alex D Wearable, portable, light-weight artificial kidney
DE4309410A1 (en) * 1993-03-19 1995-02-16 Stange Jan Material, process and equipment for the selective separation of freely dissolved and substance-bound substances from liquid substance mixtures as well as process for the production of the material
US5415532A (en) * 1993-11-30 1995-05-16 The United States Of America As Represented By The Secretary Of The Army High effieciency balanced oscillating shuttle pump
US5577891A (en) 1993-11-30 1996-11-26 Instech Laboratories, Inc. Low power portable resuscitation pump
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
JPH07328110A (en) 1994-06-10 1995-12-19 Nissho Corp Water removing control mechanism for dialyzer
US5782796A (en) 1995-02-10 1998-07-21 Baxter International Inc. Foldable dialysis unit with integral pump and a method for performing solution exchange
US5591344A (en) * 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US5873853A (en) * 1995-05-23 1999-02-23 Baxter International Inc. Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same
US5932100A (en) 1995-06-16 1999-08-03 University Of Washington Microfabricated differential extraction device and method
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5944684A (en) 1995-08-31 1999-08-31 The Regents Of The University Of California Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications
US5948684A (en) 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US20020090644A1 (en) 1999-05-21 2002-07-11 Weigl Bernhard H. Microscale diffusion immunoassay
US5885829A (en) * 1996-05-28 1999-03-23 The Regents Of The University Of Michigan Engineering oral tissues
JP2000512541A (en) 1996-06-14 2000-09-26 ユニバーシティ オブ ワシントン Difference extraction device with improved absorption
US5833954A (en) 1996-08-20 1998-11-10 American Dental Association Health Foundation Anti-carious chewing gums, candies, gels, toothpastes and dentifrices
JP2002503334A (en) 1996-09-04 2002-01-29 テクニカル ユニバーシティ オブ デンマーク Microflow system for particle separation and analysis
US5917322A (en) * 1996-10-08 1999-06-29 Massachusetts Institute Of Technology Method and apparatus for quantum information processing
US5902336A (en) * 1996-10-15 1999-05-11 Mirimedical, Inc. Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure
US5871360A (en) * 1996-12-31 1999-02-16 Gc Corporation Method for restoration of a cavity of a tooth using a resin reinforced type glass ionomer cement
ES2129344B1 (en) 1997-01-07 2000-03-01 Univ Barcelona Autonoma REMINERALIZING MATERIAL OF ORGANOMINERAL TISSUES.
US5855562A (en) * 1997-01-07 1999-01-05 Hudson Respiratory Care Inc. Suction control valve
US6001897A (en) 1997-01-13 1999-12-14 American Dental Association Health Foundation Polymerizable conditioners for adhesive bonding to dentin and enamel
US6128764A (en) 1997-02-06 2000-10-03 California Institute Of Technology Quantum error-correcting codes and devices
US6159739A (en) 1997-03-26 2000-12-12 University Of Washington Device and method for 3-dimensional alignment of particles in microfabricated flow channels
JP4085341B2 (en) 1997-03-31 2008-05-14 ザ、リージエンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン Open pore biodegradable matrix
US5980481A (en) 1997-05-08 1999-11-09 Transvivo, Inc. Method and apparatus for continuous peritoneal cascade dialysis and hemofiltration (CPCD/H)
US6117100A (en) 1997-06-06 2000-09-12 Powers; Kathleen M. Hemodialysis-double dialyzers in parallel
US6472210B1 (en) 1997-11-14 2002-10-29 Bonetec Corporation Polymer scaffold having microporous polymer struts defining interconnected macropores
US6200814B1 (en) 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
US6114408A (en) 1998-02-06 2000-09-05 American Dental Association Health Foundation Single-solution adhesive resin formulations
US6582385B2 (en) 1998-02-19 2003-06-24 Nstage Medical, Inc. Hemofiltration system including ultrafiltrate purification and re-infusion system
US6317766B1 (en) 1998-11-02 2001-11-13 Lucent Technologies Inc. Fast quantum mechanical algorithms
SE512683C2 (en) 1998-11-20 2000-05-02 Gambro Ab Method and apparatus for preventing protein loss in peritoneal dialysis
US6398859B1 (en) * 1998-12-24 2002-06-04 American Dental Association Health Foundation Resin-based pulp capping and basing cements
WO2000050049A2 (en) * 1999-02-24 2000-08-31 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Artificial salivary gland
US6551842B1 (en) * 1999-03-26 2003-04-22 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6511814B1 (en) * 1999-03-26 2003-01-28 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6602719B1 (en) 1999-03-26 2003-08-05 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6332985B1 (en) 1999-03-29 2001-12-25 Uop Llc Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions
CA2369576C (en) * 1999-04-23 2005-07-05 William Frederick Weitzel Extracorporeal circuit and related methods
US6406631B1 (en) * 1999-07-30 2002-06-18 Nephros, Inc. Two stage diafiltration method and apparatus
US7015499B1 (en) * 1999-12-01 2006-03-21 D-Wave Systems, Inc. Permanent readout superconducting qubit
US6459097B1 (en) 2000-01-07 2002-10-01 D-Wave Systems Inc. Qubit using a Josephson junction between s-wave and d-wave superconductors
JP4733331B2 (en) 2000-03-14 2011-07-27 マイクロニックス、インコーポレーテッド Microfluidic analysis device
US6527735B1 (en) * 2000-04-27 2003-03-04 Renaltech International Llc Method of peritoneal dialysis
US20010048637A1 (en) 2000-05-24 2001-12-06 Weigl Bernhard H. Microfluidic system and method
US20010055546A1 (en) 2000-06-23 2001-12-27 Weigl Bernhard H. Method and apparatus for controlling fluid flow rate in a microfluidic circuit
US7052907B2 (en) * 2000-07-21 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Adult human dental pulp stem cells in vitro and in vivo
US20020052571A1 (en) * 2000-09-13 2002-05-02 Fazio Frank A. Artificial kidney and methods of using same
US6899915B2 (en) * 2000-11-29 2005-05-31 President And Fellows Of Harvard College Methods and compositions for culturing a biological tooth
DE20113789U1 (en) 2001-01-10 2002-05-23 Braun Melsungen Ag Medical device
US6793725B2 (en) 2001-01-24 2004-09-21 Ada Foundation Premixed calcium phosphate cement pastes
EP1399193B1 (en) 2001-02-16 2014-01-08 Piedmont Renal Clinics, P.A. Automated peritoneal dialysis system and process with in-line sterilization of dialysate
SE0103013D0 (en) * 2001-03-09 2001-09-12 Erysave Ab Ideon System and method of treatment of whole blood
US6504172B2 (en) * 2001-03-16 2003-01-07 D-Wave Systems, Inc. Superconducting dot/anti-dot flux qubit based on time-reversal symmetry breaking effects
US20020159920A1 (en) 2001-04-03 2002-10-31 Weigl Bernhard H. Multiple redundant microfluidic structures cross reference to related applications
US6742661B1 (en) * 2001-04-03 2004-06-01 Micronics, Inc. Well-plate microfluidics
US6803599B2 (en) 2001-06-01 2004-10-12 D-Wave Systems, Inc. Quantum processing system for a superconducting phase qubit
US7481936B2 (en) 2001-10-17 2009-01-27 Transvivo Inc. Method and apparatus for patient fluid management
US7309323B2 (en) * 2001-11-16 2007-12-18 National Quality Care, Inc. Wearable continuous renal replacement therapy device
EP1314442A1 (en) * 2001-11-26 2003-05-28 Infomed S.A. Intra- and extracorporeal purification device
US6614047B2 (en) 2001-12-17 2003-09-02 D-Wave Systems, Inc. Finger squid qubit device
US20040016918A1 (en) * 2001-12-18 2004-01-29 Amin Mohammad H. S. System and method for controlling superconducting qubits
US7002174B2 (en) * 2001-12-18 2006-02-21 D-Wave Systems, Inc. Characterization and measurement of superconducting structures
US6796955B2 (en) 2002-02-14 2004-09-28 Chf Solutions, Inc. Method to control blood and filtrate flowing through an extracorporeal device
US6670630B2 (en) 2002-03-16 2003-12-30 D-Wave Systems, Inc. Quantum phase-charge coupled device
US6605822B1 (en) 2002-03-16 2003-08-12 D-Wave Systems, Inc. Quantum phase-charge coupled device
US6911664B2 (en) * 2002-04-15 2005-06-28 D-Wave Systems, Inc. Extra-substrate control system
US6900454B2 (en) * 2002-04-20 2005-05-31 D-Wave Systems, Inc. Resonant controlled qubit system
US20040009096A1 (en) * 2002-06-08 2004-01-15 Wellman Parris S. Substantially inertia free hemodialysis
US20030226806A1 (en) 2002-06-11 2003-12-11 Young Lincoln C. Methods and devices for liquid extraction
EP2298377A1 (en) * 2002-07-19 2011-03-23 Baxter International Inc. Systems and methods for peritoneal dialysis
US7118676B2 (en) 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US7150834B2 (en) 2003-07-31 2006-12-19 Arryx, Inc. Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components
US7582482B2 (en) 2002-09-03 2009-09-01 Dionex Corporation Continuous ion species removal device and method
US7094345B2 (en) 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
US6878271B2 (en) * 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US7351218B2 (en) * 2002-12-20 2008-04-01 Gambro Lundia Ab Device and process for extracorporeal treatment by citrate anticoagulant
US20060076295A1 (en) * 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US7309232B2 (en) 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
JP2005224775A (en) 2004-02-16 2005-08-25 Fuji Xerox Co Ltd Method and apparatus for treating fine particle
EP1804959B1 (en) * 2004-10-06 2014-02-26 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University Mecs dialyzer
US20070179436A1 (en) 2005-12-21 2007-08-02 Braig James R Analyte detection system with periodic sample draw and laboratory-grade analyzer
US8133194B2 (en) * 2006-02-22 2012-03-13 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
CN101534917A (en) 2006-05-22 2009-09-16 纽约市哥伦比亚大学理事会 Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040225249A1 (en) * 2003-03-14 2004-11-11 Leonard Edward F. Systems and methods of blood-based therapies having a microfluidic membraneless exchange device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8496606B2 (en) 2008-02-04 2013-07-30 The Trustees Of Columbia University In The City Of New York Fluid separation devices, systems and methods

Also Published As

Publication number Publication date
US7850633B2 (en) 2010-12-14
US8021318B2 (en) 2011-09-20
WO2006124431A2 (en) 2006-11-23
US20090292234A1 (en) 2009-11-26
US20110056884A1 (en) 2011-03-10
US20060076295A1 (en) 2006-04-13

Similar Documents

Publication Publication Date Title
WO2006124431A3 (en) Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
WO2004082796A3 (en) Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
WO2009038628A3 (en) Liquid containment for integrated assays
WO2007009125A3 (en) Microfluidic devices and methods of preparing and using the same
CA2588420E (en) Device and method for detection of analytes
WO2008097559A3 (en) Manipulation of fluids and reactions in microfluidic systems
WO2004092702A3 (en) Microfluidic detection device
WO2007137245A3 (en) Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
WO2005084380A3 (en) System for delivering a diluted solution
DK1766400T3 (en) Procedure for performing whole blood assays
WO2008131048A3 (en) Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells
WO2007035586A3 (en) Systems and methods for enrichment of analytes
WO2007035585A3 (en) Systems and methods for enrichment of analytes
WO2006081324A3 (en) Dnd purification and analysis on nanoengineered surfaces
WO2005011867A3 (en) Processing particle-containing samples
WO2004046712A3 (en) Isolation of sperm cells from other biological materials using microfabricated devices and related methods thereof
Xu et al. Isolation of a low number of sperm cells from female DNA in a glass–PDMS–glass microchip via bead-assisted acoustic differential extraction
WO2008034833A3 (en) Apparatus for receiving biological specimens and method for laser dissection of biological specimens
WO2007106483A3 (en) Capillary-channeled polymeric fiber as solid phase extraction media
WO2005010147A3 (en) Device and method for contacting pocoliter volumes of fluids
WO2007014222A3 (en) Blood processing device and associated systems and methods
WO2006110537A3 (en) Particulate separation filters and methods
WO2010080978A3 (en) Pre-depletion of leukocytes in whole blood samples prior to the capture of whole blood sample components
WO2009039239A3 (en) Lateral flow assay using centrifugal force
WO2007041734A3 (en) Device for the analysis of liquid samples

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 06770155

Country of ref document: EP

Kind code of ref document: A2