WO2006128740A3 - Anti-vascular methods and therapies employing lysyl oxidase inhibitors - Google Patents

Anti-vascular methods and therapies employing lysyl oxidase inhibitors Download PDF

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Publication number
WO2006128740A3
WO2006128740A3 PCT/EP2006/006692 EP2006006692W WO2006128740A3 WO 2006128740 A3 WO2006128740 A3 WO 2006128740A3 EP 2006006692 W EP2006006692 W EP 2006006692W WO 2006128740 A3 WO2006128740 A3 WO 2006128740A3
Authority
WO
WIPO (PCT)
Prior art keywords
lysyl oxidase
oxidase inhibitors
methods
therapies employing
vascular
Prior art date
Application number
PCT/EP2006/006692
Other languages
French (fr)
Other versions
WO2006128740A2 (en
Inventor
Mark Nesbit
Original Assignee
Centelion
Mark Nesbit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centelion, Mark Nesbit filed Critical Centelion
Publication of WO2006128740A2 publication Critical patent/WO2006128740A2/en
Publication of WO2006128740A3 publication Critical patent/WO2006128740A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

The present invention relates to pharmaceutical compositions and methods of treating angiogenesis related diseases, such as cancer. Specifically, the invention relates to a composition comprising a lysyl oxidase inhibitor alone or in combination with at least one chemotherapeutic agent, as well as use of the composition and/or combination in the treatment of angiogenesis related disease, such as cancer.
PCT/EP2006/006692 2005-06-02 2006-06-02 Anti-vascular methods and therapies employing lysyl oxidase inhibitors WO2006128740A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68640605P 2005-06-02 2005-06-02
US60/686,406 2005-06-02

Publications (2)

Publication Number Publication Date
WO2006128740A2 WO2006128740A2 (en) 2006-12-07
WO2006128740A3 true WO2006128740A3 (en) 2007-04-12

Family

ID=37482014

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/006692 WO2006128740A2 (en) 2005-06-02 2006-06-02 Anti-vascular methods and therapies employing lysyl oxidase inhibitors

Country Status (1)

Country Link
WO (1) WO2006128740A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168180B2 (en) 2002-11-27 2012-05-01 Technion Research & Development Foundation Ltd. Methods and compositions for modulating angiogenesis
US8927700B2 (en) 2009-08-21 2015-01-06 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US9176139B2 (en) 2007-08-02 2015-11-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL184627A0 (en) 2007-07-15 2008-12-29 Technion Res & Dev Foundation Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue
CN113321743B (en) * 2021-07-02 2022-10-21 海南精准医疗科技有限公司 Chimeric antigen receptor of targeting lysyl oxidase 1 and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011667A2 (en) * 2000-08-08 2002-02-14 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
WO2004037992A2 (en) * 2002-10-23 2004-05-06 Exelixis, Inc. Mapk7 as modifier of branching morphogenesis and methods of use
WO2005038465A2 (en) * 2003-10-07 2005-04-28 Centelion Anti-vascular and anti-proliferation methods, therapies, and combinations employing specific tyrosine kinase inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011667A2 (en) * 2000-08-08 2002-02-14 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
WO2004037992A2 (en) * 2002-10-23 2004-05-06 Exelixis, Inc. Mapk7 as modifier of branching morphogenesis and methods of use
WO2005038465A2 (en) * 2003-10-07 2005-04-28 Centelion Anti-vascular and anti-proliferation methods, therapies, and combinations employing specific tyrosine kinase inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GOLDBRUNNER R H ET AL: "MODELS FOR ASSESSMENT OF ANGIOGENESIS IN GLIOMAS", JOURNAL OF NEURO-ONCOLOGY, KLUWER, BOSTON, US, vol. 50, no. 1/2, October 2000 (2000-10-01), pages 53 - 62, XP009035224, ISSN: 0167-594X *
KIRSCHMANN DAWN A ET AL: "A molecular role for lysyl oxidase in breast cancer invasion", CANCER RESEARCH, vol. 62, no. 15, 1 August 2002 (2002-08-01), pages 4478 - 4483, XP002414351, ISSN: 0008-5472 *
KLAUBER N ET AL: "INHIBITION OF ANGIOGENESIS AND BREAST CANCER IN MICE BY THE MICROTUBULE INHIBITORS 2-METHOXYESTRADIOL AND TAXOL", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, no. 1, 1 January 1997 (1997-01-01), pages 81 - 86, XP000982726, ISSN: 0008-5472 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168180B2 (en) 2002-11-27 2012-05-01 Technion Research & Development Foundation Ltd. Methods and compositions for modulating angiogenesis
US9176139B2 (en) 2007-08-02 2015-11-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US9289447B2 (en) 2009-01-06 2016-03-22 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US8927700B2 (en) 2009-08-21 2015-01-06 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2

Also Published As

Publication number Publication date
WO2006128740A2 (en) 2006-12-07

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