WO2006131862A2 - Fail-safe remote control - Google Patents

Fail-safe remote control Download PDF

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Publication number
WO2006131862A2
WO2006131862A2 PCT/IB2006/051762 IB2006051762W WO2006131862A2 WO 2006131862 A2 WO2006131862 A2 WO 2006131862A2 IB 2006051762 W IB2006051762 W IB 2006051762W WO 2006131862 A2 WO2006131862 A2 WO 2006131862A2
Authority
WO
WIPO (PCT)
Prior art keywords
signal
remote control
safety
switch
switch control
Prior art date
Application number
PCT/IB2006/051762
Other languages
French (fr)
Other versions
WO2006131862A3 (en
Inventor
Matthias Teders
Gerhard Hornfeldt
Original Assignee
Philips Intellectual Property & Standards Gmbh
Koninklijke Philips Electronics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Intellectual Property & Standards Gmbh, Koninklijke Philips Electronics N.V. filed Critical Philips Intellectual Property & Standards Gmbh
Priority to DE602006008611T priority Critical patent/DE602006008611D1/en
Priority to JP2008515345A priority patent/JP5281396B2/en
Priority to AT06765713T priority patent/ATE440353T1/en
Priority to US11/916,542 priority patent/US8125309B2/en
Priority to EP06765713A priority patent/EP1891617B1/en
Publication of WO2006131862A2 publication Critical patent/WO2006131862A2/en
Publication of WO2006131862A3 publication Critical patent/WO2006131862A3/en

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Classifications

    • GPHYSICS
    • G08SIGNALLING
    • G08CTRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C17/00Arrangements for transmitting signals characterised by the use of a wireless electrical link
    • GPHYSICS
    • G08SIGNALLING
    • G08CTRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C25/00Arrangements for preventing or correcting errors; Monitoring arrangements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/54Control of apparatus or devices for radiation diagnosis
    • A61B6/548Remote control of the apparatus or devices

Definitions

  • the present invention relates to a fail-safe interface for in an environment with strict safety requirements.
  • the present invention also relates to a remote control that requires a fail- safe interface.
  • the present invention is particularly relevant for a wireless remote control that can control movements of in a patient table in a medical environment but can be used in any system where adjustments of articles need to be made while safety concerns due to erroneous conditions are high.
  • a wireless remote control that can control movements of in a patient table in a medical environment but can be used in any system where adjustments of articles need to be made while safety concerns due to erroneous conditions are high.
  • Such an environment includes a hospital operation and investigation room, which have adjustable patient tables for use with a wide variety of equipment such as X-ray machines, MRI scanners etc.
  • IEC accepted the IEC 61508 standard ("Functional Safety of Electrical/Electronic/Programmable Electronic Safety-Related System") to support companies that use Safety Instrumented Systems (SIS) to protect persons and facilities from hazardous events.
  • SIS Safety Instrumented Systems
  • SIL level 1 - 4
  • the SIL takes into account device integrity, architecture, voting, diagnostics, systematic and common cause failures, testing, operation, and maintenance.
  • a SIL establishes an order of magnitude targets for risk reduction.
  • This target failure measure is the intended probability of dangerous mode failures to be achieved in respect of the safety integrity requirements, specified in terms of either the average probability of failure to perform the safety function on demand (for a low demand of operation); or the probability of a dangerous failure per hour (for a high demand or continuous mode of operation).
  • the higher the SIL the greater the impact of a failure and therefore the lower the failure rate that is acceptable.
  • the method used to derive the SIL designation must be carefully documented using well-established methods.
  • the first step to determine or designate a SIL is to conduct a process hazards analysis (PHA).
  • PHA process hazards analysis
  • a micro-controller scans the inputs of a keyboard of a wireless remote control and/or a footswitch that is used to control a movable patient table.
  • a person controls the remote an output of its microprocessor will control a relay.
  • a micro-controller in a remote control could get in an error situation. When an output would get stuck the patient table could then move uncontrollable something that can be very dangerous and must be prevented.
  • an object of the present invention to provide a safety interface for a remote control.
  • a micro-controller is controlling a relay using a safety filter.
  • the safety filter comprises a band-filter that outputs a relay control activation signal only when the micro-controller outputs a signal with a main component that lies within a certain frequency range.
  • the safety filter comprises a transformer that is known from the past to be reliable enough to be used in fail-safe systems.
  • present invention provides an adjustable patient table (100) comprising a fail-safe wireless remote control for controlling an actuator to adjust the table.
  • the invention provides a remote control (160) for controlling a safety relevant function. It comprises a first user input signal path and a second user input signal path, a transmitter (110) for transmitting a first signal from the first signal path and a second signal from the second signal path, a receiver (120) for receiving the first signal and the second signal, a first switch control that in response of a validated first signal can output a first switch control output signal, a second switch control comprising a safety filter (150) that in response of a validated second signal can output a second switch control output signal.
  • the safety relevant function can only be activated when the first switch control outputs a validated first switch control output signal and the safety filter outputs a validated second switch control output signal.
  • Fig. 1 shows a block-diagram of a remote control system 160 in a safety relevant system 100 in accordance with the invention
  • Fig. 2 shows a best mode implementation of a safety filter 150 for use in the remote control system 100 in a safety relevant system 100 in accordance with the invention
  • Fig. 3 shows the frequency response of safety filter 150 and the relay 170 sensitivity with respect to the safety filter response in accordance of a best mode embodiment in accordance with the invention.
  • Fig. 1 shows a block-diagram of a remote control system 160 in a safety relevant system 100 in accordance with the invention.
  • System 100 comprises a keyboard scanner 102, a footswitch 104 (with open contacts on off-state), remote control system 160, and safety relevant device 190.
  • Remote control system 160 comprises a dual executed and redundant signal path (visualized as 1 st 103 and 2 nd 105) and comprises microcontroller 106, 108, 122, 124, transmitter 110, transmission path 115, receiver 120, relay switch driver 144, amplifier 140 and safety filter 150.
  • Device 190 comprises relays 170 and 172 and motor 180. Motor 180 can only be activated when both relays 170 and 172 are activated.
  • Relay 170 can only be activated with a validated first switch control signal 153 and relay 172 can only be activated with a validated second switch control signal 155.
  • An example of device 190 is a patient table that can, e.g., be moved up and down using motor 180 as part of an actuator. However any movement will abruptly be stopped when system 100 would get into an error condition by at least de-activating relay 170 or relay 172, which would otherwise pose a hazardous situation for, e.g., a patient lying on the table.
  • a control line is typically be executed double, the second being redundant to the first one.
  • Microcontrollers 106 and 108 check the integrity of the signal on 1 st 103 and the signal on 2 nd 105 and they check each other status as well. In case of any fault condition, microcontroller will not output a signal that could effect an action.
  • Another task of microcontrollers 106 and 108 is to prepare their respective input signals for transmission my transmitter 110.
  • Receiver 120 will receive a multiplex of the transmitted signals and will separate them in respective output signals to microcontrollers 122 and 124.
  • Transmission path 115 can be wireless (e.g., radio frequent, RF), infra-red (IR), or cable conducted (e.g., with the 1 st and the 2 nd signal modulated on one and the same conducting carrier).
  • Microcontrollers 122 and 124 will check the integrity of each respective input signal and will check each other on a fault condition as well (by preferably a handshake). If again no error condition has been detected microcontroller 122 will output a first control signal 126 for relay switch driver 144. Also if again no error condition has been detected microcontroller 122 will output a second control signal 128 to amplifier 140.
  • Second control signal 128 comprises a periodic pulse train signal (with a block form shape) with a ground frequency component between Fl and F2, typically FO.
  • microcontroller when microcontroller would be in an error condition, it would not be able to output such a, typically software generated, block form shaped signal.
  • Fl will be larger than 0 Hz and F2 will be smaller than the tact frequency of microcontroller 124.
  • the pulse train signal will be used to control relay 170. But before the pulse train reaches the relay it will pass amplifier 140 followed by (preferably narrow band) filter 150. Amplifier may be needed as the signal 128 coming from microcontroller 124 will typically not be powerful enough to drive relay 170 after passing filter 150. This band-pass filter only will output a substantial signal when the pulse-train has a main frequency component that matches the band-pass filter (so with Fl ⁇ frequency ⁇ F2).
  • Fig. 2 shows a best mode implementation of a safety filter 150 for use in the remote control system 100 in a safety relevant system 100 in accordance with the invention
  • Filter 150 includes LC Band pass filter 152 comprising capacitor CO and transformer TO, rectifier diode Dl and capacitor Cl.
  • filter 150 will receive a block wave signal that will be band-pass filtered by a selection transformer comprising capacitor CO and transformer TO and then substantially rectified by diode Dl and capacitor Cl. The resulting DC-output signal will be powerful enough to close the switch by driving relay 170.
  • Fig. 3 shows the frequency response 310 of safety filter 150 and the relay 170 sensitivity 320 with respect to the safety filter response in accordance of a best mode embodiment in accordance with the invention.
  • LC Band pass filter 152 acts as a narrow band filter with a characteristic as in 310.
  • a pulse train with a main frequency component with Fl ⁇ frequency ⁇ F2 is offered to filter 150 a DC signal will appear at the output of filter 150 that is large enough to activate relay switch 170.
  • the filter rectifies the filtered pulse train by means of Dl and Cl.
  • an error condition Software error or hardware error within the micro-controller
  • the dedicated frequency will not be transmitted by microcontroller 124.
  • the fail-safe wired or wireless remote control is very useful in a medical setting where cables can be hazardous and make operation of medical equipment awkward.
  • the remote control can for instance be used for controlling movements of a patient table. That can for instance be useful when maneuvering the table to an medical system for examining a patient who is lying on the table.
  • the remote control may well be used for controlling a vertical/horizontal movement of the patient table with a remote control in such a system the remote control can be applicated in a much wider area of use where safety concerns play a role.
  • microcontrollers 106 and 108 could be connected to microcontrollers 106 and 108 for controlling different (e.g., safety related) functions. Consequently microcontrollers 122 and 124 could output a multiple of signals for controlling the different functions. Per function a different safety filter 150 could be devised with a different pass band behavior.

Abstract

The present invention relates to a remote control (160) operates fail-safe. The remote control comprises a safety filter (150) in order to provide a fail save operation. The present invention also relates to an adjustable patient table (100) comprising a fail-safe wireless remote control for controlling an actuator to adjust the table.

Description

Fail-safe remote control.
FIELD OF THE INVENTION
The present invention relates to a fail-safe interface for in an environment with strict safety requirements.
The present invention also relates to a remote control that requires a fail- safe interface.
The present invention is particularly relevant for a wireless remote control that can control movements of in a patient table in a medical environment but can be used in any system where adjustments of articles need to be made while safety concerns due to erroneous conditions are high. Such an environment includes a hospital operation and investigation room, which have adjustable patient tables for use with a wide variety of equipment such as X-ray machines, MRI scanners etc.
BACKGROUND OF THE INVENTION
In 2000, IEC accepted the IEC 61508 standard ("Functional Safety of Electrical/Electronic/Programmable Electronic Safety-Related System") to support companies that use Safety Instrumented Systems (SIS) to protect persons and facilities from hazardous events. Four safety integrity levels (SIL, level 1 - 4) are defined by IEC 61508 to statistically represent the integrity of the SIS when a process demand occurs. The SIL takes into account device integrity, architecture, voting, diagnostics, systematic and common cause failures, testing, operation, and maintenance. A SIL establishes an order of magnitude targets for risk reduction. This target failure measure is the intended probability of dangerous mode failures to be achieved in respect of the safety integrity requirements, specified in terms of either the average probability of failure to perform the safety function on demand (for a low demand of operation); or the probability of a dangerous failure per hour (for a high demand or continuous mode of operation). The higher the SIL, the greater the impact of a failure and therefore the lower the failure rate that is acceptable. The method used to derive the SIL designation, must be carefully documented using well-established methods. The first step to determine or designate a SIL, is to conduct a process hazards analysis (PHA). The methodology of IEC 61508 focuses most of the actual evaluation on the potential injury, fatality, or other risk to individual persons.
In an environment where articles need to be adjusted using a wired or wireless remote control, actuators may be used switched by relays. Especially when the articles comprise hospital patient table, safety concerns take a high priority. In a typical embodiment, a micro-controller scans the inputs of a keyboard of a wireless remote control and/or a footswitch that is used to control a movable patient table. When a person controls the remote an output of its microprocessor will control a relay. Typically, a micro-controller in a remote control could get in an error situation. When an output would get stuck the patient table could then move uncontrollable something that can be very dangerous and must be prevented.
When a micro-controller is connected to a relay an error analysis is difficult to perform as semiconductors and software are involved. For this reason an error or a fault condition is not always detectable. In case of safety relevant applications, this is a serious problem. When an error condition would occur however, it is desirable that any movement will stop immediately to prevent any damage, or worse, patient harm.
It is also desirable to use components in a fail-safe system that are known from the past and that have a well known (reliable) behaviour.
SUMMARY OF THE INVENTION
It is, accordingly, an object of the present invention to provide a safety interface for a remote control.
It is another object of the invention to provide the safety filter for the remote control to adjust a patient table that will cause any movement to halt in case an error condition has been detected.
In one embodiment, a micro-controller is controlling a relay using a safety filter.
In another embodiment, the safety filter comprises a band-filter that outputs a relay control activation signal only when the micro-controller outputs a signal with a main component that lies within a certain frequency range. In a preferred embodiment, the safety filter comprises a transformer that is known from the past to be reliable enough to be used in fail-safe systems.
In another embodiment present invention provides an adjustable patient table (100) comprising a fail-safe wireless remote control for controlling an actuator to adjust the table.
In a preferred embodiment the invention provides a remote control (160) for controlling a safety relevant function. It comprises a first user input signal path and a second user input signal path, a transmitter (110) for transmitting a first signal from the first signal path and a second signal from the second signal path, a receiver (120) for receiving the first signal and the second signal, a first switch control that in response of a validated first signal can output a first switch control output signal, a second switch control comprising a safety filter (150) that in response of a validated second signal can output a second switch control output signal. The safety relevant function can only be activated when the first switch control outputs a validated first switch control output signal and the safety filter outputs a validated second switch control output signal.
These and other aspects of the invention will be apparent from and will be elucidated with reference to the embodiments described hereinafter. DESCRIPTION OF THE DRAWINGS
The present invention will now be described in more detail, by way of example, with reference to the accompanying drawings, wherein:
Fig. 1 shows a block-diagram of a remote control system 160 in a safety relevant system 100 in accordance with the invention;
Fig. 2 shows a best mode implementation of a safety filter 150 for use in the remote control system 100 in a safety relevant system 100 in accordance with the invention;
Fig. 3 shows the frequency response of safety filter 150 and the relay 170 sensitivity with respect to the safety filter response in accordance of a best mode embodiment in accordance with the invention.
Throughout the drawings, the same reference numeral refers to the same element, or an element that performs substantially the same function.
DETAILED DESCRIPTION OF THE INVENTION
Fig. 1 shows a block-diagram of a remote control system 160 in a safety relevant system 100 in accordance with the invention. System 100 comprises a keyboard scanner 102, a footswitch 104 (with open contacts on off-state), remote control system 160, and safety relevant device 190. Remote control system 160 comprises a dual executed and redundant signal path (visualized as 1st 103 and 2nd 105) and comprises microcontroller 106, 108, 122, 124, transmitter 110, transmission path 115, receiver 120, relay switch driver 144, amplifier 140 and safety filter 150. Device 190 comprises relays 170 and 172 and motor 180. Motor 180 can only be activated when both relays 170 and 172 are activated. Relay 170 can only be activated with a validated first switch control signal 153 and relay 172 can only be activated with a validated second switch control signal 155.
An example of device 190 is a patient table that can, e.g., be moved up and down using motor 180 as part of an actuator. However any movement will abruptly be stopped when system 100 would get into an error condition by at least de-activating relay 170 or relay 172, which would otherwise pose a hazardous situation for, e.g., a patient lying on the table.
To safely control a function in the safety relevant system 100, a control line is typically be executed double, the second being redundant to the first one. This starts with footswitch 104 and keyboard 102 that have two outputs lines per function. Microcontrollers 106 and 108 check the integrity of the signal on 1st 103 and the signal on 2nd 105 and they check each other status as well. In case of any fault condition, microcontroller will not output a signal that could effect an action. Another task of microcontrollers 106 and 108 is to prepare their respective input signals for transmission my transmitter 110. Receiver 120 will receive a multiplex of the transmitted signals and will separate them in respective output signals to microcontrollers 122 and 124. Transmission path 115 can be wireless (e.g., radio frequent, RF), infra-red (IR), or cable conducted (e.g., with the 1st and the 2nd signal modulated on one and the same conducting carrier). Microcontrollers 122 and 124 will check the integrity of each respective input signal and will check each other on a fault condition as well (by preferably a handshake). If again no error condition has been detected microcontroller 122 will output a first control signal 126 for relay switch driver 144. Also if again no error condition has been detected microcontroller 122 will output a second control signal 128 to amplifier 140. Second control signal 128 comprises a periodic pulse train signal (with a block form shape) with a ground frequency component between Fl and F2, typically FO. The idea is that when microcontroller would be in an error condition, it would not be able to output such a, typically software generated, block form shaped signal. Fl will be larger than 0 Hz and F2 will be smaller than the tact frequency of microcontroller 124.
The pulse train signal will be used to control relay 170. But before the pulse train reaches the relay it will pass amplifier 140 followed by (preferably narrow band) filter 150. Amplifier may be needed as the signal 128 coming from microcontroller 124 will typically not be powerful enough to drive relay 170 after passing filter 150. This band-pass filter only will output a substantial signal when the pulse-train has a main frequency component that matches the band-pass filter (so with Fl < frequency < F2).
Fig. 2 shows a best mode implementation of a safety filter 150 for use in the remote control system 100 in a safety relevant system 100 in accordance with the invention
Filter 150 includes LC Band pass filter 152 comprising capacitor CO and transformer TO, rectifier diode Dl and capacitor Cl. In active operation filter 150 will receive a block wave signal that will be band-pass filtered by a selection transformer comprising capacitor CO and transformer TO and then substantially rectified by diode Dl and capacitor Cl. The resulting DC-output signal will be powerful enough to close the switch by driving relay 170.
Fig. 3 shows the frequency response 310 of safety filter 150 and the relay 170 sensitivity 320 with respect to the safety filter response in accordance of a best mode embodiment in accordance with the invention. LC Band pass filter 152 acts as a narrow band filter with a characteristic as in 310. When a pulse train with a main frequency component with Fl < frequency < F2 is offered to filter 150 a DC signal will appear at the output of filter 150 that is large enough to activate relay switch 170. The filter rectifies the filtered pulse train by means of Dl and Cl. In case of an error condition (Software error or hardware error within the micro-controller), the dedicated frequency will not be transmitted by microcontroller 124. No Signal of a conspicuously higher or lower frequency than FO will substantially pass the (band-) filter and will not activate relay 170. Components CO, TO, Dl, and Cl should be chosen carefully and known to be highly reliable and predictable. As these components are passive, the number of error conditions that need to be taken into account for failure analysis is much limited and thus an operation in compliance with safety standards such as IEC 61508 can be realized.
To ensure a most reliable fail-safe operation, all components used in system 100 should be chosen to be reliable and simple. For that reason it is recommended to use as much as possible well-known and tested components. As the behavior of all these components is known, all error cases can be analyzed and simulated in the design phase.
The fail-safe wired or wireless remote control is very useful in a medical setting where cables can be hazardous and make operation of medical equipment awkward. The remote control can for instance be used for controlling movements of a patient table. That can for instance be useful when maneuvering the table to an medical system for examining a patient who is lying on the table. The remote control may well be used for controlling a vertical/horizontal movement of the patient table with a remote control in such a system the remote control can be applicated in a much wider area of use where safety concerns play a role.
One of ordinary skill in the art will recognize that alternative schemes can be devised to create a fail-safe remote control by making tweaks in the control and/or system described. For instance, pre-programmed state machines could replace microcontrollers 106, 108, 122 and 124. Instead of controlling a motor, also other functions could be switches using relays 170 and 172, such as activating an exposure of an X-ray machine or activating (or de- activating) any other function which use has safety regulations.
The foregoing merely illustrates the principles of the invention. It will thus be appreciated that those skilled in the art will be able to devise various arrangements which, although not explicitly described or shown herein, embody the principles of the invention and are thus within its spirit and scope.
For instance a multiple of independent footswitches and/or keyboard signal could be connected to microcontrollers 106 and 108 for controlling different (e.g., safety related) functions. Consequently microcontrollers 122 and 124 could output a multiple of signals for controlling the different functions. Per function a different safety filter 150 could be devised with a different pass band behavior.

Claims

CLAIMS:
1 A remote control (160) for controlling a safety relevant function comprising: a first input signal path and a second input signal path; a transmitter (110) for transmitting a first signal from the first signal path and a second signal from the second signal path; a receiver (120) for receiving the first signal and the second signal; a first switch control that can output a first switch control signal (153) in response to a first signal; a second switch control comprising a safety filter (150) that can output a second switch control signal (155) in response to a second signal, wherein the safety relevant function can only be activated when the first switch control outputs a validated first switch control signal (153) and the safety filter outputs a validated second switch control signal (155).
2 The remote control of claim 1, wherein the first switch control signal (153) can be coupled to a first switch for controlling the safety relevant function; the second switch control (155) can be coupled to a second switch for controlling the safety relevant function; and wherein - the safety filter (150) comprises a band-pass filter (152) comprising a transformer.
3 The remote control of claim 2, wherein at least one of the first and the second switch comprises a relay (170, 172). 4 The remote control of claims 1, 2 or 3, wherein the remote control comprises a wireless remote control.
5 A safety relevant system (100) including: - a device (190) comprising a motor (180) for adjusting the device; the remote control (160) of claims 1 and 2 for enabling an operator to adjust the device to a desired state, wherein the motor can only be activated when the validated first switch control signal (153) and the validated second switch control signal (155) are present.
6 The safety relevant system (100) of claim 5, wherein the remote control comprises a wireless remote control.
7 A safety relevant system (100) including: - a device (190) comprising a motor (180) for adjusting the device; and the remote control of claim 3 for enabling an operator to adjust the device to a desired state, wherein the motor can only be activated when the validated first switch control signal (153) activates the first switch and the validated second switch control signal (155) activates the second switch.
8 The safety relevant system (100) of claim 7 wherein at least one of the first and the second switch comprise a relay (170, 172).
9 The safety relevant system (100) of claim 8 wherein the device (190) comprises an adjustable patient table.
10 The safety relevant system (100) of claims 7, 8 or 9, wherein the remote control comprises a wireless remote control.
PCT/IB2006/051762 2005-06-07 2006-06-01 Fail-safe remote control WO2006131862A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE602006008611T DE602006008611D1 (en) 2005-06-07 2006-06-01 FAILSAFE REMOTE CONTROL
JP2008515345A JP5281396B2 (en) 2005-06-07 2006-06-01 Fail-safe remote control
AT06765713T ATE440353T1 (en) 2005-06-07 2006-06-01 FAIL-SAFE REMOTE CONTROL
US11/916,542 US8125309B2 (en) 2005-06-07 2006-06-01 Fail-safe remote control
EP06765713A EP1891617B1 (en) 2005-06-07 2006-06-01 Fail-safe remote control

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05104915.3 2005-06-07
EP05104915 2005-06-07

Publications (2)

Publication Number Publication Date
WO2006131862A2 true WO2006131862A2 (en) 2006-12-14
WO2006131862A3 WO2006131862A3 (en) 2007-04-12

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PCT/IB2006/051762 WO2006131862A2 (en) 2005-06-07 2006-06-01 Fail-safe remote control

Country Status (7)

Country Link
US (1) US8125309B2 (en)
EP (1) EP1891617B1 (en)
JP (1) JP5281396B2 (en)
CN (1) CN100520850C (en)
AT (1) ATE440353T1 (en)
DE (1) DE602006008611D1 (en)
WO (1) WO2006131862A2 (en)

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DE602006008611D1 (en) 2009-10-01
EP1891617A2 (en) 2008-02-27
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EP1891617B1 (en) 2009-08-19
JP5281396B2 (en) 2013-09-04
US8125309B2 (en) 2012-02-28
CN101194297A (en) 2008-06-04
JP2008541978A (en) 2008-11-27
ATE440353T1 (en) 2009-09-15
CN100520850C (en) 2009-07-29

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