WO2007000651A1 - Pharmaceutical and cosmetic compositions containing colostrum, tocopherols, zinc oxide and hyaluronic acid - Google Patents

Pharmaceutical and cosmetic compositions containing colostrum, tocopherols, zinc oxide and hyaluronic acid Download PDF

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Publication number
WO2007000651A1
WO2007000651A1 PCT/IB2006/001757 IB2006001757W WO2007000651A1 WO 2007000651 A1 WO2007000651 A1 WO 2007000651A1 IB 2006001757 W IB2006001757 W IB 2006001757W WO 2007000651 A1 WO2007000651 A1 WO 2007000651A1
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
colostrum
hyaluronic acid
tocopherols
zinc oxide
Prior art date
Application number
PCT/IB2006/001757
Other languages
French (fr)
Inventor
Rosa Gobbi
Original Assignee
Bionest Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionest Ltd. filed Critical Bionest Ltd.
Publication of WO2007000651A1 publication Critical patent/WO2007000651A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/986—Milk; Derivatives thereof, e.g. butter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • This invention relates to pharmaceutical and cosmetic compositions containing colostrum, tocopherols, zinc oxide and hyaluronic acid for the treatment of skin disorders, sores, burns, diabetic lesions, rashes and the like.
  • Colostrum is known to have properties useful for the treatment of skin diseases such as acne, seborrhoeic dermatitis, irritations, dyskeratosis and the like (see, for example, IT 1265252 and IT 1264637).
  • the tocopherols are known for their cell antioxidant action.
  • Zinc oxide is widely used in dermatological formulations for its protective, astringent and antiseptic activity.
  • Hyaluronic acid is a natural mucopolysaccharide polymer with high viscosity and a molecular weight ranging between 50,000 and 8xlO 6 , obtainable from animal tissues or micro-organisms.
  • Hyaluronic acid and its salts have long been used in pharmaceutical and cosmetic formulations for their viscosity-controlling, healing, reparatory and protective properties. DESCRIPTION OF THE INVENTION
  • This invention relates to pharmaceutical and cosmetic compositions containing: a) colostrum; b) tocopherols; c) zinc oxide; d) hyaluronic acid or its salts; for the treatment of dermatological disorders, sores, burns, diabetic lesions, rashes and the like.
  • compositions according to the invention have an anti-irritant, emollient, soothing, decongestant, healing, sun filtering and sebum- normalising action, and repair the damage caused by sunlight, physical and chemical agents and atmospheric agents.
  • compositions according to the invention are therefore useful for the treatment of skin diseases such as seborrhoeic dermatitis and alopecia, sores, burns, rashes, diabetic lesions and the like.
  • the colostrum will be obtained from mammals such as cattle, horses and sheep. According to a preferred aspect of the invention, the colostrum will be of bovine origin.
  • the tocopherols will be chosen from vitamin E and vitamin E acetate.
  • the colostrum content of the compositions according to the invention will range between approximately 10 and 20% in weight of the composition.
  • the tocopherol content of the compositions according to the invention will range between approximately 0.1 and 2% in weight of the composition.
  • the zinc oxide content of the compositions according to the invention will range between approximately 10 and 20% in weight of the composition.
  • Hyaluronic acid or its salts preferably sodium hyaluronan
  • the compositions according to the invention can be formulated in a way suitable for topical administration, and will be prepared according to conventional methods well known in pharmaceutical technology, such as those described in "Remington's Pharmaceutical Handbook", Mack Publishing Co., N. Y., USA, using excipients and diluents conventionally employed in the preparation of pharmaceutical and cosmetic formulations, such as thickeners, emulsifiers, detergents, surfactants, preservatives, perfumes, etc..
  • formulations according to the invention are ointments, creams, lotions, gels, tonic lotions, emulsions, foams, milks, dusting powders, occlusive plasters with Hydrogel, and the like.
  • compositions according to the invention may contain other active constituents with a complementary or otherwise useful activity, such as anti-inflammatory, antibacterial, moisturising, emollient, healing and repair agents, and plant extracts such as Edera helix, Centella asiatica, borage, calendula, sage, rosemary, vegetable oils, pineapple, seaweed, papaya, bilberry, sweet chestnut, red vine, mallow, elastin, collagen, witch hazel, wheatgerm, carrot, green clay, thyme, propolis, etc.
  • active constituents with a complementary or otherwise useful activity such as anti-inflammatory, antibacterial, moisturising, emollient, healing and repair agents, and plant extracts such as Edera helix, Centella asiatica, borage, calendula, sage, rosemary, vegetable oils, pineapple, seaweed, papaya, bilberry, sweet chestnut, red vine, mallow, elastin, collagen, witch hazel, wheatgerm, carrot, green clay, thyme
  • compositions according to the invention are some examples of compositions according to the invention.
  • Hyaluronic acid sodium hyaluronan 0.6%
  • Hyaluronic acid sodium hyaluronan 0.8% Beeswax 10%

Abstract

This invention relates to pharmaceutical and cosmetic compositions containing colostrum, tocopherols, zinc oxide and hyaluronic acid for the treatment of skin disorders, sores, burns, rashes and the like.

Description

PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING COLOSTRUM, TOCOPHEROLS, ZINC OXIDE AND HYALURONIC ACID
FIELD OF INVENTION
This invention relates to pharmaceutical and cosmetic compositions containing colostrum, tocopherols, zinc oxide and hyaluronic acid for the treatment of skin disorders, sores, burns, diabetic lesions, rashes and the like. PRIOR ART
Colostrum is known to have properties useful for the treatment of skin diseases such as acne, seborrhoeic dermatitis, irritations, dyskeratosis and the like (see, for example, IT 1265252 and IT 1264637).
The tocopherols are known for their cell antioxidant action. Zinc oxide is widely used in dermatological formulations for its protective, astringent and antiseptic activity.
Hyaluronic acid is a natural mucopolysaccharide polymer with high viscosity and a molecular weight ranging between 50,000 and 8xlO6, obtainable from animal tissues or micro-organisms. Hyaluronic acid and its salts have long been used in pharmaceutical and cosmetic formulations for their viscosity-controlling, healing, reparatory and protective properties. DESCRIPTION OF THE INVENTION
This invention relates to pharmaceutical and cosmetic compositions containing: a) colostrum; b) tocopherols; c) zinc oxide; d) hyaluronic acid or its salts; for the treatment of dermatological disorders, sores, burns, diabetic lesions, rashes and the like.
The compositions according to the invention have an anti-irritant, emollient, soothing, decongestant, healing, sun filtering and sebum- normalising action, and repair the damage caused by sunlight, physical and chemical agents and atmospheric agents.
The compositions according to the invention are therefore useful for the treatment of skin diseases such as seborrhoeic dermatitis and alopecia, sores, burns, rashes, diabetic lesions and the like.
It has now surprisingly been found that a combination of the constituents of the compositions according to the invention produces far superior effects to the separate administration of each individual component, probably due to a synergic action between said constituents.
According to the invention, the colostrum will be obtained from mammals such as cattle, horses and sheep. According to a preferred aspect of the invention, the colostrum will be of bovine origin.
According to a preferred aspect of the invention, the tocopherols will be chosen from vitamin E and vitamin E acetate.
According to a preferred aspect of the invention, the colostrum content of the compositions according to the invention will range between approximately 10 and 20% in weight of the composition.
According to a preferred aspect of the invention, the tocopherol content of the compositions according to the invention will range between approximately 0.1 and 2% in weight of the composition.
According to a preferred aspect of the invention, the zinc oxide content of the compositions according to the invention will range between approximately 10 and 20% in weight of the composition.
Hyaluronic acid or its salts, preferably sodium hyaluronan, will be present in concentrations ranging between approximately 0.5 and 0.8% in weight. The compositions according to the invention can be formulated in a way suitable for topical administration, and will be prepared according to conventional methods well known in pharmaceutical technology, such as those described in "Remington's Pharmaceutical Handbook", Mack Publishing Co., N. Y., USA, using excipients and diluents conventionally employed in the preparation of pharmaceutical and cosmetic formulations, such as thickeners, emulsifiers, detergents, surfactants, preservatives, perfumes, etc..
Examples of formulations according to the invention are ointments, creams, lotions, gels, tonic lotions, emulsions, foams, milks, dusting powders, occlusive plasters with Hydrogel, and the like.
Moreover, the compositions according to the invention may contain other active constituents with a complementary or otherwise useful activity, such as anti-inflammatory, antibacterial, moisturising, emollient, healing and repair agents, and plant extracts such as Edera helix, Centella asiatica, borage, calendula, sage, rosemary, vegetable oils, pineapple, seaweed, papaya, bilberry, sweet chestnut, red vine, mallow, elastin, collagen, witch hazel, wheatgerm, carrot, green clay, thyme, propolis, etc..
The methods and frequency of application will obviously depend on the type of formulation and the required effect, but broadly speaking could be 1 to 3 times a day or more.
The following are some examples of compositions according to the invention.
EXAMPLE 1
Body cream
INGREDIENTS percentages in weight
Bovine colostrum 15%
Tocopherol acetate 1%
ZnO 10% Hyaluronic acid (sodium hyaluronan) 0.6%
Wheatgerm oil 10%
Karite butter 3%
Sodium lactate 2% Glycerol 2%
Water q.b.
EXAMPLE 2
Dermatological cream for the treatment of bedsores, diabetes sores, rashes and burns INGREDIENTS percentages in weight
Bovine colostrum 20%
ZnO 15%
Tocopherol acetate 2%
Hyaluronic acid (sodium hyaluronan) 0.8% Beeswax 10%
Wheatgerm oil 10%
Panthenol 3%
Water q.b.

Claims

1. Topical pharmaceutical and cosmetic compositions containing: a) colostrum; b) tocopherols; c) zinc oxide; d) hyaluronic acid or its salts.
2. Compositions as claimed in claim 1, containing colostrum originating from mammals chosen from among cattle, horses and sheep.
3. Compositions as claimed in claim 2, wherein the colostrum is of bovine origin.
4. Compositions as claimed in claim 1, wherein the tocopherols are chosen from among vitamin E and vitamin E acetate.
5. Compositions as claimed in claims 1-3, wherein the colostrum content ranges between 10 and 20% in weight of the composition.
6. Compositions as claimed in the preceding claims, wherein the tocopherol content ranges between 0.1 and 2% of the weight of the composition.
7. Compositions as claimed in the preceding claims, wherein the zinc oxide content ranges between 10 and 20% of the weight of the composition.
8. Compositions as claimed in the preceding claims, wherein the content of hyaluronic acid or its salts ranges between 0.5 and 0.8% of the weight of the composition.
9. Compositions as claimed in the preceding claims, in the form of ointments, creams, lotions, gels, tonic lotions, emulsions, foams, milks, dusting powders, occlusive plasters, and occlusive plasters with Hydrogel.
10. Use of a combination of: a) colostrum; b) tocopherols; c) zinc oxide; d) hyaluronic acid or its salts; to prepare compositions for the treatment of skin disorders, sores, burns, diabetic lesions and rashes.
PCT/IB2006/001757 2005-06-29 2006-06-27 Pharmaceutical and cosmetic compositions containing colostrum, tocopherols, zinc oxide and hyaluronic acid WO2007000651A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2005A001230 2005-06-29
ITMI20051230 ITMI20051230A1 (en) 2005-06-29 2005-06-29 PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING COLOSTRO TOCOFEROLI ZINC OXIDE AND HYALURONIC ACID

Publications (1)

Publication Number Publication Date
WO2007000651A1 true WO2007000651A1 (en) 2007-01-04

Family

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PCT/IB2006/001757 WO2007000651A1 (en) 2005-06-29 2006-06-27 Pharmaceutical and cosmetic compositions containing colostrum, tocopherols, zinc oxide and hyaluronic acid

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IT (1) ITMI20051230A1 (en)
WO (1) WO2007000651A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010028652A1 (en) 2008-09-12 2010-03-18 Nanoko A/S Colostrum composition
ITMI20112444A1 (en) * 2011-12-30 2013-07-01 Bionest Ltd COMPOSITIONS FOR TISSUE REPAIR INCLUDING CYTOKINES, GROWTH AND RNA FACTORS
ITMI20112445A1 (en) * 2011-12-30 2013-07-01 Bionest Ltd USE OF CYTOCHINES, GROWTH FACTORS, ANTIBACTERIAL FACTORS AND ANTIBODIES, FOR THE TOPIC THERAPY OF ULCERS, PLEASURES AND SKIN BURNS
ITMI20112438A1 (en) * 2011-12-30 2013-07-01 Bionest Ltd INJECTABLE FORMULATIONS OF CYTOKINES, GROWTH FACTORS, CHEMOTACTIC FACTORS, STAMINAL STIMULATION FATORS AND RNA FOR DERMA REGENERATION
RU2560844C2 (en) * 2009-12-21 2015-08-20 Профешнл Дайететикс С.Р.Л. Combination for treating osteoarthritis
RU2645082C2 (en) * 2011-12-30 2018-02-15 Инномед С.А. COMBINATION OF GROWTH FACTORS, CYTOKINES, ANTIBACTERIAL/ANTIVIRAL FACTORS, STEM CELL FACTORS, C3a/C4a COMPLEMENT PROTEINS AND CHEMOTAXIC FACTORS
US20210290737A1 (en) * 2018-07-20 2021-09-23 Semiocare Sas Compositions for cosmetic and dermatological use

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010195A1 (en) * 1990-12-06 1992-06-25 Skandigen Ab Cell proliferation matrix and use thereof
WO1995000155A1 (en) * 1993-06-23 1995-01-05 Viable Bioproducts Ltd. Method for the improvement of wound healing and compositions therefor
EP1270013A1 (en) * 2000-02-15 2003-01-02 AlphaMed Pharmaceuticals Corporation Topical wound healing compositions comprising hyaluronic acid and a serine protease inhibitor
US20030158165A1 (en) * 2001-03-06 2003-08-21 Wilk J. Ronald Wound treatment solution and method for using same
WO2003103705A1 (en) * 2002-06-06 2003-12-18 Gropep Limited Metalloproteinase inhibitors
UA54055C2 (en) * 2002-04-26 2004-12-15 Inst Problems Of Cryobiology & Cryomedicine Cryosplin: wound healing remedy
JP2005060233A (en) * 2003-08-08 2005-03-10 Rohto Pharmaceut Co Ltd External preparation for skin

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010195A1 (en) * 1990-12-06 1992-06-25 Skandigen Ab Cell proliferation matrix and use thereof
WO1995000155A1 (en) * 1993-06-23 1995-01-05 Viable Bioproducts Ltd. Method for the improvement of wound healing and compositions therefor
EP1270013A1 (en) * 2000-02-15 2003-01-02 AlphaMed Pharmaceuticals Corporation Topical wound healing compositions comprising hyaluronic acid and a serine protease inhibitor
US20030158165A1 (en) * 2001-03-06 2003-08-21 Wilk J. Ronald Wound treatment solution and method for using same
UA54055C2 (en) * 2002-04-26 2004-12-15 Inst Problems Of Cryobiology & Cryomedicine Cryosplin: wound healing remedy
WO2003103705A1 (en) * 2002-06-06 2003-12-18 Gropep Limited Metalloproteinase inhibitors
JP2005060233A (en) * 2003-08-08 2005-03-10 Rohto Pharmaceut Co Ltd External preparation for skin

Non-Patent Citations (2)

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Title
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; "Cryosplin: wound healing remedy", XP002401523 *
DATABASE WPI Week 200522, Derwent World Patents Index; AN 2005-206057, XP002401504 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010028652A1 (en) 2008-09-12 2010-03-18 Nanoko A/S Colostrum composition
US8637075B2 (en) 2008-09-12 2014-01-28 Pharma Gp Aps Colostrum composition
RU2560844C2 (en) * 2009-12-21 2015-08-20 Профешнл Дайететикс С.Р.Л. Combination for treating osteoarthritis
ITMI20112444A1 (en) * 2011-12-30 2013-07-01 Bionest Ltd COMPOSITIONS FOR TISSUE REPAIR INCLUDING CYTOKINES, GROWTH AND RNA FACTORS
ITMI20112445A1 (en) * 2011-12-30 2013-07-01 Bionest Ltd USE OF CYTOCHINES, GROWTH FACTORS, ANTIBACTERIAL FACTORS AND ANTIBODIES, FOR THE TOPIC THERAPY OF ULCERS, PLEASURES AND SKIN BURNS
ITMI20112438A1 (en) * 2011-12-30 2013-07-01 Bionest Ltd INJECTABLE FORMULATIONS OF CYTOKINES, GROWTH FACTORS, CHEMOTACTIC FACTORS, STAMINAL STIMULATION FATORS AND RNA FOR DERMA REGENERATION
RU2645082C2 (en) * 2011-12-30 2018-02-15 Инномед С.А. COMBINATION OF GROWTH FACTORS, CYTOKINES, ANTIBACTERIAL/ANTIVIRAL FACTORS, STEM CELL FACTORS, C3a/C4a COMPLEMENT PROTEINS AND CHEMOTAXIC FACTORS
US20210290737A1 (en) * 2018-07-20 2021-09-23 Semiocare Sas Compositions for cosmetic and dermatological use

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