WO2007008300A3 - Triblock copolymers for cytoplasmic delivery of gene-based drugs - Google Patents

Triblock copolymers for cytoplasmic delivery of gene-based drugs Download PDF

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Publication number
WO2007008300A3
WO2007008300A3 PCT/US2006/020760 US2006020760W WO2007008300A3 WO 2007008300 A3 WO2007008300 A3 WO 2007008300A3 US 2006020760 W US2006020760 W US 2006020760W WO 2007008300 A3 WO2007008300 A3 WO 2007008300A3
Authority
WO
WIPO (PCT)
Prior art keywords
block
gene
triblock copolymers
based drugs
cytoplasmic delivery
Prior art date
Application number
PCT/US2006/020760
Other languages
French (fr)
Other versions
WO2007008300A2 (en
Inventor
Tatiana Segura
Jeffrey A Hubbell
Original Assignee
Ecole Polytech
Tatiana Segura
Jeffrey A Hubbell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecole Polytech, Tatiana Segura, Jeffrey A Hubbell filed Critical Ecole Polytech
Priority to EP06799931.8A priority Critical patent/EP1891141B1/en
Priority to JP2008514756A priority patent/JP5329949B2/en
Priority to US11/916,252 priority patent/US9505867B2/en
Publication of WO2007008300A2 publication Critical patent/WO2007008300A2/en
Publication of WO2007008300A3 publication Critical patent/WO2007008300A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F297/00—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
    • C08F297/02—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L53/005—Modified block copolymers

Abstract

The invention features a triblock copolymer including a hydrophilic block; a hydrophobic block; and a positively charged block capable of reversibly complexing a negatively charged molecule, e.g., a nucleic acid, wherein the hydrophobic block is disposed between the hydrophilic block and the positively charged block. Desirably, the triblock copolymer is capable of self-assembling into a supramolecular structure, such as a micelle or vesicle. The invention further features methods of delivering negatively charged molecules and methods of treating a disease or condition using the polymers of the invention.
PCT/US2006/020760 2005-05-31 2006-05-31 Triblock copolymers for cytoplasmic delivery of gene-based drugs WO2007008300A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06799931.8A EP1891141B1 (en) 2005-05-31 2006-05-31 Triblock copolymers for cytoplasmic delivery of gene-based drugs
JP2008514756A JP5329949B2 (en) 2005-05-31 2006-05-31 Triblock copolymers for cytoplasmic delivery of gene-based drugs
US11/916,252 US9505867B2 (en) 2005-05-31 2006-05-31 Triblock copolymers for cytoplasmic delivery of gene-based drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68618805P 2005-05-31 2005-05-31
US60/686,188 2005-05-31

Publications (2)

Publication Number Publication Date
WO2007008300A2 WO2007008300A2 (en) 2007-01-18
WO2007008300A3 true WO2007008300A3 (en) 2007-06-14

Family

ID=37637653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/020760 WO2007008300A2 (en) 2005-05-31 2006-05-31 Triblock copolymers for cytoplasmic delivery of gene-based drugs

Country Status (4)

Country Link
US (1) US9505867B2 (en)
EP (2) EP1891141B1 (en)
JP (1) JP5329949B2 (en)
WO (1) WO2007008300A2 (en)

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US9314535B2 (en) 2009-09-03 2016-04-19 Curevac Ag Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
US9518087B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US11965000B2 (en) 2013-08-21 2024-04-23 CureVac SE Respiratory syncytial virus (RSV) vaccine

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