WO2007008894A3 - Cyclosporin compositions - Google Patents

Cyclosporin compositions Download PDF

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Publication number
WO2007008894A3
WO2007008894A3 PCT/US2006/026881 US2006026881W WO2007008894A3 WO 2007008894 A3 WO2007008894 A3 WO 2007008894A3 US 2006026881 W US2006026881 W US 2006026881W WO 2007008894 A3 WO2007008894 A3 WO 2007008894A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclosporin compositions
cyclosporin
compositions
surfactant
useful
Prior art date
Application number
PCT/US2006/026881
Other languages
French (fr)
Other versions
WO2007008894A2 (en
Inventor
James N Chang
Orest Olejnik
Bruce A Firestone
Original Assignee
Allergan Inc
James N Chang
Orest Olejnik
Bruce A Firestone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/181,409 external-priority patent/US20070015691A1/en
Priority claimed from US11/181,187 external-priority patent/US7276476B2/en
Priority claimed from US11/181,178 external-priority patent/US7297679B2/en
Priority claimed from US11/181,509 external-priority patent/US20070015693A1/en
Priority claimed from US11/181,428 external-priority patent/US7202209B2/en
Priority to CA002602452A priority Critical patent/CA2602452A1/en
Priority to EP06786892A priority patent/EP1901711A2/en
Priority to AU2006268264A priority patent/AU2006268264A1/en
Priority to BRPI0613533-1A priority patent/BRPI0613533A2/en
Application filed by Allergan Inc, James N Chang, Orest Olejnik, Bruce A Firestone filed Critical Allergan Inc
Priority to US11/917,448 priority patent/US8288348B2/en
Priority to JP2008521528A priority patent/JP2009501228A/en
Publication of WO2007008894A2 publication Critical patent/WO2007008894A2/en
Publication of WO2007008894A3 publication Critical patent/WO2007008894A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Abstract

Cyclosporin A compositions are disclosed herein comprising an oil and a surfactant. These are useful in the treatment of dry eye disease.
PCT/US2006/026881 2005-07-13 2006-07-12 Cyclosporin compositions WO2007008894A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008521528A JP2009501228A (en) 2005-07-13 2006-07-12 Cyclosporine composition
US11/917,448 US8288348B2 (en) 2005-07-13 2006-07-12 Cyclosporin compositions
CA002602452A CA2602452A1 (en) 2005-07-13 2006-07-12 Cyclosporin compositions
BRPI0613533-1A BRPI0613533A2 (en) 2005-07-13 2006-07-12 cyclosporine compositions
AU2006268264A AU2006268264A1 (en) 2005-07-13 2006-07-12 Cyclosporin compositions
EP06786892A EP1901711A2 (en) 2005-07-13 2006-07-12 Cyclosporin compositions

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US11/181,409 US20070015691A1 (en) 2005-07-13 2005-07-13 Cyclosporin compositions
US11/181,428 US7202209B2 (en) 2005-07-13 2005-07-13 Cyclosporin compositions
US11/181,509 US20070015693A1 (en) 2005-07-13 2005-07-13 Cyclosporin compositions
US11/181,178 US7297679B2 (en) 2005-07-13 2005-07-13 Cyclosporin compositions
US11/181,509 2005-07-13
US11/181,409 2005-07-13
US11/181,187 US7276476B2 (en) 2005-07-13 2005-07-13 Cyclosporin compositions
US11/181,428 2005-07-13
US11/181,178 2005-07-13
US11/181,187 2005-07-13

Publications (2)

Publication Number Publication Date
WO2007008894A2 WO2007008894A2 (en) 2007-01-18
WO2007008894A3 true WO2007008894A3 (en) 2007-06-28

Family

ID=37496860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/026881 WO2007008894A2 (en) 2005-07-13 2006-07-12 Cyclosporin compositions

Country Status (7)

Country Link
US (2) US7288520B2 (en)
EP (1) EP1901711A2 (en)
JP (1) JP2009501228A (en)
AU (1) AU2006268264A1 (en)
BR (1) BRPI0613533A2 (en)
CA (1) CA2602452A1 (en)
WO (1) WO2007008894A2 (en)

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US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US8288348B2 (en) * 2005-07-13 2012-10-16 Allergan, Inc. Cyclosporin compositions
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
AU2016203191B2 (en) * 2006-07-25 2018-03-01 Allergan, Inc. Cyclosporin compositions
US8536190B2 (en) * 2007-01-30 2013-09-17 Allergan, Inc. Treating unwanted ocular conditions using an ascomycin macrolactam
MX2010003364A (en) 2007-10-08 2010-07-06 Lux Biosciences Inc Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors.
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US9480645B2 (en) * 2009-06-02 2016-11-01 Abbott Medical Optics Inc. Omega-3 oil containing ophthalmic emulsions
US20100305046A1 (en) * 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Stable cyclosporine containing ophthalmic emulsion for treating dry eyes
AU2014250656B2 (en) * 2009-06-02 2016-05-05 Johnson & Johnson Surgical Vision, Inc. Omega-3 oil containing ophthalmic emulsions
US20100303915A1 (en) * 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Therapeutic opthalmic emulsions
CA2764802A1 (en) 2009-06-05 2010-12-09 Allergan, Inc. Artificial tears and therapeutic uses
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EP3078385A1 (en) * 2010-05-25 2016-10-12 Allergan, Inc. Cyclosporin emulsions
WO2012015211A2 (en) * 2010-07-30 2012-02-02 주식회사종근당 Opthalmic formulation containing cyclosporine a
AU2011316690C1 (en) 2010-10-12 2017-01-19 Allergan, Inc. Cyclosporin analogs
EP2763649A2 (en) * 2011-10-05 2014-08-13 Allergan, Inc. Compositions for enhancing nail health
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
WO2013074625A1 (en) * 2011-11-15 2013-05-23 Allergan, Inc. Suspensions of cyclosporin a form 2
EP2779993B1 (en) 2011-11-15 2018-04-04 Allergan, Inc. Autoclavable suspensions of cyclosporin a form 2
SI2787969T1 (en) * 2011-12-07 2021-12-31 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US9278132B2 (en) * 2012-02-13 2016-03-08 Bausch & Lomb Incorporated Ophthalmic pharmaceutical compositions and methods of making and using same
WO2013181339A2 (en) 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
CN104602670A (en) * 2012-08-31 2015-05-06 博士伦公司 Ophthalmic compositions with omega-3 fatty acids
US9402913B2 (en) 2013-03-08 2016-08-02 Allergan, Inc. Cyclosporine A steroid conjugates
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
MA41462A (en) 2015-02-03 2021-05-12 Chiasma Inc METHOD OF TREATMENT OF DISEASES
US20180095929A1 (en) * 2016-09-30 2018-04-05 Intel Corporation Scratchpad memory with bank tiling for localized and random data access
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
WO2021049825A1 (en) * 2019-09-09 2021-03-18 주식회사태준제약 Nanoemulsion ophthalmic composition comprising cyclosporine and menthol, and preparation method thereof
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

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Also Published As

Publication number Publication date
JP2009501228A (en) 2009-01-15
WO2007008894A2 (en) 2007-01-18
EP1901711A2 (en) 2008-03-26
US7288520B2 (en) 2007-10-30
CA2602452A1 (en) 2007-01-18
US8211855B2 (en) 2012-07-03
US20070015694A1 (en) 2007-01-18
BRPI0613533A2 (en) 2011-01-18
AU2006268264A1 (en) 2007-01-18
US20080009436A1 (en) 2008-01-10

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