WO2007011601A3 - Cancer treatment using viruses, fluoropyrimidines and camptothecins - Google Patents

Cancer treatment using viruses, fluoropyrimidines and camptothecins Download PDF

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Publication number
WO2007011601A3
WO2007011601A3 PCT/US2006/027018 US2006027018W WO2007011601A3 WO 2007011601 A3 WO2007011601 A3 WO 2007011601A3 US 2006027018 W US2006027018 W US 2006027018W WO 2007011601 A3 WO2007011601 A3 WO 2007011601A3
Authority
WO
WIPO (PCT)
Prior art keywords
virus
fluoropyrimidines
camptothecins
viruses
cancer treatment
Prior art date
Application number
PCT/US2006/027018
Other languages
French (fr)
Other versions
WO2007011601A2 (en
Inventor
Robert M Lorence
Michael S Roberts
Original Assignee
Wellstat Biologics Corp
Robert M Lorence
Michael S Roberts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US11/913,362 priority Critical patent/US7767200B2/en
Application filed by Wellstat Biologics Corp, Robert M Lorence, Michael S Roberts filed Critical Wellstat Biologics Corp
Priority to JP2008521556A priority patent/JP5190958B2/en
Priority to NZ562951A priority patent/NZ562951A/en
Priority to EP06774644A priority patent/EP1907015B1/en
Priority to AU2006270297A priority patent/AU2006270297B2/en
Priority to CA2612949A priority patent/CA2612949C/en
Priority to CN2006800198745A priority patent/CN101400368B/en
Priority to MX2007015407A priority patent/MX2007015407A/en
Priority to AT06774644T priority patent/ATE540698T1/en
Publication of WO2007011601A2 publication Critical patent/WO2007011601A2/en
Priority to IL186730A priority patent/IL186730A0/en
Publication of WO2007011601A3 publication Critical patent/WO2007011601A3/en
Priority to US12/839,829 priority patent/US20110117060A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Mammalian subjects having a neoplasm are treated with a virus, a fluoropyrimidine, for example 5-fluorouracil, and a camptothecin compound. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus.
PCT/US2006/027018 2005-07-14 2006-07-12 Cancer treatment using viruses, fluoropyrimidines and camptothecins WO2007011601A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA2612949A CA2612949C (en) 2005-07-14 2006-07-12 Cancer treatment using viruses, fluoropyrimidines and camptothecins
JP2008521556A JP5190958B2 (en) 2005-07-14 2006-07-12 Treatment of cancer using viruses, fluoropyrimidine and camptothecin
NZ562951A NZ562951A (en) 2005-07-14 2006-07-12 Cancer treatment using a Newcastle disease virus, a fluoropyrimidine and a camptothecin combination
EP06774644A EP1907015B1 (en) 2005-07-14 2006-07-12 Cancer treatment using viruses, fluoropyrimidines and camptothecins
AU2006270297A AU2006270297B2 (en) 2005-07-14 2006-07-12 Cancer treatment using viruses, fluoropyrimidines and camptothecins
US11/913,362 US7767200B2 (en) 2005-07-14 2006-07-12 Cancer treatment using viruses, fluoropyrimidines and camptothecins
CN2006800198745A CN101400368B (en) 2005-07-14 2006-07-12 Cancer treatment using viruses, fluoropyrimidines and camptothecins
MX2007015407A MX2007015407A (en) 2005-07-14 2006-07-12 Cancer treatment using viruses, fluoropyrimidines and camptothecins.
AT06774644T ATE540698T1 (en) 2005-07-14 2006-07-12 CANCER TREATMENT WITH VIRUSES, FLUOROPYRIMIDINES AND CAMPTOTHECINES
IL186730A IL186730A0 (en) 2005-07-14 2007-10-17 Cancer treatment using viruses, fluoropyrimidines and camptothecins
US12/839,829 US20110117060A1 (en) 2005-07-14 2010-07-20 Cancer treatment using viruses, fluoropyrimidines and camptothecins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69919505P 2005-07-14 2005-07-14
US60/699,195 2005-07-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/839,829 Division US20110117060A1 (en) 2005-07-14 2010-07-20 Cancer treatment using viruses, fluoropyrimidines and camptothecins

Publications (2)

Publication Number Publication Date
WO2007011601A2 WO2007011601A2 (en) 2007-01-25
WO2007011601A3 true WO2007011601A3 (en) 2007-11-08

Family

ID=37669342

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027018 WO2007011601A2 (en) 2005-07-14 2006-07-12 Cancer treatment using viruses, fluoropyrimidines and camptothecins

Country Status (14)

Country Link
US (2) US7767200B2 (en)
EP (1) EP1907015B1 (en)
JP (1) JP5190958B2 (en)
KR (1) KR20080039344A (en)
CN (1) CN101400368B (en)
AT (1) ATE540698T1 (en)
AU (1) AU2006270297B2 (en)
CA (1) CA2612949C (en)
IL (1) IL186730A0 (en)
MX (1) MX2007015407A (en)
NZ (1) NZ562951A (en)
RU (1) RU2435586C2 (en)
WO (1) WO2007011601A2 (en)
ZA (1) ZA200708840B (en)

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US20070207149A1 (en) 2004-04-27 2007-09-06 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
US7900230B2 (en) * 2005-04-01 2011-03-01 The Directv Group, Inc. Intelligent two-way switching network
US7991348B2 (en) 2005-10-12 2011-08-02 The Directv Group, Inc. Triple band combining approach to satellite signal distribution
US8019275B2 (en) 2005-10-12 2011-09-13 The Directv Group, Inc. Band upconverter approach to KA/KU signal distribution
KR101585702B1 (en) * 2008-05-22 2016-01-15 제일약품주식회사 Tumor suppressor-based susceptibility of hyperproliferative cells to oncolytic viral therapy
EP2327764B1 (en) 2009-11-30 2011-12-28 United Cancer Research Institute New clone of Newcastle disease virus, its manufacture and its application in the medical treatment of cancer
RU2496873C1 (en) * 2012-06-04 2013-10-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (НГУ) STRAIN OF ENTEROVIRUS COXSACKIE B6 SELECTIVELY INFECTING AND LYSING TUMOROUS HUMAN CELLS in vitro
CN112773812A (en) * 2020-12-30 2021-05-11 烟台大学 Application of novel camptothecin derivative in preparation of antitumor drugs
CN112704683A (en) * 2020-12-30 2021-04-27 烟台大学 Novel camptothecin derivative and application thereof in preparing antitumor drugs

Citations (2)

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WO1994025627A1 (en) * 1993-04-30 1994-11-10 Lorence Robert M Methods of treating and detecting cancer using viruses
US20050147591A1 (en) * 1995-10-06 2005-07-07 Hallahan Dennis E. Methods and compositions for viral enhancement of cell killing

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US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
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ATE301659T1 (en) 1995-11-02 2005-08-15 Osi Pharm Inc METHOD FOR PRODUCING CAMPOTHECINE DERIVATIVES
GB9600438D0 (en) 1996-01-10 1996-03-13 Pharmacia Spa Hexacyclic camptothecin analogues, and process for preparing them
GB9601779D0 (en) 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
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Also Published As

Publication number Publication date
RU2435586C2 (en) 2011-12-10
CN101400368A (en) 2009-04-01
NZ562951A (en) 2011-09-30
JP5190958B2 (en) 2013-04-24
EP1907015A4 (en) 2009-03-18
RU2008105603A (en) 2009-08-20
CA2612949C (en) 2015-04-28
AU2006270297B2 (en) 2013-01-17
MX2007015407A (en) 2008-02-19
US20110117060A1 (en) 2011-05-19
KR20080039344A (en) 2008-05-07
US7767200B2 (en) 2010-08-03
WO2007011601A2 (en) 2007-01-25
EP1907015B1 (en) 2012-01-11
AU2006270297A1 (en) 2007-01-25
US20080193419A1 (en) 2008-08-14
CA2612949A1 (en) 2007-01-25
JP2009501230A (en) 2009-01-15
CN101400368B (en) 2012-10-03
IL186730A0 (en) 2008-02-09
EP1907015A2 (en) 2008-04-09
ATE540698T1 (en) 2012-01-15
ZA200708840B (en) 2008-08-27

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