WO2007015906A3 - Methods and compositions for smooth muscle reconstruction - Google Patents

Methods and compositions for smooth muscle reconstruction Download PDF

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Publication number
WO2007015906A3
WO2007015906A3 PCT/US2006/028040 US2006028040W WO2007015906A3 WO 2007015906 A3 WO2007015906 A3 WO 2007015906A3 US 2006028040 W US2006028040 W US 2006028040W WO 2007015906 A3 WO2007015906 A3 WO 2007015906A3
Authority
WO
WIPO (PCT)
Prior art keywords
smooth muscle
population
composition
compositions
provides
Prior art date
Application number
PCT/US2006/028040
Other languages
French (fr)
Other versions
WO2007015906A2 (en
Inventor
Larissa V Rodriguez
Ben Wu
Original Assignee
Univ California
Larissa V Rodriguez
Ben Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Larissa V Rodriguez, Ben Wu filed Critical Univ California
Publication of WO2007015906A2 publication Critical patent/WO2007015906A2/en
Publication of WO2007015906A3 publication Critical patent/WO2007015906A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Abstract

This invention also provides a purified or isolated population of ADSCs that can differentiate into a cell of the leiomyogenic lineage, e.g., smooth muscle or skeletal muscle. In yet another aspect, the population additionally can be differentiated into a lineage selected from the group consisting of osteogenic, adipogenic, chondrogenic, myogenic and neuronal. This invention further provides a composition comprising a substantially homogeneous expanded population of smooth muscle cells. This invention provides a composition comprising a substantially homogeneous expanded population of skeletal muscle cells. Also provided herein is an isolated composition comprising a purified adipose-derived stem cell (ADSC) or progeny of said ADSC and an effective amount of laminin or heparin, effective to induce leiomyogenic differentiation. Diagnostic and therapeutic uses for these compositions are provided herein.
PCT/US2006/028040 2005-07-29 2006-07-18 Methods and compositions for smooth muscle reconstruction WO2007015906A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/192,753 2005-07-29
US11/192,753 US7531355B2 (en) 2005-07-29 2005-07-29 Methods and compositions for smooth muscle reconstruction

Publications (2)

Publication Number Publication Date
WO2007015906A2 WO2007015906A2 (en) 2007-02-08
WO2007015906A3 true WO2007015906A3 (en) 2009-04-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/028040 WO2007015906A2 (en) 2005-07-29 2006-07-18 Methods and compositions for smooth muscle reconstruction

Country Status (2)

Country Link
US (1) US7531355B2 (en)
WO (1) WO2007015906A2 (en)

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Publication number Publication date
WO2007015906A2 (en) 2007-02-08
US7531355B2 (en) 2009-05-12
US20070025972A1 (en) 2007-02-01

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